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Items: 1 to 50 of 65

1.

Antimycobacterial Rufomycin Analogues from Streptomyces atratus Strain MJM3502.

Zhou B, Shetye G, Yu Y, Santarsiero BD, Klein LL, Abad-Zapatero C, Wolf NM, Cheng J, Jin Y, Lee H, Suh JW, Lee H, Bisson J, McAlpine JB, Chen SN, Cho SH, Franzblau SG, Pauli GF.

J Nat Prod. 2020 Mar 27;83(3):657-667. doi: 10.1021/acs.jnatprod.9b01095. Epub 2020 Feb 7.

PMID:
32031795
2.

High-Resolution Structure of ClpC1-Rufomycin and Ligand Binding Studies Provide a Framework to Design and Optimize Anti-Tuberculosis Leads.

Wolf NM, Lee H, Choules MP, Pauli GF, Phansalkar R, Anderson JR, Gao W, Ren J, Santarsiero BD, Lee H, Cheng J, Jin YY, Ho NA, Duc NM, Suh JW, Abad-Zapatero C, Cho S.

ACS Infect Dis. 2019 Jun 14;5(6):829-840. doi: 10.1021/acsinfecdis.8b00276. Epub 2019 May 3.

3.

Correction to Improvements to Practical Usability of the "Crystalline Sponge" Method for Organic Structure Determination.

Waldhart GW, Mankad NP, Santarsiero BD.

Org Lett. 2018 Jun 15;20(12):3714. doi: 10.1021/acs.orglett.8b01553. Epub 2018 May 25. No abstract available.

PMID:
29798676
4.

Structural characterization of Porphyromonas gingivalis enoyl-ACP reductase II (FabK).

Hevener KE, Santarsiero BD, Lee H, Jones JA, Boci T, Johnson ME, Mehboob S.

Acta Crystallogr F Struct Biol Commun. 2018 Feb 1;74(Pt 2):105-112. doi: 10.1107/S2053230X18000262. Epub 2018 Jan 26.

5.

Ribocyclophanes A-E, Glycosylated Cyclophanes with Antiproliferative Activity from Two Cultured Terrestrial Cyanobacteria.

May DS, Kang HS, Santarsiero BD, Krunic A, Shen Q, Burdette JE, Swanson SM, Orjala J.

J Nat Prod. 2018 Mar 23;81(3):572-578. doi: 10.1021/acs.jnatprod.7b00954. Epub 2018 Jan 30.

6.

Richard E. Marsh (1922-2017).

Santarsiero BD.

Acta Crystallogr C Struct Chem. 2017 Dec 1;73(Pt 12):1038-1039. doi: 10.1107/S2053229617017090. Epub 2017 Nov 1. No abstract available.

PMID:
29206112
7.

Synthesis and Properties of New N-Heteroheptacenes for Solution-Based Organic Field Effect Transistors.

Zhou F, Liu S, Santarsiero BD, Wink DJ, Boudinet D, Facchetti A, Driver T.

Chemistry. 2017 Sep 12;23(51):12542-12549. doi: 10.1002/chem.201701966. Epub 2017 Aug 10.

PMID:
28719724
8.

Improvements to the Practical Usability of the "Crystalline Sponge" Method for Organic Structure Determination.

Waldhart GW, Mankad NP, Santarsiero BD.

Org Lett. 2016 Dec 2;18(23):6112-6115. Epub 2016 Nov 15. Erratum in: Org Lett. 2018 Jun 15;20(12):3714.

9.

Correction to Di-nor and 17-nor-pimaranes from Icacina trichantha.

Guo B, Onakpa MM, Huang XJ, Santarsiero BD, Chen WL, Zhao M, Zhang XQ, Swanson SM, Burdette JE, Che CT.

J Nat Prod. 2016 Oct 28;79(10):2765. Epub 2016 Oct 17. No abstract available.

PMID:
27749052
10.

Ca-asp bound X-ray structure and inhibition of Bacillus anthracis dihydroorotase (DHOase).

Rice AJ, Lei H, Santarsiero BD, Lee H, Johnson ME.

Bioorg Med Chem. 2016 Oct 1;24(19):4536-4543. doi: 10.1016/j.bmc.2016.07.055. Epub 2016 Jul 29.

11.

Structure of the Adenovirus Type 4 (Species E) E3-19K/HLA-A2 Complex Reveals Species-Specific Features in MHC Class I Recognition.

Li L, Santarsiero BD, Bouvier M.

J Immunol. 2016 Aug 15;197(4):1399-407. doi: 10.4049/jimmunol.1600541. Epub 2016 Jul 6.

12.

Di-nor- and 17-nor-pimaranes from Icacina trichantha.

Guo B, Onakpa MM, Huang XJ, Santarsiero BD, Chen WL, Zhao M, Zhang XQ, Swanson SM, Burdette JE, Che CT.

J Nat Prod. 2016 Jul 22;79(7):1815-21. doi: 10.1021/acs.jnatprod.6b00289. Epub 2016 Jun 24. Erratum in: J Nat Prod. 2016 Oct 28;79(10 ):2765.

13.

α-Glucosidase Inhibitory Prenylated Anthranols from Harungana madagascariensis.

Johnson OO, Zhao M, Gunn J, Santarsiero BD, Yin ZQ, Ayoola GA, Coker HA, Che CT.

J Nat Prod. 2016 Jan 22;79(1):224-9. doi: 10.1021/acs.jnatprod.5b00924. Epub 2016 Jan 4.

PMID:
26727375
14.

(9βH)-Pimaranes and Derivatives from the Tuber of Icacina trichantha.

Zhao M, Onakpa MM, Santarsiero BD, Chen WL, Szymulanska-Ramamurthy KM, Swanson SM, Burdette JE, Che CT.

J Nat Prod. 2015 Nov 25;78(11):2731-7. doi: 10.1021/acs.jnatprod.5b00688. Epub 2015 Nov 2.

15.

Icacinlactone H and Icacintrichantholide from the Tuber of Icacina trichantha.

Zhao M, Onakpa MM, Santarsiero BD, Huang XJ, Zhang XQ, Chen J, Cheng JJ, Longnecker R, Che CT.

Org Lett. 2015 Aug 7;17(15):3834-7. doi: 10.1021/acs.orglett.5b01806. Epub 2015 Jul 17.

PMID:
26183449
16.

Indole trimers with antibacterial activity against Gram-positive organisms produced using combinatorial biocatalysis.

McClay K, Mehboob S, Yu J, Santarsiero BD, Deng J, Cook JL, Jeong H, Johnson ME, Steffan RJ.

AMB Express. 2015 Dec;5(1):125. doi: 10.1186/s13568-015-0125-4. Epub 2015 Jun 26.

17.

17-Norpimaranes and (9βH)-17-Norpimaranes from the Tuber of Icacina trichantha.

Zhao M, Onakpa MM, Chen WL, Santarsiero BD, Swanson SM, Burdette JE, Asuzu IU, Che CT.

J Nat Prod. 2015 Apr 24;78(4):789-96. doi: 10.1021/np5010328. Epub 2015 Mar 17.

18.

Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV.

Lee H, Lei H, Santarsiero BD, Gatuz JL, Cao S, Rice AJ, Patel K, Szypulinski MZ, Ojeda I, Ghosh AK, Johnson ME.

ACS Chem Biol. 2015 Jun 19;10(6):1456-65. doi: 10.1021/cb500917m. Epub 2015 Mar 16.

19.

Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI).

Mehboob S, Song J, Hevener KE, Su PC, Boci T, Brubaker L, Truong L, Mistry T, Deng J, Cook JL, Santarsiero BD, Ghosh AK, Johnson ME.

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1292-6. doi: 10.1016/j.bmcl.2015.01.048. Epub 2015 Jan 29.

20.

Cytotoxic (9βH)-pimarane and (9βH)-17-norpimarane diterpenes from the tuber of Icacina trichantha.

Monday Onakpa M, Zhao M, Gödecke T, Chen WL, Che CT, Santarsiero BD, Swanson SM, Uzoma Asuzu I.

Chem Biodivers. 2014 Dec;11(12):1914-22. doi: 10.1002/cbdv.201400151.

PMID:
25491335
21.

Elucidation of the bicarbonate binding site and insights into the carboxylation mechanism of (N(5))-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus anthracis.

Tuntland ML, Santarsiero BD, Johnson ME, Fung LW.

Acta Crystallogr D Biol Crystallogr. 2014 Nov;70(Pt 11):3057-65. doi: 10.1107/S1399004714021166. Epub 2014 Oct 29.

PMID:
25372694
22.

Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.

Nomme J, Li Z, Gipson RM, Wang J, Armijo AL, Le T, Poddar S, Smith T, Santarsiero BD, Nguyen HA, Czernin J, Alexandrova AN, Jung ME, Radu CG, Lavie A.

J Med Chem. 2014 Nov 26;57(22):9480-94. doi: 10.1021/jm501124j. Epub 2014 Nov 7.

23.

Diazaquinomycins E-G, novel diaza-anthracene analogs from a marine-derived Streptomyces sp.

Mullowney MW, Ó hAinmhire E, Shaikh A, Wei X, Tanouye U, Santarsiero BD, Burdette JE, Murphy BT.

Mar Drugs. 2014 Jun 11;12(6):3574-86. doi: 10.3390/md12063574.

24.

Absolute configuration of naturally occurring glabridin.

Simmler C, Fronczek FR, Pauli GF, Santarsiero BD.

Acta Crystallogr C. 2013 Nov;69(Pt 11):1212-6. doi: 10.1107/S0108270113018842. Epub 2013 Oct 9.

25.

Potential chemopreventive activity of a new macrolide antibiotic from a marine-derived Micromonospora sp.

Carlson S, Marler L, Nam SJ, Santarsiero BD, Pezzuto JM, Murphy BT.

Mar Drugs. 2013 Apr 3;11(4):1152-61. doi: 10.3390/md11041152.

26.

Expression, purification and characterization of enoyl-ACP reductase II, FabK, from Porphyromonas gingivalis.

Hevener KE, Mehboob S, Boci T, Truong K, Santarsiero BD, Johnson ME.

Protein Expr Purif. 2012 Sep;85(1):100-8. doi: 10.1016/j.pep.2012.07.003. Epub 2012 Jul 20.

27.

Structural and enzymatic analyses reveal the binding mode of a novel series of Francisella tularensis enoyl reductase (FabI) inhibitors.

Mehboob S, Hevener KE, Truong K, Boci T, Santarsiero BD, Johnson ME.

J Med Chem. 2012 Jun 28;55(12):5933-41. doi: 10.1021/jm300489v. Epub 2012 Jun 8.

28.

Merocyclophanes A and B, antiproliferative cyclophanes from the cultured terrestrial Cyanobacterium Nostoc sp.

Kang HS, Santarsiero BD, Kim H, Krunic A, Shen Q, Swanson SM, Chai H, Kinghorn AD, Orjala J.

Phytochemistry. 2012 Jul;79:109-15. doi: 10.1016/j.phytochem.2012.03.005. Epub 2012 May 7.

29.

Structure of N5-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus anthracis.

Tuntland ML, Johnson ME, Fung LW, Santarsiero BD.

Acta Crystallogr D Biol Crystallogr. 2011 Oct;67(Pt 10):870-4. doi: 10.1107/S0907444911029210. Epub 2011 Sep 8.

30.

Structure of the Francisella tularensis enoyl-acyl carrier protein reductase (FabI) in complex with NAD(+) and triclosan.

Mehboob S, Truong K, Santarsiero BD, Johnson ME.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt 11):1436-40. doi: 10.1107/S1744309110039862. Epub 2010 Oct 27.

31.

Structure of dihydroorotase from Bacillus anthracis at 2.6 Å resolution.

Mehboob S, Mulhearn DC, Truong K, Johnson ME, Santarsiero BD.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt 11):1432-5. doi: 10.1107/S1744309110037085. Epub 2010 Oct 27.

32.

Hapalindole-related alkaloids from the cultured cyanobacterium Fischerella ambigua.

Mo S, Krunic A, Santarsiero BD, Franzblau SG, Orjala J.

Phytochemistry. 2010 Dec;71(17-18):2116-23. doi: 10.1016/j.phytochem.2010.09.004. Epub 2010 Oct 19.

33.

Pleiotropic mechanisms facilitated by resveratrol and its metabolites.

Calamini B, Ratia K, Malkowski MG, Cuendet M, Pezzuto JM, Santarsiero BD, Mesecar AD.

Biochem J. 2010 Jul 15;429(2):273-82. doi: 10.1042/BJ20091857.

34.

Crystal structure of the nonerythroid alpha-spectrin tetramerization site reveals differences between erythroid and nonerythroid spectrin tetramer formation.

Mehboob S, Song Y, Witek M, Long F, Santarsiero BD, Johnson ME, Fung LW.

J Biol Chem. 2010 May 7;285(19):14572-84. doi: 10.1074/jbc.M109.080028. Epub 2010 Mar 14.

35.

Structural basis for thermostability revealed through the identification and characterization of a highly thermostable phosphotriesterase-like lactonase from Geobacillus stearothermophilus.

Hawwa R, Aikens J, Turner RJ, Santarsiero BD, Mesecar AD.

Arch Biochem Biophys. 2009 Aug 15;488(2):109-20. doi: 10.1016/j.abb.2009.06.005. Epub 2009 Jul 16.

36.

Kinetic and X-ray structural evidence for negative cooperativity in substrate binding to nicotinate mononucleotide adenylyltransferase (NMAT) from Bacillus anthracis.

Sershon VC, Santarsiero BD, Mesecar AD.

J Mol Biol. 2009 Jan 23;385(3):867-88. doi: 10.1016/j.jmb.2008.10.037. Epub 2008 Oct 19.

37.

The structures of T87I phosphono-CheY and T87I/Y106W phosphono-CheY help to explain their binding affinities to the FliM and CheZ peptides.

McAdams K, Casper ES, Matthew Haas R, Santarsiero BD, Eggler AL, Mesecar A, Halkides CJ.

Arch Biochem Biophys. 2008 Nov 15;479(2):105-13. doi: 10.1016/j.abb.2008.08.019. Epub 2008 Sep 5.

38.

Design and synthesis of aryl ether inhibitors of the Bacillus anthracis enoyl-ACP reductase.

Tipparaju SK, Mulhearn DC, Klein GM, Chen Y, Tapadar S, Bishop MH, Yang S, Chen J, Ghassemi M, Santarsiero BD, Cook JL, Johlfs M, Mesecar AD, Johnson ME, Kozikowski AP.

ChemMedChem. 2008 Aug;3(8):1250-68. doi: 10.1002/cmdc.200800047.

39.

Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2.

Calamini B, Santarsiero BD, Boutin JA, Mesecar AD.

Biochem J. 2008 Jul 1;413(1):81-91. doi: 10.1042/BJ20071373.

40.

Structural and functional analysis of two glutamate racemase isozymes from Bacillus anthracis and implications for inhibitor design.

May M, Mehboob S, Mulhearn DC, Wang Z, Yu H, Thatcher GR, Santarsiero BD, Johnson ME, Mesecar AD.

J Mol Biol. 2007 Aug 31;371(5):1219-37. Epub 2007 Jun 4.

41.

GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels.

Deng S, Chen SN, Lu J, Wang ZJ, Nikolic D, van Breemen RB, Santarsiero BD, Mesecar A, Fong HH, Farnsworth NR, Pauli GF.

Phytochem Anal. 2006 Nov-Dec;17(6):398-405.

PMID:
17144247
42.

Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme.

Ratia K, Saikatendu KS, Santarsiero BD, Barretto N, Baker SC, Stevens RC, Mesecar AD.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5717-22. Epub 2006 Mar 31.

43.

Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza.

Homhual S, Zhang HJ, Bunyapraphatsara N, Kondratyuk TP, Santarsiero BD, Mesecar AD, Herunsalee A, Chaukul W, Pezzuto JM, Fong HH.

Planta Med. 2006 Feb;72(3):255-60.

PMID:
16534731
44.

Miliusanes, a class of cytotoxic agents from Miliusa sinensis.

Zhang HJ, Ma C, Nguyen VH, Nguyen MC, Tan GT, Santarsiero BD, Mesecar AD, Soejarto DD, Pezzuto JM, Fong HH.

J Med Chem. 2006 Jan 26;49(2):693-708.

PMID:
16420055
45.

Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors.

Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD.

J Med Chem. 2005 Nov 3;48(22):6767-71.

PMID:
16250632
46.

Activity-guided isolation of cytotoxic constituents from the bark of Aglaia crassinervia collected in Indonesia.

Su BN, Chai H, Mi Q, Riswan S, Kardono LB, Afriastini JJ, Santarsiero BD, Mesecar AD, Farnsworth NR, Cordell GA, Swanson SM, Kinghorn AD.

Bioorg Med Chem. 2006 Feb 15;14(4):960-72. Epub 2005 Oct 10.

PMID:
16216518
47.

Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.

Dombrauckas JD, Santarsiero BD, Mesecar AD.

Biochemistry. 2005 Jul 12;44(27):9417-29.

PMID:
15996096
48.

New 3-O-acyl betulinic acids from Strychnos vanprukii Craib.

Nguyen QC, Nguyen VH, Santarsiero BD, Mesecar AD, Nguyen MC, Soejarto DD, Pezzuto JM, Fong HH, Tan GT.

J Nat Prod. 2004 Jun;67(6):994-8.

PMID:
15217281
49.

Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris.

Hwang BY, Su BN, Chai H, Mi Q, Kardono LB, Afriastini JJ, Riswan S, Santarsiero BD, Mesecar AD, Wild R, Fairchild CR, Vite GD, Rose WC, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kinghorn AD.

J Org Chem. 2004 May 14;69(10):3350-8. Erratum in: J Org Chem. 2004 Sep 3;69(18):6156.

PMID:
15132542
50.

Antimycobacterial Naphthopyrones from Senna obliqua.

Graham JG, Zhang H, Pendland SL, Santarsiero BD, Mesecar AD, Cabieses F, Farnsworth NR.

J Nat Prod. 2004 Feb;67(2):225-7.

PMID:
14987063

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