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Distinct PLZF+CD8αα+ Unconventional T Cells Enriched in Liver Use a Cytotoxic Mechanism to Limit Autoimmunity.

Sheng H, Marrero I, Maricic I, Fanchiang SS, Zhang S, Sant'Angelo DB, Kumar V.

J Immunol. 2019 Oct 15;203(8):2150-2162. doi: 10.4049/jimmunol.1900832. Epub 2019 Sep 25.


The Transcription Factor PLZF Is Necessary for the Development and Function of Mouse Basophils.

Zhang S, Vieth JA, Krzyzanowska A, Henry EK, Denzin LK, Siracusa MC, Sant'Angelo DB.

J Immunol. 2019 Sep 1;203(5):1230-1241. doi: 10.4049/jimmunol.1900068. Epub 2019 Jul 31.


Coexpression of YY1 Is Required to Elaborate the Effector Functions Controlled by PLZF in NKT Cells.

Darcy PW, Jin K, Osorio L, Denzin LK, Sant'Angelo DB.

J Immunol. 2019 Aug 1;203(3):627-638. doi: 10.4049/jimmunol.1900055. Epub 2019 Jun 21.


Histone deacetylase 3 is required for iNKT cell development.

Thapa P, Romero Arocha S, Chung JY, Sant'Angelo DB, Shapiro VS.

Sci Rep. 2017 Jul 19;7(1):5784. doi: 10.1038/s41598-017-06102-5.


Corrigendum: TCRα-TCRβ pairing controls recognition of CD1d and directs the development of adipose NKT cells.

Vieth JA, Das J, Ranaivoson FM, Comoletti D, Denzin LK, Sant'Angelo DB.

Nat Immunol. 2017 Jul 19;18(8):951. doi: 10.1038/ni0817-951a. No abstract available.


Are fat NKT cells born that way?

Vieth JA, Sant'Angelo DB.

Cell Mol Immunol. 2017 Aug;14(8):658-661. doi: 10.1038/cmi.2017.42. Epub 2017 Jul 3. No abstract available.


TCRα-TCRβ pairing controls recognition of CD1d and directs the development of adipose NKT cells.

Vieth JA, Das J, Ranaivoson FM, Comoletti D, Denzin LK, Sant'Angelo DB.

Nat Immunol. 2017 Jan;18(1):36-44. doi: 10.1038/ni.3622. Epub 2016 Nov 21. Erratum in: Nat Immunol. 2017 Jul 19;18(8):951.


Transcription factor Bcl11b sustains iNKT1 and iNKT2 cell programs, restricts iNKT17 cell program, and governs iNKT cell survival.

Uddin MN, Sultana DA, Lorentsen KJ, Cho JJ, Kirst ME, Brantly ML, Califano D, Sant'Angelo DB, Avram D.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7608-13. doi: 10.1073/pnas.1521846113. Epub 2016 Jun 21.


NKAP Regulates Invariant NKT Cell Proliferation and Differentiation into ROR-γt-Expressing NKT17 Cells.

Thapa P, Chen MW, McWilliams DC, Belmonte P, Constans M, Sant'Angelo DB, Shapiro VS.

J Immunol. 2016 Jun 15;196(12):4987-98. doi: 10.4049/jimmunol.1501653. Epub 2016 May 9.


Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53.

Chen L, Foreman DP, Sant'Angelo DB, Krangel MS.

J Immunol. 2016 Mar 15;196(6):2572-82. doi: 10.4049/jimmunol.1501916. Epub 2016 Feb 3.


Zbtb16 (PLZF) is stably suppressed and not inducible in non-innate T cells via T cell receptor-mediated signaling.

Zhang S, Laouar A, Denzin LK, Sant'Angelo DB.

Sci Rep. 2015 Jul 16;5:12113. doi: 10.1038/srep12113.


Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue.

Lynch L, Michelet X, Zhang S, Brennan PJ, Moseman A, Lester C, Besra G, Vomhof-Dekrey EE, Tighe M, Koay HF, Godfrey DI, Leadbetter EA, Sant'Angelo DB, von Andrian U, Brenner MB.

Nat Immunol. 2015 Jan;16(1):85-95. doi: 10.1038/ni.3047. Epub 2014 Dec 1.


Label retention identifies a multipotent mesenchymal stem cell-like population in the postnatal thymus.

Osada M, Singh VJ, Wu K, Sant'Angelo DB, Pezzano M.

PLoS One. 2013 Dec 10;8(12):e83024. doi: 10.1371/journal.pone.0083024. eCollection 2013.


A transgenic TCR directs the development of IL-4+ and PLZF+ innate CD4 T cells.

Zhu L, Qiao Y, Choi ES, Das J, Sant'angelo DB, Chang CH.

J Immunol. 2013 Jul 15;191(2):737-44. doi: 10.4049/jimmunol.1300862. Epub 2013 Jun 17.


The transcriptional repressor NKAP is required for the development of iNKT cells.

Thapa P, Das J, McWilliams D, Shapiro M, Sundsbak R, Nelson-Holte M, Tangen S, Anderson J, Desiderio S, Hiebert S, Sant'angelo DB, Shapiro VS.

Nat Commun. 2013;4:1582. doi: 10.1038/ncomms2580.


Direct identification of rat iNKT cells reveals remarkable similarities to human iNKT cells and a profound deficiency in LEW rats.

Monzon-Casanova E, Paletta D, Starick L, Müller I, Sant'Angelo DB, Pyz E, Herrmann T.

Eur J Immunol. 2013 Feb;43(2):404-15. doi: 10.1002/eji.201242565. Epub 2012 Dec 26.


Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.

Qiao Y, Zhu L, Sofi H, Lapinski PE, Horai R, Mueller K, Stritesky GL, He X, Teh HS, Wiest DL, Kappes DJ, King PD, Hogquist KA, Schwartzberg PL, Sant'Angelo DB, Chang CH.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16264-9. doi: 10.1073/pnas.1207528109. Epub 2012 Sep 17.


Altered development of NKT cells, γδ T cells, CD8 T cells and NK cells in a PLZF deficient patient.

Eidson M, Wahlstrom J, Beaulieu AM, Zaidi B, Carsons SE, Crow PK, Yuan J, Wolchok JD, Horsthemke B, Wieczorek D, Sant'Angelo DB.

PLoS One. 2011;6(9):e24441. doi: 10.1371/journal.pone.0024441. Epub 2011 Sep 6.


The BTB-ZF family of transcription factors: key regulators of lineage commitment and effector function development in the immune system.

Beaulieu AM, Sant'Angelo DB.

J Immunol. 2011 Sep 15;187(6):2841-7. doi: 10.4049/jimmunol.1004006.


The Paf oncogene is essential for hematopoietic stem cell function and development.

Amrani YM, Gill J, Matevossian A, Alonzo ES, Yang C, Shieh JH, Moore MA, Park CY, Sant'Angelo DB, Denzin LK.

J Exp Med. 2011 Aug 29;208(9):1757-65. doi: 10.1084/jem.20102170. Epub 2011 Aug 15.


TCR affinity for self-ligands influences the development and function of encephalitogenic T cells.

Li J, Vandal O, Sant'Angelo DB.

PLoS One. 2011 Mar 17;6(3):e17702. doi: 10.1371/journal.pone.0017702.


Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells.

Gordon SM, Carty SA, Kim JS, Zou T, Smith-Garvin J, Alonzo ES, Haimm E, Sant'Angelo DB, Koretzky GA, Reiner SL, Jordan MS.

J Immunol. 2011 Apr 15;186(8):4573-8. doi: 10.4049/jimmunol.1100037. Epub 2011 Mar 7.


Development of PLZF-expressing innate T cells.

Alonzo ES, Sant'Angelo DB.

Curr Opin Immunol. 2011 Apr;23(2):220-7. doi: 10.1016/j.coi.2010.12.016. Epub 2011 Jan 21. Review.


Ectopic T cell receptor-α locus control region activity in B cells is suppressed by direct linkage to two flanking genes at once.

Knirr S, Gomos-Klein J, Andino BE, Harrow F, Erhard KF, Kovalovsky D, Sant'Angelo DB, Ortiz BD.

PLoS One. 2010 Nov 22;5(11):e15527. doi: 10.1371/journal.pone.0015527.


Transcriptional control of invariant NKT cell development.

Das R, Sant'Angelo DB, Nichols KE.

Immunol Rev. 2010 Nov;238(1):195-215. doi: 10.1111/j.1600-065X.2010.00962.x.


Selective depletion of eosinophils or neutrophils in mice impacts the efficiency of apoptotic cell clearance in the thymus.

Kim HJ, Alonzo ES, Dorothee G, Pollard JW, Sant'Angelo DB.

PLoS One. 2010 Jul 6;5(7):e11439. doi: 10.1371/journal.pone.0011439.


PLZF induces the spontaneous acquisition of memory/effector functions in T cells independently of NKT cell-related signals.

Kovalovsky D, Alonzo ES, Uche OU, Eidson M, Nichols KE, Sant'Angelo DB.

J Immunol. 2010 Jun 15;184(12):6746-55. doi: 10.4049/jimmunol.1000776. Epub 2010 May 21.


Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence.

Yi W, Seth NP, Martillotti T, Wucherpfennig KW, Sant'Angelo DB, Denzin LK.

J Clin Invest. 2010 Apr;120(4):1324-36. doi: 10.1172/JCI40220.


A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway.

Kovalovsky D, Pezzano M, Ortiz BD, Sant'Angelo DB.

PLoS One. 2010 Jan 13;5(1):e8675. doi: 10.1371/journal.pone.0008675.


Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3.

Alonzo ES, Gottschalk RA, Das J, Egawa T, Hobbs RM, Pandolfi PP, Pereira P, Nichols KE, Koretzky GA, Jordan MS, Sant'Angelo DB.

J Immunol. 2010 Feb 1;184(3):1268-79. doi: 10.4049/jimmunol.0903218. Epub 2009 Dec 28.


The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions.

Kovalovsky D, Uche OU, Eladad S, Hobbs RM, Yi W, Alonzo E, Chua K, Eidson M, Kim HJ, Im JS, Pandolfi PP, Sant'Angelo DB.

Nat Immunol. 2008 Sep;9(9):1055-64. doi: 10.1038/ni.1641. Epub 2008 Jul 27.


Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors.

Zakrzewski JL, Suh D, Markley JC, Smith OM, King C, Goldberg GL, Jenq R, Holland AM, Grubin J, Cabrera-Perez J, Brentjens RJ, Lu SX, Rizzuto G, Sant'Angelo DB, Riviere I, Sadelain M, Heller G, Zúñiga-Pflücker JC, Lu C, van den Brink MR.

Nat Biotechnol. 2008 Apr;26(4):453-61. doi: 10.1038/nbt1395. Epub 2008 Mar 30.


Innate immune activation and CD4+ T cell priming during respiratory fungal infection.

Rivera A, Ro G, Van Epps HL, Simpson T, Leiner I, Sant'Angelo DB, Pamer EG.

Immunity. 2006 Oct;25(4):665-75. Epub 2006 Oct 5.


An alternate pathway for CD4 T cell development: thymocyte-expressed MHC class II selects a distinct T cell population.

Li W, Kim MG, Gourley TS, McCarthy BP, Sant'Angelo DB, Chang CH.

Immunity. 2005 Oct;23(4):375-86.


Fulminant experimental autoimmune encephalo-myelitis induced by retrovirally mediated TCR gene transfer.

Stolzer AL, Sadelain M, Sant'Angelo DB.

Eur J Immunol. 2005 Jun;35(6):1822-30.


Dipping into the cytosol to broaden the MHC class II peptide repertoire.

Denzin LK, Sant'angelo DB.

Immunity. 2005 May;22(5):536-7. No abstract available.


Coevolution of TCR-MHC interactions: conserved MHC tertiary structure is not sufficient for interactions with the TCR.

Kim HJ, Guo D, Sant'Angelo DB.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7263-7. Epub 2005 May 9.


Development of CD1d-restricted NKT cells in the mouse thymus.

Dao T, Guo D, Ploss A, Stolzer A, Saylor C, Boursalian TE, Im JS, Sant'Angelo DB.

Eur J Immunol. 2004 Dec;34(12):3542-52.


Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation.

Fallas JL, Tobin HM, Lou O, Guo D, Sant'Angelo DB, Denzin LK.

J Immunol. 2004 Aug 1;173(3):1549-60.


A pool of central memory-like CD4 T cells contains effector memory precursors.

Blander JM, Sant'Angelo DB, Metz D, Kim SW, Flavell RA, Bottomly K, Janeway CA Jr.

J Immunol. 2003 Mar 15;170(6):2940-8.


Recognition of core and flanking amino acids of MHC class II-bound peptides by the T cell receptor.

Sant'Angelo DB, Robinson E, Janeway CA Jr, Denzin LK.

Eur J Immunol. 2002 Sep;32(9):2510-20.


Negative selection of thymocytes expressing the D10 TCR.

Sant'Angelo DB, Janeway CA Jr.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6931-6.


Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers.

Sant'Angelo DB, Cresswell P, Janeway CA Jr, Denzin LK.

Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6824-9. Epub 2001 May 29.


A role for accessibility to self-peptide-self-MHC complexes in intrathymic negative selection.

Viret C, Sant'Angelo DB, He X, Ramaswamy H, Janeway CA Jr.

J Immunol. 2001 Apr 1;166(7):4429-37.


A B-cell receptor-specific selection step governs immature to mature B cell differentiation.

Levine MH, Haberman AM, Sant'Angelo DB, Hannum LG, Cancro MP, Janeway CA Jr, Shlomchik MJ.

Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2743-8.


A molecular map of T cell development.

Sant'Angelo DB, Lucas B, Waterbury PG, Cohen B, Brabb T, Goverman J, Germain RN, Janeway CA Jr.

Immunity. 1998 Aug;9(2):179-86.


The imprint of intrathymic self-peptides on the mature T cell receptor repertoire.

Sant'Angelo DB, Waterbury PG, Cohen BE, Martin WD, Van Kaer L, Hayday AC, Janeway CA Jr.

Immunity. 1997 Oct;7(4):517-24.


The orientation of a T cell receptor to its MHC class II:peptide ligands.

Hong SC, Sant'Angelo DB, Dittel BN, Medzhitov R, Yoon ST, Waterbury PG, Janeway CA Jr.

J Immunol. 1997 Nov 1;159(9):4395-402.


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