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Next-generation sequencing informs diagnosis and identifies unexpected therapeutic targets in lung squamous cell carcinomas.

Sands JM, Nguyen T, Shivdasani P, Sacher AG, Cheng ML, Alden RS, Jänne PA, Kuo FC, Oxnard GR, Sholl LM.

Lung Cancer. 2020 Feb;140:35-41. doi: 10.1016/j.lungcan.2019.12.005. Epub 2019 Dec 16.


High urea induces depression and LTP impairment through mTOR signalling suppression caused by carbamylation.

Wang H, Huang B, Wang W, Li J, Chen Y, Flynn T, Zhao M, Zhou Z, Lin X, Zhang Y, Xu M, Li K, Tian K, Yuan D, Zhou P, Hu L, Zhong D, Zhu S, Li J, Chen D, Wang K, Liang J, He Q, Sun J, Shi J, Yan L, Sands JM, Xie Z, Lian X, Xu D, Ran J, Yang B.

EBioMedicine. 2019 Oct;48:478-490. doi: 10.1016/j.ebiom.2019.09.049. Epub 2019 Oct 15.


E3 ligase MDM2 mediates urea transporter-A1 ubiquitination under either constitutive or stimulatory conditions.

Su H, Ye C, Sands JM, Zhang C.

Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1331-F1341. doi: 10.1152/ajprenal.00316.2019. Epub 2019 Sep 11.


Translating kidney fibrosis: Role of the EP2 receptor.

Sands JM.

Acta Physiol (Oxf). 2019 Sep;227(1):e13318. doi: 10.1111/apha.13318. Epub 2019 Jun 19. No abstract available.


Time Dependent Structure and Property Evolution in Fibres during Continuous Carbon Fibre Manufacturing.

Nunna S, Maghe M, Rana R, Varley RJ, Knorr DB Jr, Sands JM, Creighton C, Henderson LC, Naebe M.

Materials (Basel). 2019 Apr 1;12(7). pii: E1069. doi: 10.3390/ma12071069.


Age-related decline in urine concentration may not be universal: Comparative study from the U.S. and two small-scale societies.

Rosinger AY, Pontzer H, Raichlen DA, Wood BM, Tanner SN, Sands JM.

Am J Phys Anthropol. 2019 Apr;168(4):705-716. doi: 10.1002/ajpa.23788. Epub 2019 Jan 31.


Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC.

Rogers RT, Sun MA, Yue Q, Bao HF, Sands JM, Blount MA, Eaton DC.

Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F539-F549. doi: 10.1152/ajprenal.00166.2018. Epub 2018 Dec 12.


GDE5 inhibition accumulates intracellular glycerophosphocholine and suppresses adipogenesis at a mitotic clonal expansion stage.

Okazaki Y, Nakamura K, Takeda S, Yoshizawa I, Yoshida F, Ohshima N, Izumi T, Klein JD, Kumrungsee T, Sands JM, Yanaka N.

Am J Physiol Cell Physiol. 2019 Feb 1;316(2):C162-C174. doi: 10.1152/ajpcell.00305.2018. Epub 2018 Nov 21.


Glucagon infusion alters the hyperpolarized 13 C-urea renal hemodynamic signature.

Qi H, Mariager CØ, Nielsen PM, Schroeder M, Lindhardt J, Nørregaard R, Klein JD, Sands JM, Laustsen C.

NMR Biomed. 2019 Jan;32(1):e4028. doi: 10.1002/nbm.4028. Epub 2018 Nov 14.


APS: Moving Forward to Aid Our Membership.

Sands JM, Hay M, Brown D.

Physiology (Bethesda). 2018 Nov 1;33(6):370-371. doi: 10.1152/physiol.00039.2018. No abstract available.


GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation.

Hinze C, Ruffert J, Walentin K, Himmerkus N, Nikpey E, Tenstad O, Wiig H, Mutig K, Yurtdas ZY, Klein JD, Sands JM, Branchi F, Schumann M, Bachmann S, Bleich M, Schmidt-Ott KM.

J Am Soc Nephrol. 2018 Mar;29(3):857-868. doi: 10.1681/ASN.2017030353. Epub 2017 Dec 13.


Ascending Vasa Recta Are Angiopoietin/Tie2-Dependent Lymphatic-Like Vessels.

Kenig-Kozlovsky Y, Scott RP, Onay T, Carota IA, Thomson BR, Gil HJ, Ramirez V, Yamaguchi S, Tanna CE, Heinen S, Wu C, Stan RV, Klein JD, Sands JM, Oliver G, Quaggin SE.

J Am Soc Nephrol. 2018 Apr;29(4):1097-1107. doi: 10.1681/ASN.2017090962. Epub 2017 Dec 13.


APS: The Times They Are A-Changin'.

Brown D, Sands JM, Reckelhoff JF.

Physiology (Bethesda). 2017 Nov;32(6):400-401. doi: 10.1152/physiol.00025.2017. No abstract available.


Identification of a Novel UT-B Urea Transporter in Human Urothelial Cancer.

Hou R, Alemozaffar M, Yang B, Sands JM, Kong X, Chen G.

Front Physiol. 2017 Apr 28;8:245. doi: 10.3389/fphys.2017.00245. eCollection 2017.


High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation.

Kitada K, Daub S, Zhang Y, Klein JD, Nakano D, Pedchenko T, Lantier L, LaRocque LM, Marton A, Neubert P, Schröder A, Rakova N, Jantsch J, Dikalova AE, Dikalov SI, Harrison DG, Müller DN, Nishiyama A, Rauh M, Harris RC, Luft FC, Wassermann DH, Sands JM, Titze J.

J Clin Invest. 2017 May 1;127(5):1944-1959. doi: 10.1172/JCI88532. Epub 2017 Apr 17.


Effect of Dapagliflozin Treatment on Fluid and Electrolyte Balance in Diabetic Rats.

Chen L, LaRocque LM, Efe O, Wang J, Sands JM, Klein JD.

Am J Med Sci. 2016 Nov;352(5):517-523. doi: 10.1016/j.amjms.2016.08.015. Epub 2016 Aug 24.


Urea Transporter B and MicroRNA-200c Differ in Kidney Outer Versus Inner Medulla Following Dehydration.

Wang J, Wang XH, Wang H, Chen L, Klein JD, Sands JM.

Am J Med Sci. 2016 Sep;352(3):296-301. doi: 10.1016/j.amjms.2016.06.003. Epub 2016 Jun 11.


Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry.

Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB.

Tomography. 2016 Jun;2(2):125-135.


Physiological insights into novel therapies for nephrogenic diabetes insipidus.

Sands JM, Klein JD.

Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1149-F1152. doi: 10.1152/ajprenal.00418.2016. Epub 2016 Aug 17. Review.


Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane.

Ren H, Yang B, Ruiz JA, Efe O, Ilori TO, Sands JM, Klein JD.

Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1189-F1197. doi: 10.1152/ajprenal.00150.2016. Epub 2016 Aug 3.


Metformin improves urine concentration in rodents with nephrogenic diabetes insipidus.

Efe O, Klein JD, LaRocque LM, Ren H, Sands JM.

JCI Insight. 2016 Jul 21;1(11). pii: 88409. doi: 10.1172/jci.insight.88409.


Urea transport and clinical potential of urearetics.

Klein JD, Sands JM.

Curr Opin Nephrol Hypertens. 2016 Sep;25(5):444-51. doi: 10.1097/MNH.0000000000000252. Review.


Urea transporters and sweat response to uremia.

Keller RW, Bailey JL, Wang Y, Klein JD, Sands JM.

Physiol Rep. 2016 Jun;4(11). pii: e12825. doi: 10.14814/phy2.12825.


Modulation of kidney urea transporter UT-A3 activity by alpha2,6-sialylation.

Qian X, Sands JM, Song X, Chen G.

Pflugers Arch. 2016 Jul;468(7):1161-1170. doi: 10.1007/s00424-016-1802-0. Epub 2016 Mar 14.


Metformin, an AMPK activator, stimulates the phosphorylation of aquaporin 2 and urea transporter A1 in inner medullary collecting ducts.

Klein JD, Wang Y, Blount MA, Molina PA, LaRocque LM, Ruiz JA, Sands JM.

Am J Physiol Renal Physiol. 2016 May 15;310(10):F1008-12. doi: 10.1152/ajprenal.00102.2016. Epub 2016 Mar 9.


Water, Water Everywhere: A New Cause and a New Treatment for Nephrogenic Diabetes Insipidus.

Sands JM.

J Am Soc Nephrol. 2016 Jul;27(7):1872-4. doi: 10.1681/ASN.2015111223. Epub 2015 Dec 28. No abstract available.


NSAIDs Alter Phosphorylated Forms of AQP2 in the Inner Medullary Tip.

Ren H, Yang B, Molina PA, Sands JM, Klein JD.

PLoS One. 2015 Oct 30;10(10):e0141714. doi: 10.1371/journal.pone.0141714. eCollection 2015.


Transgenic Restoration of Urea Transporter A1 Confers Maximal Urinary Concentration in the Absence of Urea Transporter A3.

Klein JD, Wang Y, Mistry A, LaRocque LM, Molina PA, Rogers RT, Blount MA, Sands JM.

J Am Soc Nephrol. 2016 May;27(5):1448-55. doi: 10.1681/ASN.2014121267. Epub 2015 Sep 25.


Activation of protein kinase Cα increases phosphorylation of the UT-A1 urea transporter at serine 494 in the inner medullary collecting duct.

Blount MA, Cipriani P, Redd SK, Ordas RJ, Black LN, Gumina DL, Hoban CA, Klein JD, Sands JM.

Am J Physiol Cell Physiol. 2015 Nov 1;309(9):C608-15. doi: 10.1152/ajpcell.00171.2014. Epub 2015 Sep 2.


Downregulation of urea transporter UT-A1 activity by 14-3-3 protein.

Feng X, Li Z, Du Y, Fu H, Klein JD, Cai H, Sands JM, Chen G.

Am J Physiol Renal Physiol. 2015 Jul 1;309(1):F71-8. doi: 10.1152/ajprenal.00546.2014. Epub 2015 May 20.


Understanding renal physiology leads to therapeutic advances in renal disease.

Sands JM.

Physiology (Bethesda). 2015 May;30(3):171-2. doi: 10.1152/physiol.00005.2015. No abstract available.


Prospective evaluation of low-dose ketoconazole plus hydrocortisone in docetaxel pre-treated castration-resistant prostate cancer patients.

Lo EN, Beckett LA, Pan CX, Robles D, Suga JM, Sands JM, Lara PN Jr.

Prostate Cancer Prostatic Dis. 2015 Jun;18(2):144-8. doi: 10.1038/pcan.2015.2. Epub 2015 Feb 10.


PKC-α contributes to high NaCl-induced activation of NFAT5 (TonEBP/OREBP) through MAPK ERK1/2.

Wang H, Ferraris JD, Klein JD, Sands JM, Burg MB, Zhou X.

Am J Physiol Renal Physiol. 2015 Jan 15;308(2):F140-8. doi: 10.1152/ajprenal.00471.2014. Epub 2014 Nov 12.


Vasopressin regulation of multisite phosphorylation of UT-A1 in the inner medullary collecting duct.

Hoban CA, Black LN, Ordas RJ, Gumina DL, Pulous FE, Sim JH, Sands JM, Blount MA.

Am J Physiol Renal Physiol. 2015 Jan 1;308(1):F49-55. doi: 10.1152/ajprenal.00642.2013. Epub 2014 Nov 5.


Activation of protein kinase C-α and Src kinase increases urea transporter A1 α-2, 6 sialylation.

Li X, Yang B, Chen M, Klein JD, Sands JM, Chen G.

J Am Soc Nephrol. 2015 Apr;26(4):926-34. doi: 10.1681/ASN.2014010026. Epub 2014 Oct 9.


Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters.

Ren H, Wang Y, Xing Y, Ran J, Liu M, Lei T, Zhou H, Li R, Sands JM, Yang B.

Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1363-72. doi: 10.1152/ajprenal.00421.2014. Epub 2014 Oct 8.


Genes and proteins of urea transporters.

Sands JM, Blount MA.

Subcell Biochem. 2014;73:45-63. doi: 10.1007/978-94-017-9343-8_4. Review.


Overview and historical perspective.

Yang B, Sands JM.

Subcell Biochem. 2014;73:1-5. doi: 10.1007/978-94-017-9343-8_1. No abstract available.


The kidney research national dialogue: gearing up to move forward.

Bonventre JV, Boulware LE, Dember LM, Freedman BI, Furth SL, Holzman LB, Ketchum CJ, Little MH, Mehrotra R, Moe SM, Sands JM, Sedor JR, Somlo S, Star RA, Rys-Sikora KE; Kidney Research National Dialogue (KRND).

Clin J Am Soc Nephrol. 2014 Oct 7;9(10):1806-11. doi: 10.2215/CJN.07310714. Epub 2014 Sep 15. Review.


Urea and Ammonia Metabolism and the Control of Renal Nitrogen Excretion.

Weiner ID, Mitch WE, Sands JM.

Clin J Am Soc Nephrol. 2015 Aug 7;10(8):1444-58. doi: 10.2215/CJN.10311013. Epub 2014 Jul 30. Review.


Defining kidney biology to understand renal disease.

Little MH, Brown D, Humphreys BD, McMahon AP, Miner JH, Sands JM, Weisz OA, Mullins C, Hoshizaki D; Kidney Research National Dialogue (KRND).

Clin J Am Soc Nephrol. 2014 Apr;9(4):809-11. doi: 10.2215/CJN.10851013. Epub 2013 Dec 26.


ENaC activity is increased in isolated, split-open cortical collecting ducts from protein kinase Cα knockout mice.

Bao HF, Thai TL, Yue Q, Ma HP, Eaton AF, Cai H, Klein JD, Sands JM, Eaton DC.

Am J Physiol Renal Physiol. 2014 Feb 1;306(3):F309-20. doi: 10.1152/ajprenal.00519.2013. Epub 2013 Dec 11.


Advances in understanding the urine-concentrating mechanism.

Sands JM, Layton HE.

Annu Rev Physiol. 2014;76:387-409. doi: 10.1146/annurev-physiol-021113-170350. Epub 2013 Nov 13. Review.


Urea transporter inhibitors: en route to new diuretics.

Sands JM.

Chem Biol. 2013 Oct 24;20(10):1201-2. doi: 10.1016/j.chembiol.2013.10.003.


Activation of the cAMP/PKA pathway induces UT-A1 urea transporter monoubiquitination and targets it for lysosomal degradation.

Su H, Chen M, Sands JM, Chen G.

Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1775-82. doi: 10.1152/ajprenal.00393.2013. Epub 2013 Oct 16.


Small GTPase Rab14 down-regulates UT-A1 urea transport activity through enhanced clathrin-dependent endocytosis.

Su H, Liu B, Fröhlich O, Ma H, Sands JM, Chen G.

FASEB J. 2013 Oct;27(10):4100-7. doi: 10.1096/fj.13-229294. Epub 2013 Jun 24.


Erlotinib preserves renal function and prevents salt retention in doxorubicin treated nephrotic rats.

Bou Matar RN, Klein JD, Sands JM.

PLoS One. 2013;8(1):e54738. doi: 10.1371/journal.pone.0054738. Epub 2013 Jan 18.


Urine concentration in the diabetic mouse requires both urea and water transporters.

Ilori TO, Blount MA, Martin CF, Sands JM, Klein JD.

Am J Physiol Renal Physiol. 2013 Jan 1;304(1):F103-11. doi: 10.1152/ajprenal.00385.2012. Epub 2012 Nov 7.


Role of protein kinase C-α in hypertonicity-stimulated urea permeability in mouse inner medullary collecting ducts.

Wang Y, Klein JD, Froehlich O, Sands JM.

Am J Physiol Renal Physiol. 2013 Jan 15;304(2):F233-8. doi: 10.1152/ajprenal.00484.2012. Epub 2012 Oct 24.

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