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Items: 1 to 50 of 233

1.

Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides.

Merlino F, Billard É, Yousif AM, Di Maro S, Brancaccio D, Abate L, Carotenuto A, Bellavita R, d'Emmanuele di Villa Bianca R, Santicioli P, Marinelli L, Novellino E, Hébert TE, Lubell WD, Chatenet D, Grieco P.

J Med Chem. 2019 Feb 14;62(3):1455-1467. doi: 10.1021/acs.jmedchem.8b01601. Epub 2019 Jan 23.

PMID:
30615452
2.

Structure-Activity Study of the Peptides P5U and Urantide by the Development of Analogues Containing Uncoded Amino Acids at Position 9.

Merlino F, Brancaccio D, Yousif AM, Piras L, Campiglia P, Gomez-Monterrey I, Santicioli P, Meini S, Maggi CA, Novellino E, Carotenuto A, Grieco P.

ChemMedChem. 2016 Aug 19;11(16):1856-64. doi: 10.1002/cmdc.201500607. Epub 2016 Apr 9.

PMID:
27061352
3.

Gender-related differential effect of tachykinin NK2 receptor-mediated visceral hyperalgesia in guinea pig colon.

Bellucci F, Buéno L, Bugianesi R, Crea A, D'Aranno V, Meini S, Santicioli P, Tramontana M, Maggi CA.

Br J Pharmacol. 2016 Apr;173(8):1329-38. doi: 10.1111/bph.13427. Epub 2016 Mar 7.

4.

Inner and outer portions of colonic circular muscle: ultrastructural and immunohistochemical changes in rat chronically treated with otilonium bromide.

Traini C, Faussone-Pellegrini MS, Evangelista S, Mazzaferro K, Cipriani G, Santicioli P, Vannucchi MG.

PLoS One. 2014 Aug 14;9(8):e103237. doi: 10.1371/journal.pone.0103237. eCollection 2014.

5.

Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor.

Carotenuto A, Auriemma L, Merlino F, Yousif AM, Marasco D, Limatola A, Campiglia P, Gomez-Monterrey I, Santicioli P, Meini S, Maggi CA, Novellino E, Grieco P.

J Med Chem. 2014 Jul 24;57(14):5965-74. doi: 10.1021/jm500218x. Epub 2014 Jul 10.

PMID:
24992374
6.

Antagonist profile of ibodutant at the tachykinin NK(2) receptor in guinea pig isolated bronchi.

Santicioli P, Meini S, Giuliani S, Lecci A, Maggi CA.

Eur J Pharmacol. 2013 Nov 15;720(1-3):180-5.

PMID:
24436990
7.

Chronic treatment with otilonium bromide induces changes in L-type Ca²⁺ channel, tachykinins, and nitric oxide synthase expression in rat colon muscle coat.

Traini C, Cipriani G, Evangelista S, Santicioli P, Faussone-Pellegrini MS, Vannucchi MG.

Neurogastroenterol Motil. 2013 Nov;25(11):e728-39. doi: 10.1111/nmo.12197. Epub 2013 Jul 31.

PMID:
23901937
8.

New insight into the binding mode of peptides at urotensin-II receptor by Trp-constrained analogues of P5U and urantide.

Carotenuto A, Auriemma L, Merlino F, Limatola A, Campiglia P, Gomez-Monterrey I, di Villa Bianca Rd, Brancaccio D, Santicioli P, Meini S, Maggi CA, Novellino E, Grieco P.

J Pept Sci. 2013 May;19(5):293-300. doi: 10.1002/psc.2498. Epub 2013 Mar 25.

PMID:
23526702
9.

Characterization of ibodutant at NK(2) receptor in human colon.

Santicioli P, Meini S, Giuliani S, Catalani C, Bechi P, Riccadonna S, Ringressi MN, Maggi CA.

Eur J Pharmacol. 2013 Feb 28;702(1-3):32-7. doi: 10.1016/j.ejphar.2013.01.021. Epub 2013 Jan 29.

PMID:
23376417
10.

Effect of otilonium bromide and ibodutant on the internalization of the NK2 receptor in human colon.

Cipriani G, Santicioli P, Evangelista S, Maggi CA, Riccadonna S, Ringressi MN, Bechi P, Faussone-Pellegrini MS, Vannucchi MG.

Neurogastroenterol Motil. 2011 Jan;23(1):96-102, e10. doi: 10.1111/j.1365-2982.2010.01594.x.

PMID:
20879991
11.

Radioligand binding characterization of the bradykinin B(2) receptor in the rabbit and pig ileal smooth muscle.

Meini S, Cucchi P, Catalani C, Bellucci F, Santicioli P, Giuliani S, Maggi CA.

Eur J Pharmacol. 2010 Jun 10;635(1-3):34-9. doi: 10.1016/j.ejphar.2010.03.012. Epub 2010 Mar 20.

PMID:
20307535
12.

Pharmacological characterization of the bradykinin B2 receptor antagonist MEN16132 in rat in vitro bioassays.

Meini S, Cucchi P, Catalani C, Bellucci F, Giuliani S, Santicioli P, Maggi CA.

Eur J Pharmacol. 2009 Aug 1;615(1-3):10-6. doi: 10.1016/j.ejphar.2009.04.057. Epub 2009 May 13.

PMID:
19445925
13.

New insight into the binding mode of peptide ligands at Urotensin-II receptor: structure-activity relationships study on P5U and urantide.

Grieco P, Carotenuto A, Campiglia P, Gomez-Monterrey I, Auriemma L, Sala M, Marcozzi C, d'Emmanuele di Villa Bianca R, Brancaccio D, Rovero P, Santicioli P, Meini S, Maggi CA, Novellino E.

J Med Chem. 2009 Jul 9;52(13):3927-40. doi: 10.1021/jm900148c.

PMID:
19432421
14.

Multifaceted approach to determine the antagonist molecular mechanism and interaction of ibodutant ([1-(2-phenyl-1R-[[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-ylmethyl]-carbamoyl]-ethylcarbamoyl)-cyclopentyl]-amide) at the human tachykinin NK2 receptor.

Meini S, Bellucci F, Catalani C, Cucchi P, Giolitti A, Santicioli P, Giuliani S.

J Pharmacol Exp Ther. 2009 May;329(2):486-95. doi: 10.1124/jpet.108.150201. Epub 2009 Feb 13.

PMID:
19218528
15.

Characterization of kinin receptors in human cultured detrusor smooth muscle cells.

Bellucci F, Cucchi P, Santicioli P, Lazzeri M, Turini D, Meini S.

Br J Pharmacol. 2007 Jan;150(2):192-9. Epub 2006 Dec 18.

16.

Comparative antagonist pharmacology at the native mouse bradykinin B2 receptor: radioligand binding and smooth muscle contractility studies.

Meini S, Cucchi P, Bellucci F, Catalani C, Giuliani S, Santicioli P, Maggi CA.

Br J Pharmacol. 2007 Feb;150(3):313-20. Epub 2006 Dec 18.

17.

MEN16132, a novel potent and selective nonpeptide antagonist for the human bradykinin B2 receptor. In vitro pharmacology and molecular characterization.

Cucchi P, Meini S, Bressan A, Catalani C, Bellucci F, Santicioli P, Lecci A, Faiella A, Rotondaro L, Giuliani S, Giolitti A, Quartara L, Maggi CA.

Eur J Pharmacol. 2005 Dec 28;528(1-3):7-16. Epub 2005 Dec 1.

PMID:
16324696
18.

Urotensin-II receptor ligands. From agonist to antagonist activity.

Grieco P, Carotenuto A, Campiglia P, Marinelli L, Lama T, Patacchini R, Santicioli P, Maggi CA, Rovero P, Novellino E.

J Med Chem. 2005 Nov 17;48(23):7290-7.

PMID:
16279788
19.

Pharmacological investigation of hydrogen sulfide (H2S) contractile activity in rat detrusor muscle.

Patacchini R, Santicioli P, Giuliani S, Maggi CA.

Eur J Pharmacol. 2005 Feb 21;509(2-3):171-7.

PMID:
15733553
20.

Hydrogen sulfide (H2S) stimulates capsaicin-sensitive primary afferent neurons in the rat urinary bladder.

Patacchini R, Santicioli P, Giuliani S, Maggi CA.

Br J Pharmacol. 2004 May;142(1):31-4. Epub 2004 Mar 29.

21.

Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta.

Patacchini R, Santicioli P, Giuliani S, Grieco P, Novellino E, Rovero P, Maggi CA.

Br J Pharmacol. 2003 Dec;140(7):1155-8.

22.

Pharmacology of transmission to gastrointestinal muscle.

Lecci A, Santicioli P, Maggi CA.

Curr Opin Pharmacol. 2002 Dec;2(6):630-41. Review.

PMID:
12482724
23.

Role of tachykinins in sephadex-induced airway hyperreactivity and inflammation in guinea pigs.

Tramontana M, Santicioli P, Giuliani S, Catalioto RM, Lecci A, Carini F, Maggi CA.

Eur J Pharmacol. 2002 Mar 29;439(1-3):149-58.

PMID:
11937105
24.

The role of sensory neuropeptides in motor innervation of the hamster isolated urinary bladder.

Giuliani S, Santicioli P, Lippi A, Lecci A, Tramontana M, Maggi CA.

Naunyn Schmiedebergs Arch Pharmacol. 2001 Sep;364(3):242-8.

PMID:
11521167
25.

Urodynamic effects induced by intravesical capsaicin in rats and hamsters.

Lecci A, Carini F, Tramontana M, Birder LA, de Groat WC, Santicioli P, Giuliani S, Maggi CA.

Auton Neurosci. 2001 Aug 13;91(1-2):37-46.

PMID:
11515800
26.

Differences in electromechanical coupling between bradykinin and the nonpeptide kinin B2 receptor agonist, FR 190997, in the circular muscle of guinea-pig colon.

Santicioli P, Catalioto RM, Meini S, Maggi CA.

Naunyn Schmiedebergs Arch Pharmacol. 2001 Feb;363(2):175-81.

PMID:
11218070
27.
28.

Tachykinin-mediated effect of nociceptin in the rat urinary bladder in vivo.

Lecci A, Giuliani S, Tramontana M, Meini S, Santicioli P, Maggi CA.

Eur J Pharmacol. 2000 Feb 11;389(1):99-102.

PMID:
10686301
29.

Antimuscarinic, calcium channel blocker and tachykinin NK2 receptor antagonist actions of otilonium bromide in the circular muscle of guinea-pig colon.

Santicioli P, Zagorodnyuk V, Renzetti AR, Maggi CA.

Naunyn Schmiedebergs Arch Pharmacol. 1999 May;359(5):420-7.

PMID:
10498293
30.

Myogenic and neurogenic factors in the control of pyeloureteral motility and ureteral peristalsis.

Santicioli P, Maggi CA.

Pharmacol Rev. 1998 Dec;50(4):683-722. Review. No abstract available.

PMID:
9860807
31.

Excitatory motor and electrical effects produced by tachykinins in the human and guinea-pig isolated ureter and guinea-pig renal pelvis.

Patacchini R, Santicioli P, Zagorodnyuk V, Lazzeri M, Turini D, Maggi CA.

Br J Pharmacol. 1998 Nov;125(5):987-96.

32.

Pharmacokinetics of the bicyclic peptide tachykinin NK2 receptor antagonist MEN 11420 (nepadutant) in rats.

Lippi A, Criscuoli M, Guelfi M, Santicioli P, Maggi CA.

Drug Metab Dispos. 1998 Nov;26(11):1077-81.

PMID:
9806949
33.

Characterization of the antibronchoconstrictor activity of MEN 11420, a tachykinin NK2 receptor antagonist, in guinea-pigs.

Tramontana M, Patacchini R, Giuliani S, Lippi A, Lecci A, Santicioli P, Criscuoli M, Maggi CA.

Eur J Pharmacol. 1998 Jul 10;352(2-3):279-88.

PMID:
9716365
34.

Bladder distension and activation of the efferent function of sensory fibres: similarities with the effect of capsaicin.

Lecci A, Giuliani S, Tramontana M, Santicioli P, Criscuoli M, Dion S, Maggi CA.

Br J Pharmacol. 1998 May;124(2):259-66.

35.
36.

Depolarization evoked co-release of tachykinins from enteric nerves in the guinea-pig proximal colon.

Lippi A, Santicioli P, Criscuoli M, Maggi CA.

Naunyn Schmiedebergs Arch Pharmacol. 1998 Mar;357(3):245-51.

PMID:
9550295
37.

Evidence for the involvement of multiple mechanisms in the excitatory action of bradykinin in the circular muscle of guinea-pig colon.

Zagorodnyuk V, Santicioli P, Maggi CA.

Naunyn Schmiedebergs Arch Pharmacol. 1998 Mar;357(3):197-204.

PMID:
9550289
38.

MEN 11420, a potent and selective tachykinin NK2 receptor antagonist in the guinea-pig and human colon.

Santicioli P, Giuliani S, Patacchini R, Tramontana M, Criscuoli M, Maggi CA.

Naunyn Schmiedebergs Arch Pharmacol. 1997 Nov;356(5):678-88.

PMID:
9402049
39.

Tachykinin receptors and intestinal motility.

Maggi CA, Catalioto RM, Criscuoli M, Cucchi P, Giuliani S, Lecci A, Lippi A, Meini S, Patacchini R, Renzetti AR, Santicioli P, Tramontana M, Zagorodnyuk V, Giachetti A.

Can J Physiol Pharmacol. 1997 Jun;75(6):696-703. Review.

PMID:
9276151
40.

Tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitatory neuromuscular transmission in the human ileum.

Zagorodnyuk V, Santicioli P, Turini D, Maggi CA.

Neuropeptides. 1997 Jun;31(3):265-71.

PMID:
9243524
41.

CGRP potentiates excitatory transmission to the circular muscle of guinea-pig colon.

Maggi CA, Giuliani S, Santicioli P.

Regul Pept. 1997 Apr 30;69(3):127-36.

PMID:
9226396
42.
43.
44.

Role of intracellular Ca2+ in the K channel opener action of CGRP in the guinea-pig ureter.

Maggi CA, Giuliani S, Santicioli P, Brading AF.

Br J Pharmacol. 1996 Jul;118(6):1493-503.

45.

Effect of niflumic acid on electromechanical coupling by tachykinin NK1 receptor activation in rabbit colon.

Patacchini R, Santicioli P, Maggi CA.

Eur J Pharmacol. 1996 May 15;303(3):197-204.

PMID:
8813568
46.

Protein kinase A inhibitors selectively inhibit the tonic contraction of the guinea pig ureter to high potassium.

Maggi CA, Santicioli P, Giuliani S.

Gen Pharmacol. 1996 Mar;27(2):341-8.

PMID:
8919654
47.

Functional, biochemical and anatomical changes in the rat urinary bladder induced by perigangliar injection of colchicine.

Lecci A, Patacchini R, De Giorgio R, Corinaldesi R, Theodorsson E, Giuliani S, Santicioli P, Maggi CA.

Neuroscience. 1996 Mar;71(1):285-96.

PMID:
8834410
48.

Effect of exercise and 2-deoxyglucose on the K+ channel opener action of CGRP in the guinea pig ureter.

Maggi CA, Santicioli P, Giuliani S.

Gen Pharmacol. 1996 Jan;27(1):95-100.

PMID:
8742502
49.

CGRP inhibition of electromechanical coupling in the guinea-pig isolated renal pelvis.

Maggi CA, Giuliani S, Santicioli P.

Naunyn Schmiedebergs Arch Pharmacol. 1995 Nov;352(5):529-39.

PMID:
8751082
50.

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