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Items: 35

1.

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia.

Gutbier B, Neuhauß AK, Reppe K, Ehrler C, Santel A, Kaufmann J, Scholz M, Weissmann N, Morawietz L, Mitchell TJ, Aliberti S, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ and PROGRESS Study Groups ‡.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):220-231. doi: 10.1164/rccm.201708-1733OC.

PMID:
29447449
2.

The Role of Akt in Chronic Liver Disease and Liver Regeneration.

Morales-Ruiz M, Santel A, Ribera J, Jiménez W.

Semin Liver Dis. 2017 Feb;37(1):11-16. doi: 10.1055/s-0036-1597819. Epub 2017 Feb 15. Review.

PMID:
28201844
3.

Gene control of tyrosine kinase TIE2 and vascular manifestations of infections.

Ghosh CC, David S, Zhang R, Berghelli A, Milam K, Higgins SJ, Hunter J, Mukherjee A, Wei Y, Tran M, Suber F, Kobzik L, Kain KC, Lu S, Santel A, Yano K, Guha P, Dumont DJ, Christiani DC, Parikh SM.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2472-7. doi: 10.1073/pnas.1519467113. Epub 2016 Feb 16.

4.

Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis.

Ghosh CC, Thamm K, Berghelli AV, Schrimpf C, Maski MR, Abid T, Milam KE, Rajakumar A, Santel A, Kielstein JT, Ahmed A, Thickett D, Wang K, Chase M, Donnino MW, Aird WC, Haller H, David S, Parikh SM.

Crit Care Med. 2015 Jul;43(7):e230-40. doi: 10.1097/CCM.0000000000000993.

5.

First-in-human phase I study of the liposomal RNA interference therapeutic Atu027 in patients with advanced solid tumors.

Schultheis B, Strumberg D, Santel A, Vank C, Gebhardt F, Keil O, Lange C, Giese K, Kaufmann J, Khan M, Drevs J.

J Clin Oncol. 2014 Dec 20;32(36):4141-8. doi: 10.1200/JCO.2013.55.0376. Epub 2014 Nov 17.

PMID:
25403217
6.

Lung-targeted RNA interference against angiopoietin-2 ameliorates multiple organ dysfunction and death in sepsis.

Stiehl T, Thamm K, Kaufmann J, Schaeper U, Kirsch T, Haller H, Santel A, Ghosh CC, Parikh SM, David S.

Crit Care Med. 2014 Oct;42(10):e654-62. doi: 10.1097/CCM.0000000000000524.

PMID:
25083983
7.

Delivery of therapeutic siRNA to the lung endothelium via novel Lipoplex formulation DACC.

Fehring V, Schaeper U, Ahrens K, Santel A, Keil O, Eisermann M, Giese K, Kaufmann J.

Mol Ther. 2014 Apr;22(4):811-20. doi: 10.1038/mt.2013.291. Epub 2014 Jan 6.

8.

Depletion of protein kinase N3 (PKN3) impairs actin and adherens junctions dynamics and attenuates endothelial cell activation.

Möpert K, Löffler K, Röder N, Kaufmann J, Santel A.

Eur J Cell Biol. 2012 Sep;91(9):694-705. doi: 10.1016/j.ejcb.2012.03.010. Epub 2012 May 19.

PMID:
22609186
9.

Phase I clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors.

Strumberg D, Schultheis B, Traugott U, Vank C, Santel A, Keil O, Giese K, Kaufmann J, Drevs J.

Int J Clin Pharmacol Ther. 2012 Jan;50(1):76-8. No abstract available.

10.

Atu027 prevents pulmonary metastasis in experimental and spontaneous mouse metastasis models.

Santel A, Aleku M, Röder N, Möpert K, Durieux B, Janke O, Keil O, Endruschat J, Dames S, Lange C, Eisermann M, Löffler K, Fechtner M, Fisch G, Vank C, Schaeper U, Giese K, Kaufmann J.

Clin Cancer Res. 2010 Nov 15;16(22):5469-80. doi: 10.1158/1078-0432.CCR-10-1994. Epub 2010 Nov 9.

11.

Adrenomedullin attenuates ventilator-induced lung injury in mice.

Müller HC, Witzenrath M, Tschernig T, Gutbier B, Hippenstiel S, Santel A, Suttorp N, Rosseau S.

Thorax. 2010 Dec;65(12):1077-84. doi: 10.1136/thx.2010.135996. Epub 2010 Oct 22.

PMID:
20971983
12.

RNAi-mediated suppression of constitutive pulmonary gene expression by small interfering RNA in mice.

Gutbier B, Kube SM, Reppe K, Santel A, Lange C, Kaufmann J, Suttorp N, Witzenrath M.

Pulm Pharmacol Ther. 2010 Aug;23(4):334-44. doi: 10.1016/j.pupt.2010.03.007. Epub 2010 Apr 1.

PMID:
20362688
13.

RNA interference for therapy in the vascular endothelium.

Kaufmann J, Ahrens K, Santel A.

Microvasc Res. 2010 Sep;80(2):286-93. doi: 10.1016/j.mvr.2010.02.002. Epub 2010 Feb 6. Review.

PMID:
20144624
14.

Loss of Drp1 function alters OPA1 processing and changes mitochondrial membrane organization.

Möpert K, Hajek P, Frank S, Chen C, Kaufmann J, Santel A.

Exp Cell Res. 2009 Aug 1;315(13):2165-80. doi: 10.1016/j.yexcr.2009.04.016. Epub 2009 May 3.

PMID:
19409380
15.

Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression.

Aleku M, Schulz P, Keil O, Santel A, Schaeper U, Dieckhoff B, Janke O, Endruschat J, Durieux B, Röder N, Löffler K, Lange C, Fechtner M, Möpert K, Fisch G, Dames S, Arnold W, Jochims K, Giese K, Wiedenmann B, Scholz A, Kaufmann J.

Cancer Res. 2008 Dec 1;68(23):9788-98. doi: 10.1158/0008-5472.CAN-08-2428.

16.

Shaping mitochondria: The complex posttranslational regulation of the mitochondrial fission protein DRP1.

Santel A, Frank S.

IUBMB Life. 2008 Jul;60(7):448-55. doi: 10.1002/iub.71. Review.

17.

Intracellular localization of lipoplexed siRNA in vascular endothelial cells of different mouse tissues.

Aleku M, Fisch G, Möpert K, Keil O, Arnold W, Kaufmann J, Santel A.

Microvasc Res. 2008 May;76(1):31-41. doi: 10.1016/j.mvr.2008.02.004. Epub 2008 Mar 18.

PMID:
18455200
18.

Isoform-specific interaction of C-RAF with mitochondria.

Galmiche A, Fueller J, Santel A, Krohne G, Wittig I, Doye A, Rolando M, Flatau G, Lemichez E, Rapp UR.

J Biol Chem. 2008 May 23;283(21):14857-66. doi: 10.1074/jbc.M709098200. Epub 2008 Mar 20.

19.

A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium.

Santel A, Aleku M, Keil O, Endruschat J, Esche V, Fisch G, Dames S, Löffler K, Fechtner M, Arnold W, Giese K, Klippel A, Kaufmann J.

Gene Ther. 2006 Aug;13(16):1222-34. Epub 2006 Apr 20.

PMID:
16625243
20.

RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy.

Santel A, Aleku M, Keil O, Endruschat J, Esche V, Durieux B, Löffler K, Fechtner M, Röhl T, Fisch G, Dames S, Arnold W, Giese K, Klippel A, Kaufmann J.

Gene Ther. 2006 Sep;13(18):1360-70. Epub 2006 Apr 20.

PMID:
16625242
21.

Get the balance right: mitofusins roles in health and disease.

Santel A.

Biochim Biophys Acta. 2006 May-Jun;1763(5-6):490-9. Epub 2006 Mar 9. Review.

22.

The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells.

Tondera D, Czauderna F, Paulick K, Schwarzer R, Kaufmann J, Santel A.

J Cell Sci. 2005 Jul 15;118(Pt 14):3049-59. Epub 2005 Jun 28.

23.

Germ-line specific variants of components of the mitochondrial outer membrane import machinery in Drosophila.

Hwa JJ, Zhu AJ, Hiller MA, Kon CY, Fuller MT, Santel A.

FEBS Lett. 2004 Aug 13;572(1-3):141-6.

24.

PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase.

Leenders F, Möpert K, Schmiedeknecht A, Santel A, Czauderna F, Aleku M, Penschuck S, Dames S, Sternberger M, Röhl T, Wellmann A, Arnold W, Giese K, Kaufmann J, Klippel A.

EMBO J. 2004 Aug 18;23(16):3303-13. Epub 2004 Jul 29.

25.

Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis.

Tondera D, Santel A, Schwarzer R, Dames S, Giese K, Klippel A, Kaufmann J.

J Biol Chem. 2004 Jul 23;279(30):31544-55. Epub 2004 May 20.

26.

Inducible shRNA expression for application in a prostate cancer mouse model.

Czauderna F, Santel A, Hinz M, Fechtner M, Durieux B, Fisch G, Leenders F, Arnold W, Giese K, Klippel A, Kaufmann J.

Nucleic Acids Res. 2003 Nov 1;31(21):e127.

27.

Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells.

Santel A, Frank S, Gaume B, Herrler M, Youle RJ, Fuller MT.

J Cell Sci. 2003 Jul 1;116(Pt 13):2763-74. Epub 2003 May 20.

28.

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis.

Karbowski M, Lee YJ, Gaume B, Jeong SY, Frank S, Nechushtan A, Santel A, Fuller M, Smith CL, Youle RJ.

J Cell Biol. 2002 Dec 23;159(6):931-8. Epub 2002 Dec 23.

29.

Differential expression of the Drosophila mitofusin genes fuzzy onions (fzo) and dmfn.

Hwa JJ, Hiller MA, Fuller MT, Santel A.

Mech Dev. 2002 Aug;116(1-2):213-6.

30.

A new translational repression element and unusual transcriptional control regulate expression of don juan during Drosophila spermatogenesis.

Blümer N, Schreiter K, Hempel L, Santel A, Hollmann M, Schäfer MA, Renkawitz-Pohl R.

Mech Dev. 2002 Jan;110(1-2):97-112.

31.

Control of mitochondrial morphology by a human mitofusin.

Santel A, Fuller MT.

J Cell Sci. 2001 Mar;114(Pt 5):867-74.

33.

Flagellar mitochondrial association of the male-specific Don Juan protein in Drosophila spermatozoa.

Santel A, Blümer N, Kämpfer M, Renkawitz-Pohl R.

J Cell Sci. 1998 Nov;111 ( Pt 22):3299-309.

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