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Items: 1 to 50 of 98

1.

Outer hair cell electromotility is low-pass filtered relative to the molecular conformational changes that produce nonlinear capacitance.

Santos-Sacchi J, Iwasa KH, Tan W.

J Gen Physiol. 2019 Nov 1. pii: jgp.201812280. doi: 10.1085/jgp.201812280. [Epub ahead of print]

PMID:
31676485
2.

Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice.

El-Hassar L, Song L, Tan WJT, Large CH, Alvaro G, Santos-Sacchi J, Kaczmarek LK.

J Neurosci. 2019 Jun 12;39(24):4797-4813. doi: 10.1523/JNEUROSCI.0839-18.2019. Epub 2019 Apr 1.

PMID:
30936239
3.

The speed limit of outer hair cell electromechanical activity.

Santos-Sacchi J.

HNO. 2019 Mar;67(3):159-164. doi: 10.1007/s00106-019-0615-9. Review.

PMID:
30747242
4.

Seeing the long tail: A novel green fluorescent protein, SiriusGFP, for ultra long timelapse imaging.

Zhong S, Rivera-Molina F, Rivetta A, Toomre D, Santos-Sacchi J, Navaratnam D.

J Neurosci Methods. 2019 Feb 1;313:68-76. doi: 10.1016/j.jneumeth.2018.12.008. Epub 2018 Dec 19.

5.

The Frequency Response of Outer Hair Cell Voltage-Dependent Motility Is Limited by Kinetics of Prestin.

Santos-Sacchi J, Tan W.

J Neurosci. 2018 Jun 13;38(24):5495-5506. doi: 10.1523/JNEUROSCI.0425-18.2018. Epub 2018 May 21.

6.

Current carried by the Slc26 family member prestin does not flow through the transporter pathway.

Bai JP, Moeini-Naghani I, Zhong S, Li FY, Bian S, Sigworth FJ, Santos-Sacchi J, Navaratnam D.

Sci Rep. 2017 Apr 19;7:46619. doi: 10.1038/srep46619.

7.

Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear.

Tan WJT, Song L, Graham M, Schettino A, Navaratnam D, Yarbrough WG, Santos-Sacchi J, Ivanova AV.

Antioxid Redox Signal. 2017 Sep 10;27(8):489-509. doi: 10.1089/ars.2016.6851. Epub 2017 Mar 9.

8.

Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels.

Lv C, Stewart WJ, Akanyeti O, Frederick C, Zhu J, Santos-Sacchi J, Sheets L, Liao JC, Zenisek D.

Cell Rep. 2016 Jun 21;15(12):2784-95. doi: 10.1016/j.celrep.2016.05.045. Epub 2016 Jun 9.

9.

Chloride Anions Regulate Kinetics but Not Voltage-Sensor Qmax of the Solute Carrier SLC26a5.

Santos-Sacchi J, Song L.

Biophys J. 2016 Jun 7;110(11):2551-2561. doi: 10.1016/j.bpj.2016.05.002.

10.

A Walkthrough of Nonlinear Capacitance Measurement of Outer Hair Cells.

Song L, Santos-Sacchi J.

Methods Mol Biol. 2016;1427:501-12. doi: 10.1007/978-1-4939-3615-1_28.

PMID:
27259945
11.

Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness.

McKay SE, Yan W, Nouws J, Thormann MJ, Raimundo N, Khan A, Santos-Sacchi J, Song L, Shadel GS.

Am J Pathol. 2015 Dec;185(12):3132-40. doi: 10.1016/j.ajpath.2015.08.014. Epub 2015 Nov 6.

12.

An electrical inspection of the subsurface cisternae of the outer hair cell.

Song L, Santos-Sacchi J.

Biophys J. 2015 Feb 3;108(3):568-77. doi: 10.1016/j.bpj.2014.12.010.

13.

Tyrosine motifs are required for prestin basolateral membrane targeting.

Zhang Y, Moeini-Naghani I, Bai J, Santos-Sacchi J, Navaratnam DS.

Biol Open. 2015 Jan 16;4(2):197-205. doi: 10.1242/bio.201410629.

14.

Chloride-driven electromechanical phase lags at acoustic frequencies are generated by SLC26a5, the outer hair cell motor protein.

Santos-Sacchi J, Song L.

Biophys J. 2014 Jul 1;107(1):126-33. doi: 10.1016/j.bpj.2014.05.018.

15.
16.

Chloride and salicylate influence prestin-dependent specific membrane capacitance: support for the area motor model.

Santos-Sacchi J, Song L.

J Biol Chem. 2014 Apr 11;289(15):10823-30. doi: 10.1074/jbc.M114.549329. Epub 2014 Feb 19.

17.

IR laser-induced perturbations of the voltage-dependent solute carrier protein SLC26a5.

Okunade O, Santos-Sacchi J.

Biophys J. 2013 Oct 15;105(8):1822-8. doi: 10.1016/j.bpj.2013.09.008.

18.

Real time measures of prestin charge and fluorescence during plasma membrane trafficking reveal sub-tetrameric activity.

Bian S, Navaratnam D, Santos-Sacchi J.

PLoS One. 2013 Jun 10;8(6):e66078. doi: 10.1371/journal.pone.0066078. Print 2013.

19.

Disparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5.

Song L, Santos-Sacchi J.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3883-8. doi: 10.1073/pnas.1218341110. Epub 2013 Feb 19.

20.

Patch-clamp recordings from lateral line neuromast hair cells of the living zebrafish.

Ricci AJ, Bai JP, Song L, Lv C, Zenisek D, Santos-Sacchi J.

J Neurosci. 2013 Feb 13;33(7):3131-4. doi: 10.1523/JNEUROSCI.4265-12.2013.

21.

Tracking vesicle fusion from hair cell ribbon synapses using a high frequency, dual sine wave stimulus paradigm.

Schnee ME, Castellano-Muñoz M, Kong JH, Santos-Sacchi J, Ricci AJ.

Commun Integr Biol. 2011 Nov 1;4(6):785-7.

22.

Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness.

Raimundo N, Song L, Shutt TE, McKay SE, Cotney J, Guan MX, Gilliland TC, Hohuan D, Santos-Sacchi J, Shadel GS.

Cell. 2012 Feb 17;148(4):716-26. doi: 10.1016/j.cell.2011.12.027.

23.

Extracellular chloride regulation of Kv2.1, contributor to the major outward Kv current in mammalian outer hair cells.

Li X, Surguchev A, Bian S, Navaratnam D, Santos-Sacchi J.

Am J Physiol Cell Physiol. 2012 Jan 1;302(1):C296-306. doi: 10.1152/ajpcell.00177.2011. Epub 2011 Sep 21.

24.

Calcium-dependent synaptic vesicle trafficking underlies indefatigable release at the hair cell afferent fiber synapse.

Schnee ME, Santos-Sacchi J, Castellano-Muñoz M, Kong JH, Ricci AJ.

Neuron. 2011 Apr 28;70(2):326-38. doi: 10.1016/j.neuron.2011.01.031.

25.

Gene expression gradients along the tonotopic axis of the chicken auditory epithelium.

Frucht CS, Uduman M, Kleinstein SH, Santos-Sacchi J, Navaratnam DS.

J Assoc Res Otolaryngol. 2011 Aug;12(4):423-35. doi: 10.1007/s10162-011-0259-2. Epub 2011 Mar 12.

26.

MicroRNA181a plays a key role in hair cell regeneration in the avian auditory epithelium.

Frucht CS, Santos-Sacchi J, Navaratnam DS.

Neurosci Lett. 2011 Apr 8;493(1-2):44-8. doi: 10.1016/j.neulet.2011.02.017. Epub 2011 Feb 21.

27.

Effect of capsaicin on potassium conductance and electromotility of the guinea pig outer hair cell.

Wu T, Song L, Shi X, Jiang Z, Santos-Sacchi J, Nuttall AL.

Hear Res. 2011 Feb;272(1-2):117-24. doi: 10.1016/j.heares.2010.10.010. Epub 2010 Oct 31.

28.

Combinatorial cysteine mutagenesis reveals a critical intramonomer role for cysteines in prestin voltage sensing.

Bai JP, Surguchev A, Bian S, Song L, Santos-Sacchi J, Navaratnam D.

Biophys J. 2010 Jul 7;99(1):85-94. doi: 10.1016/j.bpj.2010.03.066.

29.

Patch-clamp amplifiers on a chip.

Weerakoon P, Culurciello E, Yang Y, Santos-Sacchi J, Kindlmann PJ, Sigworth FJ.

J Neurosci Methods. 2010 Oct 15;192(2):187-92. doi: 10.1016/j.jneumeth.2010.06.030. Epub 2010 Jul 15.

30.

Gene expression analysis of forskolin treated basilar papillae identifies microRNA181a as a mediator of proliferation.

Frucht CS, Uduman M, Duke JL, Kleinstein SH, Santos-Sacchi J, Navaratnam DS.

PLoS One. 2010 Jul 9;5(7):e11502. doi: 10.1371/journal.pone.0011502.

31.

A highly expressing Tet-inducible cell line recapitulates in situ developmental changes in prestin's Boltzmann characteristics and reveals early maturational events.

Bian S, Koo BW, Kelleher S, Santos-Sacchi J, Navaratnam DS.

Am J Physiol Cell Physiol. 2010 Oct;299(4):C828-35. doi: 10.1152/ajpcell.00182.2010. Epub 2010 Jul 14.

32.

The remarkable cochlear amplifier.

Ashmore J, Avan P, Brownell WE, Dallos P, Dierkes K, Fettiplace R, Grosh K, Hackney CM, Hudspeth AJ, Jülicher F, Lindner B, Martin P, Meaud J, Petit C, Santos-Sacchi J, Sacchi JR, Canlon B.

Hear Res. 2010 Jul;266(1-2):1-17. doi: 10.1016/j.heares.2010.05.001. Erratum in: Hear Res. 2011 Oct;280(1-2):245. Sacchi, J R Santos [corrected to Santos-Sacchi, J].

33.

Prestin surface expression and activity are augmented by interaction with MAP1S, a microtubule-associated protein.

Bai JP, Surguchev A, Ogando Y, Song L, Bian S, Santos-Sacchi J, Navaratnam D.

J Biol Chem. 2010 Jul 2;285(27):20834-43. doi: 10.1074/jbc.M110.117853. Epub 2010 Apr 23.

34.

Conformational state-dependent anion binding in prestin: evidence for allosteric modulation.

Song L, Santos-Sacchi J.

Biophys J. 2010 Feb 3;98(3):371-6. doi: 10.1016/j.bpj.2009.10.027.

35.

WITHDRAWN: The mammalian cochlear amplifier done.

Santos-Sacchi J.

Hear Res. 2010 Jan 30. [Epub ahead of print]

PMID:
20123055
36.

Prestin's anion transport and voltage-sensing capabilities are independent.

Bai JP, Surguchev A, Montoya S, Aronson PS, Santos-Sacchi J, Navaratnam D.

Biophys J. 2009 Apr 22;96(8):3179-86. doi: 10.1016/j.bpj.2008.12.3948.

37.

Fast electromechanical amplification in the lateral membrane of the outer hair cell.

Santos-Sacchi J, Navarrete E, Song L.

Biophys J. 2009 Jan;96(2):739-47. doi: 10.1016/j.bpj.2008.10.015.

38.

Anion control of voltage sensing by the motor protein prestin in outer hair cells.

Rybalchenko V, Santos-Sacchi J.

Biophys J. 2008 Nov 1;95(9):4439-47. doi: 10.1529/biophysj.108.134197. Epub 2008 Jul 25.

39.

Cochlear mechanics: no shout but a twist in the absence of prestin.

Santos-Sacchi J.

Curr Biol. 2008 Apr 8;18(7):R304-6. doi: 10.1016/j.cub.2008.02.019.

40.

Developmental expression of the outer hair cell motor prestin in the mouse.

Abe T, Kakehata S, Kitani R, Maruya S, Navaratnam D, Santos-Sacchi J, Shinkawa H.

J Membr Biol. 2007 Jan;215(1):49-56. Epub 2007 Apr 6.

41.

En block C-terminal charge cluster reversals in prestin (SLC26A5): effects on voltage-dependent electromechanical activity.

Bai JP, Navaratnam D, Samaranayake H, Santos-Sacchi J.

Neurosci Lett. 2006 Sep 1;404(3):270-5. Epub 2006 Jul 12.

PMID:
16839688
42.

Tuning in to the amazing outer hair cell: membrane wizardry with a twist and shout.

He DZ, Zheng J, Kalinec F, Kakehata S, Santos-Sacchi J.

J Membr Biol. 2006 Feb-Mar;209(2-3):119-34. Epub 2006 May 25. Review. No abstract available.

PMID:
16773497
43.

Control of mammalian cochlear amplification by chloride anions.

Santos-Sacchi J, Song L, Zheng J, Nuttall AL.

J Neurosci. 2006 Apr 12;26(15):3992-8.

44.

On the temperature and tension dependence of the outer hair cell lateral membrane conductance GmetL and its relation to prestin.

Santos-Sacchi J, Rybalchenko V, Bai JP, Song L, Navaratnam D.

Pflugers Arch. 2006 Jun;452(3):283-9. Epub 2006 Mar 7.

PMID:
16521020
45.

On the effect of prestin on the electrical breakdown of cell membranes.

Navarrete EG, Santos-Sacchi J.

Biophys J. 2006 Feb 1;90(3):967-74. Epub 2005 Nov 18.

46.

N-terminal-mediated homomultimerization of prestin, the outer hair cell motor protein.

Navaratnam D, Bai JP, Samaranayake H, Santos-Sacchi J.

Biophys J. 2005 Nov;89(5):3345-52. Epub 2005 Aug 19.

47.

Glibenclamide stimulates fluid secretion in rodent cholangiocytes through a cystic fibrosis transmembrane conductance regulator-independent mechanism.

Spirlì C, Fiorotto R, Song L, Santos-Sacchi J, Okolicsanyi L, Masier S, Rocchi L, Vairetti MP, De Bernard M, Melero S, Pozzan T, Strazzabosco M.

Gastroenterology. 2005 Jul;129(1):220-33.

PMID:
16012949
48.
49.

Protein- and lipid-reactive agents alter outer hair cell lateral membrane motor charge movement.

Santos-Sacchi J, Wu M.

J Membr Biol. 2004 Jul 15;200(2):83-92.

PMID:
15520906

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