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Items: 11

1.

Altered adrenergic response in myocytes bordering a chronic myocardial infarction underlies in vivo triggered activity and repolarization instability.

Dries E, Amoni M, Vandenberk B, Johnson DM, Gilbert G, Nagaraju CK, Puertas RD, Abdesselem M, Santiago DJ, Roderick HL, Claus P, Willems R, Sipido KR.

J Physiol. 2020 Jan 3. doi: 10.1113/JP278839. [Epub ahead of print]

PMID:
31900932
2.

Severe Cardiac Dysfunction and Death Caused by Arrhythmogenic Right Ventricular Cardiomyopathy Type 5 Are Improved by Inhibition of Glycogen Synthase Kinase-3β.

Padrón-Barthe L, Villalba-Orero M, Gómez-Salinero JM, Domínguez F, Román M, Larrasa-Alonso J, Ortiz-Sánchez P, Martínez F, López-Olañeta M, Bonzón-Kulichenko E, Vázquez J, Martí-Gómez C, Santiago DJ, Prados B, Giovinazzo G, Gómez-Gaviro MV, Priori S, Garcia-Pavia P, Lara-Pezzi E.

Circulation. 2019 Oct;140(14):1188-1204. doi: 10.1161/CIRCULATIONAHA.119.040366. Epub 2019 Sep 5.

3.

Hyperactive ryanodine receptors in human heart failure and ischaemic cardiomyopathy reside outside of couplons.

Dries E, Santiago DJ, Gilbert G, Lenaerts I, Vandenberk B, Nagaraju CK, Johnson DM, Holemans P, Roderick HL, Macquaide N, Claus P, Sipido KR.

Cardiovasc Res. 2018 Sep 1;114(11):1512-1524. doi: 10.1093/cvr/cvy088.

4.

Arrhythmogenic Cardiomyopathy: Pathophysiology Beyond Cardiac Myocytes.

Priori SG, Santiago DJ.

Circ Res. 2017 Dec 8;121(12):1296-1298. doi: 10.1161/CIRCRESAHA.117.312211. No abstract available.

PMID:
29217704
5.

Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant.

Tzimas C, Johnson DM, Santiago DJ, Vafiadaki E, Arvanitis DA, Davos CH, Varela A, Athanasiadis NC, Dimitriou C, Katsimpoulas M, Sonntag S, Kryzhanovska M, Shmerling D, Lehnart SE, Sipido KR, Kranias EG, Sanoudou D.

Cardiovasc Res. 2017 Sep 1;113(11):1403-1417. doi: 10.1093/cvr/cvx113.

PMID:
28859293
6.

A cryo-EM-based model of phosphorylation- and FKBP12.6-mediated allosterism of the cardiac ryanodine receptor.

Dhindwal S, Lobo J, Cabra V, Santiago DJ, Nayak AR, Dryden K, Samsó M.

Sci Signal. 2017 May 23;10(480). pii: eaai8842. doi: 10.1126/scisignal.aai8842.

PMID:
28536302
7.

Calcium/calmodulin-dependent kinase II and nitric oxide synthase 1-dependent modulation of ryanodine receptors during β-adrenergic stimulation is restricted to the dyadic cleft.

Dries E, Santiago DJ, Johnson DM, Gilbert G, Holemans P, Korte SM, Roderick HL, Sipido KR.

J Physiol. 2016 Oct 15;594(20):5923-5939. doi: 10.1113/JP271965. Epub 2016 Jul 3.

8.

Calcium release near L-type calcium channels promotes beat-to-beat variability in ventricular myocytes from the chronic AV block dog.

Antoons G, Johnson DM, Dries E, Santiago DJ, Ozdemir S, Lenaerts I, Beekman JD, Houtman MJ, Sipido KR, Vos MA.

J Mol Cell Cardiol. 2015 Dec;89(Pt B):326-34. doi: 10.1016/j.yjmcc.2015.10.008. Epub 2015 Oct 8.

9.

Isoproterenol increases the fraction of spark-dependent RyR-mediated leak in ventricular myocytes.

Santiago DJ, Ríos E, Shannon TR.

Biophys J. 2013 Mar 5;104(5):976-85. doi: 10.1016/j.bpj.2013.01.026.

10.

Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes.

Santiago DJ, Curran JW, Bers DM, Lederer WJ, Stern MD, Ríos E, Shannon TR.

Biophys J. 2010 May 19;98(10):2111-20. doi: 10.1016/j.bpj.2010.01.042.

11.

Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase II.

Curran J, Brown KH, Santiago DJ, Pogwizd S, Bers DM, Shannon TR.

J Mol Cell Cardiol. 2010 Jul;49(1):25-32. doi: 10.1016/j.yjmcc.2010.03.013. Epub 2010 Mar 29.

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