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Items: 33

1.

NOTUM inhibition increases endocortical bone formation and bone strength.

Brommage R, Liu J, Vogel P, Mseeh F, Thompson AY, Potter DG, Shadoan MK, Hansen GM, Jeter-Jones S, Cui J, Bright D, Bardenhagen JP, Doree DD, Movérare-Skrtic S, Nilsson KH, Henning P, Lerner UH, Ohlsson C, Sands AT, Tarver JE, Powell DR, Zambrowicz B, Liu Q.

Bone Res. 2019 Jan 8;7:2. doi: 10.1038/s41413-018-0038-3. eCollection 2019.

2.

Telotristat Ethyl, a Tryptophan Hydroxylase Inhibitor for the Treatment of Carcinoid Syndrome.

Kulke MH, Hörsch D, Caplin ME, Anthony LB, Bergsland E, Öberg K, Welin S, Warner RR, Lombard-Bohas C, Kunz PL, Grande E, Valle JW, Fleming D, Lapuerta P, Banks P, Jackson S, Zambrowicz B, Sands AT, Pavel M.

J Clin Oncol. 2017 Jan;35(1):14-23. Epub 2016 Oct 28.

PMID:
27918724
3.

Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 Diabetes.

Sands AT, Zambrowicz BP, Rosenstock J, Lapuerta P, Bode BW, Garg SK, Buse JB, Banks P, Heptulla R, Rendell M, Cefalu WT, Strumph P.

Diabetes Care. 2015 Jul;38(7):1181-8. doi: 10.2337/dc14-2806. Epub 2015 Jun 6.

4.

High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.

Brommage R, Liu J, Hansen GM, Kirkpatrick LL, Potter DG, Sands AT, Zambrowicz B, Powell DR, Vogel P.

Bone Res. 2014 Oct 28;2:14034. doi: 10.1038/boneres.2014.34. eCollection 2014.

5.

Improved glycemic control in mice lacking Sglt1 and Sglt2.

Powell DR, DaCosta CM, Gay J, Ding ZM, Smith M, Greer J, Doree D, Jeter-Jones S, Mseeh F, Rodriguez LA, Harris A, Buhring L, Platt KA, Vogel P, Brommage R, Shadoan MK, Sands AT, Zambrowicz B.

Am J Physiol Endocrinol Metab. 2013 Jan 15;304(2):E117-30. doi: 10.1152/ajpendo.00439.2012. Epub 2012 Nov 13.

6.

Congenital hydrocephalus in genetically engineered mice.

Vogel P, Read RW, Hansen GM, Payne BJ, Small D, Sands AT, Zambrowicz BP.

Vet Pathol. 2012 Jan;49(1):166-81. doi: 10.1177/0300985811415708. Epub 2011 Jul 11.

PMID:
21746835
7.

Situs inversus in Dpcd/Poll-/-, Nme7-/- , and Pkd1l1-/- mice.

Vogel P, Read R, Hansen GM, Freay LC, Zambrowicz BP, Sands AT.

Vet Pathol. 2010 Jan;47(1):120-31. doi: 10.1177/0300985809353553.

PMID:
20080492
8.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.

Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A.

Genome Res. 2008 Oct;18(10):1670-9. doi: 10.1101/gr.078352.108. Epub 2008 Sep 17.

9.

High-throughput screening of mouse knockout lines identifies true lean and obese phenotypes.

Brommage R, Desai U, Revelli JP, Donoviel DB, Fontenot GK, Dacosta CM, Smith DD, Kirkpatrick LL, Coker KJ, Donoviel MS, Eberhart DE, Holt KH, Kelly MR, Paradee WJ, Philips AV, Platt KA, Suwanichkul A, Hansen GM, Sands AT, Zambrowicz BP, Powell DR.

Obesity (Silver Spring). 2008 Oct;16(10):2362-7. doi: 10.1038/oby.2008.361. Epub 2008 Jul 31.

10.

Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice.

Desai U, Lee EC, Chung K, Gao C, Gay J, Key B, Hansen G, Machajewski D, Platt KA, Sands AT, Schneider M, Van Sligtenhorst I, Suwanichkul A, Vogel P, Wilganowski N, Wingert J, Zambrowicz BP, Landes G, Powell DR.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11766-71. Epub 2007 Jul 3.

11.

Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.

Steinman HA, Hoover KM, Keeler ML, Sands AT, Jones SN.

Oncogene. 2005 Nov 24;24(53):7935-40.

PMID:
16027727
12.

The knockout mouse project.

Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, Koller BH, Lloyd KC, Magnuson T, Moore MW, Nagy A, Pollock JD, Roses AD, Sands AT, Seed B, Skarnes WC, Snoddy J, Soriano P, Stewart DJ, Stewart F, Stillman B, Varmus H, Varticovski L, Verma IM, Vogt TF, von Melchner H, Witkowski J, Woychik RP, Wurst W, Yancopoulos GD, Young SG, Zambrowicz B.

Nat Genet. 2004 Sep;36(9):921-4.

13.

High-throughput mouse knockouts provide a functional analysis of the genome.

Friddle CJ, Abuin A, Ramirez-Solis R, Richter LJ, Buxton EC, Edwards J, Finch RA, Gupta A, Hansen G, Holt KH, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Newhouse M, Perry T, Platt KA, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Tran D, Wann ER, Walke W, Wallace JD, Xu N, Zhu Q, Person C, Sands AT, Zambrowicz BP.

Cold Spring Harb Symp Quant Biol. 2003;68:311-5. No abstract available.

PMID:
15338631
14.

Severe retinal degeneration associated with disruption of semaphorin 4A.

Rice DS, Huang W, Jones HA, Hansen G, Ye GL, Xu N, Wilson EA, Troughton K, Vaddi K, Newton RC, Zambrowicz BP, Sands AT.

Invest Ophthalmol Vis Sci. 2004 Aug;45(8):2767-77.

PMID:
15277503
15.

Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth.

Steinman HA, Sluss HK, Sands AT, Pihan G, Jones SN.

Oncogene. 2004 Jan 8;23(1):303-6.

PMID:
14712235
16.

Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.

Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14. Epub 2003 Nov 10.

17.

Predicting drug efficacy: knockouts model pipeline drugs of the pharmaceutical industry.

Zambrowicz BP, Turner CA, Sands AT.

Curr Opin Pharmacol. 2003 Oct;3(5):563-70. Review.

PMID:
14559104
18.

The master mammal.

Sands AT.

Nat Biotechnol. 2003 Jan;21(1):31-2. No abstract available.

PMID:
12511904
19.

Knockouts model the 100 best-selling drugs--will they model the next 100?

Zambrowicz BP, Sands AT.

Nat Rev Drug Discov. 2003 Jan;2(1):38-51. doi: 10.1038/nrd987. Review.

PMID:
12509758
20.

mdmx is a negative regulator of p53 activity in vivo.

Finch RA, Donoviel DB, Potter D, Shi M, Fan A, Freed DD, Wang CY, Zambrowicz BP, Ramirez-Solis R, Sands AT, Zhang N.

Cancer Res. 2002 Jun 1;62(11):3221-5.

21.

Full-speed mammalian genetics: in vivo target validation in the drug discovery process.

Abuin A, Holt KH, Platt KA, Sands AT, Zambrowicz BP.

Trends Biotechnol. 2002 Jan;20(1):36-42. Review.

PMID:
11742676
22.

Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice.

Guidi CJ, Sands AT, Zambrowicz BP, Turner TK, Demers DA, Webster W, Smith TW, Imbalzano AN, Jones SN.

Mol Cell Biol. 2001 May;21(10):3598-603.

23.

Analysis of ku80-mutant mice and cells with deficient levels of p53.

Lim DS, Vogel H, Willerford DM, Sands AT, Platt KA, Hasty P.

Mol Cell Biol. 2000 Jun;20(11):3772-80.

24.
25.

Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells.

Zambrowicz BP, Friedrich GA, Buxton EC, Lilleberg SL, Person C, Sands AT.

Nature. 1998 Apr 9;392(6676):608-11.

PMID:
9560157
26.
27.

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

Jones SN, Sands AT, Hancock AR, Vogel H, Donehower LA, Linke SP, Wahl GM, Bradley A.

Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14106-11.

28.

High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC.

Sands AT, Abuin A, Sanchez A, Conti CJ, Bradley A.

Nature. 1995 Sep 14;377(6545):162-5.

PMID:
7675084
29.

p53 deficiency does not affect the accumulation of point mutations in a transgene target.

Sands AT, Suraokar MB, Sanchez A, Marth JE, Donehower LA, Bradley A.

Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8517-21.

30.

p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells.

Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, Bradley A, Olson EN, Harper JW, Elledge SJ.

Science. 1995 Feb 17;267(5200):1024-7.

PMID:
7863329
31.

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice.

Harvey M, Sands AT, Weiss RS, Hegi ME, Wiseman RW, Pantazis P, Giovanella BC, Tainsky MA, Bradley A, Donehower LA.

Oncogene. 1993 Sep;8(9):2457-67.

PMID:
8103211
32.

Cytoplasmic beta-actin promoter produces germ cell and preimplantation embryonic transgene expression.

Sands AT, Hansen TN, Demayo FJ, Stanley LA, Xin L, Schwartz RJ.

Mol Reprod Dev. 1993 Feb;34(2):117-26.

PMID:
8442950
33.

Targeting of gene expression to skeletal and cardiac muscle of trangenic animals.

Sands AT, DeMayo F, Lei X, Schwartz RJ.

SAAS Bull Biochem Biotechnol. 1991 Jan;4:27-33.

PMID:
1367249

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