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Items: 48

1.

Molecular determinants of acquired resistance to BRAF inhibition in human lung cancer.

Lucchesi C, Drogat B, Santamaria D, Cousin S, Italiano A.

Lung Cancer. 2018 Dec;126:227-229. doi: 10.1016/j.lungcan.2018.10.013. Epub 2018 Oct 12. No abstract available.

PMID:
30342857
2.

A putative role for Discoidin Domain Receptor 1 in cancer chemoresistance.

Ambrogio C, Darbo E, Lee SW, Santamaría D.

Cell Adh Migr. 2018;12(4):394-397. doi: 10.1080/19336918.2018.1445954. Epub 2018 Apr 3. Review.

3.

KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS.

Ambrogio C, Köhler J, Zhou ZW, Wang H, Paranal R, Li J, Capelletti M, Caffarra C, Li S, Lv Q, Gondi S, Hunter JC, Lu J, Chiarle R, Santamaría D, Westover KD, Jänne PA.

Cell. 2018 Feb 8;172(4):857-868.e15. doi: 10.1016/j.cell.2017.12.020. Epub 2018 Jan 11.

4.

A Braf kinase-inactive mutant induces lung adenocarcinoma.

Nieto P, Ambrogio C, Esteban-Burgos L, Gómez-López G, Blasco MT, Yao Z, Marais R, Rosen N, Chiarle R, Pisano DG, Barbacid M, Santamaría D.

Nature. 2017 Aug 10;548(7666):239-243. doi: 10.1038/nature23297. Epub 2017 Aug 2.

5.

KRAS-driven lung adenocarcinoma: combined DDR1/Notch inhibition as an effective therapy.

Ambrogio C, Nadal E, Villanueva A, Gómez-López G, Cash TP, Barbacid M, Santamaría D.

ESMO Open. 2016 Sep 6;1(5):e000076. eCollection 2016. Review.

6.

In vivo oncogenic conflict triggered by co-existing KRAS and EGFR activating mutations in lung adenocarcinoma.

Ambrogio C, Barbacid M, Santamaría D.

Oncogene. 2017 Apr 20;36(16):2309-2318. doi: 10.1038/onc.2016.385. Epub 2016 Oct 24.

PMID:
27775074
7.

An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia.

Lopez S, Voisset E, Tisserand JC, Mosca C, Prebet T, Santamaria D, Dubreuil P, De Sepulveda P.

Oncotarget. 2016 Aug 9;7(32):51163-51173. doi: 10.18632/oncotarget.9965.

8.

Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma.

Ambrogio C, Gómez-López G, Falcone M, Vidal A, Nadal E, Crosetto N, Blasco RB, Fernández-Marcos PJ, Sánchez-Céspedes M, Ren X, Wang Z, Ding K, Hidalgo M, Serrano M, Villanueva A, Santamaría D, Barbacid M.

Nat Med. 2016 Mar;22(3):270-7. doi: 10.1038/nm.4041. Epub 2016 Feb 8.

PMID:
26855149
9.

Functional reprogramming of polyploidization in megakaryocytes.

Trakala M, Rodríguez-Acebes S, Maroto M, Symonds CE, Santamaría D, Ortega S, Barbacid M, Méndez J, Malumbres M.

Dev Cell. 2015 Jan 26;32(2):155-67. doi: 10.1016/j.devcel.2014.12.015.

10.

CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase.

Viera A, Alsheimer M, Gómez R, Berenguer I, Ortega S, Symonds CE, Santamaría D, Benavente R, Suja JA.

J Cell Sci. 2015 Jan 1;128(1):88-99. doi: 10.1242/jcs.154922. Epub 2014 Nov 6.

11.

Lentiviral-based approach for the validation of cancer therapeutic targets in vivo.

Ambrogio C, Stern P, Scuoppo C, Kranz H, Barbacid M, Santamaría D.

Biotechniques. 2014 Oct 1;57(4):179, 181-7. doi: 10.2144/000114214. eCollection 2014 Oct.

12.

Modeling lung cancer evolution and preclinical response by orthotopic mouse allografts.

Ambrogio C, Carmona FJ, Vidal A, Falcone M, Nieto P, Romero OA, Puertas S, Vizoso M, Nadal E, Poggio T, Sánchez-Céspedes M, Esteller M, Mulero F, Voena C, Chiarle R, Barbacid M, Santamaría D, Villanueva A.

Cancer Res. 2014 Nov 1;74(21):5978-88. doi: 10.1158/0008-5472.CAN-14-1606. Epub 2014 Sep 12.

13.

The timing and spatiotemporal patterning of Neanderthal disappearance.

Higham T, Douka K, Wood R, Ramsey CB, Brock F, Basell L, Camps M, Arrizabalaga A, Baena J, Barroso-Ruíz C, Bergman C, Boitard C, Boscato P, Caparrós M, Conard NJ, Draily C, Froment A, Galván B, Gambassini P, Garcia-Moreno A, Grimaldi S, Haesaerts P, Holt B, Iriarte-Chiapusso MJ, Jelinek A, Jordá Pardo JF, Maíllo-Fernández JM, Marom A, Maroto J, Menéndez M, Metz L, Morin E, Moroni A, Negrino F, Panagopoulou E, Peresani M, Pirson S, de la Rasilla M, Riel-Salvatore J, Ronchitelli A, Santamaria D, Semal P, Slimak L, Soler J, Soler N, Villaluenga A, Pinhasi R, Jacobi R.

Nature. 2014 Aug 21;512(7514):306-9. doi: 10.1038/nature13621.

PMID:
25143113
14.

The chronology of the earliest Upper Palaeolithic in northern Iberia: New insights from L'Arbreda, Labeko Koba and La Viña.

Wood RE, Arrizabalaga A, Camps M, Fallon S, Iriarte-Chiapusso MJ, Jones R, Maroto J, de la Rasilla M, Santamaría D, Soler J, Soler N, Villaluenga A, Higham TF.

J Hum Evol. 2014 Apr;69:91-109. doi: 10.1016/j.jhevol.2013.12.017. Epub 2014 Mar 15.

PMID:
24636733
15.

Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors.

Cerqueira A, Martín A, Symonds CE, Odajima J, Dubus P, Barbacid M, Santamaría D.

Mol Cell Biol. 2014 Apr;34(8):1452-9. doi: 10.1128/MCB.01163-13. Epub 2014 Feb 10.

16.

Pearls and oy-sters: neurosyphilis presenting as mesial temporal encephalitis.

Abdelerahman KT, Santamaria DD, Rakocevic G.

Neurology. 2012 Dec 11;79(24):e206-8. doi: 10.1212/WNL.0b013e318278b5a1. No abstract available.

PMID:
23233688
17.

Posterior Reversible Encephalopathy Syndrome Presenting as Opsoclonus-Myoclonus.

Boland T, Strause J, Hu M, Santamaria D, Liang TW, Kremens D, Sergott R, Moussouttas M.

Neuroophthalmology. 2012 Oct;36(4):149-152. Epub 2012 Jul 2.

18.

Cdk7: open questions beyond the prevailing model.

Ganuza M, Santamaría D.

Cell Cycle. 2012 Oct 1;11(19):3519-20. doi: 10.4161/cc.21888. Epub 2012 Aug 30. No abstract available.

19.

Neanderthal medics? Evidence for food, cooking, and medicinal plants entrapped in dental calculus.

Hardy K, Buckley S, Collins MJ, Estalrrich A, Brothwell D, Copeland L, García-Tabernero A, García-Vargas S, de la Rasilla M, Lalueza-Fox C, Huguet R, Bastir M, Santamaría D, Madella M, Wilson J, Cortés AF, Rosas A.

Naturwissenschaften. 2012 Aug;99(8):617-26. doi: 10.1007/s00114-012-0942-0. Epub 2012 Jul 18.

PMID:
22806252
20.

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.

Ganuza M, Sáiz-Ladera C, Cañamero M, Gómez G, Schneider R, Blasco MA, Pisano D, Paramio JM, Santamaría D, Barbacid M.

EMBO J. 2012 May 30;31(11):2498-510. doi: 10.1038/emboj.2012.94. Epub 2012 Apr 13.

21.

Tumor suppression by Spinophilin.

Santamaría D, Malumbres M.

Cell Cycle. 2011 Sep 1;10(17):2831-2. Epub 2011 Sep 1. No abstract available.

PMID:
21869595
22.

Toll-like receptor-4 (TLR4) down-regulates microRNA-107, increasing macrophage adhesion via cyclin-dependent kinase 6.

Hennessy EJ, Sheedy FJ, Santamaria D, Barbacid M, O'Neill LA.

J Biol Chem. 2011 Jul 22;286(29):25531-9. doi: 10.1074/jbc.M111.256206. Epub 2011 May 31.

23.

c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma.

Blasco RB, Francoz S, Santamaría D, Cañamero M, Dubus P, Charron J, Baccarini M, Barbacid M.

Cancer Cell. 2011 May 17;19(5):652-63. doi: 10.1016/j.ccr.2011.04.002. Epub 2011 Apr 21.

24.

Cdk6-dependent regulation of G(1) length controls adult neurogenesis.

Beukelaers P, Vandenbosch R, Caron N, Nguyen L, Belachew S, Moonen G, Kiyokawa H, Barbacid M, Santamaria D, Malgrange B.

Stem Cells. 2011 Apr;29(4):713-24. doi: 10.1002/stem.616.

25.

Genetic evidence for patrilocal mating behavior among Neandertal groups.

Lalueza-Fox C, Rosas A, Estalrrich A, Gigli E, Campos PF, García-Tabernero A, García-Vargas S, Sánchez-Quinto F, Ramírez O, Civit S, Bastir M, Huguet R, Santamaría D, Gilbert MT, Willerslev E, de la Rasilla M.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):250-3. doi: 10.1073/pnas.1011553108. Epub 2010 Dec 20.

26.

Brief communication: Subvertical grooves on interproximal wear facets from the El Sidrón (Asturias, Spain) Neandertal dental sample.

Estalrrich A, Rosas A, García-Vargas S, García-Tabernero A, Santamaría D, de la Rasilla M.

Am J Phys Anthropol. 2011 Jan;144(1):154-61. doi: 10.1002/ajpa.21359.

PMID:
20623604
27.

A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.

Puyol M, Martín A, Dubus P, Mulero F, Pizcueta P, Khan G, Guerra C, Santamaría D, Barbacid M.

Cancer Cell. 2010 Jul 13;18(1):63-73. doi: 10.1016/j.ccr.2010.05.025.

28.

Overall Cdk activity modulates the DNA damage response in mammalian cells.

Cerqueira A, Santamaría D, Martínez-Pastor B, Cuadrado M, Fernández-Capetillo O, Barbacid M.

J Cell Biol. 2009 Dec 14;187(6):773-80. doi: 10.1083/jcb.200903033.

29.

Cdk1 is sufficient to drive the mammalian cell cycle.

Santamaría D, Barrière C, Cerqueira A, Hunt S, Tardy C, Newton K, Cáceres JF, Dubus P, Malumbres M, Barbacid M.

Nature. 2007 Aug 16;448(7155):811-5.

PMID:
17700700
30.

Mice thrive without Cdk4 and Cdk2.

Barrière C, Santamaría D, Cerqueira A, Galán J, Martín A, Ortega S, Malumbres M, Dubus P, Barbacid M.

Mol Oncol. 2007 Jun;1(1):72-83. doi: 10.1016/j.molonc.2007.03.001. Epub 2007 Mar 14.

31.

Paleobiology and comparative morphology of a late Neandertal sample from El Sidron, Asturias, Spain.

Rosas A, Martínez-Maza C, Bastir M, García-Tabernero A, Lalueza-Fox C, Huguet R, Ortiz JE, Julià R, Soler V, de Torres T, Martínez E, Cañaveras JC, Sánchez-Moral S, Cuezva S, Lario J, Santamaría D, de la Rasilla M, Fortea J.

Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19266-71. Epub 2006 Dec 12.

32.

Structure, metastability, and electron density of Al lattices in light of the model of anions in metallic matrices.

Marqués M, Flórez M, Recio JM, Santamaría D, Vegas A, García Baonza V.

J Phys Chem B. 2006 Sep 21;110(37):18609-18.

PMID:
16970490
33.

Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases.

Barbacid M, Ortega S, Sotillo R, Odajima J, Martín A, Santamaría D, Dubus P, Malumbres M.

Cold Spring Harb Symp Quant Biol. 2005;70:233-40.

PMID:
16869759
34.

Assessment of oxidative damage induced by acute doses of morphine sulfate in postnatal and adult rat brain.

Guzmán DC, Vázquez IE, Brizuela NO, Alvarez RG, Mejía GB, García EH, Santamaría D, de Apreza Ml, Olguín HJ.

Neurochem Res. 2006 Apr;31(4):549-54. Epub 2006 May 9.

PMID:
16758364
35.

Cyclins and CDKS in development and cancer: lessons from genetically modified mice.

Santamaria D, Ortega S.

Front Biosci. 2006 Jan 1;11:1164-88. Review.

PMID:
16146805
36.

Carbon dioxide activation assisted by a bis(chlorodimethylsilyl)cyclopentadienyl titanium compound.

Santamaría D, Cano J, Royo P, Mosquera ME, Cuenca T, Frutos LM, Castaño O.

Angew Chem Int Ed Engl. 2005 Sep 12;44(36):5828-30. No abstract available.

PMID:
16080227
37.

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6.

Malumbres M, Sotillo R, Santamaría D, Galán J, Cerezo A, Ortega S, Dubus P, Barbacid M.

Cell. 2004 Aug 20;118(4):493-504.

38.

Epidemiological, clinical, and prognostic differences between the diseases caused by Mycobacterium kansasii and Mycobacterium tuberculosis in patients infected with human immunodeficiency virus: a multicenter study.

Canueto-Quintero J, Caballero-Granado FJ, Herrero-Romero M, Domínguez-Castellano A, Martín-Rico P, Verdú EV, Santamaría DS, Cerquera RC, Torres-Tortosa M; Grupo Andaluz para el Estudio de las Esfermedades Infecciosas.

Clin Infect Dis. 2003 Aug 15;37(4):584-90. Epub 2003 Aug 1.

PMID:
12905144
39.

Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1.

Clay-Farrace L, Pelizon C, Santamaria D, Pines J, Laskey RA.

EMBO J. 2003 Feb 3;22(3):704-12.

40.

Premature termination of DNA replication in plasmids carrying two inversely oriented ColE1 origins.

Santamaría D, Hernández P, Martínez-Robles ML, Krimer DB, Schvartzman JB.

J Mol Biol. 2000 Jun 30;300(1):75-82.

PMID:
10864499
41.

Bi-directional replication and random termination.

Santamaría D, Viguera E, Martínez-Robles ML, Hyrien O, Hernández P, Krimer DB, Schvartzman JB.

Nucleic Acids Res. 2000 May 15;28(10):2099-107.

42.

Effect of quinolinic acid on endogenous antioxidants in rat corpus striatum.

Rodríguez-Martínez E, Camacho A, Maldonado PD, Pedraza-Chaverrí J, Santamaría D, Galván-Arzate S, Santamaría A.

Brain Res. 2000 Mar 10;858(2):436-9.

PMID:
10708698
43.
44.

DnaB helicase is unable to dissociate RNA-DNA hybrids. Its implication in the polar pausing of replication forks at ColE1 origins.

Santamaría D, de la Cueva G, Martínez-Robles ML, Krimer DB, Hernández P, Schvartzman JB.

J Biol Chem. 1998 Dec 11;273(50):33386-96.

45.

Effects of N omega-nitro-L-arginine and L-arginine on quinolinic acid-induced lipid peroxidation.

Santamaría A, Santamaría D, Díaz-Muñoz M, Espinoza-González V, Ríos C.

Toxicol Lett. 1997 Dec;93(2-3):117-24.

PMID:
9486947
46.

Cloning, sequencing and expression in MEL cells of a cDNA encoding the mouse ribosomal protein S5.

Vanegas N, Castañeda V, Santamaría D, Hernández P, Schvartzman JB, Krimer DB.

Biochim Biophys Acta. 1997 Jun 5;1357(1):1-4.

47.

Heavy duties? On-the-job back injuries are a bigger--and costlier--pain than you think.

Fragala G, Santamaria D.

Health Facil Manage. 1997 May;10(5):22-4, 26-7. No abstract available.

PMID:
10172987
48.

4-Aminopyridine antagonizes lethality induced by saxitoxin in mice.

Santamaria D, Rios C, Kravzov J, Altagracia M.

Proc West Pharmacol Soc. 1993;36:193-5. No abstract available.

PMID:
8378378

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