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Items: 35


Clinical and Antitumor Immune Responses in Relapsed/Refractory Follicular Lymphoma Patients after Intranodal Injections of IFNα-Dendritic Cells and Rituximab: a Phase I Clinical Trial.

Cox MC, Castiello L, Mattei M, Santodonato L, D'Agostino G, Muraro E, Martorelli D, Lapenta C, Di Napoli A, Di Landro F, Cangemi M, Pavan A, Castaldo P, Hohaus S, Donati S, Montefiore E, Berdini C, Carlei D, Monque DM, Ruco L, Prosperi D, Tafuri A, Spadaro F, Sestili P, Spada M, Dolcetti R, Santini SM, Rozera C, Aricò E, Capone I, Belardelli F.

Clin Cancer Res. 2019 Sep 1;25(17):5231-5241. doi: 10.1158/1078-0432.CCR-19-0709. Epub 2019 Jun 6.


Exploiting a new strategy to induce immunogenic cell death to improve dendritic cell-based vaccines for lymphoma immunotherapy.

Montico B, Lapenta C, Ravo M, Martorelli D, Muraro E, Zeng B, Comaro E, Spada M, Donati S, Santini SM, Tarallo R, Giurato G, Rizzo F, Weisz A, Belardelli F, Dolcetti R, Dal Col J.

Oncoimmunology. 2017 Jul 31;6(11):e1356964. doi: 10.1080/2162402X.2017.1356964. eCollection 2017.


NK Cell Activation in the Antitumor Response Induced by IFN-α Dendritic Cells Loaded with Apoptotic Cells from Follicular Lymphoma Patients.

Lapenta C, Donati S, Spadaro F, Castaldo P, Belardelli F, Cox MC, Santini SM.

J Immunol. 2016 Aug 1;197(3):795-806. doi: 10.4049/jimmunol.1600262. Epub 2016 Jun 29.


IFN-α enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing.

Spadaro F, Lapenta C, Donati S, Abalsamo L, Barnaba V, Belardelli F, Santini SM, Ferrantini M.

Blood. 2012 Feb 9;119(6):1407-17. doi: 10.1182/blood-2011-06-363564. Epub 2011 Dec 19.


Interferon-α-conditioned human monocytes combine a Th1-orienting attitude with the induction of autologous Th17 responses: role of IL-23 and IL-12.

Santini SM, Lapenta C, Donati S, Spadaro F, Belardelli F, Ferrantini M.

PLoS One. 2011 Feb 28;6(2):e17364. doi: 10.1371/journal.pone.0017364.


Strong CD8+ T cell antigenicity and immunogenicity of large foreign proteins incorporated in HIV-1 VLPs able to induce a Nef-dependent activation/maturation of dendritic cells.

Sistigu A, Bracci L, Valentini M, Proietti E, Bona R, Negri DR, Ciccaglione AR, Tritarelli E, Nisini R, Equestre M, Costantino A, Marcantonio C, Santini SM, Lapenta C, Donati S, Tataseo P, Miceli M, Cara A, Federico M.

Vaccine. 2011 Apr 18;29(18):3465-75. doi: 10.1016/j.vaccine.2011.02.059. Epub 2011 Mar 5.


Anti-tumor CD8+ T cell immunity elicited by HIV-1-based virus-like particles incorporating HPV-16 E7 protein.

Di Bonito P, Grasso F, Mochi S, Petrone L, Fanales-Belasio E, Mei A, Cesolini A, Laconi G, Conrad H, Bernhard H, Dembek CJ, Cosma A, Santini SM, Lapenta C, Donati S, Muratori C, Giorgi C, Federico M.

Virology. 2009 Dec 5;395(1):45-55. doi: 10.1016/j.virol.2009.09.012. Epub 2009 Oct 2.


IFN-alpha in the generation of dendritic cells for cancer immunotherapy.

Santini SM, Lapenta C, Santodonato L, D'Agostino G, Belardelli F, Ferrantini M.

Handb Exp Pharmacol. 2009;(188):295-317. doi: 10.1007/978-3-540-71029-5_14. Review.


IFN-alpha-conditioned dendritic cells are highly efficient in inducing cross-priming CD8(+) T cells against exogenous viral antigens.

Lapenta C, Santini SM, Spada M, Donati S, Urbani F, Accapezzato D, Franceschini D, Andreotti M, Barnaba V, Belardelli F.

Eur J Immunol. 2006 Aug;36(8):2046-60.


Differentiation of monocyte-derived dendritic cells is associated with upregulation and activation of Rac-1 small GTPase.

Giammarioli AM, Gambardella L, Quaranta MG, Lapenta C, Santini SM, Belardelli F, Viora M, Malorni W.

FEBS Lett. 2006 May 29;580(13):3335-9. Epub 2006 May 8.


Pertussis toxin B-oligomer inhibits HIV infection and replication in hu-PBL-SCID mice.

Lapenta C, Spada M, Santini SM, Racca S, Dorigatti F, Poli G, Belardelli F, Alfano M.

Int Immunol. 2005 Apr;17(4):469-75. Epub 2005 Mar 3.


A new type I IFN-mediated pathway for the rapid differentiation of monocytes into highly active dendritic cells.

Santini SM, Di Pucchio T, Lapenta C, Parlato S, Logozzi M, Belardelli F.

Stem Cells. 2003;21(3):357-62.


CD2+/CD14+ monocytes rapidly differentiate into CD83+ dendritic cells.

Di Pucchio T, Lapenta C, Santini SM, Logozzi M, Parlato S, Belardelli F.

Eur J Immunol. 2003 Feb;33(2):358-67.


The natural alliance between type I interferon and dendritic cells and its role in linking innate and adaptive immunity.

Santini SM, Di Pucchio T, Lapenta C, Parlato S, Logozzi M, Belardelli F.

J Interferon Cytokine Res. 2002 Nov;22(11):1071-80. Review.


Expression of CCR-7, MIP-3beta, and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activities.

Parlato S, Santini SM, Lapenta C, Di Pucchio T, Logozzi M, Spada M, Giammarioli AM, Malorni W, Fais S, Belardelli F.

Blood. 2001 Nov 15;98(10):3022-9.


Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice.

Santini SM, Lapenta C, Logozzi M, Parlato S, Spada M, Di Pucchio T, Belardelli F.

J Exp Med. 2000 May 15;191(10):1777-88.


Primary HIV-1 infection of human CD4+ T cells passaged into SCID mice leads to selection of chronically infected cells through a massive fas-mediated autocrine suicide of uninfected cells.

Parlato S, Santini SM, Lapenta C, Spada M, Logozzi M, Rizza P, Proietti E, Belardelli F, Fais S.

Cell Death Differ. 2000 Jan;7(1):37-47.


Cyclophosphamide induces type I interferon and augments the number of CD44(hi) T lymphocytes in mice: implications for strategies of chemoimmunotherapy of cancer.

Schiavoni G, Mattei F, Di Pucchio T, Santini SM, Bracci L, Belardelli F, Proietti E.

Blood. 2000 Mar 15;95(6):2024-30.


Type I consensus interferon (CIFN) gene transfer into human melanoma cells up-regulates p53 and enhances cisplatin-induced apoptosis: implications for new therapeutic strategies with IFN-alpha.

Mecchia M, Matarrese P, Malorni W, D'Agostino G, Sestili P, Santini SM, Gauzzi MC, Venditti M, Mazzocchi A, Parmiani G, Belardelli F, Ferrantini M.

Gene Ther. 2000 Jan;7(2):167-79.


Type I interferon is a powerful inhibitor of in vivo HIV-1 infection and preserves human CD4(+) T cells from virus-induced depletion in SCID mice transplanted with human cells.

Lapenta C, Santini SM, Proietti E, Rizza P, Logozzi M, Spada M, Parlato S, Fais S, Pitha PM, Belardelli F.

Virology. 1999 Oct 10;263(1):78-88.


Murine interferon-alpha1 gene-transduced ESb tumor cells are rejected by host-mediated mechanisms despite resistance of the parental tumor to interferon-alpha/beta therapy.

Rozera C, Mecchia M, Gresser I, Bandu MT, Proietti E, Venditti M, Sestili P, Santini SM, Fais S, Belardelli F, Ferrantini M.

Cancer Gene Ther. 1999 May-Jun;6(3):246-53.


Human intestinal lamina propria lymphocytes are naturally permissive to HIV-1 infection.

Lapenta C, Boirivant M, Marini M, Santini SM, Logozzi M, Viora M, Belardelli F, Fais S.

Eur J Immunol. 1999 Apr;29(4):1202-8.


The induction of in vivo proliferation of long-lived CD44hi CD8+ T cells after the injection of tumor cells expressing IFN-alpha1 into syngeneic mice.

Belardelli F, Ferrantini M, Santini SM, Baccarini S, Proietti E, Colombo MP, Sprent J, Tough DF.

Cancer Res. 1998 Dec 15;58(24):5795-802.


Role of cytokines in GVL (ESb lymphoma) and GVHD after adoptive transfer of allogeneic T lymphocytes in mice.

Gresser I, Greco G, Santini SM, Woodrow D, Mecchia M, Parlato S, Logozzi M, Venditti M, Maunoury MT, Belardelli F.

J Interferon Cytokine Res. 1998 Sep;18(9):667-79.


Treatment of severe combined immunodeficiency mice with anti-murine granulocyte monoclonal antibody improves human leukocyte xenotransplantation.

Santini SM, Spada M, Parlato S, Logozzi M, Lapenta C, Proietti E, Belardelli F, Fais S.

Transplantation. 1998 Feb 15;65(3):416-20.


U937-SCID mouse xenografts: a new model for acute in vivo HIV-1 infection suitable to test antiviral strategies.

Lapenta C, Fais S, Rizza P, Spada M, Logozzi MA, Parlato S, Santini SM, Pirillo M, Belardelli F, Proietti E.

Antiviral Res. 1997 Nov;36(2):81-90.


Local and systemic antitumor response after combined therapy of mouse metastatic tumors with tumor cells expressing IFN-alpha and HSVtk: perspectives for the generation of cancer vaccines.

Santodonato L, D'Agostino G, Santini SM, Carlei D, Musiani P, Modesti A, Signorelli P, Belardelli F, Ferrantini M.

Gene Ther. 1997 Nov;4(11):1246-55.


T-cell dysfunctions in hu-PBL-SCID mice infected with human immunodeficiency virus (HIV) shortly after reconstitution: in vivo effects of HIV on highly activated human immune cells.

Rizza P, Santini SM, Logozzi MA, Lapenta C, Sestili P, Gherardi G, Lande R, Spada M, Parlato S, Belardelli F, Fais S.

J Virol. 1996 Nov;70(11):7958-64.


HIV type 1 grown on interferon gamma-treated U937 cells shows selective increase in virion-associated intercellular adhesion molecule 1 and HLA-DR and enhanced infectivity for CD4-negative cells.

Castilletti C, Capobianchi MR, Fais S, Abbate I, Ficociello B, Ameglio F, Cordiali Fei P, Santini SM, Dianzani F.

AIDS Res Hum Retroviruses. 1995 May;11(5):547-53.


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