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Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as Models for Cardiac Channelopathies: A Primer for Non-Electrophysiologists.

Garg P, Garg V, Shrestha R, Sanguinetti MC, Kamp TJ, Wu JC.

Circ Res. 2018 Jul 6;123(2):224-243. doi: 10.1161/CIRCRESAHA.118.311209. Review.


Genome Editing of Induced Pluripotent Stem Cells to Decipher Cardiac Channelopathy Variant.

Garg P, Oikonomopoulos A, Chen H, Li Y, Lam CK, Sallam K, Perez M, Lux RL, Sanguinetti MC, Wu JC.

J Am Coll Cardiol. 2018 Jul 3;72(1):62-75. doi: 10.1016/j.jacc.2018.04.041.


Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3.

Gardner A, Wu W, Thomson S, Zangerl-Plessl EM, Stary-Weinzinger A, Sanguinetti MC.

Mol Pharmacol. 2017 Oct;92(4):437-450. doi: 10.1124/mol.117.108886. Epub 2017 Jul 13.


Potassium channels in the heart: structure, function and regulation.

Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V.

J Physiol. 2017 Apr 1;595(7):2209-2228. doi: 10.1113/JP272864. Epub 2016 Nov 13. Review.


Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channels.

Thomson SJ, Hansen A, Sanguinetti MC.

J Biol Chem. 2016 Oct 7;291(41):21423. No abstract available.


Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics.

Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM.

J Physiol. 2017 Apr 1;595(7):2229-2252. doi: 10.1113/JP272883. Epub 2017 Jan 5. Review.


Molecular mechanisms of Slo2 K+ channel closure.

Giese MH, Gardner A, Hansen A, Sanguinetti MC.

J Physiol. 2017 Apr 1;595(7):2321-2336. doi: 10.1113/JP273225. Epub 2016 Dec 2.


Ginsenoside Rg3, a Gating Modifier of EAG Family K+ Channels.

Wu W, Gardner A, Sachse FB, Sanguinetti MC.

Mol Pharmacol. 2016 Oct;90(4):469-82. doi: 10.1124/mol.116.104091. Epub 2016 Aug 8.


Molecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology.

Wu W, Sanguinetti MC.

Card Electrophysiol Clin. 2016 Jun;8(2):275-84. doi: 10.1016/j.ccep.2016.01.002. Epub 2016 Mar 18. Review.


Hydrophobic interactions between the S5 segment and the pore helix stabilizes the closed state of Slo2.1 potassium channels.

Suzuki T, Hansen A, Sanguinetti MC.

Biochim Biophys Acta. 2016 Apr;1858(4):783-92. doi: 10.1016/j.bbamem.2015.12.024. Epub 2015 Dec 23.


Identification of the Intracellular Na+ Sensor in Slo2.1 Potassium Channels.

Thomson SJ, Hansen A, Sanguinetti MC.

J Biol Chem. 2015 Jun 5;290(23):14528-35. doi: 10.1074/jbc.M115.653089. Epub 2015 Apr 22.


C-Linker Accounts for Differential Sensitivity of ERG1 and ERG2 K+ Channels to RPR260243-Induced Slow Deactivation.

Gardner A, Sanguinetti MC.

Mol Pharmacol. 2015 Jul;88(1):19-28. doi: 10.1124/mol.115.098384. Epub 2015 Apr 17.


The Link between Inactivation and High-Affinity Block of hERG1 Channels.

Wu W, Gardner A, Sanguinetti MC.

Mol Pharmacol. 2015 Jun;87(6):1042-50. doi: 10.1124/mol.115.098111. Epub 2015 Apr 8.


Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243.

Wu W, Gardner A, Sanguinetti MC.

Mol Pharmacol. 2015;87(3):401-9. doi: 10.1124/mol.114.096693. Epub 2014 Dec 17.


Intracellular ATP does not inhibit Slo2.1 K+ channels.

Garg P, Sanguinetti MC.

Physiol Rep. 2014 Sep 11;2(9). pii: e12118. doi: 10.14814/phy2.12118. Print 2014 Sep 1.


Cooperative subunit interactions mediate fast C-type inactivation of hERG1 K+ channels.

Wu W, Gardner A, Sanguinetti MC.

J Physiol. 2014 Oct 15;592(20):4465-80. doi: 10.1113/jphysiol.2014.277483. Epub 2014 Jul 25.


Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channels.

Thomson SJ, Hansen A, Sanguinetti MC.

J Biol Chem. 2014 Aug 22;289(34):23428-36. doi: 10.1074/jbc.M114.582437. Epub 2014 Jul 9. Retraction in: J Biol Chem. 2016 Oct 7;291(41):21423.


HERG1 channel agonists and cardiac arrhythmia.

Sanguinetti MC.

Curr Opin Pharmacol. 2014 Apr;15:22-7. doi: 10.1016/j.coph.2013.11.006. Epub 2013 Nov 27. Review.


Stoichiometry of altered hERG1 channel gating by small molecule activators.

Wu W, Sachse FB, Gardner A, Sanguinetti MC.

J Gen Physiol. 2014 Apr;143(4):499-512. doi: 10.1085/jgp.201311038. Epub 2014 Mar 17.


Structural basis of ion permeation gating in Slo2.1 K+ channels.

Garg P, Gardner A, Garg V, Sanguinetti MC.

J Gen Physiol. 2013 Nov;142(5):523-42. doi: 10.1085/jgp.201311064.


Side pockets provide the basis for a new mechanism of Kv channel-specific inhibition.

Marzian S, Stansfeld PJ, Rapedius M, Rinné S, Nematian-Ardestani E, Abbruzzese JL, Steinmeyer K, Sansom MS, Sanguinetti MC, Baukrowitz T, Decher N.

Nat Chem Biol. 2013 Aug;9(8):507-13. doi: 10.1038/nchembio.1271. Epub 2013 Jun 2.


ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels.

Garg V, Stary-Weinzinger A, Sanguinetti MC.

Mol Pharmacol. 2013 Apr;83(4):805-13. doi: 10.1124/mol.112.084384. Epub 2013 Jan 14.


Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule.

Garg V, Sachse FB, Sanguinetti MC.

J Gen Physiol. 2012 Sep;140(3):307-24. doi: 10.1085/jgp.201210826.


Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels.

Twiner MJ, Doucette GJ, Rasky A, Huang XP, Roth BL, Sanguinetti MC.

Chem Res Toxicol. 2012 Sep 17;25(9):1975-84. doi: 10.1021/tx300283t. Epub 2012 Aug 10.


Structure-activity relationship of fenamates as Slo2.1 channel activators.

Garg P, Sanguinetti MC.

Mol Pharmacol. 2012 Nov;82(5):795-802. doi: 10.1124/mol.112.079194. Epub 2012 Jul 31.


Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide.

Garg V, Stary-Weinzinger A, Sachse F, Sanguinetti MC.

Mol Pharmacol. 2011 Oct;80(4):630-7. doi: 10.1124/mol.111.073809. Epub 2011 Jul 8.


Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643.

Grunnet M, Abbruzzese J, Sachse FB, Sanguinetti MC.

Mol Pharmacol. 2011 Jan;79(1):1-9. doi: 10.1124/mol.110.067728. Epub 2010 Sep 27.


Modification of hERG1 channel gating by Cd2+.

Abbruzzese J, Sachse FB, Tristani-Firouzi M, Sanguinetti MC.

J Gen Physiol. 2010 Aug;136(2):203-24. doi: 10.1085/jgp.201010450.


HERG1 channelopathies.

Sanguinetti MC.

Pflugers Arch. 2010 Jul;460(2):265-76. doi: 10.1007/s00424-009-0758-8. Epub 2009 Nov 22. Review.


Molecular determinants of Kv1.5 channel block by diphenyl phosphine oxide-1.

Du YM, Zhang XX, Tu DN, Zhao N, Liu YJ, Xiao H, Sanguinetti MC, Zou A, Liao YH.

J Mol Cell Cardiol. 2010 Jun;48(6):1111-20. doi: 10.1016/j.yjmcc.2010.02.010. Epub 2010 Feb 23.


Activation of Slo2.1 channels by niflumic acid.

Dai L, Garg V, Sanguinetti MC.

J Gen Physiol. 2010 Mar;135(3):275-95. doi: 10.1085/jgp.200910316.


PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance.

Perry M, Sachse FB, Abbruzzese J, Sanguinetti MC.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20075-80. doi: 10.1073/pnas.0906597106. Epub 2009 Nov 5.


Niflumic acid alters gating of HCN2 pacemaker channels by interaction with the outer region of S4 voltage sensing domains.

Cheng L, Sanguinetti MC.

Mol Pharmacol. 2009 May;75(5):1210-21. doi: 10.1124/mol.108.054437. Epub 2009 Feb 13.


A highly conserved alanine in the S6 domain of the hERG1 K+ channel is required for normal gating.

Brown S, Sonntag DP, Sanguinetti MC.

Cell Physiol Biochem. 2008;22(5-6):601-10. doi: 10.1159/000185544. Epub 2008 Dec 9.


Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channels.

Seebohm G, Strutz-Seebohm N, Ureche ON, Henrion U, Baltaev R, Mack AF, Korniychuk G, Steinke K, Tapken D, Pfeufer A, Kääb S, Bucci C, Attali B, Merot J, Tavare JM, Hoppe UC, Sanguinetti MC, Lang F.

Circ Res. 2008 Dec 5;103(12):1451-7. doi: 10.1161/CIRCRESAHA.108.177360. Epub 2008 Nov 13.


Structural determinants of Kvbeta1.3-induced channel inactivation: a hairpin modulated by PIP2.

Decher N, Gonzalez T, Streit AK, Sachse FB, Renigunta V, Soom M, Heinemann SH, Daut J, Sanguinetti MC.

EMBO J. 2008 Dec 3;27(23):3164-74. doi: 10.1038/emboj.2008.231. Epub 2008 Nov 6.


Molecular determinants of hERG channel block by terfenadine and cisapride.

Kamiya K, Niwa R, Morishima M, Honjo H, Sanguinetti MC.

J Pharmacol Sci. 2008 Nov;108(3):301-7. Epub 2008 Nov 6.


Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channels.

Restier L, Cheng L, Sanguinetti MC.

J Physiol. 2008 Sep 1;586(17):4179-91. doi: 10.1113/jphysiol.2008.157511. Epub 2008 Jul 3.


Structural basis for ether-a-go-go-related gene K+ channel subtype-dependent activation by niflumic acid.

Fernandez D, Sargent J, Sachse FB, Sanguinetti MC.

Mol Pharmacol. 2008 Apr;73(4):1159-67. doi: 10.1124/mol.107.043505. Epub 2008 Jan 24.


Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels.

Piper DR, Rupp J, Sachse FB, Sanguinetti MC, Tristani-Firouzi M.

Cell Physiol Biochem. 2008;21(1-3):37-46. doi: 10.1159/000113745. Epub 2008 Jan 16.


Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.

Perry M, Sachse FB, Sanguinetti MC.

Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13827-32. Epub 2007 Aug 10.


Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels.

Cheng L, Kinard K, Rajamani R, Sanguinetti MC.

J Pharmacol Exp Ther. 2007 Sep;322(3):931-9. Epub 2007 Jun 19.


Impaired interaction between the slide helix and the C-terminus of Kir2.1: a novel mechanism of Andersen syndrome.

Decher N, Renigunta V, Zuzarte M, Soom M, Heinemann SH, Timothy KW, Keating MT, Daut J, Sanguinetti MC, Splawski I.

Cardiovasc Res. 2007 Sep 1;75(4):748-57. Epub 2007 May 10.


Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels.

Seebohm G, Strutz-Seebohm N, Birkin R, Dell G, Bucci C, Spinosa MR, Baltaev R, Mack AF, Korniychuk G, Choudhury A, Marks D, Pagano RE, Attali B, Pfeufer A, Kass RS, Sanguinetti MC, Tavare JM, Lang F.

Circ Res. 2007 Mar 16;100(5):686-92. Epub 2007 Feb 9.


Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death.

Antzelevitch C, Pollevick GD, Cordeiro JM, Casis O, Sanguinetti MC, Aizawa Y, Guerchicoff A, Pfeiffer R, Oliva A, Wollnik B, Gelber P, Bonaros EP Jr, Burashnikov E, Wu Y, Sargent JD, Schickel S, Oberheiden R, Bhatia A, Hsu LF, Haïssaguerre M, Schimpf R, Borggrefe M, Wolpert C.

Circulation. 2007 Jan 30;115(4):442-9. Epub 2007 Jan 15.


Binding site of a novel Kv1.5 blocker: a "foot in the door" against atrial fibrillation.

Decher N, Kumar P, Gonzalez T, Pirard B, Sanguinetti MC.

Mol Pharmacol. 2006 Oct;70(4):1204-11. Epub 2006 Jul 11.


hERG potassium channels and cardiac arrhythmia.

Sanguinetti MC, Tristani-Firouzi M.

Nature. 2006 Mar 23;440(7083):463-9. Review.


Molecular determinants of HERG channel block.

Kamiya K, Niwa R, Mitcheson JS, Sanguinetti MC.

Mol Pharmacol. 2006 May;69(5):1709-16. Epub 2006 Feb 10.


International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.

Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X.

Pharmacol Rev. 2005 Dec;57(4):473-508. Review. No abstract available.


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