Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 22

1.

The Aminotriazole Antagonist Cmpd-1 Stabilises a Distinct Inactive State of the Adenosine 2A Receptor.

Landin EJB, Lovera S, de Fabritiis G, Kelm S, Mercier J, McMillan D, Sessions RB, Taylor RJ, Sands ZA, Joedicke L, Crump MP.

Angew Chem Int Ed Engl. 2019 May 16. doi: 10.1002/anie.201902852. [Epub ahead of print]

PMID:
31095849
2.

Discovery of a small molecule modulator of the Kv1.1/Kvβ1 channel complex that reduces neuronal excitability and in vitro epileptiform activity.

Niespodziany I, Mullier B, André VM, Ghisdal P, Jnoff E, Moreno-Delgado D, Swinnen D, Sands Z, Wood M, Wolff C.

CNS Neurosci Ther. 2019 Apr;25(4):442-451. doi: 10.1111/cns.13060. Epub 2018 Sep 21.

PMID:
30242974
3.

Further evidence for a differential interaction of brivaracetam and levetiracetam with the synaptic vesicle 2A protein.

Wood MD, Sands ZA, Vandenplas C, Gillard M.

Epilepsia. 2018 Sep;59(9):e147-e151. doi: 10.1111/epi.14532. Epub 2018 Aug 24.

PMID:
30144048
4.

GRIN2B gain of function mutations are sensitive to radiprodil, a negative allosteric modulator of GluN2B-containing NMDA receptors.

Mullier B, Wolff C, Sands ZA, Ghisdal P, Muglia P, Kaminski RM, André VM.

Neuropharmacology. 2017 Sep 1;123:322-331. doi: 10.1016/j.neuropharm.2017.05.017. Epub 2017 May 19.

5.

Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket.

Sun B, Bachhawat P, Chu ML, Wood M, Ceska T, Sands ZA, Mercier J, Lebon F, Kobilka TS, Kobilka BK.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2066-2071. doi: 10.1073/pnas.1621423114. Epub 2017 Feb 6.

6.

Synaptic Vesicle Glycoprotein 2A Ligands in the Treatment of Epilepsy and Beyond.

Löscher W, Gillard M, Sands ZA, Kaminski RM, Klitgaard H.

CNS Drugs. 2016 Nov;30(11):1055-1077. Review.

7.

A Numbering System for MFS Transporter Proteins.

Lee J, Sands ZA, Biggin PC.

Front Mol Biosci. 2016 Jun 2;3:21. doi: 10.3389/fmolb.2016.00021. eCollection 2016.

8.

Alchembed: A Computational Method for Incorporating Multiple Proteins into Complex Lipid Geometries.

Jefferys E, Sands ZA, Shi J, Sansom MS, Fowler PW.

J Chem Theory Comput. 2015 Jun 9;11(6):2743-2754. Epub 2015 May 14.

9.

Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis.

Lee J, Daniels V, Sands ZA, Lebon F, Shi J, Biggin PC.

PLoS One. 2015 Feb 18;10(2):e0116589. doi: 10.1371/journal.pone.0116589. eCollection 2015.

10.

Binding mode and structure-activity relationships around direct inhibitors of the Nrf2-Keap1 complex.

Jnoff E, Albrecht C, Barker JJ, Barker O, Beaumont E, Bromidge S, Brookfield F, Brooks M, Bubert C, Ceska T, Corden V, Dawson G, Duclos S, Fryatt T, Genicot C, Jigorel E, Kwong J, Maghames R, Mushi I, Pike R, Sands ZA, Smith MA, Stimson CC, Courade JP.

ChemMedChem. 2014 Apr;9(4):699-705. doi: 10.1002/cmdc.201300525. Epub 2014 Feb 6.

PMID:
24504667
11.

Identification of novel NaV1.7 antagonists using high throughput screening platforms.

Klement G, Babich O, Larsson O, Lund PE, Malmberg A, Sandberg L, Sands ZA, Dabrowski M.

Comb Chem High Throughput Screen. 2012 Nov;15(9):713-20.

PMID:
22934951
12.

An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1.

Ramsey IS, Mokrab Y, Carvacho I, Sands ZA, Sansom MSP, Clapham DE.

Nat Struct Mol Biol. 2010 Jul;17(7):869-875. doi: 10.1038/nsmb.1826. Epub 2010 Jun 13.

13.

Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations.

Stansfeld PJ, Grottesi A, Sands ZA, Sansom MS, Gedeck P, Gosling M, Cox B, Stanfield PR, Mitcheson JS, Sutcliffe MJ.

Biochemistry. 2008 Jul 15;47(28):7414-22. doi: 10.1021/bi800475j. Epub 2008 Jun 18.

PMID:
18558719
14.
15.

SGTx1, a Kv channel gating-modifier toxin, binds to the interfacial region of lipid bilayers.

Wee CL, Bemporad D, Sands ZA, Gavaghan D, Sansom MS.

Biophys J. 2007 Jan 1;92(1):L07-9. Epub 2006 Oct 27.

16.

Vstx1, a modifier of Kv channel gating, localizes to the interfacial region of lipid bilayers.

Bemporad D, Sands ZA, Wee CL, Grottesi A, Sansom MS.

Biochemistry. 2006 Oct 3;45(39):11844-55.

PMID:
17002285
17.

Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates.

Wells G, Martin CR, Howard PW, Sands ZA, Laughton CA, Tiberghien A, Woo CK, Masterson LA, Stephenson MJ, Hartley JA, Jenkins TC, Shnyder SD, Loadman PM, Waring MJ, Thurston DE.

J Med Chem. 2006 Sep 7;49(18):5442-61.

PMID:
16942018
18.

The intrinsic flexibility of the Kv voltage sensor and its implications for channel gating.

Sands ZA, Grottesi A, Sansom MS.

Biophys J. 2006 Mar 1;90(5):1598-606. Epub 2005 Dec 2.

19.

Molecular simulations and lipid-protein interactions: potassium channels and other membrane proteins.

Sansom MS, Bond PJ, Deol SS, Grottesi A, Haider S, Sands ZA.

Biochem Soc Trans. 2005 Nov;33(Pt 5):916-20.

PMID:
16246010
20.

Potassium channels: complete and undistorted.

Grottesi A, Sands ZA, Sansom MS.

Curr Biol. 2005 Sep 20;15(18):R771-4. Review.

21.

Voltage-gated ion channels.

Sands Z, Grottesi A, Sansom MS.

Curr Biol. 2005 Jan 26;15(2):R44-7. Review. No abstract available.

22.

Supplemental Content

Support Center