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Ketotifen Modulates Mast Cell Chemotaxis to Kit-Ligand but Does Not Impact Mast Cell Numbers, Degranulation, or Tumor Behavior in Neurofibromas of Nf1-Deficient Mice.

Burks CA, Rhodes SD, Bessler WK, Chen S, Smith A, Gehlhausen JR, Hawley ET, Jiang L, Li X, Yuan J, Lu Q, Jacobsen M, Sandusky GE, Jones DR, Clapp DW, Blakeley JO.

Mol Cancer Ther. 2019 Sep 16. pii: molcanther.0123.2019. doi: 10.1158/1535-7163.MCT-19-0123. [Epub ahead of print]


Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer.

Demas DM, Demo S, Fallah Y, Clarke R, Nephew KP, Althouse S, Sandusky G, He W, Shajahan-Haq AN.

Front Oncol. 2019 Aug 2;9:686. doi: 10.3389/fonc.2019.00686. eCollection 2019.


Anti-tumor activity and mechanistic characterization of APE1/Ref-1 inhibitors in bladder cancer.

Fishel ML, Xia H, McGeown J, McIlwain DW, Elbanna M, Craft AA, Kaimakliotis HZ, Sandusky GE, Zhang C, Pili R, Kelley MR, Jerde TJ.

Mol Cancer Ther. 2019 Aug 14. pii: molcanther.1166.2018. doi: 10.1158/1535-7163.MCT-18-1166. [Epub ahead of print]


The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy.

Zhong X, Pons M, Poirier C, Jiang Y, Liu J, Sandusky GE, Shahda S, Nakeeb A, Schmidt CM, House MG, Ceppa EP, Zyromski NJ, Liu Y, Jiang G, Couch ME, Koniaris LG, Zimmers TA.

J Cachexia Sarcopenia Muscle. 2019 Jul 8. doi: 10.1002/jcsm.12461. [Epub ahead of print]


Cdkn2a (Arf) loss drives NF1-associated atypical neurofibroma and malignant transformation.

Rhodes SD, He Y, Smith A, Jiang L, Lu Q, Mund J, Li X, Bessler W, Qian S, Dyer W, Sandusky GE, Horvai AE, Armstrong AE, Clapp DW.

Hum Mol Genet. 2019 Aug 15;28(16):2752-2762. doi: 10.1093/hmg/ddz095.


Dual TGFβ/BMP Pathway Inhibition Enables Expansion and Characterization of Multiple Epithelial Cell Types of the Normal and Cancerous Breast.

Prasad M, Kumar B, Bhat-Nakshatri P, Anjanappa M, Sandusky G, Miller KD, Storniolo AM, Nakshatri H.

Mol Cancer Res. 2019 Jul;17(7):1556-1570. doi: 10.1158/1541-7786.MCR-19-0165. Epub 2019 Apr 16.


The FATZO mouse, a next generation model of type 2 diabetes, develops NAFLD and NASH when fed a Western diet supplemented with fructose.

Sun G, Jackson CV, Zimmerman K, Zhang LK, Finnearty CM, Sandusky GE, Zhang G, Peterson RG, Wang YJ.

BMC Gastroenterol. 2019 Mar 18;19(1):41. doi: 10.1186/s12876-019-0958-4.


Genetic Ancestry-dependent Differences in Breast Cancer-induced Field Defects in the Tumor-adjacent Normal Breast.

Nakshatri H, Kumar B, Burney HN, Cox ML, Jacobsen M, Sandusky GE, D'Souza-Schorey C, Storniolo AMV.

Clin Cancer Res. 2019 May 1;25(9):2848-2859. doi: 10.1158/1078-0432.CCR-18-3427. Epub 2019 Feb 4.


Identification of LIMK2 as a therapeutic target in castration resistant prostate cancer.

Nikhil K, Chang L, Viccaro K, Jacobsen M, McGuire C, Satapathy SR, Tandiary M, Broman MM, Cresswell G, He YJ, Sandusky GE, Ratliff TL, Chowdhury D, Shah K.

Cancer Lett. 2019 Apr 28;448:182-196. doi: 10.1016/j.canlet.2019.01.035. Epub 2019 Feb 1.


Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development.

Nabinger SC, Chen S, Gao R, Yao C, Kobayashi M, Vemula S, Fahey AC, Wang C, Daniels C, Boswell HS, Sandusky GE, Mayo LD, Kapur R, Liu Y.

Leukemia. 2019 Jun;33(6):1535-1539. doi: 10.1038/s41375-019-0377-0. Epub 2019 Jan 23. No abstract available.


XPC protects against smoking- and carcinogen-induced lung adenocarcinoma.

Zhou H, Saliba J, Sandusky GE, Sears CR.

Carcinogenesis. 2019 May 14;40(3):403-411. doi: 10.1093/carcin/bgz003.


Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis.

Cai Z, Kotzin JJ, Ramdas B, Chen S, Nelanuthala S, Palam LR, Pandey R, Mali RS, Liu Y, Kelley MR, Sandusky G, Mohseni M, Williams A, Henao-Mejia J, Kapur R.

Cell Stem Cell. 2018 Dec 6;23(6):833-849.e5. doi: 10.1016/j.stem.2018.10.013.


Correction: Type V Collagen Induced Tolerance Suppresses Collagen Deposition, TGF-β and Associated Transcripts in Pulmonary Fibrosis.

Vittal R, Mickler EA, Fisher AJ, Zhang C, Rothhaar K, Gu H, Brown KM, Emtiazjoo A, Lott JM, Frye SB, Smith GN, Sandusky GE, Cummings OW, Wilkes DS.

PLoS One. 2018 Dec 6;13(12):e0209107. doi: 10.1371/journal.pone.0209107. eCollection 2018.


Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14.

Sishtla K, Pitt N, Shadmand M, O'Hare MN, Sulaiman RS, Sinn AL, Condon K, Pollok KE, Sandusky GE, Corson TW.

Sci Rep. 2018 Nov 1;8(1):16152. doi: 10.1038/s41598-018-34603-4.


A proteasome-resistant fragment of NIK mediates oncogenic NF-κB signaling in schwannomas.

Gehlhausen JR, Hawley E, Wahle BM, He Y, Edwards D, Rhodes SD, Lajiness JD, Staser K, Chen S, Yang X, Yuan J, Li X, Jiang L, Smith A, Bessler W, Sandusky G, Stemmer-Rachamimov A, Stuhlmiller TJ, Angus SP, Johnson GL, Nalepa G, Yates CW, Wade Clapp D, Park SJ.

Hum Mol Genet. 2019 Feb 15;28(4):572-583. doi: 10.1093/hmg/ddy361.


Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival.

Logsdon DP, Shah F, Carta F, Supuran CT, Kamocka M, Jacobsen MH, Sandusky GE, Kelley MR, Fishel ML.

Sci Rep. 2018 Sep 13;8(1):13759. doi: 10.1038/s41598-018-32034-9.


Melanoma LAMP-2C Modulates Tumor Growth and Autophagy.

Pérez L, Sinn AL, Sandusky GE, Pollok KE, Blum JS.

Front Cell Dev Biol. 2018 Aug 29;6:101. doi: 10.3389/fcell.2018.00101. eCollection 2018.


High-speed Intraoperative Assessment of Breast Tumor Margins by Multimodal Ultrasound and Photoacoustic Tomography.

Li R, Lan L, Xia Y, Wang P, Han LK, Dunnington GL, Obeng-Gyasi S, Sandusky GE, Medley JA, Crook ST, Cheng JX.

Med Devices Sens. 2018 Jun;1(3). pii: e10018. doi: 10.1002/mds3.10018. Epub 2018 Oct 26.


Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis.

Padua MB, Bhat-Nakshatri P, Anjanappa M, Prasad MS, Hao Y, Rao X, Liu S, Wan J, Liu Y, McElyea K, Jacobsen M, Sandusky G, Althouse S, Perkins S, Nakshatri H.

Breast Cancer Res. 2018 May 2;20(1):35. doi: 10.1186/s13058-018-0963-5.


Toll-like receptor 3 (TLR3) promotes the resolution of Chlamydia muridarum genital tract infection in congenic C57BL/6N mice.

Carrasco SE, Hu S, Imai DM, Kumar R, Sandusky GE, Yang XF, Derbigny WA.

PLoS One. 2018 Apr 6;13(4):e0195165. doi: 10.1371/journal.pone.0195165. eCollection 2018.


Safety and Efficacy of AAV Retrograde Pancreatic Ductal Gene Delivery in Normal and Pancreatic Cancer Mice.

Quirin KA, Kwon JJ, Alioufi A, Factora T, Temm CJ, Jacobsen M, Sandusky GE, Shontz K, Chicoine LG, Clark KR, Mendell JT, Korc M, Kota J.

Mol Ther Methods Clin Dev. 2017 Sep 30;8:8-20. doi: 10.1016/j.omtm.2017.09.006. eCollection 2018 Mar 16.


Pharmacological Dual Inhibition of Tumor and Tumor-Induced Functional Limitations in a Transgenic Model of Breast Cancer.

Wang R, Bhat-Nakshatri P, Padua MB, Prasad MS, Anjanappa M, Jacobson M, Finnearty C, Sefcsik V, McElyea K, Redmond R, Sandusky G, Penthala N, Crooks PA, Liu J, Zimmers T, Nakshatri H.

Mol Cancer Ther. 2017 Dec;16(12):2747-2758. doi: 10.1158/1535-7163.MCT-17-0717. Epub 2017 Oct 4.


Polo-like kinase 1 (Plk1) overexpression enhances ionizing radiation-induced cancer formation in mice.

Li Z, Liu J, Li J, Kong Y, Sandusky G, Rao X, Liu Y, Wan J, Liu X.

J Biol Chem. 2017 Oct 20;292(42):17461-17472. doi: 10.1074/jbc.M117.810960. Epub 2017 Sep 12.


Precision medicine for suicidality: from universality to subtypes and personalization.

Niculescu AB, Le-Niculescu H, Levey DF, Phalen PL, Dainton HL, Roseberry K, Niculescu EM, Niezer JO, Williams A, Graham DL, Jones TJ, Venugopal V, Ballew A, Yard M, Gelbart T, Kurian SM, Shekhar A, Schork NJ, Sandusky GE, Salomon DR.

Mol Psychiatry. 2017 Sep;22(9):1250-1273. doi: 10.1038/mp.2017.128. Epub 2017 Aug 15.


Early-Stage Metastasis Requires Mdm2 and Not p53 Gain of Function.

Hauck PM, Wolf ER, Olivos DJ 3rd, Batuello CN, McElyea KC, McAtarsney CP, Cournoyer RM, Sandusky GE, Mayo LD.

Mol Cancer Res. 2017 Nov;15(11):1598-1607. doi: 10.1158/1541-7786.MCR-17-0174. Epub 2017 Aug 7.


Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers.

Prabhu L, Wei H, Chen L, Demir Ö, Sandusky G, Sun E, Wang J, Mo J, Zeng L, Fishel M, Safa A, Amaro R, Korc M, Zhang ZY, Lu T.

Oncotarget. 2017 Jun 20;8(25):39963-39977. doi: 10.18632/oncotarget.18102.


Individualized Breast Cancer Characterization through Single-Cell Analysis of Tumor and Adjacent Normal Cells.

Anjanappa M, Cardoso A, Cheng L, Mohamad S, Gunawan A, Rice S, Dong Y, Li L, Sandusky GE, Srour EF, Nakshatri H.

Cancer Res. 2017 May 15;77(10):2759-2769. doi: 10.1158/0008-5472.CAN-16-3308. Epub 2017 Mar 1.


BreastDefend enhances effect of tamoxifen in estrogen receptor-positive human breast cancer in vitro and in vivo.

Cheng S, Castillo V, Welty M, Alvarado M, Eliaz I, Temm CJ, Sandusky GE, Sliva D.

BMC Complement Altern Med. 2017 Feb 16;17(1):115. doi: 10.1186/s12906-017-1621-7.


The Aurora-A-Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma.

Wang J, Nikhil K, Viccaro K, Chang L, Jacobsen M, Sandusky G, Shah K.

J Cell Sci. 2017 Mar 15;130(6):1078-1093. doi: 10.1242/jcs.196790. Epub 2017 Feb 6.


Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine.

Albany C, Hever-Jardine MP, von Herrmann KM, Yim CY, Tam J, Warzecha JM, Shin L, Bock SE, Curran BS, Chaudhry AS, Kim F, Sandusky GE, Taverna P, Freemantle SJ, Christensen BC, Einhorn LH, Spinella MJ.

Oncotarget. 2017 Jan 10;8(2):2949-2959. doi: 10.18632/oncotarget.13811.


A Phase II Trial of Dovitinib in BCG-Unresponsive Urothelial Carcinoma with FGFR3 Mutations or Overexpression: Hoosier Cancer Research Network Trial HCRN 12-157.

Hahn NM, Bivalacqua TJ, Ross AE, Netto GJ, Baras A, Park JC, Chapman C, Masterson TA, Koch MO, Bihrle R, Foster RS, Gardner TA, Cheng L, Jones DR, McElyea K, Sandusky GE, Breen T, Liu Z, Albany C, Moore ML, Loman RL, Reed A, Turner SA, De Abreu FB, Gallagher T, Tsongalis GJ, Plimack ER, Greenberg RE, Geynisman DM.

Clin Cancer Res. 2017 Jun 15;23(12):3003-3011. doi: 10.1158/1078-0432.CCR-16-2267. Epub 2016 Dec 8.


Novel Use of Folate-Targeted Intraoperative Fluorescence, OTL38, in Robot-Assisted Laparoscopic Partial Nephrectomy: Report of the First Three Cases.

Shum CF, Bahler CD, Low PS, Ratliff TL, Kheyfets SV, Natarajan JP, Sandusky GE, Sundaram CP.

J Endourol Case Rep. 2016 Nov 1;2(1):189-197. eCollection 2016.


Hypoxia-Inducible Factor-1α Regulates CD55 in Airway Epithelium.

Pandya PH, Fisher AJ, Mickler EA, Temm CJ, Lipking KP, Gracon A, Rothhaar K, Sandusky GE, Murray M, Pollok K, Renbarger J, Blum JS, Lahm T, Wilkes DS.

Am J Respir Cell Mol Biol. 2016 Dec;55(6):889-898.


Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment.

Levey DF, Niculescu EM, Le-Niculescu H, Dainton HL, Phalen PL, Ladd TB, Weber H, Belanger E, Graham DL, Khan FN, Vanipenta NP, Stage EC, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR, Niculescu AB.

Mol Psychiatry. 2016 Jun;21(6):768-85. doi: 10.1038/mp.2016.31. Epub 2016 Apr 5.


Applying Small Molecule Signal Transducer and Activator of Transcription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics.

Arpin CC, Mac S, Jiang Y, Cheng H, Grimard M, Page BD, Kamocka MM, Haftchenary S, Su H, Ball DP, Rosa DA, Lai PS, Gómez-Biagi RF, Ali AM, Rana R, Hanenberg H, Kerman K, McElyea KC, Sandusky GE, Gunning PT, Fishel ML.

Mol Cancer Ther. 2016 May;15(5):794-805. doi: 10.1158/1535-7163.MCT-15-0003. Epub 2016 Feb 12.


Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo.

Huang W, Dong Z, Chen Y, Wang F, Wang CJ, Peng H, He Y, Hangoc G, Pollok K, Sandusky G, Fu XY, Broxmeyer HE, Zhang ZY, Liu JY, Zhang JT.

Oncogene. 2016 Feb 11;35(6):802. doi: 10.1038/onc.2015.419. No abstract available.


Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model.

Tonsing-Carter E, Bailey BJ, Saadatzadeh MR, Ding J, Wang H, Sinn AL, Peterman KM, Spragins TK, Silver JM, Sprouse AA, Georgiadis TM, Gunter TZ, Long EC, Minto RE, Marchal CC, Batuello CN, Safa AR, Hanenberg H, Territo PR, Sandusky GE, Mayo LD, Eischen CM, Shannon HE, Pollok KE.

Mol Cancer Ther. 2015 Dec;14(12):2850-63. doi: 10.1158/1535-7163.MCT-15-0237. Epub 2015 Oct 22.


Outer surface protein OspC is an antiphagocytic factor that protects Borrelia burgdorferi from phagocytosis by macrophages.

Carrasco SE, Troxell B, Yang Y, Brandt SL, Li H, Sandusky GE, Condon KW, Serezani CH, Yang XF.

Infect Immun. 2015 Dec;83(12):4848-60. doi: 10.1128/IAI.01215-15. Epub 2015 Oct 5.


Delayed Effects of Acute Radiation Exposure in a Murine Model of the H-ARS: Multiple-Organ Injury Consequent to <10 Gy Total Body Irradiation.

Unthank JL, Miller SJ, Quickery AK, Ferguson EL, Wang M, Sampson CH, Chua HL, DiStasi MR, Feng H, Fisher A, Katz BP, Plett PA, Sandusky GE, Sellamuthu R, Vemula S, Cohen EP, MacVittie TJ, Orschell CM.

Health Phys. 2015 Nov;109(5):511-21. doi: 10.1097/HP.0000000000000357.


Fibrosis and hypoxia-inducible factor-1α-dependent tumors of the soft tissue on loss of von Hippel-Lindau in mesenchymal progenitors.

Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Sandusky G, Abadie J, Lyons KM, Giaccia AJ, Schipani E.

Am J Pathol. 2015 Nov;185(11):3090-101. doi: 10.1016/j.ajpath.2015.07.008. Epub 2015 Sep 6.


Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF-κB in colon cancer.

Prabhu L, Mundade R, Wang B, Wei H, Hartley AV, Martin M, McElyea K, Temm CJ, Sandusky G, Liu Y, Lu T.

Oncotarget. 2015 Oct 6;6(30):29396-412. doi: 10.18632/oncotarget.5120.


Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach.

Niculescu AB, Levey DF, Phalen PL, Le-Niculescu H, Dainton HD, Jain N, Belanger E, James A, George S, Weber H, Graham DL, Schweitzer R, Ladd TB, Learman R, Niculescu EM, Vanipenta NP, Khan FN, Mullen J, Shankar G, Cook S, Humbert C, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR.

Mol Psychiatry. 2015 Nov;20(11):1266-85. doi: 10.1038/mp.2015.112. Epub 2015 Aug 18.


TFAP2C expression in breast cancer: correlation with overall survival beyond 10 years of initial diagnosis.

Perkins SM, Bales C, Vladislav T, Althouse S, Miller KD, Sandusky G, Badve S, Nakshatri H.

Breast Cancer Res Treat. 2015 Aug;152(3):519-31. doi: 10.1007/s10549-015-3492-2. Epub 2015 Jul 10.


Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo.

Huang W, Dong Z, Chen Y, Wang F, Wang CJ, Peng H, He Y, Hangoc G, Pollok K, Sandusky G, Fu XY, Broxmeyer HE, Zhang ZY, Liu JY, Zhang JT.

Oncogene. 2016 Feb 11;35(6):783-92. doi: 10.1038/onc.2015.215. Epub 2015 Jun 15. Erratum in: Oncogene. 2016 Feb 11;35(6):802.


FGF23 is elevated in multiple myeloma and increases heparanase expression by tumor cells.

Suvannasankha A, Tompkins DR, Edwards DF, Petyaykina KV, Crean CD, Fournier PG, Parker JM, Sandusky GE, Ichikawa S, Imel EA, Chirgwin JM.

Oncotarget. 2015 Aug 14;6(23):19647-60.


Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress.

Cheng S, Swanson K, Eliaz I, McClintick JN, Sandusky GE, Sliva D.

PLoS One. 2015 Apr 27;10(4):e0122270. doi: 10.1371/journal.pone.0122270. eCollection 2015.


Assessment of folate receptor-β expression in human neoplastic tissues.

Shen J, Putt KS, Visscher DW, Murphy L, Cohen C, Singhal S, Sandusky G, Feng Y, Dimitrov DS, Low PS.

Oncotarget. 2015 Jun 10;6(16):14700-9.


Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.

Zeng Y, Broxmeyer HE, Staser K, Chitteti BR, Park SJ, Hahn S, Cooper S, Sun Z, Jiang L, Yang X, Yuan J, Kosoff R, Sandusky G, Srour EF, Chernoff J, Clapp DW.

Stem Cells. 2015 May;33(5):1630-41. doi: 10.1002/stem.1951.


Using molecular profiled human tissue to accelerate drug discovery.

Tarvin KA, Sandusky GE.

Expert Opin Drug Discov. 2014 Dec;9(12):1383-7. doi: 10.1517/17460441.2014.959926. Epub 2014 Sep 12.


The HMGB1-RAGE axis mediates traumatic brain injury-induced pulmonary dysfunction in lung transplantation.

Weber DJ, Gracon AS, Ripsch MS, Fisher AJ, Cheon BM, Pandya PH, Vittal R, Capitano ML, Kim Y, Allette YM, Riley AA, McCarthy BP, Territo PR, Hutchins GD, Broxmeyer HE, Sandusky GE, White FA, Wilkes DS.

Sci Transl Med. 2014 Sep 3;6(252):252ra124. doi: 10.1126/scitranslmed.3009443. Retraction in: Sci Transl Med. 2018 Dec 12;10(471):.

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