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Items: 1 to 50 of 104

1.

Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia.

Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF.

J Clin Invest. 2019 Jun 4;130. pii: 124705. doi: 10.1172/JCI124705.

2.

A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia.

Prada MP, Syed AU, Buonarati OR, Reddy GR, Nystoriak MA, Ghosh D, Simó S, Sato D, Sasse KC, Ward SM, Santana LF, Xiang YK, Hell JW, Nieves-Cintrón M, Navedo MF.

Elife. 2019 Mar 1;8. pii: e42214. doi: 10.7554/eLife.42214.

3.

Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins.

Smith FD, Omar MH, Nygren PJ, Soughayer J, Hoshi N, Lau HT, Snyder CG, Branon TC, Ghosh D, Langeberg LK, Ting AY, Santana LF, Ong SE, Navedo MF, Scott JD.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11465-E11474. doi: 10.1073/pnas.1816614115. Epub 2018 Nov 19.

4.

BIN1 Induces the Formation of T-Tubules and Adult-Like Ca2+ Release Units in Developing Cardiomyocytes.

De La Mata A, Tajada S, O'Dwyer S, Matsumoto C, Dixon RE, Hariharan N, Moreno CM, Santana LF.

Stem Cells. 2019 Jan;37(1):54-64. doi: 10.1002/stem.2927. Epub 2018 Nov 22.

5.

Genomic and epidemiological monitoring of yellow fever virus transmission potential.

Faria NR, Kraemer MUG, Hill SC, Goes de Jesus J, Aguiar RS, Iani FCM, Xavier J, Quick J, du Plessis L, Dellicour S, Thézé J, Carvalho RDO, Baele G, Wu CH, Silveira PP, Arruda MB, Pereira MA, Pereira GC, Lourenço J, Obolski U, Abade L, Vasylyeva TI, Giovanetti M, Yi D, Weiss DJ, Wint GRW, Shearer FM, Funk S, Nikolay B, Fonseca V, Adelino TER, Oliveira MAA, Silva MVF, Sacchetto L, Figueiredo PO, Rezende IM, Mello EM, Said RFC, Santos DA, Ferraz ML, Brito MG, Santana LF, Menezes MT, Brindeiro RM, Tanuri A, Dos Santos FCP, Cunha MS, Nogueira JS, Rocco IM, da Costa AC, Komninakis SCV, Azevedo V, Chieppe AO, Araujo ESM, Mendonça MCL, Dos Santos CC, Dos Santos CD, Mares-Guia AM, Nogueira RMR, Sequeira PC, Abreu RG, Garcia MHO, Abreu AL, Okumoto O, Kroon EG, de Albuquerque CFC, Lewandowski K, Pullan ST, Carroll M, de Oliveira T, Sabino EC, Souza RP, Suchard MA, Lemey P, Trindade GS, Drumond BP, Filippis AMB, Loman NJ, Cauchemez S, Alcantara LCJ, Pybus OG.

Science. 2018 Aug 31;361(6405):894-899. doi: 10.1126/science.aat7115. Epub 2018 Aug 23.

PMID:
30139911
6.

Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating.

Ghosh D, Nieves-Cintrón M, Tajada S, Brust-Mascher I, Horne MC, Hell JW, Dixon RE, Santana LF, Navedo MF.

Biochim Biophys Acta Mol Cell Res. 2018 Sep;1865(9):1341-1355. doi: 10.1016/j.bbamcr.2018.06.013. Epub 2018 Jun 28.

7.

A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics.

Sato D, Dixon RE, Santana LF, Navedo MF.

PLoS Comput Biol. 2018 Jan 16;14(1):e1005906. doi: 10.1371/journal.pcbi.1005906. eCollection 2018 Jan.

8.

Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes.

Nieves-Cintrón M, Syed AU, Buonarati OR, Rigor RR, Nystoriak MA, Ghosh D, Sasse KC, Ward SM, Santana LF, Hell JW, Navedo MF.

Sci Rep. 2017 Oct 25;7(1):14058. doi: 10.1038/s41598-017-14565-9.

9.

A New Mutation in FIG4 Causes a Severe Form of CMT4J Involving TRPV4 in the Pathogenic Cascade.

Gentil BJ, O'Ferrall E, Chalk C, Santana LF, Durham HD, Massie R.

J Neuropathol Exp Neurol. 2017 Sep 1;76(9):789-799. doi: 10.1093/jnen/nlx062.

10.

Proximal clustering between BK and CaV1.3 channels promotes functional coupling and BK channel activation at low voltage.

Vivas O, Moreno CM, Santana LF, Hille B.

Elife. 2017 Jun 30;6. pii: e28029. doi: 10.7554/eLife.28029.

11.

Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes.

Tajada S, Moreno CM, O'Dwyer S, Woods S, Sato D, Navedo MF, Santana LF.

J Gen Physiol. 2017 Jun 5;149(6):639-659. doi: 10.1085/jgp.201611709. Epub 2017 May 15.

12.

Calcium Channels in Vascular Smooth Muscle.

Ghosh D, Syed AU, Prada MP, Nystoriak MA, Santana LF, Nieves-Cintrón M, Navedo MF.

Adv Pharmacol. 2017;78:49-87. doi: 10.1016/bs.apha.2016.08.002. Epub 2016 Oct 14. Review.

13.

Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve.

Li L, Li J, Drum BM, Chen Y, Yin H, Guo X, Luckey SW, Gilbert ML, McKnight GS, Scott JD, Santana LF, Liu Q.

Cardiovasc Res. 2017 Feb;113(2):147-159. doi: 10.1093/cvr/cvw221. Epub 2016 Nov 17.

14.

Ca(2+) entry into neurons is facilitated by cooperative gating of clustered CaV1.3 channels.

Moreno CM, Dixon RE, Tajada S, Yuan C, Opitz-Araya X, Binder MD, Santana LF.

Elife. 2016 May 17;5. pii: e15744. doi: 10.7554/eLife.15744.

15.

Oxidative stress decreases microtubule growth and stability in ventricular myocytes.

Drum BM, Yuan C, Li L, Liu Q, Wordeman L, Santana LF.

J Mol Cell Cardiol. 2016 Apr;93:32-43. doi: 10.1016/j.yjmcc.2016.02.012. Epub 2016 Feb 19.

16.

AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction.

Nieves-Cintrón M, Hirenallur-Shanthappa D, Nygren PJ, Hinke SA, Dell'Acqua ML, Langeberg LK, Navedo M, Santana LF, Scott JD.

Cell Signal. 2016 Jul;28(7):733-40. doi: 10.1016/j.cellsig.2015.12.015. Epub 2015 Dec 24.

17.

A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells.

Hehnly H, Canton D, Bucko P, Langeberg LK, Ogier L, Gelman I, Santana LF, Wordeman L, Scott JD.

Elife. 2015 Sep 25;4:e09384. doi: 10.7554/eLife.09384.

18.

Graded Ca²⁺/calmodulin-dependent coupling of voltage-gated CaV1.2 channels.

Dixon RE, Moreno CM, Yuan C, Opitz-Araya X, Binder MD, Navedo MF, Santana LF.

Elife. 2015 Feb 25;4. doi: 10.7554/eLife.05608.

19.

The long and winding road home: how junctin and triadin find their way to the junctional SR.

Drum BM, Santana LF.

J Mol Cell Cardiol. 2015 Apr;81:15-7. doi: 10.1016/j.yjmcc.2015.01.020. Epub 2015 Feb 2. No abstract available.

20.

AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension.

Sonkusare SK, Dalsgaard T, Bonev AD, Hill-Eubanks DC, Kotlikoff MI, Scott JD, Santana LF, Nelson MT.

Sci Signal. 2014 Jul 8;7(333):ra66. doi: 10.1126/scisignal.2005052.

21.

Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle.

Mercado J, Baylie R, Navedo MF, Yuan C, Scott JD, Nelson MT, Brayden JE, Santana LF.

J Gen Physiol. 2014 May;143(5):559-75. doi: 10.1085/jgp.201311050.

22.

Evaluation of clinical safety and anthelmintic efficacy of aurixazole administed orally at 24 mg/kg in cattle.

Sakamoto CA, Lopes WD, Buzzulini C, Cruz BC, Felippelli G, Teixeira WF, Silva HM, Santana LF, Soares VE, Henrique CH, de Oliveira GP, da Costa AJ.

Res Vet Sci. 2014 Jun;96(3):493-500. doi: 10.1016/j.rvsc.2014.03.007. Epub 2014 Mar 18.

PMID:
24656344
23.

Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure.

Zhang C, Chen B, Guo A, Zhu Y, Miller JD, Gao S, Yuan C, Kutschke W, Zimmerman K, Weiss RM, Wehrens XH, Hong J, Johnson FL, Santana LF, Anderson ME, Song LS.

Circulation. 2014 Apr 29;129(17):1742-50. doi: 10.1161/CIRCULATIONAHA.113.008452. Epub 2014 Feb 11.

24.

Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery.

Guan X, Mack DL, Moreno CM, Strande JL, Mathieu J, Shi Y, Markert CD, Wang Z, Liu G, Lawlor MW, Moorefield EC, Jones TN, Fugate JA, Furth ME, Murry CE, Ruohola-Baker H, Zhang Y, Santana LF, Childers MK.

Stem Cell Res. 2014 Mar;12(2):467-80. doi: 10.1016/j.scr.2013.12.004. Epub 2013 Dec 23.

25.

AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus.

Nystoriak MA, Nieves-Cintrón M, Nygren PJ, Hinke SA, Nichols CB, Chen CY, Puglisi JL, Izu LT, Bers DM, Dell'acqua ML, Scott JD, Santana LF, Navedo MF.

Circ Res. 2014 Feb 14;114(4):607-15. doi: 10.1161/CIRCRESAHA.114.302168. Epub 2013 Dec 9.

26.

Cellular mechanisms of ventricular arrhythmias in a mouse model of Timothy syndrome (long QT syndrome 8).

Drum BM, Dixon RE, Yuan C, Cheng EP, Santana LF.

J Mol Cell Cardiol. 2014 Jan;66:63-71. doi: 10.1016/j.yjmcc.2013.10.021. Epub 2013 Nov 9.

27.

Down-regulation of CaV1.2 channels during hypertension: how fewer CaV1.2 channels allow more Ca(2+) into hypertensive arterial smooth muscle.

Tajada S, Cidad P, Colinas O, Santana LF, López-López JR, Pérez-García MT.

J Physiol. 2013 Dec 15;591(24):6175-91. doi: 10.1113/jphysiol.2013.265751. Epub 2013 Oct 28.

28.

Anthelmintic efficacy of an oral formulation of Aurixazol against gastrointestinal nematodes of naturally and experimentally infected sheep.

Sakamoto CA, Lopes WD, Buzzulini C, Cruz BC, Felippelli G, de Lima RC, dos Santos TR, Santana LF, de Mendonça RP, Soares VE, Henrique CH, da Costa AJ.

Vet Parasitol. 2013 Dec 6;198(3-4):336-44. doi: 10.1016/j.vetpar.2013.09.008. Epub 2013 Sep 20.

PMID:
24138723
29.

Regulation of L-type calcium channel sparklet activity by c-Src and PKC-α.

Gulia J, Navedo MF, Gui P, Chao JT, Mercado JL, Santana LF, Davis MJ.

Am J Physiol Cell Physiol. 2013 Sep;305(5):C568-77. doi: 10.1152/ajpcell.00381.2011. Epub 2013 Jun 26.

30.

A Ca2+- and PKC-driven regulatory network in airway smooth muscle.

Dixon RE, Santana LF.

J Gen Physiol. 2013 Feb;141(2):161-4. doi: 10.1085/jgp.201210953. No abstract available.

31.

CaV1.2 sparklets in heart and vascular smooth muscle.

Navedo MF, Santana LF.

J Mol Cell Cardiol. 2013 May;58:67-76. doi: 10.1016/j.yjmcc.2012.11.018. Epub 2012 Dec 6. Review.

32.

L-type Ca2+ channel function during Timothy syndrome.

Dixon RE, Cheng EP, Mercado JL, Santana LF.

Trends Cardiovasc Med. 2012 Apr;22(3):72-6. doi: 10.1016/j.tcm.2012.06.015. Review.

33.

Adding accessories for hypertension: α2δ-1 subunits upregulate CaV1.2 channels in arterial myocytes in a model of genetic hypertension.

Santana LF, Mercado JL.

Hypertension. 2012 Oct;60(4):894-5. doi: 10.1161/HYPERTENSIONAHA.112.200964. Epub 2012 Sep 4. No abstract available.

34.

Anchored phosphatases modulate glucose homeostasis.

Hinke SA, Navedo MF, Ulman A, Whiting JL, Nygren PJ, Tian G, Jimenez-Caliani AJ, Langeberg LK, Cirulli V, Tengholm A, Dell'Acqua ML, Santana LF, Scott JD.

EMBO J. 2012 Oct 17;31(20):3991-4004. doi: 10.1038/emboj.2012.244. Epub 2012 Aug 31. Erratum in: EMBO J. 2012 Nov 28;31(23):4481.

35.

Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice.

Frock RL, Chen SC, Da DF, Frett E, Lau C, Brown C, Pak DN, Wang Y, Muchir A, Worman HJ, Santana LF, Ladiges WC, Rabinovitch PS, Kennedy BK.

PLoS One. 2012;7(8):e42918. doi: 10.1371/journal.pone.0042918. Epub 2012 Aug 15.

36.

Single-cell expression analysis of BMP15 and GDF9 in mature oocytes and BMPR2 in cumulus cells of women with polycystic ovary syndrome undergoing controlled ovarian hyperstimulation.

de Resende LO, Vireque AA, Santana LF, Moreno DA, de Sá Rosa e Silva AC, Ferriani RA, Scrideli CA, Reis RM.

J Assist Reprod Genet. 2012 Oct;29(10):1057-65. doi: 10.1007/s10815-012-9825-8. Epub 2012 Jul 24.

37.

Ca2+ signaling amplification by oligomerization of L-type Cav1.2 channels.

Dixon RE, Yuan C, Cheng EP, Navedo MF, Santana LF.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1749-54. doi: 10.1073/pnas.1116731109. Epub 2012 Jan 17.

38.

Single cell transcriptional profiling of adult mouse cardiomyocytes.

Flynn JM, Santana LF, Melov S.

J Vis Exp. 2011 Dec 28;(58):e3302. doi: 10.3791/3302.

39.

Dynamic changes in sarcoplasmic reticulum structure in ventricular myocytes.

Vega AL, Yuan C, Votaw VS, Santana LF.

J Biomed Biotechnol. 2011;2011:382586. doi: 10.1155/2011/382586. Epub 2011 Nov 1.

40.

An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria.

Means CK, Lygren B, Langeberg LK, Jain A, Dixon RE, Vega AL, Gold MG, Petrosyan S, Taylor SS, Murphy AN, Ha T, Santana LF, Tasken K, Scott JD.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):E1227-35. doi: 10.1073/pnas.1107182108. Epub 2011 Nov 14.

41.

Relationship between Ca2+ sparklets and sarcoplasmic reticulum Ca2+ load and release in rat cerebral arterial smooth muscle.

Takeda Y, Nystoriak MA, Nieves-Cintrón M, Santana LF, Navedo MF.

Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2285-94. doi: 10.1152/ajpheart.00488.2011. Epub 2011 Oct 7.

42.

Restoration of normal L-type Ca2+ channel function during Timothy syndrome by ablation of an anchoring protein.

Cheng EP, Yuan C, Navedo MF, Dixon RE, Nieves-Cintrón M, Scott JD, Santana LF.

Circ Res. 2011 Jul 22;109(3):255-61. doi: 10.1161/CIRCRESAHA.111.248252. Epub 2011 Jun 23.

43.

Mitochondrial targeted antioxidant Peptide ameliorates hypertensive cardiomyopathy.

Dai DF, Chen T, Szeto H, Nieves-Cintrón M, Kutyavin V, Santana LF, Rabinovitch PS.

J Am Coll Cardiol. 2011 Jun 28;58(1):73-82. doi: 10.1016/j.jacc.2010.12.044. Epub 2011 May 27.

44.

Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure.

Dai DF, Johnson SC, Villarin JJ, Chin MT, Nieves-Cintrón M, Chen T, Marcinek DJ, Dorn GW 2nd, Kang YJ, Prolla TA, Santana LF, Rabinovitch PS.

Circ Res. 2011 Apr 1;108(7):837-46. doi: 10.1161/CIRCRESAHA.110.232306. Epub 2011 Feb 10.

45.

[Concentration of steroid hormones in the follicular fluid of mature and immature ovarian follicles of patients with polycystic ovary syndrome submitted to in vitro fertilization].

de Resende LO, dos Reis RM, Ferriani RA, Vireque AA, Santana LF, de Sá Rosa e Silva AC, Martins Wde P.

Rev Bras Ginecol Obstet. 2010 Sep;32(9):447-53. Portuguese.

PMID:
21271150
46.

Eosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X.

Lai Y, Oslund RC, Bollinger JG, Henderson WR Jr, Santana LF, Altemeier WA, Gelb MH, Hallstrand TS.

J Biol Chem. 2010 Dec 31;285(53):41491-500. doi: 10.1074/jbc.M110.153338. Epub 2010 Oct 25.

47.

Detection of Toxoplasma gondii in the reproductive system of male goats.

Santana LF, da Costa AJ, Pieroni J, Lopes WD, Santos RS, de Oliveira GP, de Mendonça RP, Sakamoto CA.

Rev Bras Parasitol Vet. 2010 Jul-Sep;19(3):179-82.

48.

How does the shape of the cardiac action potential control calcium signaling and contraction in the heart?

Santana LF, Cheng EP, Lederer WJ.

J Mol Cell Cardiol. 2010 Dec;49(6):901-3. doi: 10.1016/j.yjmcc.2010.09.005. Epub 2010 Sep 17. No abstract available.

49.

Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels.

Nichols CB, Rossow CF, Navedo MF, Westenbroek RE, Catterall WA, Santana LF, McKnight GS.

Circ Res. 2010 Sep 17;107(6):747-56. doi: 10.1161/CIRCRESAHA.109.216127. Epub 2010 Jul 29.

50.

Natural inequalities: why some L-type Ca2+ channels work harder than others.

Santana LF, Navedo MF.

J Gen Physiol. 2010 Aug;136(2):143-7. doi: 10.1085/jgp.200910391. No abstract available.

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