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Items: 32

1.

Architecture of human Rag GTPase heterodimers and their complex with mTORC1.

Anandapadamanaban M, Masson GR, Perisic O, Berndt A, Kaufman J, Johnson CM, Santhanam B, Rogala KB, Sabatini DM, Williams RL.

Science. 2019 Oct 11;366(6462):203-210. doi: 10.1126/science.aax3939.

PMID:
31601764
2.

A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation.

Pruneda JN, Bastidas RJ, Bertsoulaki E, Swatek KN, Santhanam B, Clague MJ, Valdivia RH, Urbé S, Komander D.

Nat Microbiol. 2018 Dec;3(12):1377-1384. doi: 10.1038/s41564-018-0271-y. Epub 2018 Nov 5.

3.

Architecture of eukaryotic mRNA 3'-end processing machinery.

Casañal A, Kumar A, Hill CH, Easter AD, Emsley P, Degliesposti G, Gordiyenko Y, Santhanam B, Wolf J, Wiederhold K, Dornan GL, Skehel M, Robinson CV, Passmore LA.

Science. 2017 Nov 24;358(6366):1056-1059. doi: 10.1126/science.aao6535. Epub 2017 Oct 26.

4.

Structures of closed and open conformations of dimeric human ATM.

Baretić D, Pollard HK, Fisher DI, Johnson CM, Santhanam B, Truman CM, Kouba T, Fersht AR, Phillips C, Williams RL.

Sci Adv. 2017 May 10;3(5):e1700933. doi: 10.1126/sciadv.1700933. eCollection 2017 May.

5.

The Long Noncoding RNA Transcriptome of Dictyostelium discoideum Development.

Rosengarten RD, Santhanam B, Kokosar J, Shaulsky G.

G3 (Bethesda). 2017 Feb 9;7(2):387-398. doi: 10.1534/g3.116.037150.

6.

Terpene synthase genes in eukaryotes beyond plants and fungi: Occurrence in social amoebae.

Chen X, Köllner TG, Jia Q, Norris A, Santhanam B, Rabe P, Dickschat JS, Shaulsky G, Gershenzon J, Chen F.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12132-12137. Epub 2016 Oct 7.

7.

Wideband image demodulation via bi-dimensional multirate frequency transformations.

Liu W, Santhanam B.

J Opt Soc Am A Opt Image Sci Vis. 2016 Sep 1;33(9):1668-78. doi: 10.1364/JOSAA.33.001668.

PMID:
27607487
8.

The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs.

Pasternak M, Pfender S, Santhanam B, Schuh M.

Open Biol. 2016 Sep;6(9). pii: 160184. doi: 10.1098/rsob.160184.

9.

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.

Pruneda JN, Durkin CH, Geurink PP, Ovaa H, Santhanam B, Holden DW, Komander D.

Mol Cell. 2016 Jul 21;63(2):261-276. doi: 10.1016/j.molcel.2016.06.015. Epub 2016 Jul 14.

10.

Gene discovery by chemical mutagenesis and whole-genome sequencing in Dictyostelium.

Li CL, Santhanam B, Webb AN, Zupan B, Shaulsky G.

Genome Res. 2016 Sep;26(9):1268-76. doi: 10.1101/gr.205682.116. Epub 2016 Jun 15.

11.

An inter-species protein-protein interaction network across vast evolutionary distance.

Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Taşan M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barabási AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M.

Mol Syst Biol. 2016 Apr 22;12(4):865. doi: 10.15252/msb.20156484.

12.

The GATA transcription factor gene gtaG is required for terminal differentiation in Dictyostelium.

Katoh-Kurasawa M, Santhanam B, Shaulsky G.

J Cell Sci. 2016 Apr 15;129(8):1722-1733.

13.

Allorecognition, via TgrB1 and TgrC1, mediates the transition from unicellularity to multicellularity in the social amoeba Dictyostelium discoideum.

Hirose S, Santhanam B, Katoh-Kurosawa M, Shaulsky G, Kuspa A.

Development. 2015 Oct 15;142(20):3561-70. doi: 10.1242/dev.123281. Epub 2015 Sep 22.

14.

Live imaging RNAi screen reveals genes essential for meiosis in mammalian oocytes.

Pfender S, Kuznetsov V, Pasternak M, Tischer T, Santhanam B, Schuh M.

Nature. 2015 Aug 13;524(7564):239-242. doi: 10.1038/nature14568. Epub 2015 Jul 6.

15.

The GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium.

Santhanam B, Cai H, Devreotes PN, Shaulsky G, Katoh-Kurasawa M.

Nat Commun. 2015 Jul 6;6:7551. doi: 10.1038/ncomms8551.

16.

Leaps and lulls in the developmental transcriptome of Dictyostelium discoideum.

Rosengarten RD, Santhanam B, Fuller D, Katoh-Kurasawa M, Loomis WF, Zupan B, Shaulsky G.

BMC Genomics. 2015 Apr 13;16:294. doi: 10.1186/s12864-015-1491-7.

17.

Structure and assembly pathway of the ribosome quality control complex.

Shao S, Brown A, Santhanam B, Hegde RS.

Mol Cell. 2015 Feb 5;57(3):433-44. doi: 10.1016/j.molcel.2014.12.015. Epub 2015 Jan 8.

18.

Vitamin B₁₂-dependent taurine synthesis regulates growth and bone mass.

Roman-Garcia P, Quiros-Gonzalez I, Mottram L, Lieben L, Sharan K, Wangwiwatsin A, Tubio J, Lewis K, Wilkinson D, Santhanam B, Sarper N, Clare S, Vassiliou GS, Velagapudi VR, Dougan G, Yadav VK.

J Clin Invest. 2014 Jul;124(7):2988-3002. doi: 10.1172/JCI72606. Epub 2014 Jun 9.

19.

Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer.

Cai H, Katoh-Kurasawa M, Muramoto T, Santhanam B, Long Y, Li L, Ueda M, Iglesias PA, Shaulsky G, Devreotes PN.

Science. 2014 Mar 21;343(6177):1249531. doi: 10.1126/science.1249531.

20.

ABC transporters in Dictyostelium discoideum development.

Miranda ER, Zhuchenko O, Toplak M, Santhanam B, Zupan B, Kuspa A, Shaulsky G.

PLoS One. 2013 Aug 14;8(8):e70040. doi: 10.1371/journal.pone.0070040. eCollection 2013.

21.

Bacterial discrimination by dictyostelid amoebae reveals the complexity of ancient interspecies interactions.

Nasser W, Santhanam B, Miranda ER, Parikh A, Juneja K, Rot G, Dinh C, Chen R, Zupan B, Shaulsky G, Kuspa A.

Curr Biol. 2013 May 20;23(10):862-72. doi: 10.1016/j.cub.2013.04.034. Epub 2013 May 9.

22.

Transcriptional profiling of Dictyostelium with RNA sequencing.

Miranda ER, Rot G, Toplak M, Santhanam B, Curk T, Shaulsky G, Zupan B.

Methods Mol Biol. 2013;983:139-71. doi: 10.1007/978-1-62703-302-2_8.

23.

Viral perturbations of host networks reflect disease etiology.

Gulbahce N, Yan H, Dricot A, Padi M, Byrdsong D, Franchi R, Lee DS, Rozenblatt-Rosen O, Mar JC, Calderwood MA, Baldwin A, Zhao B, Santhanam B, Braun P, Simonis N, Huh KW, Hellner K, Grace M, Chen A, Rubio R, Marto JA, Christakis NA, Kieff E, Roth FP, Roecklein-Canfield J, Decaprio JA, Cusick ME, Quackenbush J, Hill DE, Münger K, Vidal M, Barabási AL.

PLoS Comput Biol. 2012;8(6):e1002531. doi: 10.1371/journal.pcbi.1002531. Epub 2012 Jun 28.

24.

Proto-genes and de novo gene birth.

Carvunis AR, Rolland T, Wapinski I, Calderwood MA, Yildirim MA, Simonis N, Charloteaux B, Hidalgo CA, Barbette J, Santhanam B, Brar GA, Weissman JS, Regev A, Thierry-Mieg N, Cusick ME, Vidal M.

Nature. 2012 Jul 19;487(7407):370-4. doi: 10.1038/nature11184.

25.

Independently evolved virulence effectors converge onto hubs in a plant immune system network.

Mukhtar MS, Carvunis AR, Dreze M, Epple P, Steinbrenner J, Moore J, Tasan M, Galli M, Hao T, Nishimura MT, Pevzner SJ, Donovan SE, Ghamsari L, Santhanam B, Romero V, Poulin MM, Gebreab F, Gutierrez BJ, Tam S, Monachello D, Boxem M, Harbort CJ, McDonald N, Gai L, Chen H, He Y; European Union Effectoromics Consortium, Vandenhaute J, Roth FP, Hill DE, Ecker JR, Vidal M, Beynon J, Braun P, Dangl JL.

Science. 2011 Jul 29;333(6042):596-601. doi: 10.1126/science.1203659.

26.
27.

Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection.

Venkatraman S, Bogen SL, Arasappan A, Bennett F, Chen K, Jao E, Liu YT, Lovey R, Hendrata S, Huang Y, Pan W, Parekh T, Pinto P, Popov V, Pike R, Ruan S, Santhanam B, Vibulbhan B, Wu W, Yang W, Kong J, Liang X, Wong J, Liu R, Butkiewicz N, Chase R, Hart A, Agrawal S, Ingravallo P, Pichardo J, Kong R, Baroudy B, Malcolm B, Guo Z, Prongay A, Madison V, Broske L, Cui X, Cheng KC, Hsieh Y, Brisson JM, Prelusky D, Korfmacher W, White R, Bogdanowich-Knipp S, Pavlovsky A, Bradley P, Saksena AK, Ganguly A, Piwinski J, Girijavallabhan V, Njoroge FG.

J Med Chem. 2006 Oct 5;49(20):6074-86.

PMID:
17004721
28.

Scene estimation from speckled synthetic aperture radar imagery: Markov-random-field approach.

Lankoande O, Hayat MM, Santhanam B.

J Opt Soc Am A Opt Image Sci Vis. 2006 Jun;23(6):1269-81.

PMID:
16715145
29.

Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency.

Arasappan A, Njoroge FG, Chan TY, Bennett F, Bogen SL, Chen K, Gu H, Hong L, Jao E, Liu YT, Lovey RG, Parekh T, Pike RE, Pinto P, Santhanam B, Venkatraman S, Vaccaro H, Wang H, Yang X, Zhu Z, Mckittrick B, Saksena AK, Girijavallabhan V, Pichardo J, Butkiewicz N, Ingram R, Malcolm B, Prongay A, Yao N, Marten B, Madison V, Kemp S, Levy O, Lim-Wilby M, Tamura S, Ganguly AK.

Bioorg Med Chem Lett. 2005 Oct 1;15(19):4180-4.

PMID:
16087332
30.

Synthesis and biological evaluation of a lipid A derivative that contains an aminogluconate moiety.

Santhanam B, Wolfert MA, Moore JN, Boons GJ.

Chemistry. 2004 Oct 4;10(19):4798-807.

PMID:
15372693
31.

Preparation of a lipid a derivative that contains a 27-hydroxyoctacosanoic acid moiety.

Santhanam B, Boons GJ.

Org Lett. 2004 Sep 16;6(19):3333-6.

PMID:
15355045
32.

Synthesis and biological evaluation of Rhizobium sin-1 lipid A derivatives.

Demchenko AV, Wolfert MA, Santhanam B, Moore JN, Boons GJ.

J Am Chem Soc. 2003 May 21;125(20):6103-12.

PMID:
12785841

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