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Items: 1 to 50 of 58

1.

Human cardiac myosin light chain 4 (MYL4) mosaic expression patterns vary by sex.

Wang TY, Arking DE, Maleszewski JJ, Fox-Talbot K, Nieuwenhuis TO, Santhanam L, Virmani R, Rosenberg AZ, Halushka MK.

Sci Rep. 2019 Sep 3;9(1):12681. doi: 10.1038/s41598-019-49191-0.

2.

Regenerative and durable small-diameter graft as an arterial conduit.

Elliott MB, Ginn B, Fukunishi T, Bedja D, Suresh A, Chen T, Inoue T, Dietz HC, Santhanam L, Mao HQ, Hibino N, Gerecht S.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12710-12719. doi: 10.1073/pnas.1905966116. Epub 2019 Jun 10.

PMID:
31182572
3.

Lysyl oxidase-like 2 depletion is protective in age-associated vascular stiffening.

Steppan J, Wang H, Bergman Y, Rauer MJ, Tan S, Jandu S, Nandakumar K, Barreto-Ortiz S, Cole RN, Boronina TN, Zhu W, Halushka MK, An SS, Berkowitz DE, Santhanam L.

Am J Physiol Heart Circ Physiol. 2019 Jul 1;317(1):H49-H59. doi: 10.1152/ajpheart.00670.2018. Epub 2019 Apr 19.

PMID:
31002285
4.

Oxidative Stress Contributes to Microvascular Endothelial Dysfunction in Men and Women With Major Depressive Disorder.

Greaney JL, Saunders EFH, Santhanam L, Alexander LM.

Circ Res. 2019 Feb 15;124(4):564-574. doi: 10.1161/CIRCRESAHA.118.313764.

PMID:
30582458
5.

Erratum for McCarthy et al., "Identification of a Shared Cytochrome p4502E1 Epitope Found in Anesthetic Drug-Induced and Viral Hepatitis".

McCarthy EK, Vakos A, Cottagiri M, Mantilla JJ, Santhanam L, Thomas DL, Amzel LM, Rose NR, Njoku DB.

mSphere. 2018 Dec 5;3(6). pii: e00654-18. doi: 10.1128/mSphere.00654-18. No abstract available.

6.

Knockdown of transglutaminase-2 prevents early age-induced vascular changes in mice1.

Armstrong DMF, Sikka G, Armstrong ADC, Saad KR, Freitas WR, Berkowitz DE, Fagundes DJ, Santhanam L, Taha MO.

Acta Cir Bras. 2018 Nov;33(11):991-999. doi: 10.1590/s0102-865020180110000006.

7.

Formation of Neoarteries with Optimal Remodeling Using Rapidly Degrading Textile Vascular Grafts.

Fukunishi T, Ong CS, Lui C, Pitaktong I, Smoot C, Harris J, Gabriele P, Vricella L, Santhanam L, Lu S, Hibino N.

Tissue Eng Part A. 2019 Apr;25(7-8):632-641. doi: 10.1089/ten.TEA.2018.0167. Epub 2019 Jan 7.

PMID:
30382009
8.

Identification of a Shared Cytochrome p4502E1 Epitope Found in Anesthetic Drug-Induced and Viral Hepatitis.

McCarthy EK, Vakos A, Cottagiri M, Mantilla JJ, Santhanam L, Thomas DL, Amzel LM, Rose NR, Njoku DB.

mSphere. 2018 Oct 10;3(5). pii: e00453-18. doi: 10.1128/mSphere.00453-18. Erratum in: mSphere. 2018 Dec 5;3(6):. Mantila, Joel J [corrected to Mantilla, Joel J].

9.

Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium.

Pandey D, Nomura Y, Rossberg MC, Hori D, Bhatta A, Keceli G, Leucker T, Santhanam L, Shimoda LA, Berkowitz D, Romer L.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):913-926. doi: 10.1161/ATVBAHA.117.310660. Epub 2018 Feb 22.

10.

Imatinib Is Protective Against Ischemia-Reperfusion Injury in an Ex Vivo Rabbit Model of Lung Injury.

Magruder JT, Grimm JC, Crawford TC, Johnston L, Santhanam L, Stephens RS, Berkowitz DE, Shah AS, Bush EL, Damarla M, Damico RL, Hassoun PM, Kim BS.

Ann Thorac Surg. 2018 Mar;105(3):950-956. doi: 10.1016/j.athoracsur.2017.10.002. Epub 2017 Dec 28.

PMID:
29289364
11.

Acute lysyl oxidase inhibition alters microvascular function in normotensive but not hypertensive men and women.

Craighead DH, Wang H, Santhanam L, Alexander LM.

Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H424-H433. doi: 10.1152/ajpheart.00521.2017. Epub 2017 Nov 22.

12.

A Special Report on the NHLBI Initiative to Study Cellular and Molecular Mechanisms of Arterial Stiffness and Its Association With Hypertension.

Oh YS, Berkowitz DE, Cohen RA, Figueroa CA, Harrison DG, Humphrey JD, Larson DF, Leopold JA, Mecham RP, Ruiz-Opazo N, Santhanam L, Seta F, Shyy JYJ, Sun Z, Tsao PS, Wagenseil JE, Galis ZS.

Circ Res. 2017 Nov 10;121(11):1216-1218. doi: 10.1161/CIRCRESAHA.117.311703. Review. No abstract available.

13.

Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia.

Stanhewicz AE, Jandu S, Santhanam L, Alexander LM.

Clin Sci (Lond). 2017 Nov 23;131(23):2777-2789. doi: 10.1042/CS20171292. Print 2017 Dec 22.

14.

Opsin 3 and 4 mediate light-induced pulmonary vasorelaxation that is potentiated by G protein-coupled receptor kinase 2 inhibition.

Barreto Ortiz S, Hori D, Nomura Y, Yun X, Jiang H, Yong H, Chen J, Paek S, Pandey D, Sikka G, Bhatta A, Gillard A, Steppan J, Kim JH, Adachi H, Barodka VM, Romer L, An SS, Shimoda LA, Santhanam L, Berkowitz DE.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L93-L106. doi: 10.1152/ajplung.00091.2017. Epub 2017 Sep 7.

15.

Increased Angiotensin II Sensitivity Contributes to Microvascular Dysfunction in Women Who Have Had Preeclampsia.

Stanhewicz AE, Jandu S, Santhanam L, Alexander LM.

Hypertension. 2017 Aug;70(2):382-389. doi: 10.1161/HYPERTENSIONAHA.117.09386. Epub 2017 Jun 26.

16.

Impaired Hydrogen Sulfide-Mediated Vasodilation Contributes to Microvascular Endothelial Dysfunction in Hypertensive Adults.

Greaney JL, Kutz JL, Shank SW, Jandu S, Santhanam L, Alexander LM.

Hypertension. 2017 May;69(5):902-909. doi: 10.1161/HYPERTENSIONAHA.116.08964. Epub 2017 Mar 27.

17.

miR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling.

Hori D, Dunkerly-Eyring B, Nomura Y, Biswas D, Steppan J, Henao-Mejia J, Adachi H, Santhanam L, Berkowitz DE, Steenbergen C, Flavell RA, Das S.

PLoS One. 2017 Mar 21;12(3):e0174108. doi: 10.1371/journal.pone.0174108. eCollection 2017.

18.

Cystathionine γ-lyase protects vascular endothelium: a role for inhibition of histone deacetylase 6.

Leucker TM, Nomura Y, Kim JH, Bhatta A, Wang V, Wecker A, Jandu S, Santhanam L, Berkowitz D, Romer L, Pandey D.

Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H711-H720. doi: 10.1152/ajpheart.00724.2016. Epub 2017 Feb 10.

19.

Tissue Transglutaminase Modulates Vascular Stiffness and Function Through Crosslinking-Dependent and Crosslinking-Independent Functions.

Steppan J, Bergman Y, Viegas K, Armstrong D, Tan S, Wang H, Melucci S, Hori D, Park SY, Barreto SF, Isak A, Jandu S, Flavahan N, Butlin M, An SS, Avolio A, Berkowitz DE, Halushka MK, Santhanam L.

J Am Heart Assoc. 2017 Feb 3;6(2). pii: e004161. doi: 10.1161/JAHA.116.004161.

20.

Defining an olfactory receptor function in airway smooth muscle cells.

Aisenberg WH, Huang J, Zhu W, Rajkumar P, Cruz R, Santhanam L, Natarajan N, Yong HM, De Santiago B, Oh JJ, Yoon AR, Panettieri RA, Homann O, Sullivan JK, Liggett SB, Pluznick JL, An SS.

Sci Rep. 2016 Dec 1;6:38231. doi: 10.1038/srep38231.

21.

Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice.

Steppan J, Tran HT, Bead VR, Oh YJ, Sikka G, Bivalacqua TJ, Burnett AL, Berkowitz DE, Santhanam L.

Anesth Analg. 2016 Sep;123(3):652-8. doi: 10.1213/ANE.0000000000001378.

22.

Role of tissue transglutaminase in age-associated ventricular stiffness.

Oh YJ, Pau VC, Steppan J, Sikka G, Bead VR, Nyhan D, Levine BD, Berkowitz DE, Santhanam L.

Amino Acids. 2017 Mar;49(3):695-704. doi: 10.1007/s00726-016-2295-z. Epub 2016 Jul 20.

PMID:
27438265
23.

MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery.

Kuo MM, Kim DH, Jandu S, Bergman Y, Tan S, Wang H, Pandey DR, Abraham TP, Shoukas AA, Berkowitz DE, Santhanam L.

Am J Physiol Heart Circ Physiol. 2016 Jan 1;310(1):H71-9. doi: 10.1152/ajpheart.00574.2014. Epub 2015 Oct 30.

24.

Evidence for a functional vasodilatatory role for hydrogen sulphide in the human cutaneous microvasculature.

Kutz JL, Greaney JL, Santhanam L, Alexander LM.

J Physiol. 2015 May 1;593(9):2121-9. doi: 10.1113/JP270054. Epub 2015 Mar 25.

25.

Measuring ascending aortic stiffness in vivo in mice using ultrasound.

Kuo MM, Barodka V, Abraham TP, Steppan J, Shoukas AA, Butlin M, Avolio A, Berkowitz DE, Santhanam L.

J Vis Exp. 2014 Dec 2;(94). doi: 10.3791/52200.

26.

Melanopsin mediates light-dependent relaxation in blood vessels.

Sikka G, Hussmann GP, Pandey D, Cao S, Hori D, Park JT, Steppan J, Kim JH, Barodka V, Myers AC, Santhanam L, Nyhan D, Halushka MK, Koehler RC, Snyder SH, Shimoda LA, Berkowitz DE.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17977-82. doi: 10.1073/pnas.1420258111. Epub 2014 Nov 17.

27.

Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.

Mattison JA, Wang M, Bernier M, Zhang J, Park SS, Maudsley S, An SS, Santhanam L, Martin B, Faulkner S, Morrell C, Baur JA, Peshkin L, Sosnowska D, Csiszar A, Herbert RL, Tilmont EM, Ungvari Z, Pearson KJ, Lakatta EG, de Cabo R.

Cell Metab. 2014 Jul 1;20(1):183-90. doi: 10.1016/j.cmet.2014.04.018. Epub 2014 May 29.

28.

Exercise, vascular stiffness, and tissue transglutaminase.

Steppan J, Sikka G, Jandu S, Barodka V, Halushka MK, Flavahan NA, Belkin AM, Nyhan D, Butlin M, Avolio A, Berkowitz DE, Santhanam L.

J Am Heart Assoc. 2014 Apr 10;3(2):e000599. doi: 10.1161/JAHA.113.000599.

29.

Contribution of arginase activation to vascular dysfunction in cigarette smoking.

Sikka G, Pandey D, Bhuniya AK, Steppan J, Armstrong D, Santhanam L, Nyhan D, Berkowitz DE.

Atherosclerosis. 2013 Nov;231(1):91-4. doi: 10.1016/j.atherosclerosis.2013.08.026. Epub 2013 Sep 4.

PMID:
24125417
30.

Arterial stiffening precedes systolic hypertension in diet-induced obesity.

Weisbrod RM, Shiang T, Al Sayah L, Fry JL, Bajpai S, Reinhart-King CA, Lob HE, Santhanam L, Mitchell G, Cohen RA, Seta F.

Hypertension. 2013 Dec;62(6):1105-10. doi: 10.1161/HYPERTENSIONAHA.113.01744. Epub 2013 Sep 23.

31.

Increased tissue transglutaminase activity contributes to central vascular stiffness in eNOS knockout mice.

Jung SM, Jandu S, Steppan J, Belkin A, An SS, Pak A, Choi EY, Nyhan D, Butlin M, Viegas K, Avolio A, Berkowitz DE, Santhanam L.

Am J Physiol Heart Circ Physiol. 2013 Sep 15;305(6):H803-10. doi: 10.1152/ajpheart.00103.2013. Epub 2013 Jul 19.

32.

Nitroprusside inhibits calcium-induced impairment of red blood cell deformability.

Barodka V, Mohanty JG, Mustafa AK, Santhanam L, Nyhan A, Bhunia AK, Sikka G, Nyhan D, Berkowitz DE, Rifkind JM.

Transfusion. 2014 Feb;54(2):434-44. doi: 10.1111/trf.12291. Epub 2013 Jun 19.

PMID:
23781865
33.

Rho-Kinase activity and cutaneous vasoconstriction is upregulated in essential hypertensive humans.

Smith CJ, Santhanam L, Alexander LM.

Microvasc Res. 2013 May;87:58-64. doi: 10.1016/j.mvr.2013.02.005. Epub 2013 Feb 26.

34.

A physiologic and biochemical profile of clinically rejected lungs on a normothermic ex vivo lung perfusion platform.

George TJ, Arnaoutakis GJ, Beaty CA, Jandu SK, Santhanam L, Berkowitz DE, Shah AS.

J Surg Res. 2013 Jul;183(1):75-83. doi: 10.1016/j.jss.2012.11.012. Epub 2012 Nov 27.

35.

Inhaled hydrogen sulfide improves graft function in an experimental model of lung transplantation.

George TJ, Arnaoutakis GJ, Beaty CA, Jandu SK, Santhanam L, Berkowitz DE, Shah AS.

J Surg Res. 2012 Dec;178(2):593-600. doi: 10.1016/j.jss.2012.06.037. Epub 2012 Jun 27.

36.

Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin.

Bruning RS, Santhanam L, Stanhewicz AE, Smith CJ, Berkowitz DE, Kenney WL, Holowatz LA.

J Appl Physiol (1985). 2012 Jun;112(12):2019-26. doi: 10.1152/japplphysiol.01354.2011. Epub 2012 Apr 12.

37.

Hydrogen sulfide decreases reactive oxygen in a model of lung transplantation.

George TJ, Arnaoutakis GJ, Beaty CA, Jandu SK, Santhanam L, Berkowitz DE, Shah AS.

J Surg Res. 2012 Nov;178(1):494-501. doi: 10.1016/j.jss.2012.02.065. Epub 2012 Mar 18.

38.

Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve.

Khan M, Steppan J, Schuleri KH, Ryoo S, Tuday E, Bugaj L, Santhanam L, Berkowitz T, Nyhan D, Shoukas AA, Berkowitz DE.

Eur J Appl Physiol. 2012 Aug;112(8):2933-41. doi: 10.1007/s00421-011-2257-9. Epub 2011 Dec 8. Erratum in: Eur J Appl Physiol. 2012 Dec;112(12):4189. Schuleri, Karl [corrected to Schuleri, Karl H].

PMID:
22160208
39.

Nitric oxide regulates non-classical secretion of tissue transglutaminase.

Santhanam L, Berkowitz DE, Belkin AM.

Commun Integr Biol. 2011 Sep;4(5):584-6. doi: 10.4161/cib.4.5.16512. Epub 2011 Sep 1.

40.

Nitric oxide regulates tissue transglutaminase localization and function in the vasculature.

Jandu SK, Webb AK, Pak A, Sevinc B, Nyhan D, Belkin AM, Flavahan NA, Berkowitz DE, Santhanam L.

Amino Acids. 2013 Jan;44(1):261-9. doi: 10.1007/s00726-011-1090-0. Epub 2011 Oct 8.

41.

Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans.

Smith CJ, Santhanam L, Bruning RS, Stanhewicz A, Berkowitz DE, Holowatz LA.

Hypertension. 2011 Nov;58(5):935-42. doi: 10.1161/HYPERTENSIONAHA.111.178129. Epub 2011 Sep 19.

42.

S-nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase.

Dunn J, Gutbrod S, Webb A, Pak A, Jandu SK, Bhunia A, Berkowitz DE, Santhanam L.

Mol Cell Biochem. 2011 Sep;355(1-2):83-9. doi: 10.1007/s11010-011-0841-2. Epub 2011 May 1.

43.

Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans.

Holowatz LA, Santhanam L, Webb A, Berkowitz DE, Kenney WL.

J Physiol. 2011 Apr 15;589(Pt 8):2093-103. doi: 10.1113/jphysiol.2010.203935. Epub 2011 Feb 21.

44.

Decreased S-nitrosylation of tissue transglutaminase contributes to age-related increases in vascular stiffness.

Santhanam L, Tuday EC, Webb AK, Dowzicky P, Kim JH, Oh YJ, Sikka G, Kuo M, Halushka MK, Macgregor AM, Dunn J, Gutbrod S, Yin D, Shoukas A, Nyhan D, Flavahan NA, Belkin AM, Berkowitz DE.

Circ Res. 2010 Jul 9;107(1):117-25. doi: 10.1161/CIRCRESAHA.109.215228. Epub 2010 May 20. Erratum in: Circ Res. 2011 Apr 29;108(9):e12.

PMID:
20489165
45.

Dietary inhibition of xanthine oxidase attenuates radiation-induced endothelial dysfunction in rat aorta.

Soucy KG, Lim HK, Attarzadeh DO, Santhanam L, Kim JH, Bhunia AK, Sevinc B, Ryoo S, Vazquez ME, Nyhan D, Shoukas AA, Berkowitz DE.

J Appl Physiol (1985). 2010 May;108(5):1250-8. doi: 10.1152/japplphysiol.00946.2009. Epub 2010 Feb 18.

46.

Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats.

Kim JH, Bugaj LJ, Oh YJ, Bivalacqua TJ, Ryoo S, Soucy KG, Santhanam L, Webb A, Camara A, Sikka G, Nyhan D, Shoukas AA, Ilies M, Christianson DW, Champion HC, Berkowitz DE.

J Appl Physiol (1985). 2009 Oct;107(4):1249-57. doi: 10.1152/japplphysiol.91393.2008. Epub 2009 Aug 6.

47.

Cyclohexanone contamination from extracorporeal circuits impairs cardiovascular function.

Thompson-Torgerson CS, Champion HC, Santhanam L, Harris ZL, Shoukas AA.

Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1926-32. doi: 10.1152/ajpheart.00184.2009. Epub 2009 May 1.

48.

Arginase and vascular aging.

Santhanam L, Christianson DW, Nyhan D, Berkowitz DE.

J Appl Physiol (1985). 2008 Nov;105(5):1632-42. doi: 10.1152/japplphysiol.90627.2008. Epub 2008 Aug 21. Review.

49.

Selective fluorescent labeling of S-nitrosothiols (S-FLOS): a novel method for studying S-nitrosation.

Santhanam L, Gucek M, Brown TR, Mansharamani M, Ryoo S, Lemmon CA, Romer L, Shoukas AA, Berkowitz DE, Cole RN.

Nitric Oxide. 2008 Nov;19(3):295-302. doi: 10.1016/j.niox.2008.07.007. Epub 2008 Jul 30.

50.

Endothelial arginase II: a novel target for the treatment of atherosclerosis.

Ryoo S, Gupta G, Benjo A, Lim HK, Camara A, Sikka G, Lim HK, Sohi J, Santhanam L, Soucy K, Tuday E, Baraban E, Ilies M, Gerstenblith G, Nyhan D, Shoukas A, Christianson DW, Alp NJ, Champion HC, Huso D, Berkowitz DE.

Circ Res. 2008 Apr 25;102(8):923-32. doi: 10.1161/CIRCRESAHA.107.169573. Epub 2008 Feb 28.

PMID:
18309100

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