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The Amino Terminus of LeuT Changes Conformation in an Environment Sensitive Manner.

Khan JA, Sohail A, Jayaraman K, Szöllősi D, Sandtner W, Sitte HH, Stockner T.

Neurochem Res. 2019 Dec 19. doi: 10.1007/s11064-019-02928-9. [Epub ahead of print]


Kinetic Models of Secondary Active Transporters.

Burtscher V, Schicker K, Freissmuth M, Sandtner W.

Int J Mol Sci. 2019 Oct 28;20(21). pii: E5365. doi: 10.3390/ijms20215365.


Serotonin transport in the 21st century.

Rudnick G, Sandtner W.

J Gen Physiol. 2019 Nov 4;151(11):1248-1264. doi: 10.1085/jgp.201812066. Epub 2019 Sep 30. Review.


An Electrophysiological Approach to Measure Changes in the Membrane Surface Potential in Real Time.

Burtscher V, Hotka M, Freissmuth M, Sandtner W.

Biophys J. 2019 Jul 5. pii: S0006-3495(19)30542-9. doi: 10.1016/j.bpj.2019.06.033. [Epub ahead of print]


A comparison of the transport kinetics of glycine transporter 1 and glycine transporter 2.

Erdem FA, Ilic M, Koppensteiner P, Gołacki J, Lubec G, Freissmuth M, Sandtner W.

J Gen Physiol. 2019 Aug 5;151(8):1035-1050. doi: 10.1085/jgp.201912318. Epub 2019 Jul 3.


para-Trifluoromethyl-methcathinone is an allosteric modulator of the serotonin transporter.

Niello M, Cintulova D, Hellsberg E, Jäntsch K, Holy M, Ayatollahi LH, Cozzi NV, Freissmuth M, Sandtner W, Ecker GF, Mihovilovic MD, Sitte HH.

Neuropharmacology. 2019 Dec 15;161:107615. doi: 10.1016/j.neuropharm.2019.04.021. Epub 2019 Apr 24.


Detection of Ligand-binding to Membrane Proteins by Capacitance Measurements.

Burtscher V, Hotka M, Sandtner W.

Bio Protoc. 2019 Jan 5;9(1). pii: e3138. doi: 10.21769/BioProtoc.3138.


Functional Selectivity and Partial Efficacy at the Monoamine Transporters: A Unified Model of Allosteric Modulation and Amphetamine-Induced Substrate Release.

Hasenhuetl PS, Bhat S, Freissmuth M, Sandtner W.

Mol Pharmacol. 2019 Mar;95(3):303-312. doi: 10.1124/mol.118.114793. Epub 2018 Dec 19. Review.


The synthetic cathinones, butylone and pentylone, are stimulants that act as dopamine transporter blockers but 5-HT transporter substrates.

Saha K, Li Y, Holy M, Lehner KR, Bukhari MO, Partilla JS, Sandtner W, Sitte HH, Baumann MH.

Psychopharmacology (Berl). 2019 Mar;236(3):953-962. doi: 10.1007/s00213-018-5075-5. Epub 2018 Oct 22.


A label-free approach to detect ligand binding to cell surface proteins in real time.

Burtscher V, Hotka M, Li Y, Freissmuth M, Sandtner W.

Elife. 2018 Apr 26;7. pii: e34944. doi: 10.7554/eLife.34944.


A kinetic account for amphetamine-induced monoamine release.

Hasenhuetl PS, Bhat S, Mayer FP, Sitte HH, Freissmuth M, Sandtner W.

J Gen Physiol. 2018 Mar 5;150(3):431-451. doi: 10.1085/jgp.201711915. Epub 2018 Feb 9.


Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na+ channels: mechanistic insights from recent crystal structures.

Cervenka R, Lukacs P, Gawali VS, Ke S, Koenig X, Rubi L, Zarrabi T, Hilber K, Sandtner W, Stary-Weinzinger A, Todt H.

Sci Rep. 2018 Jan 12;8(1):631. doi: 10.1038/s41598-017-18919-1.


Fluorinated phenmetrazine "legal highs" act as substrates for high-affinity monoamine transporters of the SLC6 family.

Mayer FP, Burchardt NV, Decker AM, Partilla JS, Li Y, McLaughlin G, Kavanagh PV, Sandtner W, Blough BE, Brandt SD, Baumann MH, Sitte HH.

Neuropharmacology. 2018 May 15;134(Pt A):149-157. doi: 10.1016/j.neuropharm.2017.10.006. Epub 2017 Oct 6.


Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates.

Bhat S, Hasenhuetl PS, Kasture A, El-Kasaby A, Baumann MH, Blough BE, Sucic S, Sandtner W, Freissmuth M.

J Biol Chem. 2017 Oct 6;292(40):16773-16786. doi: 10.1074/jbc.M117.794081. Epub 2017 Aug 23.


Occupancy of the zinc-binding site by transition metals decreases the substrate affinity of the human dopamine transporter by an allosteric mechanism.

Li Y, Mayer FP, Hasenhuetl PS, Burtscher V, Schicker K, Sitte HH, Freissmuth M, Sandtner W.

J Biol Chem. 2017 Apr 28;292(17):7161. doi: 10.1074/jbc.A116.760140. No abstract available.


The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter.

Kern C, Erdem FA, El-Kasaby A, Sandtner W, Freissmuth M, Sucic S.

J Biol Chem. 2017 Mar 3;292(9):3603-3613. doi: 10.1074/jbc.M116.771360. Epub 2017 Jan 19.


Occupancy of the Zinc-binding Site by Transition Metals Decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism.

Li Y, Mayer FP, Hasenhuetl PS, Burtscher V, Schicker K, Sitte HH, Freissmuth M, Sandtner W.

J Biol Chem. 2017 Mar 10;292(10):4235-4243. doi: 10.1074/jbc.M116.760140. Epub 2017 Jan 17. Erratum in: J Biol Chem. 2017 Apr 28;292(17 ):7161.


The Environment Shapes the Inner Vestibule of LeuT.

Sohail A, Jayaraman K, Venkatesan S, Gotfryd K, Daerr M, Gether U, Loland CJ, Wanner KT, Freissmuth M, Sitte HH, Sandtner W, Stockner T.

PLoS Comput Biol. 2016 Nov 11;12(11):e1005197. doi: 10.1371/journal.pcbi.1005197. eCollection 2016 Nov.


Electrogenic Binding of Intracellular Cations Defines a Kinetic Decision Point in the Transport Cycle of the Human Serotonin Transporter.

Hasenhuetl PS, Freissmuth M, Sandtner W.

J Biol Chem. 2016 Dec 9;291(50):25864-25876. Epub 2016 Oct 18.


Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites.

Zhu R, Sinwel D, Hasenhuetl PS, Saha K, Kumar V, Zhang P, Rankl C, Holy M, Sucic S, Kudlacek O, Karner A, Sandtner W, Stockner T, Gruber HJ, Freissmuth M, Newman AH, Sitte HH, Hinterdorfer P.

Angew Chem Int Ed Engl. 2016 Jan 26;55(5):1719-22. doi: 10.1002/anie.201508755. Epub 2015 Dec 22.


Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters.

Sandtner W, Stockner T, Hasenhuetl PS, Partilla JS, Seddik A, Zhang YW, Cao J, Holy M, Steinkellner T, Rudnick G, Baumann MH, Ecker GF, Newman AH, Sitte HH.

Mol Pharmacol. 2016 Jan;89(1):165-75. doi: 10.1124/mol.115.101394. Epub 2015 Oct 30.


Dual Action of Zn2+ on the Transport Cycle of the Dopamine Transporter.

Li Y, Hasenhuetl PS, Schicker K, Sitte HH, Freissmuth M, Sandtner W.

J Biol Chem. 2015 Dec 25;290(52):31069-76. doi: 10.1074/jbc.M115.688275. Epub 2015 Oct 26.


Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site.

Venkatesan S, Saha K, Sohail A, Sandtner W, Freissmuth M, Ecker GF, Sitte HH, Stockner T.

PLoS Comput Biol. 2015 Oct 20;11(10):e1004551. doi: 10.1371/journal.pcbi.1004551. eCollection 2015 Oct.


Mechanism of Modification, by Lidocaine, of Fast and Slow Recovery from Inactivation of Voltage-Gated Na⁺ Channels.

Gawali VS, Lukacs P, Cervenka R, Koenig X, Rubi L, Hilber K, Sandtner W, Todt H.

Mol Pharmacol. 2015 Nov;88(5):866-79. doi: 10.1124/mol.115.099580. Epub 2015 Sep 10.


Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction.

Hasenhuetl PS, Schicker K, Koenig X, Li Y, Sarker S, Stockner T, Sucic S, Sitte HH, Freissmuth M, Sandtner W.

Mol Pharmacol. 2015 Jul;88(1):12-8. doi: 10.1124/mol.115.099036. Epub 2015 Apr 14.


'Second-generation' mephedrone analogs, 4-MEC and 4-MePPP, differentially affect monoamine transporter function.

Saha K, Partilla JS, Lehner KR, Seddik A, Stockner T, Holy M, Sandtner W, Ecker GF, Sitte HH, Baumann MH.

Neuropsychopharmacology. 2015 May;40(6):1321-31. doi: 10.1038/npp.2014.325. Epub 2014 Dec 15.


The conservative view: is it necessary to implant a stent into the dopamine transporter?

Schmid D, Koenig X, Bulusu S, Schicker K, Freissmuth M, Sitte HH, Sandtner W.

Br J Pharmacol. 2015 Oct;172(19):4775-8. doi: 10.1111/bph.12766. No abstract available.


A repulsion mechanism explains magnesium permeation and selectivity in CorA.

Dalmas O, Sandtner W, Medovoy D, Frezza L, Bezanilla F, Perozo E.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3002-7. doi: 10.1073/pnas.1319054111. Epub 2014 Feb 10.


Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine.

Thurner P, Stary-Weinzinger A, Gafar H, Gawali VS, Kudlacek O, Zezula J, Hilber K, Boehm S, Sandtner W, Koenig X.

J Pharmacol Exp Ther. 2014 Feb;348(2):346-58. doi: 10.1124/jpet.113.209643. Epub 2013 Dec 4.


The two Na+ sites in the human serotonin transporter play distinct roles in the ion coupling and electrogenicity of transport.

Felts B, Pramod AB, Sandtner W, Burbach N, Bulling S, Sitte HH, Henry LK.

J Biol Chem. 2014 Jan 17;289(3):1825-40. doi: 10.1074/jbc.M113.504654. Epub 2013 Nov 29.


Evidence for a role of transporter-mediated currents in the depletion of brain serotonin induced by serotonin transporter substrates.

Baumann MH, Bulling S, Benaderet TS, Saha K, Ayestas MA, Partilla JS, Ali SF, Stockner T, Rothman RB, Sandtner W, Sitte HH.

Neuropsychopharmacology. 2014 May;39(6):1355-65. doi: 10.1038/npp.2013.331. Epub 2013 Nov 28.


A quantitative model of amphetamine action on the 5-HT transporter.

Sandtner W, Schmid D, Schicker K, Gerstbrein K, Koenig X, Mayer FP, Boehm S, Freissmuth M, Sitte HH.

Br J Pharmacol. 2014 Feb;171(4):1007-18. doi: 10.1111/bph.12520.


Sensing charges of the Ciona intestinalis voltage-sensing phosphatase.

Villalba-Galea CA, Frezza L, Sandtner W, Bezanilla F.

J Gen Physiol. 2013 Nov;142(5):543-55. doi: 10.1085/jgp.201310993. Epub 2013 Oct 14.


Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: a study to assess the drug's cardiac ion channel profile.

Koenig X, Kovar M, Rubi L, Mike AK, Lukacs P, Gawali VS, Todt H, Hilber K, Sandtner W.

Toxicol Appl Pharmacol. 2013 Dec 1;273(2):259-68. doi: 10.1016/j.taap.2013.05.012. Epub 2013 May 22.


Nano-positioning system for structural analysis of functional homomeric proteins in multiple conformations.

Hyde HC, Sandtner W, Vargas E, Dagcan AT, Robertson JL, Roux B, Correa AM, Bezanilla F.

Structure. 2012 Oct 10;20(10):1629-40. doi: 10.1016/j.str.2012.08.022.


Anti-addiction drug ibogaine inhibits hERG channels: a cardiac arrhythmia risk.

Koenig X, Kovar M, Boehm S, Sandtner W, Hilber K.

Addict Biol. 2014 Mar;19(2):237-239. doi: 10.1111/j.1369-1600.2012.00447.x. Epub 2012 Mar 28.


The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters.

Bulling S, Schicker K, Zhang YW, Steinkellner T, Stockner T, Gruber CW, Boehm S, Freissmuth M, Rudnick G, Sitte HH, Sandtner W.

J Biol Chem. 2012 May 25;287(22):18524-34. doi: 10.1074/jbc.M112.343681. Epub 2012 Mar 26.


Unifying concept of serotonin transporter-associated currents.

Schicker K, Uzelac Z, Gesmonde J, Bulling S, Stockner T, Freissmuth M, Boehm S, Rudnick G, Sitte HH, Sandtner W.

J Biol Chem. 2012 Jan 2;287(1):438-45. doi: 10.1074/jbc.M111.304261. Epub 2011 Nov 9.


Ouabain binding site in a functioning Na+/K+ ATPase.

Sandtner W, Egwolf B, Khalili-Araghi F, Sánchez-Rodríguez JE, Roux B, Bezanilla F, Holmgren M.

J Biol Chem. 2011 Nov 4;286(44):38177-83. doi: 10.1074/jbc.M111.267682. Epub 2011 Sep 12.


A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel.

Zarrabi T, Cervenka R, Sandtner W, Lukacs P, Koenig X, Hilber K, Mille M, Lipkind GM, Fozzard HA, Todt H.

J Biol Chem. 2010 Dec 10;285(50):39458-70. doi: 10.1074/jbc.M110.132886. Epub 2010 Oct 6.


Charge movement of a voltage-sensitive fluorescent protein.

Villalba-Galea CA, Sandtner W, Dimitrov D, Mutoh H, Knöpfel T, Bezanilla F.

Biophys J. 2009 Jan;96(2):L19-21. doi: 10.1016/j.bpj.2008.11.003.


S4-based voltage sensors have three major conformations.

Villalba-Galea CA, Sandtner W, Starace DM, Bezanilla F.

Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17600-7. doi: 10.1073/pnas.0807387105. Epub 2008 Sep 25.


In vivo measurement of intramolecular distances using genetically encoded reporters.

Sandtner W, Bezanilla F, Correa AM.

Biophys J. 2007 Nov 1;93(9):L45-7. Epub 2007 Aug 31.


Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door?

Szendroedi J, Sandtner W, Zarrabi T, Zebedin E, Hilber K, Dudley SC Jr, Fozzard HA, Todt H.

Biophys J. 2007 Dec 15;93(12):4209-24. Epub 2007 Aug 24.


C2C12 skeletal muscle cells adopt cardiac-like sodium current properties in a cardiac cell environment.

Zebedin E, Mille M, Speiser M, Zarrabi T, Sandtner W, Latzenhofer B, Todt H, Hilber K.

Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H439-50. Epub 2006 Sep 15.


Selectivity filter residues contribute unequally to pore stabilization in voltage-gated sodium channels.

Hilber K, Sandtner W, Zarrabi T, Zebedin E, Kudlacek O, Fozzard HA, Todt H.

Biochemistry. 2005 Oct 25;44(42):13874-82.


Serotonin-transporter mediated efflux: a pharmacological analysis of amphetamines and non-amphetamines.

Hilber B, Scholze P, Dorostkar MM, Sandtner W, Holy M, Boehm S, Singer EA, Sitte HH.

Neuropharmacology. 2005 Nov;49(6):811-9. Epub 2005 Sep 26.


Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel.

Sandtner W, Szendroedi J, Zarrabi T, Zebedin E, Hilber K, Glaaser I, Fozzard HA, Dudley SC, Todt H.

Mol Pharmacol. 2004 Sep;66(3):648-57.


Fiber type conversion alters inactivation of voltage-dependent sodium currents in murine C2C12 skeletal muscle cells.

Zebedin E, Sandtner W, Galler S, Szendroedi J, Just H, Todt H, Hilber K.

Am J Physiol Cell Physiol. 2004 Aug;287(2):C270-80. Epub 2004 Mar 24.


Interaction between fast and ultra-slow inactivation in the voltage-gated sodium channel. Does the inactivation gate stabilize the channel structure?

Hilber K, Sandtner W, Kudlacek O, Schreiner B, Glaaser I, Schütz W, Fozzard HA, Dudley SC, Todt H.

J Biol Chem. 2002 Oct 4;277(40):37105-15. Epub 2002 Jul 23.

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