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Items: 17


Determinants and clinical implications of chromosomal instability in cancer.

Sansregret L, Vanhaesebroeck B, Swanton C.

Nat Rev Clin Oncol. 2018 Mar;15(3):139-150. doi: 10.1038/nrclinonc.2017.198. Epub 2018 Jan 3. Review.


Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.

Berenjeno IM, Piñeiro R, Castillo SD, Pearce W, McGranahan N, Dewhurst SM, Meniel V, Birkbak NJ, Lau E, Sansregret L, Morelli D, Kanu N, Srinivas S, Graupera M, Parker VER, Montgomery KG, Moniz LS, Scudamore CL, Phillips WA, Semple RK, Clarke A, Swanton C, Vanhaesebroeck B.

Nat Commun. 2017 Nov 24;8(1):1773. doi: 10.1038/s41467-017-02002-4.


Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis.

Turajlic S, Litchfield K, Xu H, Rosenthal R, McGranahan N, Reading JL, Wong YNS, Rowan A, Kanu N, Al Bakir M, Chambers T, Salgado R, Savas P, Loi S, Birkbak NJ, Sansregret L, Gore M, Larkin J, Quezada SA, Swanton C.

Lancet Oncol. 2017 Aug;18(8):1009-1021. doi: 10.1016/S1470-2045(17)30516-8. Epub 2017 Jul 7.


BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer.

López-García C, Sansregret L, Domingo E, McGranahan N, Hobor S, Birkbak NJ, Horswell S, Grönroos E, Favero F, Rowan AJ, Matthews N, Begum S, Phillimore B, Burrell R, Oukrif D, Spencer-Dene B, Kovac M, Stamp G, Stewart A, Danielsen H, Novelli M, Tomlinson I, Swanton C.

Cancer Cell. 2017 Jan 9;31(1):79-93. doi: 10.1016/j.ccell.2016.11.001.


APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability.

Sansregret L, Patterson JO, Dewhurst S, López-García C, Koch A, McGranahan N, Chao WCH, Barry DJ, Rowan A, Instrell R, Horswell S, Way M, Howell M, Singleton MR, Medema RH, Nurse P, Petronczki M, Swanton C.

Cancer Discov. 2017 Feb;7(2):218-233. doi: 10.1158/2159-8290.CD-16-0645. Epub 2017 Jan 9.


The Role of Aneuploidy in Cancer Evolution.

Sansregret L, Swanton C.

Cold Spring Harb Perspect Med. 2017 Jan 3;7(1). pii: a028373. doi: 10.1101/cshperspect.a028373. Review.


Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase.

Vázquez-Novelle MD, Sansregret L, Dick AE, Smith CA, McAinsh AD, Gerlich DW, Petronczki M.

Curr Biol. 2014 Mar 17;24(6):638-45. doi: 10.1016/j.cub.2014.01.034. Epub 2014 Feb 27.


Born equal: dual safeguards for daughter cell size symmetry.

Sansregret L, Petronczki M.

Cell. 2013 Jul 18;154(2):269-71. doi: 10.1016/j.cell.2013.06.035.


Gene signatures of genomic instability as prognostic tools for breast cancer.

Sansregret L, Nepveu A.

Future Oncol. 2011 May;7(5):591-4. doi: 10.2217/fon.11.34. No abstract available.


Cut homeobox 1 causes chromosomal instability by promoting bipolar division after cytokinesis failure.

Sansregret L, Vadnais C, Livingstone J, Kwiatkowski N, Awan A, Cadieux C, Leduy L, Hallett MT, Nepveu A.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1949-54. doi: 10.1073/pnas.1008403108. Epub 2011 Jan 18.


Hyperphosphorylation by cyclin B/CDK1 in mitosis resets CUX1 DNA binding clock at each cell cycle.

Sansregret L, Gallo D, Santaguida M, Leduy L, Harada R, Nepveu A.

J Biol Chem. 2010 Oct 22;285(43):32834-43. doi: 10.1074/jbc.M110.156406. Epub 2010 Aug 19.


p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin.

Kedinger V, Sansregret L, Harada R, Vadnais C, Cadieux C, Fathers K, Park M, Nepveu A.

J Biol Chem. 2009 Oct 2;284(40):27701-11. doi: 10.1074/jbc.M109.031849. Epub 2009 Jul 27.


The multiple roles of CUX1: insights from mouse models and cell-based assays.

Sansregret L, Nepveu A.

Gene. 2008 Apr 15;412(1-2):84-94. doi: 10.1016/j.gene.2008.01.017. Epub 2008 Feb 2. Review.


Genome-wide location analysis and expression studies reveal a role for p110 CUX1 in the activation of DNA replication genes.

Harada R, Vadnais C, Sansregret L, Leduy L, Bérubé G, Robert F, Nepveu A.

Nucleic Acids Res. 2008 Jan;36(1):189-202. Epub 2007 Nov 14.


Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation.

Goulet B, Sansregret L, Leduy L, Bogyo M, Weber E, Chauhan SS, Nepveu A.

Mol Cancer Res. 2007 Sep;5(9):899-907.


The p110 isoform of the CDP/Cux transcription factor accelerates entry into S phase.

Sansregret L, Goulet B, Harada R, Wilson B, Leduy L, Bertoglio J, Nepveu A.

Mol Cell Biol. 2006 Mar;26(6):2441-55.


A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor.

Goulet B, Baruch A, Moon NS, Poirier M, Sansregret LL, Erickson A, Bogyo M, Nepveu A.

Mol Cell. 2004 Apr 23;14(2):207-19.

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