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Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization.

Granato M, Gilardini Montani MS, Zompetta C, Santarelli R, Gonnella R, Romeo MA, D'Orazi G, Faggioni A, Cirone M.

Biomolecules. 2019 Sep 12;9(9). pii: E482. doi: 10.3390/biom9090482.


Kaposi Sarcoma Herpes Virus (KSHV) infection inhibits macrophage formation and survival by counteracting Macrophage Colony-Stimulating Factor (M-CSF)-induced increase of Reactive Oxygen Species (ROS), c-Jun N-terminal kinase (JNK) phosphorylation and autophagy.

Gilardini Montani MS, Falcinelli L, Santarelli R, Romeo MA, Granato M, Faggioni A, Cirone M.

Int J Biochem Cell Biol. 2019 Sep;114:105560. doi: 10.1016/j.biocel.2019.06.008. Epub 2019 Jun 17.


Hearing Dysfunction in a Large Family Affected by Dominant Optic Atrophy (OPA8-Related DOA): A Human Model of Hidden Auditory Neuropathy.

Santarelli R, La Morgia C, Valentino ML, Barboni P, Monteleone A, Scimemi P, Carelli V.

Front Neurosci. 2019 May 28;13:501. doi: 10.3389/fnins.2019.00501. eCollection 2019.


STAT3 phosphorylation affects p53/p21 axis and KSHV lytic cycle activation.

Santarelli R, Carillo V, Romeo MA, Gaeta A, Nazzari C, Gonnella R, Granato M, D'Orazi G, Faggioni A, Cirone M.

Virology. 2019 Feb;528:137-143. doi: 10.1016/j.virol.2018.12.015. Epub 2019 Jan 5.


EBV reduces autophagy, intracellular ROS and mitochondria to impair monocyte survival and differentiation.

Gilardini Montani MS, Santarelli R, Granato M, Gonnella R, Torrisi MR, Faggioni A, Cirone M.

Autophagy. 2019 Apr;15(4):652-667. doi: 10.1080/15548627.2018.1536530. Epub 2018 Oct 23.


EBV up-regulates PD-L1 on the surface of primary monocytes by increasing ROS and activating TLR signaling and STAT3.

Gilardini Montani MS, Santarelli R, Falcinelli L, Gonnella R, Granato M, Di Renzo L, Cuomo L, Vitillo M, Faggioni A, Cirone M.

J Leukoc Biol. 2018 Oct;104(4):821-832. doi: 10.1002/JLB.2A0118-029RR. Epub 2018 Jul 24.


European 17 countries consensus endorses more approaches to APD than reported in Wilson 2018.

Iliadou VV, Ptok M, Grech H, Pedersen ER, Brechmann A, Deggouj N, Kiese-Himmel C, S Liwin Ska-Kowalska M, Nickisch A, Demanez L, Veuillet E, Thai-Van H, Sirimanna T, Callimachou M, Santarelli R, Kuske S, Barajas de Prat JJ, Hedever M, Konukseven O, Veraguth D, Mattsson TS, Martins JH, Bamiou DE.

Int J Audiol. 2018 May;57(5):395-396. doi: 10.1080/14992027.2018.1442937. Epub 2018 Feb 28. No abstract available.


A novel mutation of the EYA4 gene associated with post-lingual hearing loss in a proband is co-segregating with a novel PAX3 mutation in two congenitally deaf family members.

Cesca F, Bettella E, Polli R, Cama E, Scimemi P, Santarelli R, Murgia A.

Int J Pediatr Otorhinolaryngol. 2018 Jan;104:88-93. doi: 10.1016/j.ijporl.2017.10.042. Epub 2017 Oct 31.


A European Perspective on Auditory Processing Disorder-Current Knowledge and Future Research Focus.

Iliadou VV, Ptok M, Grech H, Pedersen ER, Brechmann A, Deggouj N, Kiese-Himmel C, Śliwińska-Kowalska M, Nickisch A, Demanez L, Veuillet E, Thai-Van H, Sirimanna T, Callimachou M, Santarelli R, Kuske S, Barajas J, Hedjever M, Konukseven O, Veraguth D, Stokkereit Mattsson T, Martins JH, Bamiou DE.

Front Neurol. 2017 Nov 21;8:622. doi: 10.3389/fneur.2017.00622. eCollection 2017.


Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death.

Granato M, Gilardini Montani MS, Santarelli R, D'Orazi G, Faggioni A, Cirone M.

J Exp Clin Cancer Res. 2017 Nov 28;36(1):167. doi: 10.1186/s13046-017-0632-z.


Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy.

Granato M, Romeo MA, Tiano MS, Santarelli R, Gonnella R, Gilardini Montani MS, Faggioni A, Cirone M.

Sci Rep. 2017 Oct 12;7(1):13052. doi: 10.1038/s41598-017-13533-7.


Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation.

Granato M, Gilardini Montani MS, Romeo MA, Santarelli R, Gonnella R, D'Orazi G, Faggioni A, Cirone M.

Cell Signal. 2017 Dec;40:239-247. doi: 10.1016/j.cellsig.2017.09.020. Epub 2017 Sep 28.


Oxidant species are involved in T/B-mediated ERK1/2 phosphorylation that activates p53-p21 axis to promote KSHV lytic cycle in PEL cells.

Gonnella R, Yadav S, Gilardini Montani MS, Granato M, Santarelli R, Garufi A, D'Orazi G, Faggioni A, Cirone M.

Free Radic Biol Med. 2017 Nov;112:327-335. doi: 10.1016/j.freeradbiomed.2017.08.005. Epub 2017 Aug 8.


Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways.

Granato M, Rizzello C, Gilardini Montani MS, Cuomo L, Vitillo M, Santarelli R, Gonnella R, D'Orazi G, Faggioni A, Cirone M.

J Nutr Biochem. 2017 Mar;41:124-136. doi: 10.1016/j.jnutbio.2016.12.011. Epub 2017 Jan 5.


KSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin and ATG5 expression.

Santarelli R, Granato M, Pentassuglia G, Lacconi V, Gilardini Montani MS, Gonnella R, Tafani M, Torrisi MR, Faggioni A, Cirone M.

Autophagy. 2016 Dec;12(12):2311-2325. Epub 2016 Oct 7.


Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt's lymphoma.

Granato M, Rizzello C, Romeo MA, Yadav S, Santarelli R, D'Orazi G, Faggioni A, Cirone M.

Int J Biochem Cell Biol. 2016 Oct;79:393-400. doi: 10.1016/j.biocel.2016.09.006. Epub 2016 Sep 9.


Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.

Vogl C, Panou I, Yamanbaeva G, Wichmann C, Mangosing SJ, Vilardi F, Indzhykulian AA, Pangršič T, Santarelli R, Rodriguez-Ballesteros M, Weber T, Jung S, Cardenas E, Wu X, Wojcik SM, Kwan KY, Del Castillo I, Schwappach B, Strenzke N, Corey DP, Lin SY, Moser T.

EMBO J. 2016 Dec 1;35(23):2536-2552. Epub 2016 Jul 25.


Reply: Both mitochondrial DNA and mitonuclear gene mutations cause hearing loss through cochlear dysfunction.

Santarelli R, Cama E, Scimemi P, La Morgia C, Caporali L, Valentino ML, Liguori R, Carelli V.

Brain. 2016 Jun;139(Pt 6):e34. doi: 10.1093/brain/aww052. Epub 2016 Mar 25. No abstract available.


The activation of KSHV lytic cycle blocks autophagy in PEL cells.

Granato M, Santarelli R, Filardi M, Gonnella R, Farina A, Torrisi MR, Faggioni A, Cirone M.

Autophagy. 2015 Nov 2;11(11):1978-1986. doi: 10.1080/15548627.2015.1091911.


Audibility, speech perception and processing of temporal cues in ribbon synaptic disorders due to OTOF mutations.

Santarelli R, del Castillo I, Cama E, Scimemi P, Starr A.

Hear Res. 2015 Dec;330(Pt B):200-12. doi: 10.1016/j.heares.2015.07.007. Epub 2015 Jul 15. Review.


Interference with the Autophagic Process as a Viral Strategy to Escape from the Immune Control: Lesson from Gamma Herpesviruses.

Santarelli R, Granato M, Faggioni A, Cirone M.

J Immunol Res. 2015;2015:546063. doi: 10.1155/2015/546063. Epub 2015 May 18. Review.


PKC theta and p38 MAPK activate the EBV lytic cycle through autophagy induction.

Gonnella R, Granato M, Farina A, Santarelli R, Faggioni A, Cirone M.

Biochim Biophys Acta. 2015 Jul;1853(7):1586-95. doi: 10.1016/j.bbamcr.2015.03.011. Epub 2015 Mar 27.


Abnormal Cochlear Potentials in Friedreich's Ataxia Point to Disordered Synchrony of Auditory Nerve Fiber Activity.

Santarelli R, Cama E, Pegoraro E, Scimemi P.

Neurodegener Dis. 2015;15(2):114-20. doi: 10.1159/000375307. Epub 2015 Mar 17.


Targeting of prosurvival pathways as therapeutic approaches against primary effusion lymphomas: past, present, and Future.

Granato M, Santarelli R, Gonnella R, Farina A, Trivedi P, Faggioni A, Cirone M.

Biomed Res Int. 2015;2015:104912. doi: 10.1155/2015/104912. Epub 2015 Jan 28. Review.


A central role for heme iron in colon carcinogenesis associated with red meat intake.

Bastide NM, Chenni F, Audebert M, Santarelli RL, Taché S, Naud N, Baradat M, Jouanin I, Surya R, Hobbs DA, Kuhnle GG, Raymond-Letron I, Gueraud F, Corpet DE, Pierre FH.

Cancer Res. 2015 Mar 1;75(5):870-9. doi: 10.1158/0008-5472.CAN-14-2554. Epub 2015 Jan 15.


OPA1-related auditory neuropathy: site of lesion and outcome of cochlear implantation.

Santarelli R, Rossi R, Scimemi P, Cama E, Valentino ML, La Morgia C, Caporali L, Liguori R, Magnavita V, Monteleone A, Biscaro A, Arslan E, Carelli V.

Brain. 2015 Mar;138(Pt 3):563-76. doi: 10.1093/brain/awu378. Epub 2015 Jan 5.


Auditory brainstem responses to clicks and tone bursts in C57 BL/6J mice.

Scimemi P, Santarelli R, Selmo A, Mammano F.

Acta Otorhinolaryngol Ital. 2014 Aug;34(4):264-71.


Epstein-barr virus blocks the autophagic flux and appropriates the autophagic machinery to enhance viral replication.

Granato M, Santarelli R, Farina A, Gonnella R, Lotti LV, Faggioni A, Cirone M.

J Virol. 2014 Nov;88(21):12715-26. doi: 10.1128/JVI.02199-14. Epub 2014 Aug 20.


STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells.

Santarelli R, Gonnella R, Di Giovenale G, Cuomo L, Capobianchi A, Granato M, Gentile G, Faggioni A, Cirone M.

Sci Rep. 2014 Feb 28;4:4241. doi: 10.1038/srep04241.


Kaposi sarcoma associated herpesvirus (KSHV) induces AKT hyperphosphorylation, bortezomib-resistance and GLUT-1 plasma membrane exposure in THP-1 monocytic cell line.

Gonnella R, Santarelli R, Farina A, Granato M, D'Orazi G, Faggioni A, Cirone M.

J Exp Clin Cancer Res. 2013 Oct 23;32:79. doi: 10.1186/1756-9966-32-79.


JNK and macroautophagy activation by bortezomib has a pro-survival effect in primary effusion lymphoma cells.

Granato M, Santarelli R, Lotti LV, Di Renzo L, Gonnella R, Garufi A, Trivedi P, Frati L, D'Orazi G, Faggioni A, Cirone M.

PLoS One. 2013 Sep 26;8(9):e75965. doi: 10.1371/journal.pone.0075965. eCollection 2013.


Calcium and α-tocopherol suppress cured-meat promotion of chemically induced colon carcinogenesis in rats and reduce associated biomarkers in human volunteers.

Pierre FH, Martin OC, Santarelli RL, Taché S, Naud N, Guéraud F, Audebert M, Dupuy J, Meunier N, Attaix D, Vendeuvre JL, Mirvish SS, Kuhnle GC, Cano N, Corpet DE.

Am J Clin Nutr. 2013 Nov;98(5):1255-62. doi: 10.3945/ajcn.113.061069. Epub 2013 Sep 11.


HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.

Granato M, Lacconi V, Peddis M, Lotti LV, Di Renzo L, Gonnella R, Santarelli R, Trivedi P, Frati L, D'Orazi G, Faggioni A, Cirone M.

Cell Death Dis. 2013 Jul 18;4:e730. doi: 10.1038/cddis.2013.263. Erratum in: Cell Death Dis. 2014;5:e2154. Renzo, L D [corrected to Di Renzo, L].


Calcium inhibits promotion by hot dog of 1,2-dimethylhydrazine-induced mucin-depleted foci in rat colon.

Santarelli RL, Naud N, Taché S, Guéraud F, Vendeuvre JL, Zhou L, Anwar MM, Mirvish SS, Corpet DE, Pierre FH.

Int J Cancer. 2013 Dec 1;133(11):2533-41. doi: 10.1002/ijc.28286. Epub 2013 Jun 21.


KSHV ORF67 encoded lytic protein localizes on the nuclear membrane and alters emerin distribution.

Farina A, Santarelli R, Bloise R, Gonnella R, Granato M, Bei R, Modesti A, Cirone M, Bengtsson L, Angeloni A, Faggioni A.

Virus Res. 2013 Aug;175(2):143-50. doi: 10.1016/j.virusres.2013.04.001. Epub 2013 Apr 23.


Activation of dendritic cells by tumor cell death.

Cirone M, Di Renzo L, Lotti LV, Conte V, Trivedi P, Santarelli R, Gonnella R, Frati L, Faggioni A.

Oncoimmunology. 2012 Oct 1;1(7):1218-1219.


Targeting COX-2/PGE(2) pathway in HIPK2 knockdown cancer cells: impact on dendritic cell maturation.

Garufi A, Pistritto G, Ceci C, Di Renzo L, Santarelli R, Faggioni A, Cirone M, D'Orazi G.

PLoS One. 2012;7(11):e48342. doi: 10.1371/journal.pone.0048342. Epub 2012 Nov 7.


HHV-8 reduces dendritic cell migration through down-regulation of cell-surface CCR6 and CCR7 and cytoskeleton reorganization.

Cirone M, Conte V, Farina A, Valia S, Trivedi P, Granato M, Santarelli R, Frati L, Faggioni A.

Virol J. 2012 May 14;9:92. doi: 10.1186/1743-422X-9-92.


Primary effusion lymphoma cell death induced by bortezomib and AG 490 activates dendritic cells through CD91.

Cirone M, Di Renzo L, Lotti LV, Conte V, Trivedi P, Santarelli R, Gonnella R, Frati L, Faggioni A.

PLoS One. 2012;7(3):e31732. doi: 10.1371/journal.pone.0031732. Epub 2012 Mar 7.


Temporal bone high-resolution computed tomography in non-syndromic unilateral hearing loss in children.

Cama E, Inches I, Muzzi E, Sadushi O, Santarelli R, De Colle W, Rossi R, di Paola F, Arslan E.

ORL J Otorhinolaryngol Relat Spec. 2012;74(2):70-7. doi: 10.1159/000335586. Epub 2012 Feb 21.


Cochlear implant electrode array misplacement: a cautionary case report.

Muzzi E, Boscolo-Rizzo P, Santarelli R, Beltrame MA.

J Laryngol Otol. 2012 Apr;126(4):414-7. doi: 10.1017/S0022215112000059. Epub 2012 Feb 1.


Sudden hearing loss in sarcoidosis: otoneurological study and neuroradiological correlates.

Cama E, Santarelli R, Muzzi E, Inches I, Curtolo S, DI Paola F, Arslan E, Faccini E.

Acta Otorhinolaryngol Ital. 2011 Aug;31(4):235-8.


BAAV mediated GJB2 gene transfer restores gap junction coupling in cochlear organotypic cultures from deaf Cx26Sox10Cre mice.

Crispino G, Di Pasquale G, Scimemi P, Rodriguez L, Galindo Ramirez F, De Siati RD, Santarelli RM, Arslan E, Bortolozzi M, Chiorini JA, Mammano F.

PLoS One. 2011;6(8):e23279. doi: 10.1371/journal.pone.0023279. Epub 2011 Aug 18.


The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice.

Schütz M, Scimemi P, Majumder P, De Siati RD, Crispino G, Rodriguez L, Bortolozzi M, Santarelli R, Seydel A, Sonntag S, Ingham N, Steel KP, Willecke K, Mammano F.

Hum Mol Genet. 2010 Dec 15;19(24):4759-73. doi: 10.1093/hmg/ddq402. Epub 2010 Sep 21.


Freeze-dried ham promotes azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colon.

Pierre FH, Santarelli RL, Allam O, Tache S, Naud N, Gueraud F, Corpet DE.

Nutr Cancer. 2010;62(5):567-73. doi: 10.1080/01635580903532408.


Meat processing and colon carcinogenesis: cooked, nitrite-treated, and oxidized high-heme cured meat promotes mucin-depleted foci in rats.

Santarelli RL, Vendeuvre JL, Naud N, Taché S, Guéraud F, Viau M, Genot C, Corpet DE, Pierre FH.

Cancer Prev Res (Phila). 2010 Jul;3(7):852-64. doi: 10.1158/1940-6207.CAPR-09-0160. Epub 2010 Jun 8.


[A simplified occupational health and safety management system designed for small enterprises. Initial validation results].

Bacchi R, Veneri L, Ghini P, Caso MA, Baldassarri G, Renzetti F, Santarelli R.

Med Lav. 2009;100 Suppl 1:52-4. Italian.


Mutation of OPA1 gene causes deafness by affecting function of auditory nerve terminals.

Huang T, Santarelli R, Starr A.

Brain Res. 2009 Dec 1;1300:97-104. doi: 10.1016/j.brainres.2009.08.083. Epub 2009 Sep 3.


Abnormal cochlear potentials from deaf patients with mutations in the otoferlin gene.

Santarelli R, Del Castillo I, Rodríguez-Ballesteros M, Scimemi P, Cama E, Arslan E, Starr A.

J Assoc Res Otolaryngol. 2009 Dec;10(4):545-56. doi: 10.1007/s10162-009-0181-z. Epub 2009 Jul 28.

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