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Hospital Volume of Antireflux Surgery in Relation to Endoscopic and Surgical Re-interventions.

Markar S, Santoni G, Maret-Ouda J, Artama M, Färkkilä M, Lynge E, Pukkala E, Ness-Jensen E, von Euler-Chelpin M, Lagergren J.

Ann Surg. 2020 Jan 6. doi: 10.1097/SLA.0000000000003776. [Epub ahead of print]


Association Between Metformin Use and Risk of Esophageal Squamous Cell Carcinoma in a Population-Based Cohort Study.

Wang QL, Santoni G, Ness-Jensen E, Lagergren J, Xie SH.

Am J Gastroenterol. 2020 Jan;115(1):73-78. doi: 10.14309/ajg.0000000000000478.


Transient Receptor Potential Cation Channels in Cancer Therapy.

Santoni G, Maggi F, Morelli MB, Santoni M, Marinelli O.

Med Sci (Basel). 2019 Nov 30;7(12). pii: E108. doi: 10.3390/medsci7120108. Review.


Esophageal Adenocarcinoma After Antireflux Surgery in a Cohort Study From the 5 Nordic Countries.

Maret-Ouda J, Santoni G, Wahlin K, Artama M, Brusselaers N, Färkkilä M, Lynge E, Mattsson F, Pukkala E, Romundstad P, Tryggvadóttir L, von Euler-Chelpin M, Lagergren J.

Ann Surg. 2019 Nov 27. doi: 10.1097/SLA.0000000000003709. [Epub ahead of print]


Human infection with Pseudoterranova cattani by ingestion of "ceviche" in Buenos Aires, Argentina.

Menghi CI, Gatta CL, Arias LE, Santoni G, Nicola F, Smayevsky J, Degese MF, Krivokapich SJ.

Rev Argent Microbiol. 2019 Nov 27. pii: S0325-7541(19)30084-7. doi: 10.1016/j.ram.2019.06.005. [Epub ahead of print]


The Controversial Role of PD-1 and Its Ligands in Gynecological Malignancies.

Marinelli O, Annibali D, Aguzzi C, Tuyaerts S, Amant F, Morelli MB, Santoni G, Amantini C, Maggi F, Nabissi M.

Front Oncol. 2019 Oct 15;9:1073. doi: 10.3389/fonc.2019.01073. eCollection 2019. Review.


The TRPV2 cation channels: from urothelial cancer invasiveness to glioblastoma multiforme interactome signature.

Santoni G, Amantini C, Maggi F, Marinelli O, Santoni M, Nabissi M, Morelli MB.

Lab Invest. 2019 Oct 25. doi: 10.1038/s41374-019-0333-7. [Epub ahead of print] Review.


Targeting Transient Receptor Potential Channels by MicroRNAs Drives Tumor Development and Progression.

Santoni G, Morelli MB, Santoni M, Nabissi M, Marinelli O, Amantini C.

Adv Exp Med Biol. 2020;1131:605-623. doi: 10.1007/978-3-030-12457-1_24. Review.


Calcium Signaling and the Regulation of Chemosensitivity in Cancer Cells: Role of the Transient Receptor Potential Channels.

Santoni G, Morelli MB, Marinelli O, Nabissi M, Santoni M, Amantini C.

Adv Exp Med Biol. 2020;1131:505-517. doi: 10.1007/978-3-030-12457-1_20. Review.


Metformin use and risk of gastric adenocarcinoma in a Swedish population-based cohort study.

Zheng J, Xie SH, Santoni G, Lagergren J.

Br J Cancer. 2019 Nov;121(10):877-882. doi: 10.1038/s41416-019-0598-z. Epub 2019 Oct 8.


Expression Profiling of Circulating Tumor Cells in Pancreatic Ductal Adenocarcinoma Patients: Biomarkers Predicting Overall Survival.

Amantini C, Morelli MB, Nabissi M, Piva F, Marinelli O, Maggi F, Bianchi F, Bittoni A, Berardi R, Giampieri R, Santoni G.

Front Oncol. 2019 Sep 10;9:874. doi: 10.3389/fonc.2019.00874. eCollection 2019.


Protein crystal structure determination with the crystallophore, a nucleating and phasing agent.

Engilberge S, Wagner T, Santoni G, Breyton C, Shima S, Franzetti B, Riobé F, Maury O, Girard E.

J Appl Crystallogr. 2019 Jun 28;52(Pt 4):722-731. doi: 10.1107/S1600576719006381. eCollection 2019 Aug 1.


Gastric bypass surgery in the treatment of gastro-oesophageal reflux symptoms.

Holmberg D, Santoni G, Xie S, Lagergren J.

Aliment Pharmacol Ther. 2019 Jul;50(2):159-166. doi: 10.1111/apt.15274. Epub 2019 Jun 4.


Prediabetes and diabetes in relation to risk of gastric adenocarcinoma.

Zheng J, Rutegård M, Santoni G, Wallner B, Johansson I, Sund M, Xie SH, Lagergren J.

Br J Cancer. 2019 Jun;120(12):1147-1152. doi: 10.1038/s41416-019-0470-1. Epub 2019 May 7.


Clinical impact of different exosomes' protein expression in pancreatic ductal carcinoma patients treated with standard first line palliative chemotherapy.

Giampieri R, Piva F, Occhipinti G, Bittoni A, Righetti A, Pagliaretta S, Murrone A, Bianchi F, Amantini C, Giulietti M, Ricci G, Principato G, Santoni G, Berardi R, Cascinu S.

PLoS One. 2019 May 2;14(5):e0215990. doi: 10.1371/journal.pone.0215990. eCollection 2019.


Transient Receptor Potential Mucolipin-1 Channels in Glioblastoma: Role in Patient's Survival.

Morelli MB, Amantini C, Tomassoni D, Nabissi M, Arcella A, Santoni G.

Cancers (Basel). 2019 Apr 12;11(4). pii: E525. doi: 10.3390/cancers11040525.


Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells.

Morelli MB, Amantini C, Nabissi M, Santoni G, Wünsch B, Schepmann D, Cimarelli C, Pellei M, Santini C, Fontana S, Mammoli V, Quaglia W, Bonifazi A, Giannella M, Giorgioni G, Piergentili A, Del Bello F.

ACS Med Chem Lett. 2019 Jan 28;10(4):511-516. doi: 10.1021/acsmedchemlett.8b00536. eCollection 2019 Apr 11.


Structure Solution of the Fluorescent Protein Cerulean Using MeshAndCollect.

Hutin S, Santoni G, Zander U, Foos N, Aumonier S, Gotthard G, Royant A, Mueller-Dieckmann C, Leonard G.

J Vis Exp. 2019 Mar 19;(145). doi: 10.3791/58594.


Effects of Obesity Surgery on Overall and Disease-Specific Mortality in a 5-Country Population-Based Study.

Kauppila JH, Tao W, Santoni G, von Euler-Chelpin M, Lynge E, Tryggvadóttir L, Ness-Jensen E, Romundstad P, Pukkala E, Lagergren J.

Gastroenterology. 2019 Jul;157(1):119-127.e1. doi: 10.1053/j.gastro.2019.03.048. Epub 2019 Mar 30.


Chemical manipulations on the 1,4-dioxane ring of 5-HT1A receptor agonists lead to antagonists endowed with antitumor activity in prostate cancer cells.

Del Bello F, Bonifazi A, Giorgioni G, Quaglia W, Amantini C, Morelli MB, Santoni G, Battiti FO, Vistoli G, Cilia A, Piergentili A.

Eur J Med Chem. 2019 Apr 15;168:461-473. doi: 10.1016/j.ejmech.2019.02.056. Epub 2019 Feb 25.


Cohort profile: the Swedish Prescribed Drugs and Health Cohort (SPREDH).

Xie SH, Santoni G, Mattsson F, Ness-Jensen E, Lagergren J.

BMJ Open. 2019 Jan 28;9(1):e023155. doi: 10.1136/bmjopen-2018-023155.


Using an Integrated Clinical and Functional Assessment Tool to Describe the Use of Social and Medical Care in an Urban Community-Dwelling Swedish Older Population.

Santoni G, Meinow B, Wimo A, Marengoni A, Fratiglioni L, Calderón-Larrañaga A.

J Am Med Dir Assoc. 2019 Aug;20(8):988-994.e2. doi: 10.1016/j.jamda.2018.11.017. Epub 2019 Jan 17.


Isofuranodiene synergizes with temozolomide in inducing glioma cells death.

Brunetti A, Marinelli O, Morelli MB, Iannarelli R, Amantini C, Russotti D, Santoni G, Maggi F, Nabissi M.

Phytomedicine. 2019 Jan;52:51-59. doi: 10.1016/j.phymed.2018.09.220. Epub 2018 Sep 26.


Geriatric Health Charts for Individual Assessment and Prediction of Care Needs: A Population-Based Prospective Study.

Santoni G, Calderón-Larrañaga A, Vetrano DL, Welmer AK, Orsini N, Fratiglioni L.

J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):131-138. doi: 10.1093/gerona/gly272.


Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase.

Lalut J, Santoni G, Karila D, Lecoutey C, Davis A, Nachon F, Silman I, Sussman J, Weik M, Maurice T, Dallemagne P, Rochais C.

Eur J Med Chem. 2019 Jan 15;162:234-248. doi: 10.1016/j.ejmech.2018.10.064. Epub 2018 Nov 8.


Atrial fibrillation, antithrombotic treatment, and cognitive aging: A population-based study.

Ding M, Fratiglioni L, Johnell K, Santoni G, Fastbom J, Ljungman P, Marengoni A, Qiu C.

Neurology. 2018 Nov 6;91(19):e1732-e1740. doi: 10.1212/WNL.0000000000006456. Epub 2018 Oct 10.


Urinary Markers in Bladder Cancer: An Update.

Santoni G, Morelli MB, Amantini C, Battelli N.

Front Oncol. 2018 Sep 7;8:362. doi: 10.3389/fonc.2018.00362. eCollection 2018. Review.


Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents.

Santoni G, de Sousa J, de la Mora E, Dias J, Jean L, Sussman JL, Silman I, Renard PY, Brown RCD, Weik M, Baati R, Nachon F.

J Med Chem. 2018 Sep 13;61(17):7630-7639. doi: 10.1021/acs.jmedchem.8b00592. Epub 2018 Aug 31.


Population-based cohort study of diabetes mellitus and mortality in gastric adenocarcinoma.

Zheng J, Xie SH, Santoni G, Lagergren J.

Br J Surg. 2018 Dec;105(13):1799-1806. doi: 10.1002/bjs.10930. Epub 2018 Jul 27.


Thyme extract increases mucociliary-beating frequency in primary cell lines from chronic obstructive pulmonary disease patients.

Nabissi M, Marinelli O, Morelli MB, Nicotra G, Iannarelli R, Amantini C, Santoni G, Maggi F.

Biomed Pharmacother. 2018 Sep;105:1248-1253. doi: 10.1016/j.biopha.2018.06.004. Epub 2018 Jun 22.


Cardiovascular Risk Factors and the Risk of Disability in Older Adults: Variation by Age and Functional Status.

Heiland EG, Welmer AK, Wang R, Santoni G, Fratiglioni L, Qiu C.

J Am Med Dir Assoc. 2019 Feb;20(2):208-212.e3. doi: 10.1016/j.jamda.2018.05.013. Epub 2018 Jul 10.


"Immuno-Transient Receptor Potential Ion Channels": The Role in Monocyte- and Macrophage-Mediated Inflammatory Responses.

Santoni G, Morelli MB, Amantini C, Santoni M, Nabissi M, Marinelli O, Santoni A.

Front Immunol. 2018 Jun 6;9:1273. doi: 10.3389/fimmu.2018.01273. eCollection 2018. Review.


Temporal trends in impairments of physical function among older adults during 2001-16 in Sweden: towards a healthier ageing.

Santoni G, Angleman SB, Ek S, Heiland EG, Lagergren M, Fratiglioni L, Welmer AK.

Age Ageing. 2018 Sep 1;47(5):698-704. doi: 10.1093/ageing/afy085.


ICOS-L as a Potential Therapeutic Target for Cancer Immunotherapy.

Marinelli O, Nabissi M, Morelli MB, Torquati L, Amantini C, Santoni G.

Curr Protein Pept Sci. 2018;19(11):1107-1113. doi: 10.2174/1389203719666180608093913. Review.


High CTLA-4 expression correlates with poor prognosis in thymoma patients.

Santoni G, Amantini C, Morelli MB, Tomassoni D, Santoni M, Marinelli O, Nabissi M, Cardinali C, Paolucci V, Torniai M, Rinaldi S, Morgese F, Bernardini G, Berardi R.

Oncotarget. 2018 Mar 30;9(24):16665-16677. doi: 10.18632/oncotarget.24645. eCollection 2018 Mar 30.


A neuronal basis for fear discrimination in the lateral amygdala.

Grosso A, Santoni G, Manassero E, Renna A, Sacchetti B.

Nat Commun. 2018 Mar 23;9(1):1214. doi: 10.1038/s41467-018-03682-2.


Rapidly developing multimorbidity and disability in older adults: does social background matter?

Calderón-Larrañaga A, Santoni G, Wang HX, Welmer AK, Rizzuto D, Vetrano DL, Marengoni A, Fratiglioni L.

J Intern Med. 2018 May;283(5):489-499. doi: 10.1111/joim.12739. Epub 2018 Mar 12.


Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles.

Dolles D, Hoffmann M, Gunesch S, Marinelli O, Möller J, Santoni G, Chatonnet A, Lohse MJ, Wittmann HJ, Strasser A, Nabissi M, Maurice T, Decker M.

J Med Chem. 2018 Feb 22;61(4):1646-1663. doi: 10.1021/acs.jmedchem.7b01760. Epub 2018 Feb 5.


Hierarchical clustering for multiple-crystal macromolecular crystallography experiments: the ccCluster program.

Santoni G, Zander U, Mueller-Dieckmann C, Leonard G, Popov A.

J Appl Crystallogr. 2017 Nov 29;50(Pt 6):1844-1851. doi: 10.1107/S1600576717015229. eCollection 2017 Dec 1.


The TRPV1 ion channel regulates thymocyte differentiation by modulating autophagy and proteasome activity.

Amantini C, Farfariello V, Cardinali C, Morelli MB, Marinelli O, Nabissi M, Santoni M, Bonfili L, Cecarini V, Eleuteri AM, Santoni G.

Oncotarget. 2017 Oct 11;8(53):90766-90780. doi: 10.18632/oncotarget.21798. eCollection 2017 Oct 31.


EULAR/ACR classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups: a methodology report.

Bottai M, Tjärnlund A, Santoni G, Werth VP, Pilkington C, de Visser M, Alfredsson L, Amato AA, Barohn RJ, Liang MH, Singh JA, Aggarwal R, Arnardottir S, Chinoy H, Cooper RG, Danko K, Dimachkie MM, Feldman BM, García-De La Torre I, Gordon P, Hayashi T, Katz JD, Kohsaka H, Lachenbruch PA, Lang BA, Li Y, Oddis CV, Olesinka M, Reed AM, Rutkowska-Sak L, Sanner H, Selva-O'Callaghan A, Wook Song Y, Vencovsky J, Ytterberg SR, Miller FW, Rider LG, Lundberg IE; International Myositis Classification Criteria Project consortium, the Euromyositis register and the Juvenile Dermatomyositis Cohort Biomarker Study and Repository (JDRG) (UK and Ireland) .

RMD Open. 2017 Nov 14;3(2):e000507. doi: 10.1136/rmdopen-2017-000507. eCollection 2017.


Cardiovascular Risk Burden and Future Risk of Walking Speed Limitation in Older Adults.

Heiland EG, Qiu C, Wang R, Santoni G, Liang Y, Fratiglioni L, Welmer AK.

J Am Geriatr Soc. 2017 Nov;65(11):2418-2424. doi: 10.1111/jgs.15158.


Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development.

Brazzolotto X, Igert A, Guillon V, Santoni G, Nachon F.

Molecules. 2017 Oct 27;22(11). pii: E1828. doi: 10.3390/molecules22111828.


Actions and Regulation of Ionotropic Cannabinoid Receptors.

De Petrocellis L, Nabissi M, Santoni G, Ligresti A.

Adv Pharmacol. 2017;80:249-289. doi: 10.1016/bs.apha.2017.04.001. Epub 2017 Jun 12. Review.


Ru(ii)-(PTA) and -mPTA complexes with N2-donor ligands bipyridyl and phenanthroline and their antiproliferative activities on human multiple myeloma cell lines.

Wołoszyn A, Pettinari C, Pettinari R, Badillo Patzmay GV, Kwiecień A, Lupidi G, Nabissi M, Santoni G, Smoleński P.

Dalton Trans. 2017 Aug 14;46(30):10073-10081. doi: 10.1039/c7dt02051a. Epub 2017 Jul 21.


Personality and Survival in Older Age: The Role of Lifestyle Behaviors and Health Status.

Rizzuto D, Mossello E, Fratiglioni L, Santoni G, Wang HX.

Am J Geriatr Psychiatry. 2017 Dec;25(12):1363-1372. doi: 10.1016/j.jagp.2017.06.008. Epub 2017 Jun 8.


New nanoparticles obtained by co-assembly of amphiphilic cyclodextrins and nonlamellar single-chain lipids: Preparation and characterization.

Nguyễn CH, Putaux JL, Santoni G, Tfaili S, Fourmentin S, Coty JB, Choisnard L, Gèze A, Wouessidjewe D, Barratt G, Lesieur S, Legrand FX.

Int J Pharm. 2017 Oct 15;531(2):444-456. doi: 10.1016/j.ijpharm.2017.07.007. Epub 2017 Jul 8.


Cognitive Trajectories of Older Adults With Prediabetes and Diabetes: A Population-Based Cohort Study.

Marseglia A, Dahl Aslan AK, Fratiglioni L, Santoni G, Pedersen NL, Xu W.

J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):400-406. doi: 10.1093/gerona/glx112.


Assessing and Measuring Chronic Multimorbidity in the Older Population: A Proposal for Its Operationalization.

Calderón-Larrañaga A, Vetrano DL, Onder G, Gimeno-Feliu LA, Coscollar-Santaliestra C, Carfí A, Pisciotta MS, Angleman S, Melis RJF, Santoni G, Mangialasche F, Rizzuto D, Welmer AK, Bernabei R, Prados-Torres A, Marengoni A, Fratiglioni L.

J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1417-1423. doi: 10.1093/gerona/glw233.

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