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Items: 29


Alginate encapsulant incorporating CXCL12 supports long-term allo- and xenoislet transplantation without systemic immune suppression.

Chen T, Yuan J, Duncanson S, Hibert ML, Kodish BC, Mylavaganam G, Maker M, Li H, Sremac M, Santosuosso M, Forbes B, Kashiwagi S, Cao J, Lei J, Thomas M, Hartono C, Sachs D, Markmann J, Sambanis A, Poznansky MC.

Am J Transplant. 2015 Mar;15(3):618-27. doi: 10.1111/ajt.13049.


Rosiglitazone promotes the differentiation of Langerhans cells and inhibits that of other dendritic cell types from CD133 positive hematopoietic precursors.

Bonetti MI, Bacci S, Santosuosso M, Mazzanti B, Aldinucci A, Ballerini C, Guasti D, Calosi L, Bosi A, Romagnoli P.

Histol Histopathol. 2014 Mar;29(3):323-32. doi: 10.14670/HH-29.323. Epub 2013 Jul 24.


Treatment of experimental esophagogastric myotomy with bone marrow mesenchymal stem cells in a rat model.

Mazzanti B, Lorenzi B, Lorenzoni P, Borghini A, Boieri M, Lorenzi M, Santosuosso M, Bosi A, Saccardi R, Weber E, Pessina F.

Neurogastroenterol Motil. 2013 Oct;25(10):e669-79. doi: 10.1111/nmo.12182. Epub 2013 Jul 17.


Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy.

Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, Jain RK, Poznansky MC.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17561-6. doi: 10.1073/pnas.1215397109. Epub 2012 Oct 8.


EphA2-mediated mesenchymal-amoeboid transition induced by endothelial progenitor cells enhances metastatic spread due to cancer-associated fibroblasts.

Giannoni E, Taddei ML, Parri M, Bianchini F, Santosuosso M, Grifantini R, Fibbi G, Mazzanti B, Calorini L, Chiarugi P.

J Mol Med (Berl). 2013 Jan;91(1):103-15. doi: 10.1007/s00109-012-0941-9. Epub 2012 Aug 19.


Endothelial progenitor cell-dependent angiogenesis requires localization of the full-length form of uPAR in caveolae.

Margheri F, Chillà A, Laurenzana A, Serratì S, Mazzanti B, Saccardi R, Santosuosso M, Danza G, Sturli N, Rosati F, Magnelli L, Papucci L, Calorini L, Bianchini F, Del Rosso M, Fibbi G.

Blood. 2011 Sep 29;118(13):3743-55. doi: 10.1182/blood-2011-02-338681. Epub 2011 Jul 29.


CXCL12/CXCR4 blockade induces multimodal antitumor effects that prolong survival in an immunocompetent mouse model of ovarian cancer.

Righi E, Kashiwagi S, Yuan J, Santosuosso M, Leblanc P, Ingraham R, Forbes B, Edelblute B, Collette B, Xing D, Kowalski M, Mingari MC, Vianello F, Birrer M, Orsulic S, Dranoff G, Poznansky MC.

Cancer Res. 2011 Aug 15;71(16):5522-5534. doi: 10.1158/0008-5472.CAN-10-3143. Epub 2011 Jul 8.


R5-SHIV induces multiple defects in T cell function during early infection of rhesus macaques including accumulation of T reg cells in lymph nodes.

Santosuosso M, Righi E, Hill ED, Leblanc PR, Kodish B, Mylvaganam HN, Siddappa NB, Stevceva L, Hu SL, Ghebremichael M, Chenine AL, Hovav AH, Ruprecht RM, Poznansky MC.

PLoS One. 2011 Apr 5;6(4):e18465. doi: 10.1371/journal.pone.0018465.


Human mesenchymal stromal cells preserve their stem features better when cultured in the Dulbecco's modified Eagle medium.

Pieri L, Urbani S, Mazzanti B, Dal Pozzo S, Santosuosso M, Saccardi R, Bosi A, Faussone-Pellegrini MS, Vannucchi MG.

Cytotherapy. 2011 May;13(5):539-48. doi: 10.3109/14653249.2010.542459. Epub 2011 Jan 3.


R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models.

Siddappa NB, Watkins JD, Wassermann KJ, Song R, Wang W, Kramer VG, Lakhashe S, Santosuosso M, Poznansky MC, Novembre FJ, Villinger F, Else JG, Montefiori DC, Rasmussen RA, Ruprecht RM.

PLoS One. 2010 Jul 21;5(7):e11689. doi: 10.1371/journal.pone.0011689.


Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transmission in humans via different routes.

Chenine AL, Siddappa NB, Kramer VG, Sciaranghella G, Rasmussen RA, Lee SJ, Santosuosso M, Poznansky MC, Velu V, Amara RR, Souder C, Anderson DC, Villinger F, Else JG, Novembre FJ, Strobert E, O'Neil SP, Secor WE, Ruprecht RM.

J Infect Dis. 2010 Apr 15;201(8):1155-63. doi: 10.1086/651274.


HIV-1 envelope protein gp120 is present at high concentrations in secondary lymphoid organs of individuals with chronic HIV-1 infection.

Santosuosso M, Righi E, Lindstrom V, Leblanc PR, Poznansky MC.

J Infect Dis. 2009 Oct 1;200(7):1050-3. doi: 10.1086/605695.


X4 human immunodeficiency virus type 1 gp120 down-modulates expression and immunogenicity of codelivered antigens.

Hovav AH, Santosuosso M, Bivas-Benita M, Plair A, Cheng A, Elnekave M, Righi E, Chen T, Kashiwagi S, Panas MW, Xiang SH, Furmanov K, Letvin NL, Poznansky MC.

J Virol. 2009 Nov;83(21):10941-50. doi: 10.1128/JVI.00394-09. Epub 2009 Aug 19.


The efficacy of T cell-mediated immune responses is reduced by the envelope protein of the chimeric HIV-1/SIV-KB9 virus in vivo.

Stevceva L, Yoon V, Carville A, Pacheco B, Santosuosso M, Korioth-Schmitz B, Mansfield K, Poznansky MC.

J Immunol. 2008 Oct 15;181(8):5510-21.


Mucosally delivered dendritic cells activate T cells independently of IL-12 and endogenous APCs.

McCormick S, Santosuosso M, Small CL, Shaler CR, Zhang X, Jeyanathan M, Mu J, Takenaka S, Ngai P, Gauldie J, Wan Y, Xing Z.

J Immunol. 2008 Aug 15;181(4):2356-67.


NK cells play a critical protective role in host defense against acute extracellular Staphylococcus aureus bacterial infection in the lung.

Small CL, McCormick S, Gill N, Kugathasan K, Santosuosso M, Donaldson N, Heinrichs DE, Ashkar A, Xing Z.

J Immunol. 2008 Apr 15;180(8):5558-68.


Mucosal luminal manipulation of T cell geography switches on protective efficacy by otherwise ineffective parenteral genetic immunization.

Santosuosso M, McCormick S, Roediger E, Zhang X, Zganiacz A, Lichty BD, Xing Z.

J Immunol. 2007 Feb 15;178(4):2387-95.


Intramuscular immunization with a monogenic plasmid DNA tuberculosis vaccine: Enhanced immunogenicity by electroporation and co-expression of GM-CSF transgene.

Zhang X, Divangahi M, Ngai P, Santosuosso M, Millar J, Zganiacz A, Wang J, Bramson J, Xing Z.

Vaccine. 2007 Jan 26;25(7):1342-52. Epub 2006 Oct 10.


Manipulation of dendritic cells for host defence against intracellular infections.

McCormick S, Santosuosso M, Zhang XZ, Xing Z.

Biochem Soc Trans. 2006 Apr;34(Pt 2):283-6.


Development of cell-based tuberculosis vaccines: genetically modified dendritic cell vaccine is a much more potent activator of CD4 and CD8 T cells than peptide- or protein-loaded counterparts.

Malowany JI, McCormick S, Santosuosso M, Zhang X, Aoki N, Ngai P, Wang J, Leitch J, Bramson J, Wan Y, Xing Z.

Mol Ther. 2006 Apr;13(4):766-75. Epub 2005 Dec 15.


Recent advances in the development of adenovirus- and poxvirus-vectored tuberculosis vaccines.

Xing Z, Santosuosso M, McCormick S, Yang TC, Millar J, Hitt M, Wan Y, Bramson J, Vordermeier HM.

Curr Gene Ther. 2005 Oct;5(5):485-92. Review.


Adenoviral vectors for mucosal vaccination against infectious diseases.

Santosuosso M, McCormick S, Xing Z.

Viral Immunol. 2005;18(2):283-91. Review.


Single mucosal, but not parenteral, immunization with recombinant adenoviral-based vaccine provides potent protection from pulmonary tuberculosis.

Wang J, Thorson L, Stokes RW, Santosuosso M, Huygen K, Zganiacz A, Hitt M, Xing Z.

J Immunol. 2004 Nov 15;173(10):6357-65.


Activation of CD8 T cells by mycobacterial vaccination protects against pulmonary tuberculosis in the absence of CD4 T cells.

Wang J, Santosuosso M, Ngai P, Zganiacz A, Xing Z.

J Immunol. 2004 Oct 1;173(7):4590-7.


TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection.

Zganiacz A, Santosuosso M, Wang J, Yang T, Chen L, Anzulovic M, Alexander S, Gicquel B, Wan Y, Bramson J, Inman M, Xing Z.

J Clin Invest. 2004 Feb;113(3):401-13.

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