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Effects of N-trans-feruloyltyramine isolated from laba garlic on antioxidant, cytotoxic activities and H2O2-induced oxidative damage in HepG2 and L02 cells.

Gao X, Wang C, Chen Z, Chen Y, Santhanam RK, Xue Z, Ma Q, Guo Q, Liu W, Zhang M, Chen H.

Food Chem Toxicol. 2019 Aug;130:130-141. doi: 10.1016/j.fct.2019.05.021. Epub 2019 May 16.


Type B Lactic Acidosis: A Rare Initial Presentation of Childhood Acute Lymphoblastic Leukemia.

Narayani S, Balu P, Santhanam R, Scott JX.

Indian J Nephrol. 2019 Jan-Feb;29(1):71-73. doi: 10.4103/ijn.IJN_181_16. No abstract available.


Structural characterization of corn silk polysaccharides and its effect in H2O2 induced oxidative damage in L6 skeletal muscle cells.

Guo Q, Xu L, Chen Y, Ma Q, Santhanam RK, Xue Z, Gao X, Chen H.

Carbohydr Polym. 2019 Mar 15;208:161-167. doi: 10.1016/j.carbpol.2018.12.049. Epub 2018 Dec 19.


A suite of complementary biocontrol traits allows a native consortium of root-associated bacteria to protect their host plant from a fungal sudden-wilt disease.

Santhanam R, Menezes RC, Grabe V, Li D, Baldwin IT, Groten K.

Mol Ecol. 2019 Mar;28(5):1154-1169. doi: 10.1111/mec.15012.


Inhibitory effect of epigallocatechin-3-O-gallate on α-glucosidase and its hypoglycemic effect via targeting PI3K/AKT signaling pathway in L6 skeletal muscle cells.

Xu L, Li W, Chen Z, Guo Q, Wang C, Santhanam RK, Chen H.

Int J Biol Macromol. 2019 Mar 15;125:605-611. doi: 10.1016/j.ijbiomac.2018.12.064. Epub 2018 Dec 7.


Hypoglycemic effects of polysaccharides from corn silk (Maydis stigma) and their beneficial roles via regulating the PI3K/Akt signaling pathway in L6 skeletal muscle myotubes.

Guo Q, Chen Z, Santhanam RK, Xu L, Gao X, Ma Q, Xue Z, Chen H.

Int J Biol Macromol. 2019 Jan;121:981-988. doi: 10.1016/j.ijbiomac.2018.10.100. Epub 2018 Oct 18.


Effect of different drying methods on the physicochemical properties and antioxidant activities of mulberry leaves polysaccharides.

Ma Q, Santhanam RK, Xue Z, Guo Q, Gao X, Chen H.

Int J Biol Macromol. 2018 Nov;119:1137-1143. doi: 10.1016/j.ijbiomac.2018.08.023. Epub 2018 Aug 8.


Anti-leukemic effects of all-trans retinoic acid in combination with Daratumumab in acute myeloid leukemia.

Buteyn NJ, Fatehchand K, Santhanam R, Fang H, Dettorre GM, Gautam S, Harrington BK, Henderson SE, Merchand-Reyes G, Mo X, Benson DM, Carson WE 3rd, Vasu S, Byrd JC, Butchar JP, Tridandapani S.

Int Immunol. 2018 Jul 24;30(8):375-383. doi: 10.1093/intimm/dxy040.


Effects of polysaccharides from Inonotus obliquus and its chromium (III) complex on advanced glycation end-products formation, α-amylase, α-glucosidase activity and H2O2-induced oxidative damage in hepatic L02 cells.

Wang C, Gao X, Santhanam RK, Chen Z, Chen Y, Xu L, Wang C, Ferri N, Chen H.

Food Chem Toxicol. 2018 Jun;116(Pt B):335-345. doi: 10.1016/j.fct.2018.04.047. Epub 2018 Apr 22.


Inhibition of UVB-induced pro-inflammatory cytokines and MMP expression by Zanthoxylum rhetsa bark extract and its active constituent hesperidin.

Santhanam RK, Fakurazi S, Ahmad S, Abas F, Ismail IS, Rukayadi Y, Akhtar MT, Shaari K.

Phytother Res. 2018 Aug;32(8):1608-1616. doi: 10.1002/ptr.6092. Epub 2018 Apr 19.


Poly-ligand profiling differentiates trastuzumab-treated breast cancer patients according to their outcomes.

Domenyuk V, Gatalica Z, Santhanam R, Wei X, Stark A, Kennedy P, Toussaint B, Levenberg S, Wang J, Xiao N, Greil R, Rinnerthaler G, Gampenrieder SP, Heimberger AB, Berry DA, Barker A, Quackenbush J, Marshall JL, Poste G, Vacirca JL, Vidal GA, Schwartzberg LS, Halbert DD, Voss A, Magee D, Miglarese MR, Famulok M, Mayer G, Spetzler D.

Nat Commun. 2018 Mar 23;9(1):1219. doi: 10.1038/s41467-018-03631-z.


Active hexose-correlated compound enhances extrinsic-pathway-mediated apoptosis of Acute Myeloid Leukemic cells.

Fatehchand K, Santhanam R, Shen B, Erickson EL, Gautam S, Elavazhagan S, Mo X, Belay T, Tridandapani S, Butchar JP.

PLoS One. 2017 Jul 20;12(7):e0181729. doi: 10.1371/journal.pone.0181729. eCollection 2017.


Specificity of root microbiomes in native-grown Nicotiana attenuata and plant responses to UVB increase Deinococcus colonization.

Santhanam R, Oh Y, Kumar R, Weinhold A, Luu VT, Groten K, Baldwin IT.

Mol Ecol. 2017 May;26(9):2543-2562. doi: 10.1111/mec.14049. Epub 2017 Mar 8.


Interferon-γ Promotes Antibody-mediated Fratricide of Acute Myeloid Leukemia Cells.

Fatehchand K, McMichael EL, Reader BF, Fang H, Santhanam R, Gautam S, Elavazhagan S, Mehta P, Buteyn NJ, Merchand-Reyes G, Vasu S, Mo X, Benson DM Jr, Blachly JS, Carson WE 3rd, Byrd JC, Butchar JP, Tridandapani S.

J Biol Chem. 2016 Dec 2;291(49):25656-25666. Epub 2016 Oct 25.


Targeting the RAS/MAPK pathway with miR-181a in acute myeloid leukemia.

Huang X, Schwind S, Santhanam R, Eisfeld AK, Chiang CL, Lankenau M, Yu B, Hoellerbauer P, Jin Y, Tarighat SS, Khalife J, Walker A, Perrotti D, Bloomfield CD, Wang H, Lee RJ, Lee LJ, Marcucci G.

Oncotarget. 2016 Sep 13;7(37):59273-59286. doi: 10.18632/oncotarget.11150.


Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development.

Pichiorri F, Suh SS, Rocci A, De Luca L, Taccioli C, Santhanam R, Zhou W, Benson DM Jr, Hofmainster C, Alder H, Garofalo M, Di Leva G, Volinia S, Lin HJ, Perrotti D, Kuehl M, Aqeilan RI, Palumbo A, Croce CM.

Cancer Cell. 2016 Aug 8;30(2):349-351. doi: 10.1016/j.ccell.2016.07.007. Epub 2016 Aug 8. No abstract available.


Tram-track-like calcification in adult optic pathway glioma.

Sindhuja A, Indiran V, Santhanam R, Maduraimuthu P.

BJR Case Rep. 2016 Jul 28;2(3):20150378. doi: 10.1259/bjrcr.20150378. eCollection 2016.


Bioactive Constituents of Zanthoxylum rhetsa Bark and Its Cytotoxic Potential against B16-F10 Melanoma Cancer and Normal Human Dermal Fibroblast (HDF) Cell Lines.

Santhanam RK, Ahmad S, Abas F, Safinar Ismail I, Rukayadi Y, Tayyab Akhtar M, Shaari K.

Molecules. 2016 May 24;21(6). pii: E652. doi: 10.3390/molecules21060652.


Thoracic spinal osteomyelitis due to Salmonella enteritidis in an immunocompetent mimicking tuberculosis.

Lakshmi K, Santhanam R.

J Neurosci Rural Pract. 2016 Apr-Jun;7(2):317-9. doi: 10.4103/0976-3147.178669. No abstract available.


The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation.

Tarighat SS, Santhanam R, Frankhouser D, Radomska HS, Lai H, Anghelina M, Wang H, Huang X, Alinari L, Walker A, Caligiuri MA, Croce CM, Li L, Garzon R, Li C, Baiocchi RA, Marcucci G.

Leukemia. 2016 Apr;30(4):789-99. doi: 10.1038/leu.2015.308. Epub 2015 Nov 5.


Native root-associated bacteria rescue a plant from a sudden-wilt disease that emerged during continuous cropping.

Santhanam R, Luu VT, Weinhold A, Goldberg J, Oh Y, Baldwin IT.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E5013-20. doi: 10.1073/pnas.1505765112. Epub 2015 Aug 25.


A Retrospective Analysis of the Management of Postoperative Discitis: A Single Institutional Experience.

Santhanam R, Lakshmi K.

Asian Spine J. 2015 Aug;9(4):559-64. doi: 10.4184/asj.2015.9.4.559. Epub 2015 Jul 28.


Gradual Rarefaction of Hematopoietic Precursors and Atrophy in a Depleted microRNA 29a, b and c Environment.

Kauffman L, Balatti V, Cascione L, Fadda P, Racke F, Santhanam R, Costinean S.

PLoS One. 2015 Jul 6;10(7):e0131981. doi: 10.1371/journal.pone.0131981. eCollection 2015. Retraction in: PLoS One. 2017 Oct 30;12 (10 ):e0187454.


Pyridine-type alkaloid composition affects bacterial community composition of floral nectar.

Aizenberg-Gershtein Y, Izhaki I, Santhanam R, Kumar P, Baldwin IT, Halpern M.

Sci Rep. 2015 Jun 30;5:11536. doi: 10.1038/srep11536.


Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia.

Khalife J, Radomska HS, Santhanam R, Huang X, Neviani P, Saultz J, Wang H, Wu YZ, Alachkar H, Anghelina M, Dorrance A, Curfman J, Bloomfield CD, Medeiros BC, Perrotti D, Lee LJ, Lee RJ, Caligiuri MA, Pichiorri F, Croce CM, Garzon R, Guzman ML, Mendler JH, Marcucci G.

Leukemia. 2015 Oct;29(10):1981-92. doi: 10.1038/leu.2015.106. Epub 2015 May 14.


Silencing a key gene of the common symbiosis pathway in Nicotiana attenuata specifically impairs arbuscular mycorrhizal infection without influencing the root-associated microbiome or plant growth.

Groten K, Nawaz A, Nguyen NH, Santhanam R, Baldwin IT.

Plant Cell Environ. 2015 Nov;38(11):2398-416. doi: 10.1111/pce.12561. Epub 2015 Jul 7.


Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemia.

Ranganathan P, Yu X, Santhanam R, Hofstetter J, Walker A, Walsh K, Bhatnagar B, Klisovic R, Vasu S, Phelps MA, Devine S, Shacham S, Kauffman M, Marcucci G, Blum W, Garzon R.

Blood. 2015 Apr 23;125(17):2689-92. doi: 10.1182/blood-2014-10-607648. Epub 2015 Feb 25.


Small molecule specific run acceptance, specific assay operation, and chromatographic run quality assessment: recommendation for best practices and harmonization from the global bioanalysis consortium harmonization teams.

Woolf EJ, McDougall S, Fast DM, Andraus M, Barfield M, Blackburn M, Gordon B, Hoffman D, Inoue N, Marcelin-Jimenez G, Flynn A, LeLacheur R, Reuschel S, Santhanam R, Bennett P, Duncan B, Hayes R, Lausecker B, Sharma A, Togashi K, Trivedi RK, Vago M, White S, Barton H, Dunn JA, Farmen RH, Heinig K, Holliman C, Komaba J, Riccio MF, Thomas E; Global Bioanalysis Consortium Harmonization Teams.

AAPS J. 2014 Sep;16(5):885-93. doi: 10.1208/s12248-014-9633-4. Epub 2014 Jun 25.


Intronic miR-3151 within BAALC drives leukemogenesis by deregulating the TP53 pathway.

Eisfeld AK, Schwind S, Patel R, Huang X, Santhanam R, Walker CJ, Markowitz J, Hoag KW, Jarvinen TM, Leffel B, Perrotti D, Carson WE 3rd, Marcucci G, Bloomfield CD, de la Chapelle A.

Sci Signal. 2014 Apr 15;7(321):ra36. doi: 10.1126/scisignal.2004762.


Anaplastic carcinoma of the pancreas: is there a role for palliative surgical procedure?

Vaithianathan R, Panneerselvam S, Santhanam R.

Indian J Palliat Care. 2014 Jan;20(1):50-2. doi: 10.4103/0973-1075.125560.


SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome.

Alachkar H, Santhanam R, Maharry K, Metzeler KH, Huang X, Kohlschmidt J, Mendler JH, Benito JM, Hickey C, Neviani P, Dorrance AM, Anghelina M, Khalife J, Tarighat SS, Volinia S, Whitman SP, Paschka P, Hoellerbauer P, Wu YZ, Han L, Bolon BN, Blum W, Mrózek K, Carroll AJ, Perrotti D, Andreeff M, Caligiuri MA, Konopleva M, Garzon R, Bloomfield CD, Marcucci G.

J Clin Invest. 2014 Apr;124(4):1512-24. doi: 10.1172/JCI70921. Epub 2014 Mar 3.


Non-syndromic hearing impairment in India: high allelic heterogeneity among mutations in TMPRSS3, TMC1, USHIC, CDH23 and TMIE.

Ganapathy A, Pandey N, Srisailapathy CR, Jalvi R, Malhotra V, Venkatappa M, Chatterjee A, Sharma M, Santhanam R, Chadha S, Ramesh A, Agarwal AK, Rangasayee RR, Anand A.

PLoS One. 2014 Jan 8;9(1):e84773. doi: 10.1371/journal.pone.0084773. eCollection 2014.


Comprehensive quantum chemical and spectroscopic (FTIR, FT-Raman, 1H, 13C NMR) investigations of O-desmethyltramadol hydrochloride an active metabolite in tramadol--an analgesic drug.

Arjunan V, Santhanam R, Marchewka MK, Mohan S.

Spectrochim Acta A Mol Biomol Spectrosc. 2014 Mar 25;122:315-30. doi: 10.1016/j.saa.2013.11.040. Epub 2013 Nov 20.


Brain abscess as a complication of chronic thromboembolic pulmonary hypertension - a rare case report.

K L, R S, S C.

J Clin Diagn Res. 2013 Sep;7(9):2027-8. doi: 10.7860/JCDR/2013/5627.3396. Epub 2013 Sep 10.


Eradicating acute myeloid leukemia in a Mll(PTD/wt):Flt3(ITD/wt) murine model: a path to novel therapeutic approaches for human disease.

Bernot KM, Nemer JS, Santhanam R, Liu S, Zorko NA, Whitman SP, Dickerson KE, Zhang M, Yang X, McConnell KK, Ahmed EH, Muñoz MR, Siebenaler RF, Marcucci GG, Mundy-Bosse BL, Brook DL, Garman S, Dorrance AM, Zhang X, Zhang J, Lee RJ, Blum W, Caligiuri MA, Marcucci G.

Blood. 2013 Nov 28;122(23):3778-83. doi: 10.1182/blood-2013-06-507426. Epub 2013 Oct 1.


PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells.

Neviani P, Harb JG, Oaks JJ, Santhanam R, Walker CJ, Ellis JJ, Ferenchak G, Dorrance AM, Paisie CA, Eiring AM, Ma Y, Mao HC, Zhang B, Wunderlich M, May PC, Sun C, Saddoughi SA, Bielawski J, Blum W, Klisovic RB, Solt JA, Byrd JC, Volinia S, Cortes J, Huettner CS, Koschmieder S, Holyoake TL, Devine S, Caligiuri MA, Croce CM, Garzon R, Ogretmen B, Arlinghaus RB, Chen CS, Bittman R, Hokland P, Roy DC, Milojkovic D, Apperley J, Goldman JM, Reid A, Mulloy JC, Bhatia R, Marcucci G, Perrotti D.

J Clin Invest. 2013 Oct;123(10):4144-57. doi: 10.1172/JCI68951. Epub 2013 Sep 3.


Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias.

Walker CJ, Oaks JJ, Santhanam R, Neviani P, Harb JG, Ferenchak G, Ellis JJ, Landesman Y, Eisfeld AK, Gabrail NY, Smith CL, Caligiuri MA, Hokland P, Roy DC, Reid A, Milojkovic D, Goldman JM, Apperley J, Garzon R, Marcucci G, Shacham S, Kauffman MG, Perrotti D.

Blood. 2013 Oct 24;122(17):3034-44. doi: 10.1182/blood-2013-04-495374. Epub 2013 Aug 22.


Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies.

Oaks JJ, Santhanam R, Walker CJ, Roof S, Harb JG, Ferenchak G, Eisfeld AK, Van Brocklyn JR, Briesewitz R, Saddoughi SA, Nagata K, Bittman R, Caligiuri MA, Abdel-Wahab O, Levine R, Arlinghaus RB, Quintas-Cardama A, Goldman JM, Apperley J, Reid A, Milojkovic D, Ziolo MT, Marcucci G, Ogretmen B, Neviani P, Perrotti D.

Blood. 2013 Sep 12;122(11):1923-34. doi: 10.1182/blood-2013-03-492181. Epub 2013 Aug 7. Erratum in: Blood. 2014 May 8;123(19):3056.


Toward personalized therapy in AML: in vivo benefit of targeting aberrant epigenetics in MLL-PTD-associated AML.

Bernot KM, Siebenaler RF, Whitman SP, Zorko NA, Marcucci GG, Santhanam R, Ahmed EH, Ngangana M, McConnell KK, Nemer JS, Brook DL, Kulp SK, Chen CS, Frankhouser D, Yan P, Bundschuh R, Zhang X, Dorrance AM, Dickerson KE, Jarjoura D, Blum W, Marcucci G, Caligiuri MA.

Leukemia. 2013 Dec;27(12):2379-82. doi: 10.1038/leu.2013.147. Epub 2013 May 10. No abstract available.


Primidone--an antiepileptic drug--characterisation by quantum chemical and spectroscopic (FTIR, FT-Raman, 1H, 13C NMR and UV-Visible) investigations.

Arjunan V, Santhanam R, Subramanian S, Mohan S.

Spectrochim Acta A Mol Biomol Spectrosc. 2013 May 15;109:282-97. doi: 10.1016/j.saa.2013.03.025. Epub 2013 Mar 14.


Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status.

Di Leva G, Piovan C, Gasparini P, Ngankeu A, Taccioli C, Briskin D, Cheung DG, Bolon B, Anderlucci L, Alder H, Nuovo G, Li M, Iorio MV, Galasso M, Santhanam R, Marcucci G, Perrotti D, Powell KA, Bratasz A, Garofalo M, Nephew KP, Croce CM.

PLoS Genet. 2013;9(3):e1003311. doi: 10.1371/journal.pgen.1003311. Epub 2013 Mar 7. Erratum in: PLoS Genet. 2013 Apr;9(4). doi:10.1371/annotation/92dfa670-d431-4d68-b70b-706df1f93e46. Ramasamy, Santhanam [corrected to Santhanam, Ramasamy].


Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia.

Alachkar H, Santhanam R, Harb JG, Lucas DM, Oaks JJ, Hickey CJ, Pan L, Kinghorn AD, Caligiuri MA, Perrotti D, Byrd JC, Garzon R, Grever MR, Marcucci G.

J Hematol Oncol. 2013 Mar 16;6:21. doi: 10.1186/1756-8722-6-21.


Targeted delivery of microRNA-29b by transferrin-conjugated anionic lipopolyplex nanoparticles: a novel therapeutic strategy in acute myeloid leukemia.

Huang X, Schwind S, Yu B, Santhanam R, Wang H, Hoellerbauer P, Mims A, Klisovic R, Walker AR, Chan KK, Blum W, Perrotti D, Byrd JC, Bloomfield CD, Caligiuri MA, Lee RJ, Garzon R, Muthusamy N, Lee LJ, Marcucci G.

Clin Cancer Res. 2013 May 1;19(9):2355-67. doi: 10.1158/1078-0432.CCR-12-3191. Epub 2013 Mar 14.


Conformational, vibrational, NMR and DFT studies of N-methylacetanilide.

Arjunan V, Santhanam R, Rani T, Rosi H, Mohan S.

Spectrochim Acta A Mol Biomol Spectrosc. 2013 Mar;104:182-96. doi: 10.1016/j.saa.2012.11.037. Epub 2012 Nov 29.


Structural, vibrational, electronic investigations and quantum chemical studies of 2-amino-4-methoxybenzothiazole.

Arjunan V, Raj A, Santhanam R, Marchewka MK, Mohan S.

Spectrochim Acta A Mol Biomol Spectrosc. 2013 Feb;102:327-40. doi: 10.1016/j.saa.2012.09.076. Epub 2012 Oct 13.


In vivo quantification of active decitabine-triphosphate metabolite: a novel pharmacoanalytical endpoint for optimization of hypomethylating therapy in acute myeloid leukemia.

Wang H, Chen P, Wang J, Santhanam R, Aimiuwu J, Saradhi UV, Liu Z, Schwind S, Mims A, Byrd JC, Grever MR, Villalona-Calero MA, Klisovic R, Walker A, Garzon R, Blum W, Chan KK, Marcucci G.

AAPS J. 2013 Jan;15(1):242-9. doi: 10.1208/s12248-012-9427-5. Epub 2012 Nov 22.


Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia.

Mims A, Walker AR, Huang X, Sun J, Wang H, Santhanam R, Dorrance AM, Walker C, Hoellerbauer P, Tarighat SS, Chan KK, Klisovic RB, Perrotti D, Caligiuri MA, Byrd JC, Chen CS, James Lee L, Jacob S, Mrózek K, Bloomfield CD, Blum W, Garzon R, Schwind S, Marcucci G.

Leukemia. 2013 Apr;27(4):871-8. doi: 10.1038/leu.2012.342. Epub 2012 Nov 26.


miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the Eμ-miR-155 transgenic mouse model.

Sandhu SK, Volinia S, Costinean S, Galasso M, Neinast R, Santhanam R, Parthun MR, Perrotti D, Marcucci G, Garzon R, Croce CM.

Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20047-52. doi: 10.1073/pnas.1213764109. Epub 2012 Nov 19.

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