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Items: 1 to 50 of 337

1.

Pro-Apoptotic Effects of Estetrol on Long-Term Estrogen-Deprived Breast Cancer Cells and at Low Doses on Hormone-Sensitive Cells.

Yue W, Verhoeven C, Bernnink HC, Wang JP, Santen RJ.

Breast Cancer (Auckl). 2019 May 15;13:1178223419844198. doi: 10.1177/1178223419844198. eCollection 2019.

PMID:
31205415
2.

Managing vasomotor symptoms in women after cancer.

Pinkerton JV, Santen RJ.

Climacteric. 2019 May 13:1-9. doi: 10.1080/13697137.2019.1600501. [Epub ahead of print]

PMID:
31081391
3.

History of Estrogen: Its Purification, Structure, Synthesis, Biologic Actions, and Clinical Implications.

Santen RJ, Simpson E.

Endocrinology. 2019 Mar 1;160(3):605-625. doi: 10.1210/en.2018-00529.

PMID:
30566601
4.

Cause or prevention of breast cancer with estrogens: analysis from tumor biologic data, growth kinetic model and Women's Health Initiative study.

Santen RJ, Yue W.

Climacteric. 2019 Feb;22(1):3-12. doi: 10.1080/13697137.2017.1388364. Epub 2018 Nov 1.

PMID:
30380950
5.

Glucocorticoid Receptor Mutations and Hypersensitivity to Endogenous and Exogenous Glucocorticoids.

Santen RJ, Jewell CM, Yue W, Heitjan DF, Raff H, Katen KS, Cidlowski JA.

J Clin Endocrinol Metab. 2018 Oct 1;103(10):3630-3639. doi: 10.1210/jc.2018-00352.

PMID:
30020469
6.

Effect of a tissue selective estrogen complex on breast cancer: Role of unique properties of conjugated equine estrogen.

Yue W, Wang J, Atkins KA, Bottalico L, Mesaros C, Blair IA, Santen RJ.

Int J Cancer. 2018 Sep 1;143(5):1259-1268. doi: 10.1002/ijc.31401. Epub 2018 Apr 16.

7.

Estrogen Replacement in Turner Syndrome: Literature Review and Practical Considerations.

Klein KO, Rosenfield RL, Santen RJ, Gawlik AM, Backeljauw PF, Gravholt CH, Sas TCJ, Mauras N.

J Clin Endocrinol Metab. 2018 May 1;103(5):1790-1803. doi: 10.1210/jc.2017-02183. Review.

PMID:
29438552
8.

The Jewel in the Crown: Specific Aims Section of Investigator-Initiated Grant Proposals.

Santen RJ, Barrett EJ, Siragy HM, Farhi LS, Fishbein L, Carey RM.

J Endocr Soc. 2017 Aug 17;1(9):1194-1202. doi: 10.1210/js.2017-00318. eCollection 2017 Sep 1. Review.

9.

Managing Menopausal Symptoms and Associated Clinical Issues in Breast Cancer Survivors.

Santen RJ, Stuenkel CA, Davis SR, Pinkerton JV, Gompel A, Lumsden MA.

J Clin Endocrinol Metab. 2017 Oct 1;102(10):3647-3661. doi: 10.1210/jc.2017-01138. Review.

PMID:
28934376
10.

Aromatase expression in atypical ductal hyperplasia in women.

Santen RJ, Radisky DC, Degnim A, Frost MH, Vachon CM, Ghosh K, Guestini F, McNamara KM, Sasano H.

Breast Cancer Res Treat. 2017 Jun;163(3):623-629. doi: 10.1007/s10549-017-4184-x. Epub 2017 Mar 23.

PMID:
28337664
11.

Use of cardiovascular age for assessing risks and benefits of menopausal hormone therapy.

Santen RJ.

Menopause. 2017 May;24(5):589-595. doi: 10.1097/GME.0000000000000847.

PMID:
28323768
12.

Career Advancement: Meeting the Challenges Confronting the Next Generation of Endocrinologists and Endocrine Researchers.

Santen RJ, Joham A, Fishbein L, Vella KR, Ebeling PR, Gibson-Helm M, Teede H.

J Clin Endocrinol Metab. 2016 Dec;101(12):4512-4520. Epub 2016 Oct 3. Review.

PMID:
27691051
13.

Progression of Metabolic Syndrome Severity During the Menopausal Transition.

Gurka MJ, Vishnu A, Santen RJ, DeBoer MD.

J Am Heart Assoc. 2016 Aug 3;5(8). pii: e003609. doi: 10.1161/JAHA.116.003609.

14.

Undetectable Urine Calcium in a Gastric Bypass Patient.

Campbell ST, Santen RJ, Bruns DE.

Clin Chem. 2016 Aug;62(8):1161. doi: 10.1373/clinchem.2015.251868. No abstract available.

15.

Preclinical breast effects of a tissue selective estrogen complex (TSEC) including conjugated estrogen with bazedoxifene.

Santen RJ, Song Y, Wang JP, Yue W.

J Steroid Biochem Mol Biol. 2017 Jun;170:61-64. doi: 10.1016/j.jsbmb.2016.05.008. Epub 2016 May 9. Review.

PMID:
27174719
16.

An introduction to the Endocrine Society Clinical Practice Guideline on treatment of symptoms of the menopause.

Stuenkel CA, Santen RJ.

Post Reprod Health. 2016 Mar;22(1):6-8. doi: 10.1177/2053369115626029.

PMID:
26936942
17.

Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline.

Stuenkel CA, Davis SR, Gompel A, Lumsden MA, Murad MH, Pinkerton JV, Santen RJ.

J Clin Endocrinol Metab. 2015 Nov;100(11):3975-4011. doi: 10.1210/jc.2015-2236. Epub 2015 Oct 7.

PMID:
26444994
18.

Celebrating 75 years of oestradiol.

Simpson E, Santen RJ.

J Mol Endocrinol. 2015 Dec;55(3):T1-20. doi: 10.1530/JME-15-0128. Epub 2015 Oct 5. Review.

PMID:
26438567
19.

Response to the Letter by Labrie et al.

Demers LM, Ziegler R, Santen RJ.

J Clin Endocrinol Metab. 2015 Sep;100(9):L88. doi: 10.1210/jc.2015-2980. No abstract available.

PMID:
26339748
20.

Benign Breast Disease in Women.

Santen RJ.

In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.
2018 May 25.

21.

Estrogens and Their Genotoxic Metabolites Are Increased in Obese Prepubertal Girls.

Mauras N, Santen RJ, Colón-Otero G, Hossain J, Wang Q, Mesaros C, Blair IA.

J Clin Endocrinol Metab. 2015 Jun;100(6):2322-8. doi: 10.1210/jc.2015-1495. Epub 2015 Apr 9. Erratum in: J Clin Endocrinol Metab. 2016 May;101(5):2267.

22.

Measuring Estrogen Exposure and Metabolism: Workshop Recommendations on Clinical Issues.

Demers LM, Hankinson SE, Haymond S, Key T, Rosner W, Santen RJ, Stanczyk FZ, Vesper HW, Ziegler RG; Endocrine Society; PATH (Partnership for Accurate Testing of Hormones); AACC (American Association for Clinical Chemistry).

J Clin Endocrinol Metab. 2015 Jun;100(6):2165-70. doi: 10.1210/jc.2015-1040. Epub 2015 Apr 7. No abstract available.

23.

Adenosine monophosphate activated protein kinase (AMPK), a mediator of estradiol-induced apoptosis in long-term estrogen deprived breast cancer cells.

Chen H, Wang JP, Santen RJ, Yue W.

Apoptosis. 2015 Jun;20(6):821-30. doi: 10.1007/s10495-015-1111-7.

PMID:
25721362
24.

Workshop on measuring estrogen exposure and metabolism: Summary of the presentations.

Santen RJ, Demers LM, Ziegler RG.

Steroids. 2015 Jul;99(Pt A):1-7. doi: 10.1016/j.steroids.2014.12.012. Epub 2014 Dec 30. No abstract available.

PMID:
25554577
25.

Atypical hyperplasia of the breast--risk assessment and management options.

Hartmann LC, Degnim AC, Santen RJ, Dupont WD, Ghosh K.

N Engl J Med. 2015 Jan 1;372(1):78-89. doi: 10.1056/NEJMsr1407164. No abstract available.

26.

Statement of principle.

Cefalu WT, Nair KS, Seaquist ER, Zierath J, Boulton AJ, LeRoith D, Harrell RM, Grunberger G, Wartofsky L, Gore AC, Wierman ME, Hammes SR, Lange CA, Santen RJ.

Horm Cancer. 2015 Feb;6(1):1. doi: 10.1007/s12672-014-0206-x. No abstract available.

PMID:
25410830
27.

Statement of principle.

Cefalu WT, Nair KS, Seaquist ER, Zierath J, Boulton AJ, LeRoith D, Harrell RM, Grunberger G, Wartofsky L, Gore AC, Wierman ME, Hammes SR, Lange CA, Santen RJ.

Endocr Rev. 2014 Dec;35(6):850. doi: 10.1210/er.2014-1089. Epub 2014 Nov 3. No abstract available.

PMID:
25365740
28.

Statement of principle.

Seaquist ER, Boulton AJ, Harrell RM, Grunberger G, Santen RJ.

Mol Endocrinol. 2014 Dec;28(12):1918. doi: 10.1210/me.2014-1338. No abstract available.

29.

Statement of principle.

Cefalu WT, Nair KS, Seaquist ER, Zierath J, Boulton AJ, LeRoith D, Harrell RM, Grunberger G, Wartofsky L, Gore AC, Wierman ME, Hammes SR, Lange CA, Santen RJ.

J Clin Endocrinol Metab. 2014 Dec;99(12):4376. doi: 10.1210/jc.2014-3958. No abstract available.

PMID:
25365410
30.

Vaginal administration of estradiol: effects of dose, preparation and timing on plasma estradiol levels.

Santen RJ.

Climacteric. 2015 Apr;18(2):121-34. doi: 10.3109/13697137.2014.947254. Epub 2014 Oct 18. Review.

PMID:
25327484
31.

Estrogen metabolites and breast cancer.

Santen RJ, Yue W, Wang JP.

Steroids. 2015 Jul;99(Pt A):61-6. doi: 10.1016/j.steroids.2014.08.003. Epub 2014 Aug 26. Review.

PMID:
25168343
32.

Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer.

Pathiraja TN, Nayak SR, Xi Y, Jiang S, Garee JP, Edwards DP, Lee AV, Chen J, Shea MJ, Santen RJ, Gannon F, Kangaspeska S, Jelinek J, Issa JP, Richer JK, Elias A, McIlroy M, Young LS, Davidson NE, Schiff R, Li W, Oesterreich S.

Sci Transl Med. 2014 Mar 26;6(229):229ra41. doi: 10.1126/scitranslmed.3008326.

33.

Competency in menopause management: whither goest the internist?

Santen RJ, Stuenkel CA, Burger HG, Manson JE.

J Womens Health (Larchmt). 2014 Apr;23(4):281-5. doi: 10.1089/jwh.2014.4746. Epub 2014 Mar 13. Review.

PMID:
24625303
34.

Understanding the premalignant potential of atypical hyperplasia through its natural history: a longitudinal cohort study.

Hartmann LC, Radisky DC, Frost MH, Santen RJ, Vierkant RA, Benetti LL, Tarabishy Y, Ghosh K, Visscher DW, Degnim AC.

Cancer Prev Res (Phila). 2014 Feb;7(2):211-7. doi: 10.1158/1940-6207.CAPR-13-0222. Epub 2014 Jan 30.

35.

Current and evolving approaches to individualizing estrogen receptor-based therapy for menopausal women.

Santen RJ, Kagan R, Altomare CJ, Komm B, Mirkin S, Taylor HS.

J Clin Endocrinol Metab. 2014 Mar;99(3):733-47. doi: 10.1210/jc.2013-3680. Epub 2014 Jan 1. Review.

PMID:
24423357
36.

Induction of apoptosis in hormone refractory breast cancer: horizontal modulation is superior to vertical.

Yue W, Wang JP, Zhang L, Wang W, Santen RJ, Aiyar SE.

J Exp Ther Oncol. 2013;10(3):169-79.

PMID:
24416991
37.

Breast-related effects of selective estrogen receptor modulators and tissue-selective estrogen complexes.

Smith CL, Santen RJ, Komm B, Mirkin S.

Breast Cancer Res. 2014 Jun 18;16(3):212. doi: 10.1186/bcr3677. Review.

38.

Oncology in midlife and beyond.

Gompel A, Baber RJ, de Villiers TJ, Huang KE, Santen RJ, Shah D, Villaseca P, Shapiro S.

Climacteric. 2013 Oct;16(5):522-35. doi: 10.3109/13697137.2013.823539. Epub 2013 Aug 9. Review.

PMID:
23931571
39.

Menopausal hormone therapy and breast cancer.

Santen RJ.

J Steroid Biochem Mol Biol. 2014 Jul;142:52-61. doi: 10.1016/j.jsbmb.2013.06.010. Epub 2013 Jul 16.

PMID:
23871991
40.

Effects of menopausal hormonal therapy on occult breast tumors.

Santen RJ, Song Y, Yue W, Wang JP, Heitjan DF.

J Steroid Biochem Mol Biol. 2013 Sep;137:150-6. doi: 10.1016/j.jsbmb.2013.05.008. Epub 2013 Jun 7. Review.

PMID:
23748149
41.

Metabolic effects of oral versus transdermal 17β-estradiol (E₂): a randomized clinical trial in girls with Turner syndrome.

Torres-Santiago L, Mericq V, Taboada M, Unanue N, Klein KO, Singh R, Hossain J, Santen RJ, Ross JL, Mauras N.

J Clin Endocrinol Metab. 2013 Jul;98(7):2716-24. doi: 10.1210/jc.2012-4243. Epub 2013 May 15.

42.

Occult breast tumor reservoir: biological properties and clinical significance.

Santen RJ, Yue W, Heitjan DF.

Horm Cancer. 2013 Aug;4(4):195-207. doi: 10.1007/s12672-013-0145-y. Epub 2013 Apr 30.

PMID:
23632998
43.

Inhibitory effects of a bazedoxifene/conjugated equine estrogen combination on human breast cancer cells in vitro.

Song Y, Santen RJ, Wang JP, Yue W.

Endocrinology. 2013 Feb;154(2):656-65. doi: 10.1210/en.2012-2038. Epub 2012 Dec 19.

PMID:
23254198
44.

Estrogen receptor-dependent and independent mechanisms of breast cancer carcinogenesis.

Yue W, Yager JD, Wang JP, Jupe ER, Santen RJ.

Steroids. 2013 Feb;78(2):161-70. doi: 10.1016/j.steroids.2012.11.001. Epub 2012 Nov 20. Review.

PMID:
23178278
45.

Effects of the conjugated equine estrogen/bazedoxifene tissue-selective estrogen complex (TSEC) on mammary gland and breast cancer in mice.

Song Y, Santen RJ, Wang JP, Yue W.

Endocrinology. 2012 Dec;153(12):5706-15. doi: 10.1210/en.2012-1583. Epub 2012 Oct 15.

46.

Insights into mentorship for endocrinologists.

Eggleston E, Liu Z, Mirmira RG, Silva CM, Shu J, Santen RJ.

J Clin Endocrinol Metab. 2012 Nov;97(11):3891-6. doi: 10.1210/jc.2012-2215. Epub 2012 Sep 11.

47.

Hormone therapy and breast cancer risk 10 years after the WHI.

Gompel A, Santen RJ.

Climacteric. 2012 Jun;15(3):241-9. doi: 10.3109/13697137.2012.666456. Review.

PMID:
22612610
48.

Modeling of the growth kinetics of occult breast tumors: role in interpretation of studies of prevention and menopausal hormone therapy.

Santen RJ, Yue W, Heitjan DF.

Cancer Epidemiol Biomarkers Prev. 2012 Jul;21(7):1038-48. doi: 10.1158/1055-9965.EPI-12-0043. Epub 2012 May 14.

49.

Vaginal atrophy.

Pinkerton JV, Santen RJ.

J Clin Endocrinol Metab. 2011 Nov;96(11):A27, A28. English, Spanish. No abstract available.

PMID:
22058386
50.

Tetra-methoxystilbene modulates ductal growth of the developing murine mammary gland.

Kim T, Park H, Yue W, Wang JP, Atkins KA, Zhang Z, Rogan EG, Cavalieri EL, Mohammad KS, Kim S, Santen RJ, Aiyar SE.

Breast Cancer Res Treat. 2011 Apr;126(3):779-89. doi: 10.1007/s10549-010-1301-5. Epub 2010 Dec 18.

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