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Paclitaxel-loaded biodegradable ROS-sensitive nanoparticles for cancer therapy.

Pandya AD, Jäger E, Bagheri Fam S, Höcherl A, Jäger A, Sincari V, Nyström B, Štěpánek P, Skotland T, Sandvig K, Hrubý M, Mælandsmo GM.

Int J Nanomedicine. 2019 Aug 6;14:6269-6285. doi: 10.2147/IJN.S208938. eCollection 2019.


The role of PS 18:0/18:1 in membrane function.

Skotland T, Sandvig K.

Nat Commun. 2019 Jun 21;10(1):2752. doi: 10.1038/s41467-019-10711-1. Review.


Intracellular Transport and Cytotoxicity of the Protein Toxin Ricin.

Sowa-Rogozińska N, Sominka H, Nowakowska-Gołacka J, Sandvig K, Słomińska-Wojewódzka M.

Toxins (Basel). 2019 Jun 18;11(6). pii: E350. doi: 10.3390/toxins11060350. Review.


Small variations in nanoparticle structure dictate differential cellular stress responses and mode of cell death.

Szwed M, Sønstevold T, Øverbye A, Engedal N, Grallert B, Mørch Ý, Sulheim E, Iversen TG, Skotland T, Sandvig K, Torgersen ML.

Nanotoxicology. 2019 Aug;13(6):761-782. doi: 10.1080/17435390.2019.1576238. Epub 2019 Feb 14.


Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft.

Fusser M, Øverbye A, Pandya AD, Mørch Ý, Borgos SE, Kildal W, Snipstad S, Sulheim E, Fleten KG, Askautrud HA, Engebraaten O, Flatmark K, Iversen TG, Sandvig K, Skotland T, Mælandsmo GM.

J Control Release. 2019 Jan 10;293:183-192. doi: 10.1016/j.jconrel.2018.11.029. Epub 2018 Dec 4.


Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology.

Skotland T, Hessvik NP, Sandvig K, Llorente A.

J Lipid Res. 2019 Jan;60(1):9-18. doi: 10.1194/jlr.R084343. Epub 2018 Aug 3.


Clathrin-independent endocytosis: an increasing degree of complexity.

Sandvig K, Kavaliauskiene S, Skotland T.

Histochem Cell Biol. 2018 Aug;150(2):107-118. doi: 10.1007/s00418-018-1678-5. Epub 2018 May 17. Review.


Cytotoxicity of Poly(Alkyl Cyanoacrylate) Nanoparticles.

Sulheim E, Iversen TG, To Nakstad V, Klinkenberg G, Sletta H, Schmid R, Hatletveit AR, Wågbø AM, Sundan A, Skotland T, Sandvig K, Mørch Ý.

Int J Mol Sci. 2017 Nov 18;18(11). pii: E2454. doi: 10.3390/ijms18112454.


Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide.

Øverbye A, Holsæter AM, Markus F, Škalko-Basnet N, Iversen TG, Torgersen ML, Sønstevold T, Engebraaten O, Flatmark K, Mælandsmo GM, Skotland T, Sandvig K.

Oncotarget. 2017 Aug 12;8(44):76921-76934. doi: 10.18632/oncotarget.20217. eCollection 2017 Sep 29.


Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes.

Rodríguez M, Bajo-Santos C, Hessvik NP, Lorenz S, Fromm B, Berge V, Sandvig K, Linē A, Llorente A.

Mol Cancer. 2017 Oct 5;16(1):156. doi: 10.1186/s12943-017-0726-4.


A vital sugar code for ricin toxicity.

Taubenschmid J, Stadlmann J, Jost M, Klokk TI, Rillahan CD, Leibbrandt A, Mechtler K, Paulson JC, Jude J, Zuber J, Sandvig K, Elling U, Marquardt T, Thiel C, Koerner C, Penninger JM.

Cell Res. 2017 Nov;27(11):1351-1364. doi: 10.1038/cr.2017.116. Epub 2017 Sep 19.


Size and concentration analyses of extracellular vesicles by nanoparticle tracking analysis: a variation study.

Vestad B, Llorente A, Neurauter A, Phuyal S, Kierulf B, Kierulf P, Skotland T, Sandvig K, Haug KBF, Øvstebø R.

J Extracell Vesicles. 2017 Jul 19;6(1):1344087. doi: 10.1080/20013078.2017.1344087. eCollection 2017.


Benzyl alcohol induces a reversible fragmentation of the Golgi apparatus and inhibits membrane trafficking between endosomes and the trans-Golgi network.

Simm R, Kvalvaag AS, van Deurs B, Lindbäck T, Sandvig K.

Exp Cell Res. 2017 Aug 1;357(1):67-78. doi: 10.1016/j.yexcr.2017.04.025. Epub 2017 Apr 25.


Lipids in exosomes: Current knowledge and the way forward.

Skotland T, Sandvig K, Llorente A.

Prog Lipid Res. 2017 Apr;66:30-41. doi: 10.1016/j.plipres.2017.03.001. Epub 2017 Mar 23. Review.


Elongated and Shortened Peptidomimetic Inhibitors of the Proprotein Convertase Furin.

Hardes K, Ivanova T, Thaa B, McInerney GM, Klokk TI, Sandvig K, Künzel S, Lindberg I, Steinmetzer T.

ChemMedChem. 2017 Apr 20;12(8):613-620. doi: 10.1002/cmdc.201700108. Epub 2017 Apr 4.


Protection against Shiga Toxins.

Kavaliauskiene S, Dyve Lingelem AB, Skotland T, Sandvig K.

Toxins (Basel). 2017 Feb 3;9(2). pii: E44. doi: 10.3390/toxins9020044. Review.


Polyporus squamosus Lectin 1a (PSL1a) Exhibits Cytotoxicity in Mammalian Cells by Disruption of Focal Adhesions, Inhibition of Protein Synthesis and Induction of Apoptosis.

Manna D, Pust S, Torgersen ML, Cordara G, Künzler M, Krengel U, Sandvig K.

PLoS One. 2017 Jan 23;12(1):e0170716. doi: 10.1371/journal.pone.0170716. eCollection 2017.


Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis.

Ailte I, Lingelem AB, Kvalvaag AS, Kavaliauskiene S, Brech A, Koster G, Dommersnes PG, Bergan J, Skotland T, Sandvig K.

Traffic. 2017 Mar;18(3):176-191. doi: 10.1111/tra.12468. Epub 2017 Jan 30.


Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers.

Skotland T, Ekroos K, Kauhanen D, Simolin H, Seierstad T, Berge V, Sandvig K, Llorente A.

Eur J Cancer. 2017 Jan;70:122-132. doi: 10.1016/j.ejca.2016.10.011. Epub 2016 Nov 30.


The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport.

Torgersen ML, Klokk TI, Kavaliauskiene S, Klose C, Simons K, Skotland T, Sandvig K.

Oncotarget. 2016 Dec 27;7(52):86871-86888. doi: 10.18632/oncotarget.13508.


Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport.

Kavaliauskiene S, Torgersen ML, Lingelem AB, Klokk TI, Lintonen T, Simolin H, Ekroos K, Skotland T, Sandvig K.

Oncotarget. 2016 Nov 29;7(48):79885-79900. doi: 10.18632/oncotarget.13089.


Data including GROMACS input files for atomistic molecular dynamics simulations of mixed, asymmetric bilayers including molecular topologies, equilibrated structures, and force field for lipids compatible with OPLS-AA parameters.

Róg T, Orłowski A, Llorente A, Skotland T, Sylvänne T, Kauhanen D, Ekroos K, Sandvig K, Vattulainen I.

Data Brief. 2016 Mar 26;7:1171-1174. eCollection 2016 Jun.


Exosomal proteins as prostate cancer biomarkers in urine: From mass spectrometry discovery to immunoassay-based validation.

Wang L, Skotland T, Berge V, Sandvig K, Llorente A.

Eur J Pharm Sci. 2017 Feb 15;98:80-85. doi: 10.1016/j.ejps.2016.09.023. Epub 2016 Sep 21.


Addition of lysophospholipids with large head groups to cells inhibits Shiga toxin binding.

Ailte I, Lingelem AB, Kavaliauskiene S, Bergan J, Kvalvaag AS, Myrann AG, Skotland T, Sandvig K.

Sci Rep. 2016 Jul 26;6:30336. doi: 10.1038/srep30336.


PIKfyve inhibition increases exosome release and induces secretory autophagy.

Hessvik NP, Øverbye A, Brech A, Torgersen ML, Jakobsen IS, Sandvig K, Llorente A.

Cell Mol Life Sci. 2016 Dec;73(24):4717-4737. Epub 2016 Jul 20.


Determining the Turnover of Glycosphingolipid Species by Stable-Isotope Tracer Lipidomics.

Skotland T, Ekroos K, Kavaliauskiene S, Bergan J, Kauhanen D, Lintonen T, Sandvig K.

J Mol Biol. 2016 Dec 4;428(24 Pt A):4856-4866. doi: 10.1016/j.jmb.2016.06.013. Epub 2016 Jun 27.


A Bispecific Antibody Promotes Aggregation of Ricin Toxin on Cell Surfaces and Alters Dynamics of Toxin Internalization and Trafficking.

Herrera C, Klokk TI, Cole R, Sandvig K, Mantis NJ.

PLoS One. 2016 Jun 14;11(6):e0156893. doi: 10.1371/journal.pone.0156893. eCollection 2016.


Regulation of ErbB2 localization and function in breast cancer cells by ERM proteins.

Asp N, Kvalvaag A, Sandvig K, Pust S.

Oncotarget. 2016 May 3;7(18):25443-60. doi: 10.18632/oncotarget.8327.


Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin's Enzymatic Subunit Interfere with Intracellular Toxin Transport.

Yermakova A, Klokk TI, O'Hara JM, Cole R, Sandvig K, Mantis NJ.

Sci Rep. 2016 Mar 7;6:22721. doi: 10.1038/srep22721.


Interdigitation of long-chain sphingomyelin induces coupling of membrane leaflets in a cholesterol dependent manner.

Róg T, Orłowski A, Llorente A, Skotland T, Sylvänne T, Kauhanen D, Ekroos K, Sandvig K, Vattulainen I.

Biochim Biophys Acta. 2016 Feb;1858(2):281-8. doi: 10.1016/j.bbamem.2015.12.003. Epub 2015 Dec 2.


Different roles of the C-terminal end of Stx1A and Stx2A for AB5 complex integrity and retrograde transport of Stx in HeLa cells.

Kymre L, Simm R, Skotland T, Sandvig K.

Pathog Dis. 2015 Dec;73(9):ftv083. doi: 10.1093/femspd/ftv083. Epub 2015 Oct 5.


Cross-linking of glycosphingolipids at the plasma membrane: consequences for intracellular signaling and traffic.

Klokk TI, Kavaliauskiene S, Sandvig K.

Cell Mol Life Sci. 2016 Mar;73(6):1301-16. doi: 10.1007/s00018-015-2049-1. Epub 2015 Sep 25.


Novel actions of 2-deoxy-D-glucose: protection against Shiga toxins and changes in cellular lipids.

Kavaliauskiene S, Skotland T, Sylvänne T, Simolin H, Klokk TI, Torgersen ML, Lingelem AB, Simm R, Ekroos K, Sandvig K.

Biochem J. 2015 Aug 15;470(1):23-37. doi: 10.1042/BJ20141562. Epub 2015 Jun 11.


Cell-penetrating peptides: possibilities and challenges for drug delivery in vitro and in vivo.

Skotland T, Iversen TG, Torgersen ML, Sandvig K.

Molecules. 2015 Jul 22;20(7):13313-23. doi: 10.3390/molecules200713313. Review.


Identification of prostate cancer biomarkers in urinary exosomes.

Øverbye A, Skotland T, Koehler CJ, Thiede B, Seierstad T, Berge V, Sandvig K, Llorente A.

Oncotarget. 2015 Oct 6;6(30):30357-76. doi: 10.18632/oncotarget.4851.


The Role of Lectin-Carbohydrate Interactions in the Regulation of ER-Associated Protein Degradation.

Słomińska-Wojewódzka M, Sandvig K.

Molecules. 2015 May 27;20(6):9816-46. doi: 10.3390/molecules20069816. Review.


Geldanamycin Enhances Retrograde Transport of Shiga Toxin in HEp-2 Cells.

Dyve Lingelem AB, Hjelseth IA, Simm R, Torgersen ML, Sandvig K.

PLoS One. 2015 May 27;10(5):e0129214. doi: 10.1371/journal.pone.0129214. eCollection 2015.


Novel Furin Inhibitors with Potent Anti-infectious Activity.

Hardes K, Becker GL, Lu Y, Dahms SO, Köhler S, Beyer W, Sandvig K, Yamamoto H, Lindberg I, Walz L, von Messling V, Than ME, Garten W, Steinmetzer T.

ChemMedChem. 2015 Jul;10(7):1218-31. doi: 10.1002/cmdc.201500103. Epub 2015 May 14.


Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells.

Sokołowska I, Piłka ES, Sandvig K, Węgrzyn G, Słomińska-Wojewódzka M.

BMC Cell Biol. 2015 Feb 6;16:1. doi: 10.1186/s12860-015-0047-7.


The ether lipid precursor hexadecylglycerol stimulates the release and changes the composition of exosomes derived from PC-3 cells.

Phuyal S, Skotland T, Hessvik NP, Simolin H, Øverbye A, Brech A, Parton RG, Ekroos K, Sandvig K, Llorente A.

J Biol Chem. 2015 Feb 13;290(7):4225-37. doi: 10.1074/jbc.M114.593962. Epub 2014 Dec 17.


LYST affects lysosome size and quantity, but not trafficking or degradation through autophagy or endocytosis.

Holland P, Torgersen ML, Sandvig K, Simonsen A.

Traffic. 2014 Dec;15(12):1390-405. doi: 10.1111/tra.12227. Epub 2014 Oct 8.


Development of nanoparticles for clinical use.

Skotland T, Iversen TG, Sandvig K.

Nanomedicine (Lond). 2014 Jul;9(9):1295-9. doi: 10.2217/nnm.14.81. No abstract available.


Vps11, a subunit of the tethering complexes HOPS and CORVET, is involved in regulation of glycolipid degradation and retrograde toxin transport.

Kvalvaag AS, Pust S, Sandvig K.

Commun Integr Biol. 2014 Jan 1;7(1):e28129. doi: 10.4161/cib.28129. Epub 2014 Apr 3.


Flotillin depletion affects ErbB protein levels in different human breast cancer cells.

Asp N, Pust S, Sandvig K.

Biochim Biophys Acta. 2014 Sep;1843(9):1987-96. doi: 10.1016/j.bbamcr.2014.04.013. Epub 2014 Apr 18.


The fungal chimerolectin MOA inhibits protein and DNA synthesis in NIH/3T3 cells and may induce BAX-mediated apoptosis.

Cordara G, Winter HC, Goldstein IJ, Krengel U, Sandvig K.

Biochem Biophys Res Commun. 2014 May 16;447(4):586-9. doi: 10.1016/j.bbrc.2014.04.043. Epub 2014 Apr 18.


The ether lipid precursor hexadecylglycerol protects against Shiga toxins.

Bergan J, Skotland T, Lingelem AB, Simm R, Spilsberg B, Lindbäck T, Sylvänne T, Simolin H, Ekroos K, Sandvig K.

Cell Mol Life Sci. 2014 Nov;71(21):4285-300. doi: 10.1007/s00018-014-1624-1. Epub 2014 Apr 18.


Antibody-mediated inhibition of ricin toxin retrograde transport.

Yermakova A, Klokk TI, Cole R, Sandvig K, Mantis NJ.

MBio. 2014 Apr 8;5(2):e00995. doi: 10.1128/mBio.00995-13.


Regulation of exosome release by glycosphingolipids and flotillins.

Phuyal S, Hessvik NP, Skotland T, Sandvig K, Llorente A.

FEBS J. 2014 May;281(9):2214-27. doi: 10.1111/febs.12775. Epub 2014 Mar 21.


Lipid requirements for entry of protein toxins into cells.

Sandvig K, Bergan J, Kavaliauskiene S, Skotland T.

Prog Lipid Res. 2014 Apr;54:1-13. doi: 10.1016/j.plipres.2014.01.001. Epub 2014 Jan 23. Review.


The role of EDEM2 compared with EDEM1 in ricin transport from the endoplasmic reticulum to the cytosol.

Słomińska-Wojewódzka M, Pawlik A, Sokołowska I, Antoniewicz J, Węgrzyn G, Sandvig K.

Biochem J. 2014 Feb 1;457(3):485-96. doi: 10.1042/BJ20130155.


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