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Aerosol Delivery of Synthetic mRNA to Vaginal Mucosa Leads to Durable Expression of Broadly Neutralizing Antibodies against HIV.

Lindsay KE, Vanover D, Thoresen M, King H, Xiao P, Badial P, Araínga M, Park SB, Tiwari PM, Peck HE, Blanchard EL, Feugang JM, Olivier AK, Zurla C, Villinger F, Woolums AR, Santangelo PJ.

Mol Ther. 2020 Jan 10. pii: S1525-0016(20)30004-6. doi: 10.1016/j.ymthe.2020.01.002. [Epub ahead of print]


Mild Innate Immune Activation Overrides Efficient Nanoparticle-Mediated RNA Delivery.

Lokugamage MP, Gan Z, Zurla C, Levin J, Islam FZ, Kalathoor S, Sato M, Sago CD, Santangelo PJ, Dahlman JE.

Adv Mater. 2020 Jan;32(1):e1904905. doi: 10.1002/adma.201904905. Epub 2019 Nov 19.


Modification of primary amines to higher order amines reduces in vivo hematological and immunotoxicity of cationic nanocarriers through TLR4 and complement pathways.

Toy R, Pradhan P, Ramesh V, Di Paolo NC, Lash B, Liu J, Blanchard EL, Pinelli CJ, Santangelo PJ, Shayakhmetov DM, Roy K.

Biomaterials. 2019 Dec;225:119512. doi: 10.1016/j.biomaterials.2019.119512. Epub 2019 Sep 21.


Quantification and Localization of Protein-RNA Interactions in Patient-Derived Archival Tumor Tissue.

Blanchard EL, Argyropoulou D, Zurla C, Bhosle SM, Vanover D, Santangelo PJ.

Cancer Res. 2019 Oct 15;79(20):5418-5431. doi: 10.1158/0008-5472.CAN-19-1094. Epub 2019 Sep 3.


Visualization of early events in mRNA vaccine delivery in non-human primates via PET-CT and near-infrared imaging.

Lindsay KE, Bhosle SM, Zurla C, Beyersdorf J, Rogers KA, Vanover D, Xiao P, Araínga M, Shirreff LM, Pitard B, Baumhof P, Villinger F, Santangelo PJ.

Nat Biomed Eng. 2019 May;3(5):371-380. doi: 10.1038/s41551-019-0378-3. Epub 2019 Apr 1.


Proximity Ligation Assays for In Situ Detection of Innate Immune Activation: Focus on In Vitro-Transcribed mRNA.

Blanchard EL, Loomis KH, Bhosle SM, Vanover D, Baumhof P, Pitard B, Zurla C, Santangelo PJ.

Mol Ther Nucleic Acids. 2019 Mar 1;14:52-66. doi: 10.1016/j.omtn.2018.11.002. Epub 2018 Nov 20.


Exploitation of Synthetic mRNA To Drive Immune Effector Cell Recruitment and Functional Reprogramming In Vivo.

Xu Y, Huang L, Kirschman JL, Vanover DA, Tiwari PM, Santangelo PJ, Shen X, Russell DG.

J Immunol. 2019 Jan 15;202(2):608-617. doi: 10.4049/jimmunol.1800924. Epub 2018 Dec 12.


Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection.

Tiwari PM, Vanover D, Lindsay KE, Bawage SS, Kirschman JL, Bhosle S, Lifland AW, Zurla C, Santangelo PJ.

Nat Commun. 2018 Oct 1;9(1):3999. doi: 10.1038/s41467-018-06508-3.


High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing.

Sago CD, Lokugamage MP, Paunovska K, Vanover DA, Monaco CM, Shah NN, Gamboa Castro M, Anderson SE, Rudoltz TG, Lando GN, Munnilal Tiwari P, Kirschman JL, Willett N, Jang YC, Santangelo PJ, Bryksin AV, Dahlman JE.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9944-E9952. doi: 10.1073/pnas.1811276115. Epub 2018 Oct 1. Erratum in: Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11427.


Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7.

Lertjuthaporn S, Cicala C, Van Ryk D, Liu M, Yolitz J, Wei D, Nawaz F, Doyle A, Horowitch B, Park C, Lu S, Lou Y, Wang S, Pan R, Jiang X, Villinger F, Byrareddy SN, Santangelo PJ, Morris L, Wibmer CK, Biris K, Mason RD, Gorman J, Hiatt J, Martinelli E, Roederer M, Fujikawa D, Gorini G, Franchini G, Arakelyan A, Ansari AA, Pattanapanyasat K, Kong XP, Fauci AS, Arthos J.

PLoS Pathog. 2018 Aug 28;14(8):e1007278. doi: 10.1371/journal.ppat.1007278. eCollection 2018 Aug.


LEM domain-containing protein 3 antagonizes TGFβ-SMAD2/3 signaling in a stiffness-dependent manner in both the nucleus and cytosol.

Chambers DM, Moretti L, Zhang JJ, Cooper SW, Chambers DM, Santangelo PJ, Barker TH.

J Biol Chem. 2018 Oct 12;293(41):15867-15886. doi: 10.1074/jbc.RA118.003658. Epub 2018 Aug 14.


In Vitro Transcribed mRNA Vaccines with Programmable Stimulation of Innate Immunity.

Loomis KH, Lindsay KE, Zurla C, Bhosle SM, Vanover DA, Blanchard EL, Kirschman JL, Bellamkonda RV, Santangelo PJ.

Bioconjug Chem. 2018 Sep 19;29(9):3072-3083. doi: 10.1021/acs.bioconjchem.8b00443. Epub 2018 Aug 13.


A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation.

Paunovska K, Sago CD, Monaco CM, Hudson WH, Castro MG, Rudoltz TG, Kalathoor S, Vanover DA, Santangelo PJ, Ahmed R, Bryksin AV, Dahlman JE.

Nano Lett. 2018 Mar 14;18(3):2148-2157. doi: 10.1021/acs.nanolett.8b00432. Epub 2018 Mar 5.


The Role of Integrin α4β7 in HIV Pathogenesis and Treatment.

Arthos J, Cicala C, Nawaz F, Byrareddy SN, Villinger F, Santangelo PJ, Ansari AA, Fauci AS.

Curr HIV/AIDS Rep. 2018 Apr;15(2):127-135. doi: 10.1007/s11904-018-0382-3. Review.


Early treatment of SIV+ macaques with an α4β7 mAb alters virus distribution and preserves CD4+ T cells in later stages of infection.

Santangelo PJ, Cicala C, Byrareddy SN, Ortiz KT, Little D, Lindsay KE, Gumber S, Hong JJ, Jelicic K, Rogers KA, Zurla C, Villinger F, Ansari AA, Fauci AS, Arthos J.

Mucosal Immunol. 2018 May;11(3):932-946. doi: 10.1038/mi.2017.112. Epub 2017 Dec 20.


Unifying in vitro and in vivo IVT mRNA expression discrepancies in skeletal muscle via mechanotransduction.

Bhosle SM, Loomis KH, Kirschman JL, Blanchard EL, Vanover DA, Zurla C, Habrant D, Edwards D, Baumhof P, Pitard B, Santangelo PJ.

Biomaterials. 2018 Mar;159:189-203. doi: 10.1016/j.biomaterials.2018.01.010. Epub 2018 Jan 6.


RSV glycoprotein and genomic RNA dynamics reveal filament assembly prior to the plasma membrane.

Vanover D, Smith DV, Blanchard EL, Alonas E, Kirschman JL, Lifland AW, Zurla C, Santangelo PJ.

Nat Commun. 2017 Sep 22;8(1):667. doi: 10.1038/s41467-017-00732-z.


Characterizing exogenous mRNA delivery, trafficking, cytoplasmic release and RNA-protein correlations at the level of single cells.

Kirschman JL, Bhosle S, Vanover D, Blanchard EL, Loomis KH, Zurla C, Murray K, Lam BC, Santangelo PJ.

Nucleic Acids Res. 2017 Jul 7;45(12):e113. doi: 10.1093/nar/gkx290.


Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide.

Udhayakumar VK, De Beuckelaer A, McCaffrey J, McCrudden CM, Kirschman JL, Vanover D, Van Hoecke L, Roose K, Deswarte K, De Geest BG, Lienenklaus S, Santangelo PJ, Grooten J, McCarthy HO, De Koker S.

Adv Healthc Mater. 2017 Jul;6(13). doi: 10.1002/adhm.201601412. Epub 2017 Apr 24.


Correlated fluorescence microscopy and cryo-electron tomography of virus-infected or transfected mammalian cells.

Hampton CM, Strauss JD, Ke Z, Dillard RS, Hammonds JE, Alonas E, Desai TM, Marin M, Storms RE, Leon F, Melikyan GB, Santangelo PJ, Spearman PW, Wright ER.

Nat Protoc. 2017 Jan;12(1):150-167. doi: 10.1038/nprot.2016.168. Epub 2016 Dec 15.


Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy.

Byrareddy SN, Arthos J, Cicala C, Villinger F, Ortiz KT, Little D, Sidell N, Kane MA, Yu J, Jones JW, Santangelo PJ, Zurla C, McKinnon LR, Arnold KB, Woody CE, Walter L, Roos C, Noll A, Van Ryk D, Jelicic K, Cimbro R, Gumber S, Reid MD, Adsay V, Amancha PK, Mayne AE, Parslow TG, Fauci AS, Ansari AA.

Science. 2016 Oct 14;354(6309):197-202.


A Novel Method to Quantify RNA-Protein Interactions In Situ Using FMTRIP and Proximity Ligation.

Zurla C, Jung J, Blanchard EL, Santangelo PJ.

Methods Mol Biol. 2017;1468:155-70. doi: 10.1007/978-1-4939-4035-6_12.


Mirror-enhanced super-resolution microscopy.

Yang X, Xie H, Alonas E, Liu Y, Chen X, Santangelo PJ, Ren Q, Xi P, Jin D.

Light Sci Appl. 2016;5. pii: e16134. Epub 2016 Jun 17.


DNA uptake, intracellular trafficking and gene transfection after ultrasound exposure.

Liu Y, Yan J, Santangelo PJ, Prausnitz MR.

J Control Release. 2016 Jul 28;234:1-9. doi: 10.1016/j.jconrel.2016.05.013. Epub 2016 May 7.


Imaging viral RNA using multiply labeled tetravalent RNA imaging probes in live cells.

Alonas E, Vanover D, Blanchard E, Zurla C, Santangelo PJ.

Methods. 2016 Apr 1;98:91-98. doi: 10.1016/j.ymeth.2016.02.006. Epub 2016 Feb 12. Review.


Computing in mammalian cells with nucleic acid strand exchange.

Groves B, Chen YJ, Zurla C, Pochekailov S, Kirschman JL, Santangelo PJ, Seelig G.

Nat Nanotechnol. 2016 Mar;11(3):287-294. doi: 10.1038/nnano.2015.278. Epub 2015 Dec 21.


Native immunogold labeling of cell surface proteins and viral glycoproteins for cryo-electron microscopy and cryo-electron tomography applications.

Yi H, Strauss JD, Ke Z, Alonas E, Dillard RS, Hampton CM, Lamb KM, Hammonds JE, Santangelo PJ, Spearman PW, Wright ER.

J Histochem Cytochem. 2015 Oct;63(10):780-92. doi: 10.1369/0022155415593323. Epub 2015 Jun 11.


Evans blue nanocarriers visually demarcate margins of invasive gliomas.

Roller BT, Munson JM, Brahma B, Santangelo PJ, Pai SB, Bellamkonda RV.

Drug Deliv Transl Res. 2015 Apr;5(2):116-24. doi: 10.1007/s13346-013-0139-x.


Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy-treated macaques.

Santangelo PJ, Rogers KA, Zurla C, Blanchard EL, Gumber S, Strait K, Connor-Stroud F, Schuster DM, Amancha PK, Hong JJ, Byrareddy SN, Hoxie JA, Vidakovic B, Ansari AA, Hunter E, Villinger F.

Nat Methods. 2015 May;12(5):427-32. doi: 10.1038/nmeth.3320. Epub 2015 Mar 9.


Post-transcriptional regulation of programmed cell death 4 (PDCD4) mRNA by the RNA-binding proteins human antigen R (HuR) and T-cell intracellular antigen 1 (TIA1).

Wigington CP, Jung J, Rye EA, Belauret SL, Philpot AM, Feng Y, Santangelo PJ, Corbett AH.

J Biol Chem. 2015 Feb 6;290(6):3468-87. doi: 10.1074/jbc.M114.631937. Epub 2014 Dec 17.


Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection.

Byrareddy SN, Kallam B, Arthos J, Cicala C, Nawaz F, Hiatt J, Kersh EN, McNicholl JM, Hanson D, Reimann KA, Brameier M, Walter L, Rogers K, Mayne AE, Dunbar P, Villinger T, Little D, Parslow TG, Santangelo PJ, Villinger F, Fauci AS, Ansari AA.

Nat Med. 2014 Dec;20(12):1397-400. doi: 10.1038/nm.3715. Epub 2014 Nov 24.


Structural analysis of respiratory syncytial virus reveals the position of M2-1 between the matrix protein and the ribonucleoprotein complex.

Kiss G, Holl JM, Williams GM, Alonas E, Vanover D, Lifland AW, Gudheti M, Guerrero-Ferreira RC, Nair V, Yi H, Graham BS, Santangelo PJ, Wright ER.

J Virol. 2014 Jul;88(13):7602-17. doi: 10.1128/JVI.00256-14. Epub 2014 Apr 23.


Combining single RNA sensitive probes with subdiffraction-limited and live-cell imaging enables the characterization of virus dynamics in cells.

Alonas E, Lifland AW, Gudheti M, Vanover D, Jung J, Zurla C, Kirschman J, Fiore VF, Douglas A, Barker TH, Yi H, Wright ER, Crowe JE Jr, Santangelo PJ.

ACS Nano. 2014 Jan 28;8(1):302-15. doi: 10.1021/nn405998v. Epub 2013 Dec 23.


Analytical description of high-aperture STED resolution with 0-2π vortex phase modulation.

Xie H, Liu Y, Jin D, Santangelo PJ, Xi P.

J Opt Soc Am A Opt Image Sci Vis. 2013 Aug 1;30(8):1640-5. doi: 10.1364/JOSAA.30.001640.


Characterization of mRNA-cytoskeleton interactions in situ using FMTRIP and proximity ligation.

Jung J, Lifland AW, Alonas EJ, Zurla C, Santangelo PJ.

PLoS One. 2013 Sep 11;8(9):e74598. doi: 10.1371/journal.pone.0074598. eCollection 2013.


Quantifying RNA-protein interactions in situ using modified-MTRIPs and proximity ligation.

Jung J, Lifland AW, Zurla C, Alonas EJ, Santangelo PJ.

Nucleic Acids Res. 2013 Jan 7;41(1):e12. doi: 10.1093/nar/gks837. Epub 2012 Sep 4.


Achieving λ/10 resolution CW STED nanoscopy with a Ti:Sapphire oscillator.

Liu Y, Ding Y, Alonas E, Zhao W, Santangelo PJ, Jin D, Piper JA, Teng J, Ren Q, Xi P.

PLoS One. 2012;7(6):e40003. doi: 10.1371/journal.pone.0040003. Epub 2012 Jun 27.


Human respiratory syncytial virus nucleoprotein and inclusion bodies antagonize the innate immune response mediated by MDA5 and MAVS.

Lifland AW, Jung J, Alonas E, Zurla C, Crowe JE Jr, Santangelo PJ.

J Virol. 2012 Aug;86(15):8245-58. doi: 10.1128/JVI.00215-12. Epub 2012 May 23.


A critical phenylalanine residue in the respiratory syncytial virus fusion protein cytoplasmic tail mediates assembly of internal viral proteins into viral filaments and particles.

Shaikh FY, Cox RG, Lifland AW, Hotard AL, Williams JV, Moore ML, Santangelo PJ, Crowe JE Jr.

mBio. 2012 Feb 7;3(1). pii: e00270-11. doi: 10.1128/mBio.00270-11. Print 2012.


Probes for intracellular RNA imaging in live cells.

Santangelo PJ, Alonas E, Jung J, Lifland AW, Zurla C.

Methods Enzymol. 2012;505:383-99. doi: 10.1016/B978-0-12-388448-0.00028-0.


Characterizing mRNA interactions with RNA granules during translation initiation inhibition.

Zurla C, Lifland AW, Santangelo PJ.

PLoS One. 2011 May 5;6(5):e19727. doi: 10.1371/journal.pone.0019727.


Dynamics of native β-actin mRNA transport in the cytoplasm.

Lifland AW, Zurla C, Yu J, Santangelo PJ.

Traffic. 2011 Aug;12(8):1000-11. doi: 10.1111/j.1600-0854.2011.01209.x. Epub 2011 May 18.


Respiratory syncytial virus induces host RNA stress granules to facilitate viral replication.

Lindquist ME, Lifland AW, Utley TJ, Santangelo PJ, Crowe JE Jr.

J Virol. 2010 Dec;84(23):12274-84. doi: 10.1128/JVI.00260-10. Epub 2010 Sep 15.


Single molecule sensitive multivalent polyethylene glycol probes for RNA imaging.

Lifland AW, Zurla C, Santangelo PJ.

Bioconjug Chem. 2010 Mar 17;21(3):483-8. doi: 10.1021/bc9003876. Epub 2010 Feb 8.


Molecular beacons and related probes for intracellular RNA imaging.

Santangelo PJ.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 Jan-Feb;2(1):11-9. doi: 10.1002/wnan.52. Review.


Single molecule-sensitive probes for imaging RNA in live cells.

Santangelo PJ, Lifland AW, Curt P, Sasaki Y, Bassell GJ, Lindquist ME, Crowe JE Jr.

Nat Methods. 2009 May;6(5):347-9. doi: 10.1038/nmeth.1316. Epub 2009 Apr 6.


Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2.

Utley TJ, Ducharme NA, Varthakavi V, Shepherd BE, Santangelo PJ, Lindquist ME, Goldenring JR, Crowe JE Jr.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10209-14. doi: 10.1073/pnas.0712144105. Epub 2008 Jul 9.


Target accessibility and signal specificity in live-cell detection of BMP-4 mRNA using molecular beacons.

Rhee WJ, Santangelo PJ, Jo H, Bao G.

Nucleic Acids Res. 2008 Mar;36(5):e30. doi: 10.1093/nar/gkn039. Epub 2008 Feb 14.

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