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Items: 1 to 50 of 104

1.

A Novel Vaccine Strategy to Overcome Poor Immunogenicity of Avian Influenza Vaccines through Mobilization of Memory CD4 T Cells Established by Seasonal Influenza.

DiPiazza AT, Fan S, Rattan A, DeDiego ML, Chaves F, Neumann G, Kawaoka Y, Sant AJ.

J Immunol. 2019 Aug 9. pii: ji1900819. doi: 10.4049/jimmunol.1900819. [Epub ahead of print]

PMID:
31399519
2.

Protein vaccination directs the CD4+ T cell response towards shared protective epitopes that can be recalled after influenza infection.

Rattan A, Richards KA, Knowlden ZAG, Sant AJ.

J Virol. 2019 Jul 24. pii: JVI.00947-19. doi: 10.1128/JVI.00947-19. [Epub ahead of print]

PMID:
31341045
3.

Imprinting and Editing of the Human CD4 T Cell Response to Influenza Virus.

Nelson SA, Sant AJ.

Front Immunol. 2019 May 7;10:932. doi: 10.3389/fimmu.2019.00932. eCollection 2019.

4.

Editorial: Orchestration of an Immune Response to Respiratory Pathogens.

Varga SM, Sant AJ.

Front Immunol. 2019 Apr 9;10:690. doi: 10.3389/fimmu.2019.00690. eCollection 2019. No abstract available.

5.

The Way Forward: Potentiating Protective Immunity to Novel and Pandemic Influenza Through Engagement of Memory CD4 T Cells.

Sant AJ.

J Infect Dis. 2019 Apr 8;219(Supplement_1):S30-S37. doi: 10.1093/infdis/jiy666.

PMID:
30715376
6.

Analyses of Cellular Immune Responses in Ferrets Following Influenza Virus Infection.

DiPiazza AT, Richards KA, Liu WC, Albrecht RA, Sant AJ.

Methods Mol Biol. 2018;1836:513-530. doi: 10.1007/978-1-4939-8678-1_24.

PMID:
30151589
7.

Moving Forward: Recent Developments for the Ferret Biomedical Research Model.

Albrecht RA, Liu WC, Sant AJ, Tompkins SM, Pekosz A, Meliopoulos V, Cherry S, Thomas PG, Schultz-Cherry S.

MBio. 2018 Jul 17;9(4). pii: e01113-18. doi: 10.1128/mBio.01113-18. Review.

8.

CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential.

Sant AJ, DiPiazza AT, Nayak JL, Rattan A, Richards KA.

Immunol Rev. 2018 Jul;284(1):91-105. doi: 10.1111/imr.12662. Review.

9.

Overarching Immunodominance Patterns and Substantial Diversity in Specificity and Functionality in the Circulating Human Influenza A and B Virus-Specific CD4+ T-Cell Repertoire.

Richards KA, Treanor JJ, Nayak JL, Sant AJ.

J Infect Dis. 2018 Aug 24;218(7):1169-1174. doi: 10.1093/infdis/jiy288.

PMID:
29762692
10.

Diverse Epitope Specificity, Immunodominance Hierarchy, and Functional Avidity of Effector CD4 T Cells Established During Priming Is Maintained in Lung After Influenza A Virus Infection.

Richards KA, DiPiazza AT, Rattan A, Knowlden ZAG, Yang H, Sant AJ.

Front Immunol. 2018 Apr 6;9:655. doi: 10.3389/fimmu.2018.00655. eCollection 2018.

11.

CD4 T Cell Epitope Specificity and Cytokine Potential Are Preserved as Cells Transition from the Lung Vasculature to Lung Tissue following Influenza Virus Infection.

DiPiazza A, Laniewski N, Rattan A, Topham DJ, Miller J, Sant AJ.

J Virol. 2018 Jun 13;92(13). pii: e00377-18. doi: 10.1128/JVI.00377-18. Print 2018 Jul 1.

12.

Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus.

Sant AJ, Richards KA, Nayak J.

Curr Opin Immunol. 2018 Aug;53:13-21. doi: 10.1016/j.coi.2018.03.019. Epub 2018 Apr 2. Review.

13.

Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains.

Zost SJ, Parkhouse K, Gumina ME, Kim K, Diaz Perez S, Wilson PC, Treanor JJ, Sant AJ, Cobey S, Hensley SE.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12578-12583. doi: 10.1073/pnas.1712377114. Epub 2017 Nov 6.

14.

Pandemic 2009 H1N1 Influenza Venus reporter virus reveals broad diversity of MHC class II-positive antigen-bearing cells following infection in vivo.

DiPiazza A, Nogales A, Poulton N, Wilson PC, Martínez-Sobrido L, Sant AJ.

Sci Rep. 2017 Sep 7;7(1):10857. doi: 10.1038/s41598-017-11313-x.

15.

Implementation of a Personalized, Cost-Effective Physical Therapy Approach (Coach2Move) for Older Adults: Barriers and Facilitators.

van de Sant AJW, de Vries NM, Hoogeboom TJ, Nijhuis-van der Sanden MWG.

J Geriatr Phys Ther. 2019 Jul/Sep;42(3):E1-E16. doi: 10.1519/JPT.0000000000000140.

PMID:
28753136
16.

Selective pre-priming of HA-specific CD4 T cells restores immunological reactivity to HA on heterosubtypic influenza infection.

Alam S, Chan C, Qiu X, Shannon I, White CL, Sant AJ, Nayak JL.

PLoS One. 2017 May 11;12(5):e0176407. doi: 10.1371/journal.pone.0176407. eCollection 2017.

17.

Waning Immunity and Microbial Vaccines-Workshop of the National Institute of Allergy and Infectious Diseases.

Gu XX, Plotkin SA, Edwards KM, Sette A, Mills KHG, Levy O, Sant AJ, Mo A, Alexander W, Lu KT, Taylor CE.

Clin Vaccine Immunol. 2017 Jul 5;24(7). pii: e00034-17. doi: 10.1128/CVI.00034-17. Print 2017 Jul.

18.

Avian and Human Seasonal Influenza Hemagglutinin Proteins Elicit CD4 T Cell Responses That Are Comparable in Epitope Abundance and Diversity.

DiPiazza A, Richards K, Poulton N, Sant AJ.

Clin Vaccine Immunol. 2017 Mar 6;24(3). pii: e00548-16. doi: 10.1128/CVI.00548-16. Print 2017 Mar.

19.

Nanoparticles decorated with viral antigens are more immunogenic at low surface density.

Brewer MG, DiPiazza A, Acklin J, Feng C, Sant AJ, Dewhurst S.

Vaccine. 2017 Feb 1;35(5):774-781. doi: 10.1016/j.vaccine.2016.12.049. Epub 2017 Jan 3.

20.

Immunization with Pneumocystis Cross-Reactive Antigen 1 (Pca1) Protects Mice against Pneumocystis Pneumonia and Generates Antibody to Pneumocystis jirovecii.

Tesini BL, Wright TW, Malone JE, Haidaris CG, Harber M, Sant AJ, Nayak JL, Gigliotti F.

Infect Immun. 2017 Mar 23;85(4). pii: e00850-16. doi: 10.1128/IAI.00850-16. Print 2017 Apr.

21.

Flow Cytometric and Cytokine ELISpot Approaches To Characterize the Cell-Mediated Immune Response in Ferrets following Influenza Virus Infection.

DiPiazza A, Richards K, Batarse F, Lockard L, Zeng H, García-Sastre A, Albrecht RA, Sant AJ.

J Virol. 2016 Aug 12;90(17):7991-8004. doi: 10.1128/JVI.01001-16. Print 2016 Sep 1.

23.

The Role of CD4 T Cell Memory in Generating Protective Immunity to Novel and Potentially Pandemic Strains of Influenza.

DiPiazza A, Richards KA, Knowlden ZA, Nayak JL, Sant AJ.

Front Immunol. 2016 Jan 25;7:10. doi: 10.3389/fimmu.2016.00010. eCollection 2016. Review.

24.

Abundance and specificity of influenza reactive circulating memory follicular helper and non-follicular helper CD4 T cells in healthy adults.

Leddon SA, Richards KA, Treanor JJ, Sant AJ.

Immunology. 2015 Sep;146(1):157-62. doi: 10.1111/imm.12491. Epub 2015 Jul 14.

25.

Seasonal Influenza Can Poise Hosts for CD4 T-Cell Immunity to H7N9 Avian Influenza.

Richards KA, Nayak J, Chaves FA, DiPiazza A, Knowlden ZA, Alam S, Treanor JJ, Sant AJ.

J Infect Dis. 2015 Jul 1;212(1):86-94. doi: 10.1093/infdis/jiu662. Epub 2014 Dec 9.

26.

Effect of influenza A(H5N1) vaccine prepandemic priming on CD4+ T-cell responses.

Nayak JL, Richards KA, Yang H, Treanor JJ, Sant AJ.

J Infect Dis. 2015 May 1;211(9):1408-17. doi: 10.1093/infdis/jiu616. Epub 2014 Nov 6.

27.

The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilings.

Sant AJ, Chaves FA, Leddon SA, Tung J.

Front Immunol. 2013 Oct 23;4:340. doi: 10.3389/fimmu.2013.00340. Review.

28.

CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection.

Alam S, Knowlden ZA, Sangster MY, Sant AJ.

J Virol. 2014 Jan;88(1):314-24. doi: 10.1128/JVI.02077-13. Epub 2013 Oct 23.

29.

The use of nanolipoprotein particles to enhance the immunostimulatory properties of innate immune agonists against lethal influenza challenge.

Weilhammer DR, Blanchette CD, Fischer NO, Alam S, Loots GG, Corzett M, Thomas C, Lychak C, Dunkle AD, Ruitenberg JJ, Ghanekar SA, Sant AJ, Rasley A.

Biomaterials. 2013 Dec;34(38):10305-18. doi: 10.1016/j.biomaterials.2013.09.038. Epub 2013 Sep 27.

PMID:
24075406
30.

Cutting edge: Heterosubtypic influenza infection antagonizes elicitation of immunological reactivity to hemagglutinin.

Nayak JL, Alam S, Sant AJ.

J Immunol. 2013 Aug 1;191(3):1001-5. doi: 10.4049/jimmunol.1203520. Epub 2013 Jun 21.

31.

Orchestration of CD4 T cell epitope preferences after multipeptide immunization.

Tung J, Sant AJ.

J Immunol. 2013 Jul 15;191(2):764-72. doi: 10.4049/jimmunol.1300312. Epub 2013 Jun 14.

32.

CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccine.

Nayak JL, Fitzgerald TF, Richards KA, Yang H, Treanor JJ, Sant AJ.

J Infect Dis. 2013 Jan 15;207(2):297-305. doi: 10.1093/infdis/jis684. Epub 2012 Nov 12.

33.

Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins.

Richards KA, Chaves FA, Alam S, Sant AJ.

Vaccine. 2012 Dec 17;31(1):219-25. doi: 10.1016/j.vaccine.2012.10.039. Epub 2012 Oct 22.

34.

The peptide specificity of the endogenous T follicular helper cell repertoire generated after protein immunization.

Leddon SA, Sant AJ.

PLoS One. 2012;7(10):e46952. doi: 10.1371/journal.pone.0046952. Epub 2012 Oct 15.

35.

Revealing the role of CD4(+) T cells in viral immunity.

Sant AJ, McMichael A.

J Exp Med. 2012 Jul 30;209(8):1391-5. doi: 10.1084/jem.20121517. Review.

36.
37.

The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infection.

Chaves FA, Lee AH, Nayak JL, Richards KA, Sant AJ.

J Immunol. 2012 May 1;188(9):4235-48. doi: 10.4049/jimmunol.1103640. Epub 2012 Mar 30.

38.

Host differences in influenza-specific CD4 T cell and B cell responses are modulated by viral strain and route of immunization.

Sundararajan A, Huan L, Richards KA, Marcelin G, Alam S, Joo H, Yang H, Webby RJ, Topham DJ, Sant AJ, Sangster MY.

PLoS One. 2012;7(3):e34377. doi: 10.1371/journal.pone.0034377. Epub 2012 Mar 23.

39.

Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity.

Engels B, Chervin AS, Sant AJ, Kranz DM, Schreiber H.

Mol Ther. 2012 Mar;20(3):652-60. doi: 10.1038/mt.2011.286. Epub 2012 Jan 10.

41.

The memory phase of the CD4 T-cell response to influenza virus infection maintains its diverse antigen specificity.

Richards KA, Chaves FA, Sant AJ.

Immunology. 2011 Jun;133(2):246-56. doi: 10.1111/j.1365-2567.2011.03435.x. Epub 2011 Mar 29.

42.

T cell immunology for the clinician.

Nayak JL, Sant AJ.

Pediatr Infect Dis J. 2011 Mar;30(3):248-50. doi: 10.1097/INF.0b013e3182074658. Review. No abstract available.

PMID:
21317604
44.

Generation of MHC class II-peptide ligands for CD4 T-cell allorecognition of MHC class II molecules.

Leddon SA, Sant AJ.

Curr Opin Organ Transplant. 2010 Aug;15(4):505-11. doi: 10.1097/MOT.0b013e32833bfc5c. Review.

45.
46.

Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells.

Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB.

Virology. 2010 May 10;400(2):224-32. doi: 10.1016/j.virol.2010.02.001. Epub 2010 Feb 25.

47.

Abortive activation of CD4 T cell responses during competitive priming in vivo.

Weaver JM, Chaves FA, Sant AJ.

Proc Natl Acad Sci U S A. 2009 May 26;106(21):8647-52. doi: 10.1073/pnas.0811584106. Epub 2009 May 7.

49.

Understanding the focused CD4 T cell response to antigen and pathogenic organisms.

Weaver JM, Sant AJ.

Immunol Res. 2009 Dec;45(2-3):123-43. doi: 10.1007/s12026-009-8095-8. Epub 2009 Feb 7. Review.

PMID:
19198764
50.

Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design.

Weaver JM, Lazarski CA, Richards KA, Chaves FA, Jenks SA, Menges PR, Sant AJ.

J Immunol. 2008 Sep 1;181(5):3039-48.

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