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Items: 45

1.

Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML.

O' Reilly E, Dhami SPS, Baev DV, Ortutay C, Halpin-McCormick A, Morrell R, Santocanale C, Samali A, Quinn J, O'Dwyer ME, Szegezdi E.

Sci Rep. 2018 Oct 25;8(1):15752. doi: 10.1038/s41598-018-33982-y.

2.

DNA Replication Dynamics and Cellular Responses to ATP Competitive CDC7 Kinase Inhibitors.

Rainey MD, Quachthithu H, Gaboriau D, Santocanale C.

ACS Chem Biol. 2017 Jul 21;12(7):1893-1902. doi: 10.1021/acschembio.7b00117. Epub 2017 Jun 7.

PMID:
28560864
3.

DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach.

Wu KZ, Wang GN, Fitzgerald J, Quachthithu H, Rainey MD, Cattaneo A, Bachi A, Santocanale C.

Nucleic Acids Res. 2016 Oct 14;44(18):8786-8798. Epub 2016 Jul 12.

4.

The Deubiquitinase USP9X Maintains DNA Replication Fork Stability and DNA Damage Checkpoint Responses by Regulating CLASPIN during S-Phase.

McGarry E, Gaboriau D, Rainey MD, Restuccia U, Bachi A, Santocanale C.

Cancer Res. 2016 Apr 15;76(8):2384-93. doi: 10.1158/0008-5472.CAN-15-2890. Epub 2016 Feb 26.

5.

Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint.

O'Connor A, Maffini S, Rainey MD, Kaczmarczyk A, Gaboriau D, Musacchio A, Santocanale C.

Biol Open. 2015 Dec 18;5(1):11-9. doi: 10.1242/bio.014969.

6.

Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring.

Lo Re D, Zhou Y, Mucha J, Jones LF, Leahy L, Santocanale C, Krol M, Murphy PV.

Chemistry. 2015 Dec 7;21(50):17993. doi: 10.1002/chem.201504167. Epub 2015 Nov 5.

PMID:
26537992
7.

Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring.

Lo Re D, Zhou Y, Mucha J, Jones LF, Leahy L, Santocanale C, Krol M, Murphy PV.

Chemistry. 2015 Dec 7;21(50):18109-21. doi: 10.1002/chem.201502861. Epub 2015 Nov 4.

PMID:
26531227
8.

A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response.

FitzGerald J, Murillo LS, O'Brien G, O'Connell E, O'Connor A, Wu K, Wang GN, Rainey MD, Natoni A, Healy S, O'Dwyer M, Santocanale C.

PLoS One. 2014 Jun 5;9(6):e98891. doi: 10.1371/journal.pone.0098891. eCollection 2014.

9.

Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models.

Natoni A, Coyne MR, Jacobsen A, Rainey MD, O'Brien G, Healy S, Montagnoli A, Moll J, O'Dwyer M, Santocanale C.

Cancers (Basel). 2013 Jul 24;5(3):901-18. doi: 10.3390/cancers5030901.

10.

Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage.

Broderick R, Rainey MD, Santocanale C, Nasheuer HP.

FEBS J. 2013 Oct;280(19):4888-902. doi: 10.1111/febs.12465. Epub 2013 Aug 27.

11.
12.

Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint.

Rainey MD, Harhen B, Wang GN, Murphy PV, Santocanale C.

Cell Cycle. 2013 May 15;12(10):1560-8. doi: 10.4161/cc.24675. Epub 2013 Apr 17.

13.

A cell culture system that mimics chronic lymphocytic leukemia cells microenvironment for drug screening and characterization.

Natoni A, O'Dwyer M, Santocanale C.

Methods Mol Biol. 2013;986:217-26. doi: 10.1007/978-1-62703-311-4_14.

PMID:
23436415
14.

DNA mediated chromatin pull-down for the study of chromatin replication.

Kliszczak AE, Rainey MD, Harhen B, Boisvert FM, Santocanale C.

Sci Rep. 2011;1:95. doi: 10.1038/srep00095. Epub 2011 Sep 19.

15.

Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation.

Martin L, Rainey M, Santocanale C, Gardner LB.

Oncogene. 2012 Sep 6;31(36):4076-84. doi: 10.1038/onc.2011.585. Epub 2011 Dec 19.

16.

Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells.

Natoni A, Murillo LS, Kliszczak AE, Catherwood MA, Montagnoli A, Samali A, O'Dwyer M, Santocanale C.

Mol Cancer Ther. 2011 Sep;10(9):1624-34. doi: 10.1158/1535-7163.MCT-10-1119. Epub 2011 Jul 18.

17.

The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies.

Stone JG, Siedlak SL, Tabaton M, Hirano A, Castellani RJ, Santocanale C, Perry G, Smith MA, Zhu X, Lee HG.

J Neuropathol Exp Neurol. 2011 Jul;70(7):578-87. doi: 10.1097/NEN.0b013e3182204414.

18.

Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation.

Napolitano C, Natoni A, Santocanale C, Evensen L, Lorens JB, Murphy PV.

Bioorg Med Chem Lett. 2011 Feb 15;21(4):1167-70. doi: 10.1016/j.bmcl.2010.12.100. Epub 2010 Dec 24.

PMID:
21273066
19.

Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding.

Menichincheri M, Albanese C, Alli C, Ballinari D, Bargiotti A, Caldarelli M, Ciavolella A, Cirla A, Colombo M, Colotta F, Croci V, D'Alessio R, D'Anello M, Ermoli A, Fiorentini F, Forte B, Galvani A, Giordano P, Isacchi A, Martina K, Molinari A, Moll JK, Montagnoli A, Orsini P, Orzi F, Pesenti E, Pillan A, Roletto F, Scolaro A, Tatò M, Tibolla M, Valsasina B, Varasi M, Vianello P, Volpi D, Santocanale C, Vanotti E.

J Med Chem. 2010 Oct 28;53(20):7296-315. doi: 10.1021/jm100504d.

PMID:
20873740
20.

Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease.

Bonda DJ, Evans TA, Santocanale C, Llosá JC, Viña J, Bajic V, Castellani RJ, Siedlak SL, Perry G, Smith MA, Lee HG.

Aging (Albany NY). 2009 Apr;1(4):382-8.

21.

Cdc7 kinase - a new target for drug development.

Swords R, Mahalingam D, O'Dwyer M, Santocanale C, Kelly K, Carew J, Giles F.

Eur J Cancer. 2010 Jan;46(1):33-40. doi: 10.1016/j.ejca.2009.09.020. Review.

PMID:
19815406
22.

Cell division cycle 7 kinase inhibitors: 1H-pyrrolo[2,3-b]pyridines, synthesis and structure-activity relationships.

Ermoli A, Bargiotti A, Brasca MG, Ciavolella A, Colombo N, Fachin G, Isacchi A, Menichincheri M, Molinari A, Montagnoli A, Pillan A, Rainoldi S, Sirtori FR, Sola F, Thieffine S, Tibolla M, Valsasina B, Volpi D, Santocanale C, Vanotti E.

J Med Chem. 2009 Jul 23;52(14):4380-90. doi: 10.1021/jm900248g.

PMID:
19555113
23.

First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery.

Menichincheri M, Bargiotti A, Berthelsen J, Bertrand JA, Bossi R, Ciavolella A, Cirla A, Cristiani C, Croci V, D'Alessio R, Fasolini M, Fiorentini F, Forte B, Isacchi A, Martina K, Molinari A, Montagnoli A, Orsini P, Orzi F, Pesenti E, Pezzetta D, Pillan A, Poggesi I, Roletto F, Scolaro A, Tatò M, Tibolla M, Valsasina B, Varasi M, Volpi D, Santocanale C, Vanotti E.

J Med Chem. 2009 Jan 22;52(2):293-307. doi: 10.1021/jm800977q. Erratum in: J Med Chem. 2009 Feb 26;52(4):1230.

PMID:
19115845
24.

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity.

Montagnoli A, Valsasina B, Croci V, Menichincheri M, Rainoldi S, Marchesi V, Tibolla M, Tenca P, Brotherton D, Albanese C, Patton V, Alzani R, Ciavolella A, Sola F, Molinari A, Volpi D, Avanzi N, Fiorentini F, Cattoni M, Healy S, Ballinari D, Pesenti E, Isacchi A, Moll J, Bensimon A, Vanotti E, Santocanale C.

Nat Chem Biol. 2008 Jun;4(6):357-65. doi: 10.1038/nchembio.90. Epub 2008 May 11.

PMID:
18469809
25.

Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships.

Vanotti E, Amici R, Bargiotti A, Berthelsen J, Bosotti R, Ciavolella A, Cirla A, Cristiani C, D'Alessio R, Forte B, Isacchi A, Martina K, Menichincheri M, Molinari A, Montagnoli A, Orsini P, Pillan A, Roletto F, Scolaro A, Tibolla M, Valsasina B, Varasi M, Volpi D, Santocanale C.

J Med Chem. 2008 Feb 14;51(3):487-501. doi: 10.1021/jm700956r. Epub 2008 Jan 18.

PMID:
18201066
26.

Cdc7 is an active kinase in human cancer cells undergoing replication stress.

Tenca P, Brotherton D, Montagnoli A, Rainoldi S, Albanese C, Santocanale C.

J Biol Chem. 2007 Jan 5;282(1):208-15. Epub 2006 Oct 24.

27.

Identification of Mcm2 phosphorylation sites by S-phase-regulating kinases.

Montagnoli A, Valsasina B, Brotherton D, Troiani S, Rainoldi S, Tenca P, Molinari A, Santocanale C.

J Biol Chem. 2006 Apr 14;281(15):10281-90. Epub 2006 Jan 30.

28.

Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells.

Montagnoli A, Tenca P, Sola F, Carpani D, Brotherton D, Albanese C, Santocanale C.

Cancer Res. 2004 Oct 1;64(19):7110-6.

29.

Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast.

Diffley JF, Bousset K, Labib K, Noton EA, Santocanale C, Tercero JA.

Cold Spring Harb Symp Quant Biol. 2000;65:333-42. Review. No abstract available.

PMID:
12760047
30.

Drf1, a novel regulatory subunit for human Cdc7 kinase.

Montagnoli A, Bosotti R, Villa F, Rialland M, Brotherton D, Mercurio C, Berthelsen J, Santocanale C.

EMBO J. 2002 Jun 17;21(12):3171-81.

31.

Essential role of human CDT1 in DNA replication and chromatin licensing.

Rialland M, Sola F, Santocanale C.

J Cell Sci. 2002 Apr 1;115(Pt 7):1435-40.

32.

Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex.

Ferreira MF, Santocanale C, Drury LS, Diffley JF.

Mol Cell Biol. 2000 Jan;20(1):242-8.

33.

Activation of dormant origins of DNA replication in budding yeast.

Santocanale C, Sharma K, Diffley JF.

Genes Dev. 1999 Sep 15;13(18):2360-4.

34.

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication.

Santocanale C, Diffley JF.

Nature. 1998 Oct 8;395(6702):615-8.

PMID:
9783589
35.

Evidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase alpha.

Desdouets C, Santocanale C, Drury LS, Perkins G, Foiani M, Plevani P, Diffley JF.

EMBO J. 1998 Jul 15;17(14):4139-46.

36.

Genomic footprinting of budding yeast replication origins during the cell cycle.

Santocanale C, Diffley JF.

Methods Enzymol. 1997;283:377-90. No abstract available.

PMID:
9251035
38.

An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast.

Cocker JH, Piatti S, Santocanale C, Nasmyth K, Diffley JF.

Nature. 1996 Jan 11;379(6561):180-2.

PMID:
8538771
39.

Mutations in the gene encoding the 34 kDa subunit of yeast replication protein A cause defective S phase progression.

Santocanale C, Neecke H, Longhese MP, Lucchini G, Plevani P.

J Mol Biol. 1995 Dec 8;254(4):595-607.

PMID:
7500336
40.

Purification and characterization of a new DNA polymerase from budding yeast Saccharomyces cerevisiae. A probable homolog of mammalian DNA polymerase beta.

Shimizu K, Santocanale C, Ropp PA, Longhese MP, Plevani P, Lucchini G, Sugino A.

J Biol Chem. 1993 Dec 25;268(36):27148-53.

41.

The isolated 48,000-dalton subunit of yeast DNA primase is sufficient for RNA primer synthesis.

Santocanale C, Foiani M, Lucchini G, Plevani P.

J Biol Chem. 1993 Jan 15;268(2):1343-8.

42.

Overproduction and functional analysis of DNA primase subunits from yeast and mouse.

Santocanale C, Locati F, Muzi Falconi M, Piseri A, Tseng BY, Lucchini G, Plevani P.

Gene. 1992 Apr 15;113(2):199-205.

PMID:
1572541
43.

Mutations in conserved yeast DNA primase domains impair DNA replication in vivo.

Francesconi S, Longhese MP, Piseri A, Santocanale C, Lucchini G, Plevani P.

Proc Natl Acad Sci U S A. 1991 May 1;88(9):3877-81.

44.

A single essential gene, PRI2, encodes the large subunit of DNA primase in Saccharomyces cerevisiae.

Foiani M, Santocanale C, Plevani P, Lucchini G.

Mol Cell Biol. 1989 Jul;9(7):3081-7.

45.

The yeast DNA polymerase-primase complex: genes and proteins.

Plevani P, Foiani M, Muzi Falconi M, Pizzagalli A, Santocanale C, Francesconi S, Valsasnini P, Comedini A, Piatti S, Lucchini G.

Biochim Biophys Acta. 1988 Dec 20;951(2-3):268-73.

PMID:
3061469

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