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Items: 1 to 50 of 85

1.

Loss of gut barrier integrity triggers activation of islet-reactive T cells and autoimmune diabetes.

Sorini C, Cosorich I, Lo Conte M, De Giorgi L, Facciotti F, Lucianò R, Rocchi M, Ferrarese R, Sanvito F, Canducci F, Falcone M.

Proc Natl Acad Sci U S A. 2019 Jun 10. pii: 201814558. doi: 10.1073/pnas.1814558116. [Epub ahead of print]

2.

The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli.

Pedrotti S, Caccia R, Neguembor MV, Garcia-Manteiga JM, Ferri G, de Palma C, Canu T, Giovarelli M, Marra P, Fiocchi A, Molineris I, Raso M, Sanvito F, Doglioni C, Esposito A, Clementi E, Gabellini D.

Sci Adv. 2019 Apr 17;5(4):eaav1472. doi: 10.1126/sciadv.aav1472. eCollection 2019 Apr.

3.

Thrombus hallmarks reveal atherothrombotic stroke aetiology.

Semerano A, Genchi A, Callea M, Sanvito F, Simionato F, Panni P, Scomazzoni F, Doglioni C, Comi G, Falini A, Filippi M, Roveri L, Bacigaluppi M.

J Neurol. 2019 Jun;266(6):1533-1535. doi: 10.1007/s00415-019-09279-z. Epub 2019 Mar 19. No abstract available.

PMID:
30888500
4.

Multiple Integrated Non-clinical Studies Predict the Safety of Lentivirus-Mediated Gene Therapy for β-Thalassemia.

Lidonnici MR, Paleari Y, Tiboni F, Mandelli G, Rossi C, Vezzoli M, Aprile A, Lederer CW, Ambrosi A, Chanut F, Sanvito F, Calabria A, Poletti V, Mavilio F, Montini E, Naldini L, Cristofori P, Ferrari G.

Mol Ther Methods Clin Dev. 2018 Sep 13;11:9-28. doi: 10.1016/j.omtm.2018.09.001. eCollection 2018 Dec 14.

5.

Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells.

Norelli M, Camisa B, Barbiera G, Falcone L, Purevdorj A, Genua M, Sanvito F, Ponzoni M, Doglioni C, Cristofori P, Traversari C, Bordignon C, Ciceri F, Ostuni R, Bonini C, Casucci M, Bondanza A.

Nat Med. 2018 Jun;24(6):739-748. doi: 10.1038/s41591-018-0036-4. Epub 2018 May 28.

PMID:
29808007
6.

Role of human forkhead box P3 in early thymic maturation and peripheral T-cell homeostasis.

Santoni de Sio FR, Passerini L, Restelli S, Valente MM, Pramov A, Maccari ME, Sanvito F, Roncarolo MG, Porteus M, Bacchetta R.

J Allergy Clin Immunol. 2018 Dec;142(6):1909-1921.e9. doi: 10.1016/j.jaci.2018.03.015. Epub 2018 Apr 27. Erratum in: J Allergy Clin Immunol. 2019 Mar;143(3):1269.

PMID:
29705245
7.

Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1.

Schiroli G, Ferrari S, Conway A, Jacob A, Capo V, Albano L, Plati T, Castiello MC, Sanvito F, Gennery AR, Bovolenta C, Palchaudhuri R, Scadden DT, Holmes MC, Villa A, Sitia G, Lombardo A, Genovese P, Naldini L.

Sci Transl Med. 2017 Oct 11;9(411). pii: eaan0820. doi: 10.1126/scitranslmed.aan0820.

PMID:
29021165
8.

Generation of Human Induced Pluripotent Stem Cell-Derived Bona Fide Neural Stem Cells for Ex Vivo Gene Therapy of Metachromatic Leukodystrophy.

Meneghini V, Frati G, Sala D, De Cicco S, Luciani M, Cavazzin C, Paulis M, Mentzen W, Morena F, Giannelli S, Sanvito F, Villa A, Bulfone A, Broccoli V, Martino S, Gritti A.

Stem Cells Transl Med. 2017 Feb;6(2):352-368. doi: 10.5966/sctm.2015-0414. Epub 2016 Sep 16.

9.

The shedding-derived soluble receptor for advanced glycation endproducts sustains inflammation during acute Pseudomonas aeruginosa lung infection.

Antonelli A, Di Maggio S, Rejman J, Sanvito F, Rossi A, Catucci A, Gorzanelli A, Bragonzi A, Bianchi ME, Raucci A.

Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):354-364. doi: 10.1016/j.bbagen.2016.11.040. Epub 2016 Nov 30.

PMID:
27913191
10.

GM-3 Lactone Mimetic Interacts with CD4 and HIV-1 Env Proteins, Hampering HIV-1 Infection without Inducing a Histopathological Alteration.

Richichi B, Pastori C, Gherardi S, Venuti A, Cerreto A, Sanvito F, Toma L, Lopalco L, Nativi C.

ACS Infect Dis. 2016 Aug 12;2(8):564-71. doi: 10.1021/acsinfecdis.6b00056. Epub 2016 Jun 24.

PMID:
27626296
11.

Cutting Edge: IgE Plays an Active Role in Tumor Immunosurveillance in Mice.

Nigro EA, Brini AT, Yenagi VA, Ferreira LM, Achatz-Straussberger G, Ambrosi A, Sanvito F, Soprana E, van Anken E, Achatz G, Siccardi AG, Vangelista L.

J Immunol. 2016 Oct 1;197(7):2583-8. doi: 10.4049/jimmunol.1601026. Epub 2016 Aug 26.

12.

Serological immune response against ADAM10 pro-domain is associated with favourable prognosis in stage III colorectal cancer patients.

Álvarez-Fernández SM, Barbariga M, Cannizzaro L, Cannistraci CV, Hurley L, Zanardi A, Conti A, Sanvito F, Innocenzi A, Pecorelli N, Braga M, Alessio M.

Oncotarget. 2016 Nov 29;7(48):80059-80076. doi: 10.18632/oncotarget.11181.

13.

Lentiviral Vector Gene Therapy Protects XCGD Mice From Acute Staphylococcus aureus Pneumonia and Inflammatory Response.

Farinelli G, Jofra Hernandez R, Rossi A, Ranucci S, Sanvito F, Migliavacca M, Brombin C, Pramov A, Di Serio C, Bovolenta C, Gentner B, Bragonzi A, Aiuti A.

Mol Ther. 2016 Oct;24(10):1873-1880. doi: 10.1038/mt.2016.150. Epub 2016 Jul 26.

14.

Preclinical Testing of the Safety and Tolerability of Lentiviral Vector-Mediated Above-Normal Alpha-L-Iduronidase Expression in Murine and Human Hematopoietic Cells Using Toxicology and Biodistribution Good Laboratory Practice Studies.

Visigalli I, Delai S, Ferro F, Cecere F, Vezzoli M, Sanvito F, Chanut F, Benedicenti F, Spinozzi G, Wynn R, Calabria A, Naldini L, Montini E, Cristofori P, Biffi A.

Hum Gene Ther. 2016 Oct;27(10):813-829. doi: 10.1089/hum.2016.068.

PMID:
27431943
15.

Divergent in vitro/in vivo responses to drug treatments of highly aggressive NIH-Ras cancer cells: a PET imaging and metabolomics-mass-spectrometry study.

Gaglio D, Valtorta S, Ripamonti M, Bonanomi M, Damiani C, Todde S, Negri AS, Sanvito F, Mastroianni F, Di Campli A, Turacchio G, Di Grigoli G, Belloli S, Luini A, Gilardi MC, Colangelo AM, Alberghina L, Moresco RM.

Oncotarget. 2016 Aug 9;7(32):52017-52031. doi: 10.18632/oncotarget.10470.

16.

Early degeneration and endocarditis in a transcatheter heart valve.

Spartera M, Schiavo Lena M, Sanvito F, Colombo A.

Eur Heart J. 2016 Jul 21;37(28):2289. doi: 10.1093/eurheartj/ehw174. Epub 2016 May 8. No abstract available.

PMID:
27161610
17.

Pervasive supply of therapeutic lysosomal enzymes in the CNS of normal and Krabbe-affected non-human primates by intracerebral lentiviral gene therapy.

Meneghini V, Lattanzi A, Tiradani L, Bravo G, Morena F, Sanvito F, Calabria A, Bringas J, Fisher-Perkins JM, Dufour JP, Baker KC, Doglioni C, Montini E, Bunnell BA, Bankiewicz K, Martino S, Naldini L, Gritti A.

EMBO Mol Med. 2016 May 2;8(5):489-510. doi: 10.15252/emmm.201505850. Print 2016 May.

18.

Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs.

Akbarpour M, Goudy KS, Cantore A, Russo F, Sanvito F, Naldini L, Annoni A, Roncarolo MG.

Sci Transl Med. 2015 May 27;7(289):289ra81. doi: 10.1126/scitranslmed.aaa3032.

PMID:
26019217
19.

VIN usual type-from the past to the future.

Preti M, Igidbashian S, Costa S, Cristoforoni P, Mariani L, Origoni M, Sandri MT, Boveri S, Spolti N, Spinaci L, Sanvito F, Preti EP, Falasca A, Radici G, Micheletti L.

Ecancermedicalscience. 2015 Apr 29;9:531. doi: 10.3332/ecancer.2015.531. eCollection 2015. Review.

20.

Liver-directed lentiviral gene therapy in a dog model of hemophilia B.

Cantore A, Ranzani M, Bartholomae CC, Volpin M, Valle PD, Sanvito F, Sergi LS, Gallina P, Benedicenti F, Bellinger D, Raymer R, Merricks E, Bellintani F, Martin S, Doglioni C, D'Angelo A, VandenDriessche T, Chuah MK, Schmidt M, Nichols T, Montini E, Naldini L.

Sci Transl Med. 2015 Mar 4;7(277):277ra28. doi: 10.1126/scitranslmed.aaa1405.

21.

Anti-metastatic activity of the tumor vascular targeting agent NGR-TNF.

Di Matteo P, Mangia P, Tiziano E, Valentinis B, Porcellini S, Doglioni C, Sanvito F, Bordignon C, Rizzardi GP, Traversari C.

Clin Exp Metastasis. 2015 Mar;32(3):289-300. doi: 10.1007/s10585-015-9704-7. Epub 2015 Feb 4.

PMID:
25648442
22.

A novel AMPK activator reduces glucose uptake and inhibits tumor progression in a mouse xenograft model of colorectal cancer.

Valtorta S, Nicolini G, Tripodi F, Meregalli C, Cavaletti G, Avezza F, Crippa L, Bertoli G, Sanvito F, Fusi P, Pagliarin R, Orsini F, Moresco RM, Coccetti P.

Invest New Drugs. 2014 Dec;32(6):1123-33. doi: 10.1007/s10637-014-0148-8. Epub 2014 Aug 19.

PMID:
25134489
23.

The COP9 signalosome is a repressor of replicative stress responses and polyploidization in the regenerating liver.

Panattoni M, Maiorino L, Lukacs A, Zentilin L, Mazza D, Sanvito F, Sitia G, Guidotti LG, Pardi R.

Hepatology. 2014 Jun;59(6):2331-43. doi: 10.1002/hep.27028. Epub 2014 Apr 30.

PMID:
24452456
24.

Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo.

Cesana D, Ranzani M, Volpin M, Bartholomae C, Duros C, Artus A, Merella S, Benedicenti F, Sergi Sergi L, Sanvito F, Brombin C, Nonis A, Serio CD, Doglioni C, von Kalle C, Schmidt M, Cohen-Haguenauer O, Naldini L, Montini E.

Mol Ther. 2014 Apr;22(4):774-85. doi: 10.1038/mt.2014.3. Epub 2014 Jan 20.

25.

Induction of HIV-blocking anti-CCR5 IgA in Peyers's patches without histopathological alterations.

Pastori C, Diomede L, Venuti A, Fisher G, Jarvik J, Bomsel M, Sanvito F, Lopalco L.

J Virol. 2014 Apr;88(7):3623-35. doi: 10.1128/JVI.03663-13. Epub 2014 Jan 8.

26.

[Cardiovascular involvement in Erdheim-Chester syndrome: clinical and therapeutic implications].

Lauretta L, Dagna L, Alberti L, Loiacono F, De Cobelli F, Sanvito F, Moriggia S, Margonato A, Fragasso G.

Recenti Prog Med. 2013 Dec;104(12):637-42. doi: 10.1701/1373.15266. Italian.

PMID:
24362833
27.

Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4.

Volonté A, Di Tomaso T, Spinelli M, Todaro M, Sanvito F, Albarello L, Bissolati M, Ghirardelli L, Orsenigo E, Ferrone S, Doglioni C, Stassi G, Dellabona P, Staudacher C, Parmiani G, Maccalli C.

J Immunol. 2014 Jan 1;192(1):523-32. doi: 10.4049/jimmunol.1301342. Epub 2013 Nov 25.

28.

Comparison of 18F-fluoroazomycin-arabinofuranoside and 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) in preclinical models of cancer.

Valtorta S, Belloli S, Sanvito F, Masiello V, Di Grigoli G, Monterisi C, Fazio F, Picchio M, Moresco RM.

J Nucl Med. 2013 Jul;54(7):1106-12. doi: 10.2967/jnumed.112.111120. Epub 2013 May 22.

29.

Fowlpox-based survivin vaccination for malignant mesothelioma therapy.

Bertino P, Panigada M, Soprana E, Bianchi V, Bertilaccio S, Sanvito F, Rose AH, Yang H, Gaudino G, Hoffmann PR, Siccardi A, Carbone M.

Int J Cancer. 2013 Aug 1;133(3):612-23. doi: 10.1002/ijc.28048. Epub 2013 Feb 25.

30.

Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer.

Ranzani M, Cesana D, Bartholomae CC, Sanvito F, Pala M, Benedicenti F, Gallina P, Sergi LS, Merella S, Bulfone A, Doglioni C, von Kalle C, Kim YJ, Schmidt M, Tonon G, Naldini L, Montini E.

Nat Methods. 2013 Feb;10(2):155-61. doi: 10.1038/nmeth.2331. Epub 2013 Jan 13.

31.

RACK1 depletion in a mouse model causes lethality, pigmentation deficits and reduction in protein synthesis efficiency.

Volta V, Beugnet A, Gallo S, Magri L, Brina D, Pesce E, Calamita P, Sanvito F, Biffo S.

Cell Mol Life Sci. 2013 Apr;70(8):1439-50. doi: 10.1007/s00018-012-1215-y. Epub 2012 Dec 2.

PMID:
23212600
32.

Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice.

Cantore A, Nair N, Della Valle P, Di Matteo M, Màtrai J, Sanvito F, Brombin C, Di Serio C, D'Angelo A, Chuah M, Naldini L, Vandendriessche T.

Blood. 2012 Nov 29;120(23):4517-20. doi: 10.1182/blood-2012-05-432591. Epub 2012 Oct 4.

33.

Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID.

Sauer AV, Brigida I, Carriglio N, Hernandez RJ, Scaramuzza S, Clavenna D, Sanvito F, Poliani PL, Gagliani N, Carlucci F, Tabucchi A, Roncarolo MG, Traggiai E, Villa A, Aiuti A.

Blood. 2012 Feb 9;119(6):1428-39. doi: 10.1182/blood-2011-07-366781. Epub 2011 Dec 19.

34.

Polypoid atrial myxoma.

Grimaldi A, Fumero A, Taramasso M, Pappalardo F, Sanvito F, Ammirati E, Capritti E, Castiglioni A, Collu E, Pala MG, Zangrillo A, Alfieri O.

J Cardiovasc Med (Hagerstown). 2012 Aug;13(8):529-30. doi: 10.2459/JCM.0b013e32834ae647.

PMID:
22037712
35.

AAV6-mediated systemic shRNA delivery reverses disease in a mouse model of facioscapulohumeral muscular dystrophy.

Bortolanza S, Nonis A, Sanvito F, Maciotta S, Sitia G, Wei J, Torrente Y, Di Serio C, Chamberlain JR, Gabellini D.

Mol Ther. 2011 Nov;19(11):2055-64. doi: 10.1038/mt.2011.153. Epub 2011 Aug 9.

36.

Aseptic polyurethane carotid patch rejection: complication, allergy or miraculous healing?

Tshomba Y, De Dominicis D, Marone EM, Mascia D, Sanvito F, Chiesa R.

J Cardiovasc Surg (Torino). 2011 Dec;52(6):859-61. Epub 2011 Jul 13.

PMID:
21750481
37.

Absence of Rac1 and Rac3 GTPases in the nervous system hinders thymic, splenic and immune-competence development.

Basso V, Corbetta S, Gualdoni S, Tonoli D, Poliani PL, Sanvito F, Doglioni C, Mondino A, de Curtis I.

Eur J Immunol. 2011 May;41(5):1410-9. doi: 10.1002/eji.201040892. Epub 2011 Apr 15.

38.

Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase.

Acquati F, Bertilaccio S, Grimaldi A, Monti L, Cinquetti R, Bonetti P, Lualdi M, Vidalino L, Fabbri M, Sacco MG, van Rooijen N, Campomenosi P, Vigetti D, Passi A, Riva C, Capella C, Sanvito F, Doglioni C, Gribaldo L, Macchi P, Sica A, Noonan DM, Ghia P, Taramelli R.

Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1104-9. doi: 10.1073/pnas.1013746108. Epub 2010 Dec 28.

39.

Gene therapy augments the efficacy of hematopoietic cell transplantation and fully corrects mucopolysaccharidosis type I phenotype in the mouse model.

Visigalli I, Delai S, Politi LS, Di Domenico C, Cerri F, Mrak E, D'Isa R, Ungaro D, Stok M, Sanvito F, Mariani E, Staszewsky L, Godi C, Russo I, Cecere F, Del Carro U, Rubinacci A, Brambilla R, Quattrini A, Di Natale P, Ponder K, Naldini L, Biffi A.

Blood. 2010 Dec 9;116(24):5130-9. doi: 10.1182/blood-2010-04-278234. Epub 2010 Sep 16.

40.

Selective preservation of bone marrow mature recirculating but not marginal zone B cells in murine models of chronic inflammation.

Traggiai E, Casati A, Frascoli M, Porcellini S, Ponzoni M, Sanvito F, Leng L, Bucala R, Moretta L, Grassi F.

PLoS One. 2010 Jun 22;5(6):e11262. doi: 10.1371/journal.pone.0011262.

41.

Sentinel node detection by lymphoscintigraphy and sentinel lymph node biopsy in vulvar melanoma.

Trifirò G, Travaini LL, Sanvito F, Pacifici M, Mallia A, Ferrari ME, Vertua A, Maggioni A, Paganelli G, Sideri MG.

Eur J Nucl Med Mol Imaging. 2010 Apr;37(4):736-41. doi: 10.1007/s00259-009-1358-8. Epub 2010 Jan 27.

PMID:
20107788
42.

Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses.

Villablanca EJ, Raccosta L, Zhou D, Fontana R, Maggioni D, Negro A, Sanvito F, Ponzoni M, Valentinis B, Bregni M, Prinetti A, Steffensen KR, Sonnino S, Gustafsson JA, Doglioni C, Bordignon C, Traversari C, Russo V.

Nat Med. 2010 Jan;16(1):98-105. doi: 10.1038/nm.2074. Epub 2009 Dec 27.

PMID:
20037595
43.

Laser capture microdissection as a new tool to assess graft-infiltrating lymphocytes gene profile in islet transplantation.

Vergani A, Clissi B, Sanvito F, Doglioni C, Fiorina P, Pardi R.

Cell Transplant. 2009;18(8):827-32. doi: 10.3727/096368909X472278. Epub 2009 Sep 28.

PMID:
19785935
44.

Cardiotoxicity after low-dose chloroquine antimalarial therapy.

Fragasso G, Sanvito F, Baratto F, Martinenghi S, Doglioni C, Margonato A.

Heart Vessels. 2009 Sep;24(5):385-7. doi: 10.1007/s00380-008-1144-8. Epub 2009 Sep 27.

PMID:
19784824
45.

Corrigendum to "Evidence for Long-term Efficacy and Safety of Gene Therapy for Wiskott-Aldrich Syndrome in Preclinical Models".

Marangoni F, Bosticardo M, Charrier S, Draghici E, Locci M, Scaramuzza S, Panaroni C, Ponzoni M, Sanvito F, Doglioni C, Liabeuf M, Gjata B, Montus M, Siminovitch K, Aiuti A, Naldini L, Dupré L, Roncarolo MG, Galy A, Villa A.

Mol Ther. 2009 Jul;17(7):1300. doi: 10.1038/mt.2009.61. Epub 2016 Dec 6. No abstract available.

46.

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy.

Montini E, Cesana D, Schmidt M, Sanvito F, Bartholomae CC, Ranzani M, Benedicenti F, Sergi LS, Ambrosi A, Ponzoni M, Doglioni C, Di Serio C, von Kalle C, Naldini L.

J Clin Invest. 2009 Apr;119(4):964-75. doi: 10.1172/JCI37630. Epub 2009 Mar 23.

47.

Evidence for long-term efficacy and safety of gene therapy for Wiskott-Aldrich syndrome in preclinical models.

Marangoni F, Bosticardo M, Charrier S, Draghici E, Locci M, Scaramuzza S, Panaroni C, Ponzoni M, Sanvito F, Doglioni C, Liabeuf M, Gjata B, Montus M, Siminovitch K, Aiuti A, Naldini L, Dupré L, Roncarolo MG, Galy A, Villa A.

Mol Ther. 2009 Jun;17(6):1073-82. doi: 10.1038/mt.2009.31. Epub 2009 Mar 3. Erratum in: Mol Ther. 2009 Jul;17(7):1300.

48.

IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes.

Kaneko S, Mastaglio S, Bondanza A, Ponzoni M, Sanvito F, Aldrighetti L, Radrizzani M, La Seta-Catamancio S, Provasi E, Mondino A, Nagasawa T, Fleischhauer K, Russo V, Traversari C, Ciceri F, Bordignon C, Bonini C.

Blood. 2009 Jan 29;113(5):1006-15. doi: 10.1182/blood-2008-05-156059. Epub 2008 Oct 31.

49.

In vivo selection of genetically modified erythroblastic progenitors leads to long-term correction of beta-thalassemia.

Miccio A, Cesari R, Lotti F, Rossi C, Sanvito F, Ponzoni M, Routledge SJ, Chow CM, Antoniou MN, Ferrari G.

Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10547-52. doi: 10.1073/pnas.0711666105. Epub 2008 Jul 23.

50.

Prolonged islet allograft survival in diabetic mice upon macrophage depletion by clodronate-loaded erythrocytes.

Rossi L, Migliavacca B, Pierigé F, Serafini S, Sanvito F, Olivieri S, Nano R, Antonioli B, Magnani M, Bertuzzi F.

Transplantation. 2008 Feb 27;85(4):648-50. doi: 10.1097/TP.0b013e31816360f3.

PMID:
18347547

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