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Items: 1 to 50 of 58

1.

Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver microsomes.

Fujino C, Watanabe Y, Sanoh S, Nakajima H, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S.

Heliyon. 2019 Sep 12;5(9):e02466. doi: 10.1016/j.heliyon.2019.e02466. eCollection 2019 Sep.

2.

Comparative study of the effect of 17 parabens on PXR-, CAR- and PPARα-mediated transcriptional activation.

Fujino C, Watanabe Y, Sanoh S, Hattori S, Nakajima H, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S.

Food Chem Toxicol. 2019 Nov;133:110792. doi: 10.1016/j.fct.2019.110792. Epub 2019 Aug 28.

PMID:
31472229
3.

CYP1A2 Downregulation by Obeticholic Acid: Usefulness as a Positive Control for the In Vitro Evaluation of Drug-Drug Interactions.

Ishida C, Sanoh S, Kotake Y.

J Pharm Sci. 2019 Dec;108(12):3903-3910. doi: 10.1016/j.xphs.2019.08.021. Epub 2019 Aug 28.

PMID:
31472121
4.

Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver.

Sanoh S, Tamura Y, Fujino C, Sugahara G, Yoshizane Y, Yanagi A, Kisoh K, Ishida Y, Tateno C, Ohta S, Kotake Y.

Biol Pharm Bull. 2019;42(8):1366-1375. doi: 10.1248/bpb.b19-00249.

5.

Coordinated cytochrome P450 expression in mouse liver and intestine under different dietary conditions during liver regeneration after partial hepatectomy.

Fujino C, Sanoh S, Tateno C, Ohta S, Kotake Y.

Toxicol Appl Pharmacol. 2019 May 1;370:133-144. doi: 10.1016/j.taap.2019.03.010. Epub 2019 Mar 14.

PMID:
30880217
6.
7.

Inhibition of cytochrome P450 3A protein degradation and subsequent increase in enzymatic activity through p38 MAPK activation by acetaminophen and salicylate derivatives.

Ohtsuki Y, Sanoh S, Santoh M, Ejiri Y, Ohta S, Kotake Y.

Biochem Biophys Res Commun. 2019 Jan 29;509(1):287-293. doi: 10.1016/j.bbrc.2018.12.124. Epub 2018 Dec 23.

PMID:
30587336
8.

Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors.

Kojima H, Takeuchi S, Sanoh S, Okuda K, Kitamura S, Uramaru N, Sugihara K, Yoshinari K.

Toxicology. 2019 Feb 1;413:48-55. doi: 10.1016/j.tox.2018.12.001. Epub 2018 Dec 21.

PMID:
30582956
9.

[Contribution of chimeric mice with a humanized liver to the evaluation of pharmacology, toxicity, and pharmacokinetics in drug discovery and development].

Sanoh S, Ohta S.

Nihon Yakurigaku Zasshi. 2018;151(5):213-220. doi: 10.1254/fpj.151.213. Japanese.

PMID:
29760366
10.

Inhibitory effects of drugs on the metabolic activity of mouse and human aldehyde oxidases and influence on drug-drug interactions.

Takaoka N, Sanoh S, Okuda K, Kotake Y, Sugahara G, Yanagi A, Ishida Y, Tateno C, Tayama Y, Sugihara K, Kitamura S, Kurosaki M, Terao M, Garattini E, Ohta S.

Biochem Pharmacol. 2018 Aug;154:28-38. doi: 10.1016/j.bcp.2018.04.017. Epub 2018 Apr 17.

PMID:
29678521
11.

Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures.

Yokoyama Y, Sasaki Y, Terasaki N, Kawataki T, Takekawa K, Iwase Y, Shimizu T, Sanoh S, Ohta S.

Biol Pharm Bull. 2018 May 1;41(5):722-732. doi: 10.1248/bpb.b17-00913. Epub 2018 Feb 14.

12.

Tributyltin induces epigenetic changes and decreases the expression of nuclear respiratory factor-1.

Hanaoka S, Ishida K, Tanaka S, Sakamoto S, Okuda K, Sanoh S, Ohta S, Kotake Y.

Metallomics. 2018 Feb 21;10(2):337-345. doi: 10.1039/c7mt00290d.

PMID:
29345269
13.

Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery.

Naritomi Y, Sanoh S, Ohta S.

Drug Metab Pharmacokinet. 2018 Feb;33(1):31-39. doi: 10.1016/j.dmpk.2017.11.001. Epub 2017 Nov 9. Review.

PMID:
29183653
14.

Developmental changes in drug-metabolizing enzyme expression during metamorphosis of Xenopus tropicalis.

Mori J, Sanoh S, Kashiwagi K, Hanada H, Shigeta M, Suzuki KT, Yamamoto T, Kotake Y, Sugihara K, Kitamura S, Kashiwagi A, Ohta S.

J Toxicol Sci. 2017;42(5):605-613. doi: 10.2131/jts.42.605.

15.

Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver.

Sanoh S, Yamachika Y, Tamura Y, Kotake Y, Yoshizane Y, Ishida Y, Tateno C, Ohta S.

J Toxicol Sci. 2017;42(5):589-596. doi: 10.2131/jts.42.589.

16.

Low-Concentration Tributyltin Decreases GluR2 Expression via Nuclear Respiratory Factor-1 Inhibition.

Ishida K, Aoki K, Takishita T, Miyara M, Sakamoto S, Sanoh S, Kimura T, Kanda Y, Ohta S, Kotake Y.

Int J Mol Sci. 2017 Aug 11;18(8). pii: E1754. doi: 10.3390/ijms18081754.

17.

Carbofuran causes neuronal vulnerability to glutamate by decreasing GluA2 protein levels in rat primary cortical neurons.

Umeda K, Miyara M, Ishida K, Sanoh S, Ohta S, Kotake Y.

Arch Toxicol. 2018 Jan;92(1):401-409. doi: 10.1007/s00204-017-2018-6. Epub 2017 Jul 19.

PMID:
28725974
18.

Prenatal Exposure to Tributyltin Decreases GluR2 Expression in the Mouse Brain.

Ishida K, Saiki T, Umeda K, Miyara M, Sanoh S, Ohta S, Kotake Y.

Biol Pharm Bull. 2017;40(7):1121-1124. doi: 10.1248/bpb.b17-00209.

19.

Mild MPP+ exposure-induced glucose starvation enhances autophagosome synthesis and impairs its degradation.

Sakamoto S, Miyara M, Sanoh S, Ohta S, Kotake Y.

Sci Rep. 2017 Apr 26;7:46668. doi: 10.1038/srep46668.

20.

Acetaminophen analog N-acetyl-m-aminophenol, but not its reactive metabolite, N-acetyl-p-benzoquinone imine induces CYP3A activity via inhibition of protein degradation.

Santoh M, Sanoh S, Ohtsuki Y, Ejiri Y, Kotake Y, Ohta S.

Biochem Biophys Res Commun. 2017 May 6;486(3):639-644. doi: 10.1016/j.bbrc.2017.03.073. Epub 2017 Mar 21.

PMID:
28341123
21.

Altered expression of the Olr59, Ethe1, and Slc10a2 genes in the liver of F344 rats by neonatal thyroid hormone disruption.

Matsubara K, Nakamura N, Sanoh S, Ohta S, Kitamura S, Uramaru N, Miyagawa S, Iguchi T, Fujimoto N.

J Appl Toxicol. 2017 Sep;37(9):1030-1035. doi: 10.1002/jat.3452. Epub 2017 Mar 16.

PMID:
28299817
22.
23.

Lead-Induced ERK Activation Is Mediated by GluR2 Non-containing AMPA Receptor in Cortical Neurons.

Ishida K, Kotake Y, Sanoh S, Ohta S.

Biol Pharm Bull. 2017;40(3):303-309. doi: 10.1248/bpb.b16-00784.

24.

Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPARα activities.

Fujino C, Tamura Y, Tange S, Nakajima H, Sanoh S, Watanabe Y, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S.

J Toxicol Sci. 2016;41(5):677-91. doi: 10.2131/jts.41.677.

25.

Mouse aldehyde-oxidase-4 controls diurnal rhythms, fat deposition and locomotor activity.

Terao M, Barzago MM, Kurosaki M, Fratelli M, Bolis M, Borsotti A, Bigini P, Micotti E, Carli M, Invernizzi RW, Bagnati R, Passoni A, Pastorelli R, Brunelli L, Toschi I, Cesari V, Sanoh S, Garattini E.

Sci Rep. 2016 Jul 26;6:30343. doi: 10.1038/srep30343.

26.

Mild MPP+ exposure impairs autophagic degradation through a novel lysosomal acidity-independent mechanism.

Miyara M, Kotake Y, Tokunaga W, Sanoh S, Ohta S.

J Neurochem. 2016 Oct;139(2):294-308. doi: 10.1111/jnc.13700. Epub 2016 Oct 3.

27.

Perfluorooctane sulfonate induces neuronal vulnerability by decreasing GluR2 expression.

Ishida K, Tsuyama Y, Sanoh S, Ohta S, Kotake Y.

Arch Toxicol. 2017 Feb;91(2):885-895. doi: 10.1007/s00204-016-1731-x. Epub 2016 May 7.

PMID:
27155986
28.

Protein extracts from cultured cells contain nonspecific serum albumin.

Miyara M, Umeda K, Ishida K, Sanoh S, Kotake Y, Ohta S.

Biosci Biotechnol Biochem. 2016 Jun;80(6):1164-7. doi: 10.1080/09168451.2016.1151338. Epub 2016 Mar 11.

PMID:
26967711
29.

Methoxychlor and fenvalerate induce neuronal death by reducing GluR2 expression.

Umeda K, Kotake Y, Miyara M, Ishida K, Sanoh S, Ohta S.

J Toxicol Sci. 2016 Apr;41(2):255-64. doi: 10.2131/jts.41.255.

30.

Acetaminophen induces accumulation of functional rat CYP3A via polyubiquitination dysfunction.

Santoh M, Sanoh S, Takagi M, Ejiri Y, Kotake Y, Ohta S.

Sci Rep. 2016 Feb 22;6:21373. doi: 10.1038/srep21373.

31.

Detection of metabolic activation leading to drug-induced phospholipidosis in rat hepatocyte spheroids.

Takagi M, Sanoh S, Santoh M, Ejiri Y, Kotake Y, Ohta S.

J Toxicol Sci. 2016 Feb;41(1):155-64. doi: 10.2131/jts.41.155.

32.

[In Vitro and in Vivo Assessments of Drug-induced Hepatotoxicity and Drug Metabolism in Humans].

Sanoh S.

Yakugaku Zasshi. 2015;135(11):1273-9. doi: 10.1248/yakushi.15-00200. Review. Japanese.

33.

Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy.

Sanoh S, Tayama Y, Sugihara K, Kitamura S, Ohta S.

Drug Metab Pharmacokinet. 2015 Feb;30(1):52-63. doi: 10.1016/j.dmpk.2014.10.009. Epub 2014 Nov 20. Review.

PMID:
25760530
34.

Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver.

Sanoh S, Naritomi Y, Fujimoto M, Sato K, Kawamura A, Horiguchi A, Sugihara K, Kotake Y, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.

Xenobiotica. 2015;45(7):605-14. doi: 10.3109/00498254.2015.1007112. Epub 2015 Mar 3.

PMID:
25733030
35.

Development of a simple measurement method for GluR2 protein expression as an index of neuronal vulnerability.

Sugiyama C, Kotake Y, Yamaguchi M, Umeda K, Tsuyama Y, Sanoh S, Okuda K, Ohta S.

Toxicol Rep. 2015 Jan 14;2:450-460. doi: 10.1016/j.toxrep.2014.12.014. eCollection 2015.

36.

Metabolism of UV-filter benzophenone-3 by rat and human liver microsomes and its effect on endocrine-disrupting activity.

Watanabe Y, Kojima H, Takeuchi S, Uramaru N, Sanoh S, Sugihara K, Kitamura S, Ohta S.

Toxicol Appl Pharmacol. 2015 Jan 15;282(2):119-28. doi: 10.1016/j.taap.2014.12.002. Epub 2014 Dec 17.

PMID:
25528284
37.

Fluorometric assessment of acetaminophen-induced toxicity in rat hepatocyte spheroids seeded on micro-space cell culture plates.

Sanoh S, Santoh M, Takagi M, Kanayama T, Sugihara K, Kotake Y, Ejiri Y, Horie T, Kitamura S, Ohta S.

Toxicol In Vitro. 2014 Sep;28(6):1176-82. doi: 10.1016/j.tiv.2014.05.007. Epub 2014 May 28.

PMID:
24878114
38.

Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function.

Contu VR, Kotake Y, Toyama T, Okuda K, Miyara M, Sakamoto S, Samizo S, Sanoh S, Kumagai Y, Ohta S.

J Neurochem. 2014 Sep;130(6):826-38. doi: 10.1111/jnc.12762. Epub 2014 Jun 18.

39.

Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics.

Sanoh S, Ohta S.

Biopharm Drug Dispos. 2014 Mar;35(2):71-86. doi: 10.1002/bdd.1864. Epub 2013 Oct 29. Review.

PMID:
24114658
40.

Cell type-dependent agonist/antagonist activities of polybrominated diphenyl ethers.

Nakamura N, Matsubara K, Sanoh S, Ohta S, Uramaru N, Kitamura S, Yamaguchi M, Sugihara K, Fujimoto N.

Toxicol Lett. 2013 Nov 25;223(2):192-7. doi: 10.1016/j.toxlet.2013.09.007. Epub 2013 Sep 25.

PMID:
24076165
41.

Tributyltin-induced endoplasmic reticulum stress and its Ca(2+)-mediated mechanism.

Isomura M, Kotake Y, Masuda K, Miyara M, Okuda K, Samizo S, Sanoh S, Hosoi T, Ozawa K, Ohta S.

Toxicol Appl Pharmacol. 2013 Oct 1;272(1):137-46. doi: 10.1016/j.taap.2013.05.026. Epub 2013 Jun 3.

PMID:
23743301
42.

Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death.

Ishida K, Kotake Y, Miyara M, Aoki K, Sanoh S, Kanda Y, Ohta S.

J Toxicol Sci. 2013;38(3):513-21.

43.

Photodegradation of pharmaceuticals in the aquatic environment by sunlight and UV-A, -B and -C irradiation.

Kawabata K, Sugihara K, Sanoh S, Kitamura S, Ohta S.

J Toxicol Sci. 2013;38(2):215-23.

44.

2,5-Dihydroxy-4-methoxybenzophenone: a novel major in vitro metabolite of benzophenone-3 formed by rat and human liver microsomes.

Kamikyouden N, Sugihara K, Watanabe Y, Uramaru N, Murahashi T, Kuroyanagi M, Sanoh S, Ohta S, Kitamura S.

Xenobiotica. 2013 Jun;43(6):514-9. doi: 10.3109/00498254.2012.742217. Epub 2012 Nov 28.

PMID:
23190297
45.

Predictability of metabolism of ibuprofen and naproxen using chimeric mice with human hepatocytes.

Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Uramaru N, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.

Drug Metab Dispos. 2012 Dec;40(12):2267-72. doi: 10.1124/dmd.112.047555. Epub 2012 Aug 30.

PMID:
22936315
46.

Developmental changes of aldehyde oxidase activity and protein expression in human liver cytosol.

Tayama Y, Sugihara K, Sanoh S, Miyake K, Kitamura S, Ohta S.

Drug Metab Pharmacokinet. 2012;27(5):543-7. Epub 2012 Mar 27.

47.

Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver.

Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.

Drug Metab Dispos. 2012 Feb;40(2):322-8. doi: 10.1124/dmd.111.040923. Epub 2011 Nov 2.

PMID:
22048522
48.

An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide.

Matsubara K, Sanoh S, Ohta S, Kitamura S, Sugihara K, Fujimoto N.

Toxicol Lett. 2012 Jan 5;208(1):30-5. doi: 10.1016/j.toxlet.2011.10.004. Epub 2011 Oct 13.

PMID:
22015988
49.

Prediction of human metabolism of FK3453 by aldehyde oxidase using chimeric mice transplanted with human or rat hepatocytes.

Sanoh S, Nozaki K, Murai H, Terashita S, Teramura T, Ohta S.

Drug Metab Dispos. 2012 Jan;40(1):76-82. doi: 10.1124/dmd.111.041954. Epub 2011 Oct 7.

PMID:
21984595
50.

Effect of tea beverages on aldehyde oxidase activity.

Tayama Y, Sugihara K, Sanoh S, Miyake K, Morita S, Kitamura S, Ohta S.

Drug Metab Pharmacokinet. 2011;26(1):94-101. Epub 2010 Nov 12.

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