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Items: 48

1.

New Methylation Biomarker Panel for Early Diagnosis of Dysplasia or Cancer in High-Risk Inflammatory Bowel Disease Patients.

Azuara D, Aussó S, Rodriguez-Moranta F, Guardiola J, Sanjuan X, Lobaton T, Boadas J, Piqueras M, Monfort D, Guinó E, Moreno V, Capellá G, de Oca J.

Inflamm Bowel Dis. 2018 Nov 29;24(12):2555-2564. doi: 10.1093/ibd/izy255.

PMID:
30099509
2.

Telomere length alterations in microsatellite stable colorectal cancer and association with the immune response.

Lopez-Doriga A, Valle L, Alonso MH, Aussó S, Closa A, Sanjuan X, Barquero D, Rodríguez-Moranta F, Sanz-Pamplona R, Moreno V.

Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2992-3000. doi: 10.1016/j.bbadis.2018.06.010. Epub 2018 Jun 14.

3.

Phase II Study of Gemcitabine Plus Sirolimus in Previously Treated Patients with Advanced Soft-Tissue Sarcoma: a Spanish Group for Research on Sarcomas (GEIS) Study.

Martin-Liberal J, López-Pousa A, Martínez-Trufero J, Martín-Broto J, Cubedo R, Lavernia J, Redondo A, López-Martín JA, Mulet-Margalef N, Sanjuan X, Tirado ÒM, Garcia-Del-Muro X.

Target Oncol. 2018 Feb;13(1):81-87. doi: 10.1007/s11523-017-0539-9.

PMID:
29177953
4.

Prediction of pathological response to neoadjuvant treatment in rectal cancer with a two-protein immunohistochemical score derived from stromal gene-profiling.

Gonçalves-Ribeiro S, Sanz-Pamplona R, Vidal A, Sanjuan X, Guillen Díaz-Maroto N, Soriano A, Guardiola J, Albert N, Martínez-Villacampa M, López I, Santos C, Serra-Musach J, Salazar R, Capellà G, Villanueva A, Molleví DG.

Ann Oncol. 2017 Sep 1;28(9):2160-2168. doi: 10.1093/annonc/mdx293.

PMID:
28911071
5.

Mutational Heterogeneity in APC and KRAS Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis.

Gausachs M, Borras E, Chang K, Gonzalez S, Azuara D, Delgado Amador A, Lopez-Doriga A, San Lucas FA, Sanjuan X, Paules MJ, Taggart MW, Davies GE, Ehli EA, Fowler J, Moreno V, Pineda M, You YN, Lynch PM, Lazaro C, Navin NE, Scheet PA, Hawk ET, Capella G, Vilar E.

Clin Cancer Res. 2017 Oct 1;23(19):5936-5947. doi: 10.1158/1078-0432.CCR-17-0821. Epub 2017 Jun 23.

6.

Optimization of RAS/BRAF Mutational Analysis Confirms Improvement in Patient Selection for Clinical Benefit to Anti-EGFR Treatment in Metastatic Colorectal Cancer.

Santos C, Azuara D, Garcia-Carbonero R, Alfonso PG, Carrato A, Elez ME, Gomez A, Losa F, Montagut C, Massuti B, Navarro V, Varela M, Lopez-Doriga A, Moreno V, Valladares M, Manzano JL, Vieitez JM, Aranda E, Sanjuan X, Tabernero J, Capella G, Salazar R.

Mol Cancer Ther. 2017 Sep;16(9):1999-2007. doi: 10.1158/1535-7163.MCT-17-0153. Epub 2017 Jun 16.

7.

Elucidating the molecular basis of MSH2-deficient tumors by combined germline and somatic analysis.

Vargas-Parra GM, González-Acosta M, Thompson BA, Gómez C, Fernández A, Dámaso E, Pons T, Morak M, Del Valle J, Iglesias S, Velasco À, Solanes A, Sanjuan X, Padilla N, de la Cruz X, Valencia A, Holinski-Feder E, Brunet J, Feliubadaló L, Lázaro C, Navarro M, Pineda M, Capellá G.

Int J Cancer. 2017 Oct 1;141(7):1365-1380. doi: 10.1002/ijc.30820. Epub 2017 Jul 3.

8.

Elucidating the clinical significance of two PMS2 missense variants coexisting in a family fulfilling hereditary cancer criteria.

González-Acosta M, Del Valle J, Navarro M, Thompson BA, Iglesias S, Sanjuan X, Paúles MJ, Padilla N, Fernández A, Cuesta R, Teulé À, Plotz G, Cadiñanos J, de la Cruz X, Balaguer F, Lázaro C, Pineda M, Capellá G.

Fam Cancer. 2017 Oct;16(4):501-507. doi: 10.1007/s10689-017-9981-1.

PMID:
28365877
9.

DNA methylation profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with caveolin-1.

Huertas-Martínez J, Court F, Rello-Varona S, Herrero-Martín D, Almacellas-Rabaiget O, Sáinz-Jaspeado M, Garcia-Monclús S, Lagares-Tena L, Buj R, Hontecillas-Prieto L, Sastre A, Azorin D, Sanjuan X, López-Alemany R, Moran S, Roma J, Gallego S, Mora J, García Del Muro X, Giangrande PH, Peinado MA, Alonso J, de Alava E, Monk D, Esteller M, Tirado OM.

Cancer Lett. 2017 Feb 1;386:196-207. doi: 10.1016/j.canlet.2016.11.020. Epub 2016 Nov 25.

PMID:
27894957
10.

Corrigendum: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.

Lopez-Serra P, Marcilla M, Villanueva A, Ramos-Fernandez A, Palau A, Leal L, Wahi JE, Setien-Baranda F, Szczesna K, Moutinho C, Martinez-Cardus A, Heyn H, Sandoval J, Puertas S, Vidal A, Sanjuan X, Martinez-Balibrea E, Viñals F, Perales JC, Bramsem JB, Ørntoft TF, Andersen CL, Tabernero J, McDermott U, Boxer MB, Vander Heiden MG, Albar JP, Esteller M.

Nat Commun. 2016 Nov 2;7:13467. doi: 10.1038/ncomms13467. No abstract available.

11.

Improving survival and local control in rectal cancer in Catalonia (Spain) in the context of centralisation: A full cycle audit assessment.

Manchon-Walsh P, Aliste L, Espinàs JA, Prades J, Guarga A, Balart J, Biondo S, Castells A, Sanjuan X, Tabernero J, Borras JM; Catalonian Rectal Cancer Group.

Eur J Surg Oncol. 2016 Dec;42(12):1873-1880. doi: 10.1016/j.ejso.2016.08.009. Epub 2016 Aug 25.

PMID:
27624916
12.

Phosphorylated-insulin growth factor I receptor (p-IGF1R) and metalloproteinase-3 (MMP3) expression in advanced gastrointestinal stromal tumors (GIST). A GEIS 19 study.

Maurel J, López-Pousa A, Calabuig S, Bagué S, Del Muro XG, Sanjuan X, Rubió-Casadevall J, Cuatrecasas M, Martinez-Trufero J, Horndler C, Fra J, Valverde C, Redondo A, Poveda A, Sevilla I, Lainez N, Rubini M, García-Albéniz X, Martín-Broto J, de Alava E.

Clin Sarcoma Res. 2016 Jun 29;6:10. doi: 10.1186/s13569-016-0050-6. eCollection 2016.

13.

Nanofluidic Digital PCR and Extended Genotyping of RAS and BRAF for Improved Selection of Metastatic Colorectal Cancer Patients for Anti-EGFR Therapies.

Azuara D, Santos C, Lopez-Doriga A, Grasselli J, Nadal M, Sanjuan X, Marin F, Vidal J, Montal R, Moreno V, Bellosillo B, Argiles G, Elez E, Dienstmann R, Montagut C, Tabernero J, Capellá G, Salazar R.

Mol Cancer Ther. 2016 May;15(5):1106-12. doi: 10.1158/1535-7163.MCT-15-0820. Epub 2016 Apr 1.

14.

Mutanome and expression of immune response genes in microsatellite stable colon cancer.

Sanz-Pamplona R, Gil-Hoyos R, López-Doriga A, Alonso MH, Aussó S, Molleví DG, Santos C, Sanjuán X, Salazar R, Alemany R, Moreno V.

Oncotarget. 2016 Apr 5;7(14):17711-25. doi: 10.18632/oncotarget.7293.

15.

Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer.

Sanz-Pamplona R, Lopez-Doriga A, Paré-Brunet L, Lázaro K, Bellido F, Alonso MH, Aussó S, Guinó E, Beltrán S, Castro-Giner F, Gut M, Sanjuan X, Closa A, Cordero D, Morón-Duran FD, Soriano A, Salazar R, Valle L, Moreno V.

Clin Cancer Res. 2015 Oct 15;21(20):4709-18. doi: 10.1158/1078-0432.CCR-15-0159. Epub 2015 Jun 12.

16.

Hepatitis C virus infection inhibits P-body granule formation in human livers.

Pérez-Vilaró G, Fernández-Carrillo C, Mensa L, Miquel R, Sanjuan X, Forns X, Pérez-del-Pulgar S, Díez J.

J Hepatol. 2015 Apr;62(4):785-90. doi: 10.1016/j.jhep.2014.11.018. Epub 2014 Nov 21.

PMID:
25463546
17.

Discovery and validation of new potential biomarkers for early detection of colon cancer.

Solé X, Crous-Bou M, Cordero D, Olivares D, Guinó E, Sanz-Pamplona R, Rodriguez-Moranta F, Sanjuan X, de Oca J, Salazar R, Moreno V.

PLoS One. 2014 Sep 12;9(9):e106748. doi: 10.1371/journal.pone.0106748. eCollection 2014.

18.

Relationship between methylation and colonic inflammation in inflammatory bowel disease.

Lobatón T, Azuara D, Rodríguez-Moranta F, Loayza C, Sanjuan X, de Oca J, Fernández-Robles A, Guardiola J, Capellá G.

World J Gastroenterol. 2014 Aug 14;20(30):10591-8. doi: 10.3748/wjg.v20.i30.10591.

19.

Simultaneous KIT mutation and succinate dehydrogenase (SDH) deficiency in a patient with a gastrointestinal stromal tumour and Carney-Stratakis syndrome: a case report.

Jové M, Mora J, Sanjuan X, Rodriguez E, Robledo M, Farran L, Garcia del Muro X.

Histopathology. 2014 Nov;65(5):712-7. doi: 10.1111/his.12506. No abstract available.

PMID:
25130709
20.

A 5-gene classifier from the carcinoma-associated fibroblast transcriptomic profile and clinical outcome in colorectal cancer.

Berdiel-Acer M, Berenguer A, Sanz-Pamplona R, Cuadras D, Sanjuan X, Paules MJ, Santos C, Salazar R, Moreno V, Capella G, Villanueva A, Molleví DG.

Oncotarget. 2014 Aug 15;5(15):6437-52.

21.

Fecal level of calprotectin identifies histologic inflammation in patients with ulcerative colitis in clinical and endoscopic remission.

Guardiola J, Lobatón T, Rodríguez-Alonso L, Ruiz-Cerulla A, Arajol C, Loayza C, Sanjuan X, Sánchez E, Rodríguez-Moranta F.

Clin Gastroenterol Hepatol. 2014 Nov;12(11):1865-70. doi: 10.1016/j.cgh.2014.06.020. Epub 2014 Jun 30.

PMID:
24993368
22.

Differences between CAFs and their paired NCF from adjacent colonic mucosa reveal functional heterogeneity of CAFs, providing prognostic information.

Berdiel-Acer M, Sanz-Pamplona R, Calon A, Cuadras D, Berenguer A, Sanjuan X, Paules MJ, Salazar R, Moreno V, Batlle E, Villanueva A, Molleví DG.

Mol Oncol. 2014 Oct;8(7):1290-305. doi: 10.1016/j.molonc.2014.04.006. Epub 2014 May 6.

23.

A monotonic and prognostic genomic signature from fibroblasts for colorectal cancer initiation, progression, and metastasis.

Berdiel-Acer M, Cuadras D, Díaz-Maroto NG, Sanjuan X, Serrano T, Berenguer A, Moreno V, Gonçalves-Ribeiro S, Salazar R, Villanueva A, Molleví DG.

Mol Cancer Res. 2014 Sep;12(9):1254-66. doi: 10.1158/1541-7786.MCR-14-0121. Epub 2014 May 14.

24.

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.

Lopez-Serra P, Marcilla M, Villanueva A, Ramos-Fernandez A, Palau A, Leal L, Wahi JE, Setien-Baranda F, Szczesna K, Moutinho C, Martinez-Cardus A, Heyn H, Sandoval J, Puertas S, Vidal A, Sanjuan X, Martinez-Balibrea E, Viñals F, Perales JC, Bramsem JB, Ørntoft TF, Andersen CL, Tabernero J, McDermott U, Boxer MB, Vander Heiden MG, Albar JP, Esteller M.

Nat Commun. 2014 Apr 3;5:3608. doi: 10.1038/ncomms4608. Erratum in: Nat Commun. 2016 Nov 02;7:13467.

25.

Aberrant gene expression in mucosa adjacent to tumor reveals a molecular crosstalk in colon cancer.

Sanz-Pamplona R, Berenguer A, Cordero D, Molleví DG, Crous-Bou M, Sole X, Paré-Brunet L, Guino E, Salazar R, Santos C, de Oca J, Sanjuan X, Rodriguez-Moranta F, Moreno V.

Mol Cancer. 2014 Mar 5;13:46. doi: 10.1186/1476-4598-13-46.

26.

New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis.

Valle L, Hernández-Illán E, Bellido F, Aiza G, Castillejo A, Castillejo MI, Navarro M, Seguí N, Vargas G, Guarinos C, Juarez M, Sanjuán X, Iglesias S, Alenda C, Egoavil C, Segura Á, Juan MJ, Rodriguez-Soler M, Brunet J, González S, Jover R, Lázaro C, Capellá G, Pineda M, Soto JL, Blanco I.

Hum Mol Genet. 2014 Jul 1;23(13):3506-12. doi: 10.1093/hmg/ddu058. Epub 2014 Feb 5.

PMID:
24501277
27.

Engineering of weak helper interactions for high-efficiency FRET probes.

Grünberg R, Burnier JV, Ferrar T, Beltran-Sastre V, Stricher F, van der Sloot AM, Garcia-Olivas R, Mallabiabarrena A, Sanjuan X, Zimmermann T, Serrano L.

Nat Methods. 2013 Oct;10(10):1021-7. doi: 10.1038/nmeth.2625. Epub 2013 Sep 1.

PMID:
23995386
28.

Refining the role of PMS2 in Lynch syndrome: germline mutational analysis improved by comprehensive assessment of variants.

Borràs E, Pineda M, Cadiñanos J, Del Valle J, Brieger A, Hinrichsen I, Cabanillas R, Navarro M, Brunet J, Sanjuan X, Musulen E, van der Klift H, Lázaro C, Plotz G, Blanco I, Capellá G.

J Med Genet. 2013 Aug;50(8):552-63. doi: 10.1136/jmedgenet-2012-101511. Epub 2013 May 24.

PMID:
23709753
29.

Clinical value of prognosis gene expression signatures in colorectal cancer: a systematic review.

Sanz-Pamplona R, Berenguer A, Cordero D, Riccadonna S, Solé X, Crous-Bou M, Guinó E, Sanjuan X, Biondo S, Soriano A, Jurman G, Capella G, Furlanello C, Moreno V.

PLoS One. 2012;7(11):e48877. doi: 10.1371/journal.pone.0048877. Epub 2012 Nov 7. Review.

30.

Clinicopathological risk factors of Stage II colon cancer: results of a prospective study.

Santos C, López-Doriga A, Navarro M, Mateo J, Biondo S, Martínez Villacampa M, Soler G, Sanjuan X, Paules MJ, Laquente B, Guinó E, Kreisler E, Frago R, Germà JR, Moreno V, Salazar R.

Colorectal Dis. 2013 Apr;15(4):414-22. doi: 10.1111/codi.12028.

PMID:
22974322
31.

Novel methylation panel for the early detection of neoplasia in high-risk ulcerative colitis and Crohn's colitis patients.

Azuara D, Rodriguez-Moranta F, de Oca J, Sanjuan X, Guardiola J, Lobaton T, Wang A, Boadas J, Piqueras M, Monfort D, Galter S, Esteller M, Moreno V, Capellá G.

Inflamm Bowel Dis. 2013 Jan;19(1):165-73. doi: 10.1002/ibd.22994.

PMID:
22532293
32.

Hepatic carcinoma-associated fibroblasts promote an adaptative response in colorectal cancer cells that inhibit proliferation and apoptosis: nonresistant cells die by nonapoptotic cell death.

Berdiel-Acer M, Bohem ME, López-Doriga A, Vidal A, Salazar R, Martínez-Iniesta M, Santos C, Sanjuan X, Villanueva A, Molleví DG.

Neoplasia. 2011 Oct;13(10):931-46.

33.

Gene expression differences between colon and rectum tumors.

Sanz-Pamplona R, Cordero D, Berenguer A, Lejbkowicz F, Rennert H, Salazar R, Biondo S, Sanjuan X, Pujana MA, Rozek L, Giordano TJ, Ben-Izhak O, Cohen HI, Trougouboff P, Bejhar J, Sova Y, Rennert G, Gruber SB, Moreno V.

Clin Cancer Res. 2011 Dec 1;17(23):7303-12. doi: 10.1158/1078-0432.CCR-11-1570. Epub 2011 Oct 5.

34.

Caveolin-1 modulates the ability of Ewing's sarcoma to metastasize.

Sáinz-Jaspeado M, Lagares-Tena L, Lasheras J, Navid F, Rodriguez-Galindo C, Mateo-Lozano S, Notario V, Sanjuan X, Garcia Del Muro X, Fabra A, Tirado OM.

Mol Cancer Res. 2010 Nov;8(11):1489-500. doi: 10.1158/1541-7786.MCR-10-0060.

35.

Microsatellite instability of the colorectal carcinoma can be predicted in the conventional pathologic examination. A prospective multicentric study and the statistical analysis of 615 cases consolidate our previously proposed logistic regression model.

Román R, Verdú M, Calvo M, Vidal A, Sanjuan X, Jimeno M, Salas A, Autonell J, Trias I, González M, García B, Rodón N, Puig X.

Virchows Arch. 2010 May;456(5):533-41. doi: 10.1007/s00428-010-0896-6.

PMID:
20393748
36.

Colorectal Cancer OncoGuia: surgical pathology report guidelines.

Sanjuán X, Salas A, Lloreta J, Manchon Walsh P; Colorectal Cancer OncoGuia Group.

Clin Transl Oncol. 2010 Mar;12(3):211-3. doi: 10.1007/s12094-010-0490-z. No abstract available.

PMID:
20231125
37.

PRL-3 overexpression in epithelial cells is induced by surrounding stromal fibroblasts.

Molleví DG, Aytes A, Berdiel M, Padullés L, Martínez-Iniesta M, Sanjuan X, Salazar R, Villanueva A.

Mol Cancer. 2009 Jul 8;8:46. doi: 10.1186/1476-4598-8-46.

38.

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer.

Rodilla V, Villanueva A, Obrador-Hevia A, Robert-Moreno A, Fernández-Majada V, Grilli A, López-Bigas N, Bellora N, Albà MM, Torres F, Duñach M, Sanjuan X, Gonzalez S, Gridley T, Capella G, Bigas A, Espinosa L.

Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6315-20. doi: 10.1073/pnas.0813221106. Epub 2009 Mar 26.

39.

[Long-term results of emergency surgery for colon cancer compared with elective surgery].

Biondo S, Kreisler E, Millan M, Martí-Ragué J, Fraccalvieri D, Golda T, De Oca J, Osorio A, Fradera R, Salazar R, Rodriguez-Moranta F, Sanjuán X.

Cir Esp. 2007 Aug;82(2):89-98. Spanish.

40.

Characterisation and application of antibodies specific for the long platelet-derived growth factor A and B chains.

Ostergren-Lundén G, Olivas RG, Eftekhari P, Krettek A, Sanjuan X, Fager G, Vilaró S, Lustig F, Hoebeke J.

Int J Biochem Cell Biol. 2004 Nov;36(11):2226-41.

PMID:
15313468
41.

Clonality Analysis of Benign Parathyroid Lesions by Human Androgen Receptor (HUMARA) Gene Assay.

Sanjuan X, Bryant BR, Sobel ME, Merino MI.

Endocr Pathol. 1998 Winter;9(1):293-300.

PMID:
12114777
42.

Alveolar soft part sarcoma: the role of prognostic markers.

Sanjuan X, Sobel ME, Yang J, Merino MJ.

Ann Diagn Pathol. 2000 Jun;4(3):135-42.

PMID:
10919382
43.

Utilization of microdissection and the polymerase chain reaction for the diagnosis of adrenal cortical carcinoma in fine-needle aspiration cytology.

Abati A, Sanjuan X, Wilder A, Linehan WM, Hewitt SM, Merino MJ.

Cancer. 1999 Aug 25;87(4):231-7.

PMID:
10455212
44.

Differential expression of galectin 3 and galectin 1 in colorectal cancer progression.

Sanjuán X, Fernández PL, Castells A, Castronovo V, van den Brule F, Liu FT, Cardesa A, Campo E.

Gastroenterology. 1997 Dec;113(6):1906-15.

PMID:
9394730
45.

p21WAF1/Cip1 expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinomas of the larynx.

Nadal A, Jares P, Cazorla M, Fernández PL, Sanjuan X, Hernandez L, Pinyol M, Aldea M, Mallofré C, Muntané J, Traserra J, Campo E, Cardesa A.

J Pathol. 1997 Oct;183(2):156-63.

PMID:
9390027
46.

Galectin-3 and laminin expression in neoplastic and non-neoplastic thyroid tissue.

Fernández PL, Merino MJ, Gómez M, Campo E, Medina T, Castronovo V, Sanjuán X, Cardesa A, Liu FT, Sobel ME.

J Pathol. 1997 Jan;181(1):80-6.

PMID:
9072007
47.

Overexpression of the 67-kD laminin receptor correlates with tumour progression in human colorectal carcinoma.

Sanjuán X, Fernández PL, Miquel R, Muñoz J, Castronovo V, Ménard S, Palacín A, Cardesa A, Campo E.

J Pathol. 1996 Aug;179(4):376-80.

PMID:
8869283
48.

[Fever and pain in the left lumbar flank in a 74-year-old woman].

Sopena N, Sanjuán X.

Med Clin (Barc). 1994 Jun 4;103(1):30-5. Spanish. No abstract available.

PMID:
8051964

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