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Items: 1 to 50 of 73


Membrane Lipid-KIR2.x Channel Interactions Enable Hemodynamic Sensing in Cerebral Arteries.

Sancho M, Fabris S, Hald BO, Brett SE, Sandow SL, Poepping TL, Welsh DG.

Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1072-1087. doi: 10.1161/ATVBAHA.119.312493.


Agonist-evoked endothelial Ca2+ signalling microdomains.

Murphy TV, Sandow SL.

Curr Opin Pharmacol. 2019 Apr;45:8-15. doi: 10.1016/j.coph.2019.03.005. Epub 2019 Apr 12. Review.


Blockade of Pannexin-1 Channels and Purinergic P2X7 Receptors Shows Protective Effects Against Cytokines-Induced Colitis of Human Colonic Mucosa.

Diezmos EF, Markus I, Perera DS, Gan S, Zhang L, Sandow SL, Bertrand PP, Liu L.

Front Pharmacol. 2018 Aug 6;9:865. doi: 10.3389/fphar.2018.00865. eCollection 2018.


Smooth muscle Ca2+ sensitization causes hypercontractility of middle cerebral arteries in mice bearing the familial hemiplegic migraine type 2 associated mutation.

Staehr C, Hangaard L, Bouzinova EV, Kim S, Rajanathan R, Boegh Jessen P, Luque N, Xie Z, Lykke-Hartmann K, Sandow SL, Aalkjaer C, Matchkov VV.

J Cereb Blood Flow Metab. 2019 Aug;39(8):1570-1587. doi: 10.1177/0271678X18761712. Epub 2018 Mar 7.


The α2 isoform Na,K-ATPase modulates contraction of rat mesenteric small artery via cSrc-dependent Ca2+ sensitization.

Bouzinova EV, Hangaard L, Staehr C, Mazur A, Ferreira A, Chibalin AV, Sandow SL, Xie Z, Aalkjaer C, Matchkov VV.

Acta Physiol (Oxf). 2018 Sep;224(1):e13059. doi: 10.1111/apha.13059. Epub 2018 Mar 25. Erratum in: Acta Physiol (Oxf). 2019 Sep;227(1):e13343.


Abdominal aortic aneurysm and omega-3 polyunsaturated fatty acids: Mechanisms, animal models, and potential treatment.

Meital LT, Sandow SL, Calder PC, Russell FD.

Prostaglandins Leukot Essent Fatty Acids. 2017 Mar;118:1-9. doi: 10.1016/j.plefa.2017.02.001. Epub 2017 Feb 10. Review.


Transient receptor potential canonical type 3 channels: Interactions, role and relevance - A vascular focus.

Grayson TH, Murphy TV, Sandow SL.

Pharmacol Ther. 2017 Jun;174:79-96. doi: 10.1016/j.pharmthera.2017.02.022. Epub 2017 Feb 14. Review.


Vascular structural and functional changes: their association with causality in hypertension: models, remodeling and relevance.

Lee RM, Dickhout JG, Sandow SL.

Hypertens Res. 2017 Apr;40(4):311-323. doi: 10.1038/hr.2016.145. Epub 2016 Oct 27. Review.


Excitability and Synaptic Transmission in the Enteric Nervous System: Does Diet Play a Role?

Bertrand PP, Polglaze KE, Chen H, Sandow SL, Walduck A, Jenkins TA, Bertrand RL, Lomax AE, Liu L.

Adv Exp Med Biol. 2016;891:201-11. doi: 10.1007/978-3-319-27592-5_19. Review.


TRPV3 expression and vasodilator function in isolated uterine radial arteries from non-pregnant and pregnant rats.

Murphy TV, Kanagarajah A, Toemoe S, Bertrand PP, Grayson TH, Britton FC, Leader L, Senadheera S, Sandow SL.

Vascul Pharmacol. 2016 Aug;83:66-77. doi: 10.1016/j.vph.2016.04.004. Epub 2016 Apr 9.


Endothelium-Derived Hyperpolarization and Coronary Vasodilation: Diverse and Integrated Roles of Epoxyeicosatrienoic Acids, Hydrogen Peroxide, and Gap Junctions.

Ellinsworth DC, Sandow SL, Shukla N, Liu Y, Jeremy JY, Gutterman DD.

Microcirculation. 2016 Jan;23(1):15-32. doi: 10.1111/micc.12255. Review.


Activation of endothelial IKCa channels underlies NO-dependent myoendothelial feedback.

Kerr PM, Wei R, Tam R, Sandow SL, Murphy TV, Ondrusova K, Lunn SE, Tran CHT, Welsh DG, Plane F.

Vascul Pharmacol. 2015 Nov;74:130-138. doi: 10.1016/j.vph.2015.09.001. Epub 2015 Sep 9.


Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia.

Holobotovskyy V, Chong YS, Burchell J, He B, Phillips M, Leader L, Murphy TV, Sandow SL, McKitrick DJ, Charles AK, Tare M, Arnolda LF, Ganss R.

Sci Transl Med. 2015 Jun 3;7(290):290ra88. doi: 10.1126/scitranslmed.aaa5038.


Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier.

Froud KE, Wong AC, Cederholm JM, Klugmann M, Sandow SL, Julien JP, Ryan AF, Housley GD.

Nat Commun. 2015 May 12;6:7115. doi: 10.1038/ncomms8115.


Pannexin-2 is expressed in the human colon with extensive localization in the enteric nervous system.

Diezmos EF, Sandow SL, Perera DS, King DW, Bertrand PP, Liu L.

Neurogastroenterol Motil. 2015 May;27(5):672-83. doi: 10.1111/nmo.12541. Epub 2015 Mar 14.


Less is more: minimal expression of myoendothelial gap junctions optimizes cell-cell communication in virtual arterioles.

Hald BO, Jacobsen JC, Sandow SL, Holstein-Rathlou NH, Welsh DG.

J Physiol. 2014 Aug 1;592(15):3243-55. doi: 10.1113/jphysiol.2014.272815. Epub 2014 Jun 6.


Effect of diet-induced obesity on BK(Ca) function in contraction and dilation of rat isolated middle cerebral artery.

Howitt L, Morris MJ, Sandow SL, Murphy TV.

Vascul Pharmacol. 2014 Apr;61(1):10-5. doi: 10.1016/j.vph.2014.02.002. Epub 2014 Feb 24.


Role of T-type channels in vasomotor function: team player or chameleon?

Kuo IY, Howitt L, Sandow SL, McFarlane A, Hansen PB, Hill CE.

Pflugers Arch. 2014 Apr;466(4):767-79. doi: 10.1007/s00424-013-1430-x. Epub 2014 Jan 31. Review.


Motility changes induced by intraluminal FeSO4 in guinea pig jejunum.

Wang K, Bertrand RL, Senadheera S, Polglaze KE, Murphy TV, Sandow SL, Liu L, Bornstein JC, Bertrand PP.

Neurogastroenterol Motil. 2014 Mar;26(3):385-96. doi: 10.1111/nmo.12276. Epub 2013 Dec 15.


Detection of melatonin production from the intestinal epithelium using electrochemical methods.

Bertrand PP, Polglaze KE, Bertrand RL, Sandow SL, Pozo MJ.

Curr Pharm Des. 2014;20(30):4802-6. Review.


Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment.

Jelinic M, Leo CH, Post Uiterweer ED, Sandow SL, Gooi JH, Wlodek ME, Conrad KP, Parkington H, Tare M, Parry LJ.

FASEB J. 2014 Jan;28(1):275-87. doi: 10.1096/fj.13-233429. Epub 2013 Sep 13.


Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery.

Senadheera S, Bertrand PP, Grayson TH, Leader L, Tare M, Murphy TV, Sandow SL.

Am J Physiol Regul Integr Comp Physiol. 2013 Oct 15;305(8):R917-26. doi: 10.1152/ajpregu.00225.2013. Epub 2013 Aug 15.


Endothelial control of vasodilation: integration of myoendothelial microdomain signalling and modulation by epoxyeicosatrienoic acids.

Ellinsworth DC, Earley S, Murphy TV, Sandow SL.

Pflugers Arch. 2014 Mar;466(3):389-405. doi: 10.1007/s00424-013-1303-3. Epub 2013 Jun 8. Review.


Expression and localization of pannexin-1 hemichannels in human colon in health and disease.

Diezmos EF, Sandow SL, Markus I, Shevy Perera D, Lubowski DZ, King DW, Bertrand PP, Liu L.

Neurogastroenterol Motil. 2013 Jun;25(6):e395-405. doi: 10.1111/nmo.12130. Epub 2013 Apr 17.


Spreading vasodilatation in the murine microcirculation: attenuation by oxidative stress-induced change in electromechanical coupling.

Howitt L, Chaston DJ, Sandow SL, Matthaei KI, Edwards FR, Hill CE.

J Physiol. 2013 Apr 15;591(8):2157-73. doi: 10.1113/jphysiol.2013.250928. Epub 2013 Feb 25.


Increased caveolae density and caveolin-1 expression accompany impaired NO-mediated vasorelaxation in diet-induced obesity.

Grayson TH, Chadha PS, Bertrand PP, Chen H, Morris MJ, Senadheera S, Murphy TV, Sandow SL.

Histochem Cell Biol. 2013 Feb;139(2):309-21. doi: 10.1007/s00418-012-1032-2. Epub 2012 Sep 25.


Cigarette smoking and brain regulation of energy homeostasis.

Chen H, Saad S, Sandow SL, Bertrand PP.

Front Pharmacol. 2012 Jul 25;3:147. doi: 10.3389/fphar.2012.00147. eCollection 2012.


Transient receptor potential canonical type 3 channels facilitate endothelium-derived hyperpolarization-mediated resistance artery vasodilator activity.

Senadheera S, Kim Y, Grayson TH, Toemoe S, Kochukov MY, Abramowitz J, Housley GD, Bertrand RL, Chadha PS, Bertrand PP, Murphy TV, Tare M, Birnbaumer L, Marrelli SP, Sandow SL.

Cardiovasc Res. 2012 Sep 1;95(4):439-47. doi: 10.1093/cvr/cvs208. Epub 2012 Jun 21.


Serotonin availability in rat colon is reduced during a Western diet model of obesity.

Bertrand RL, Senadheera S, Tanoto A, Tan KL, Howitt L, Chen H, Murphy TV, Sandow SL, Liu L, Bertrand PP.

Am J Physiol Gastrointest Liver Physiol. 2012 Aug 1;303(3):G424-34. doi: 10.1152/ajpgi.00048.2012. Epub 2012 May 17.


Dietary obesity increases NO and inhibits BKCa-mediated, endothelium-dependent dilation in rat cremaster muscle artery: association with caveolins and caveolae.

Howitt L, Grayson TH, Morris MJ, Sandow SL, Murphy TV.

Am J Physiol Heart Circ Physiol. 2012 Jun 15;302(12):H2464-76. doi: 10.1152/ajpheart.00965.2011. Epub 2012 Apr 6.


Calcium and endothelium-mediated vasodilator signaling.

Sandow SL, Senadheera S, Grayson TH, Welsh DG, Murphy TV.

Adv Exp Med Biol. 2012;740:811-31. doi: 10.1007/978-94-007-2888-2_36. Review.


Myoendothelial contacts, gap junctions, and microdomains: anatomical links to function?

Sandow SL, Senadheera S, Bertrand PP, Murphy TV, Tare M.

Microcirculation. 2012 Jul;19(5):403-15. doi: 10.1111/j.1549-8719.2011.00146.x. Review.


Porcine bladder urothelial, myofibroblast, and detrusor muscle cells: characterization and ATP release.

Cheng Y, Mansfield KJ, Sandow SL, Sadananda P, Burcher E, Moore KH.

Front Pharmacol. 2011 Jun 7;2:27. doi: 10.3389/fphar.2011.00027. eCollection 2011.


Differential effects of diet-induced obesity on BKCa {beta}1-subunit expression and function in rat skeletal muscle arterioles and small cerebral arteries.

Howitt L, Sandow SL, Grayson TH, Ellis ZE, Morris MJ, Murphy TV.

Am J Physiol Heart Circ Physiol. 2011 Jul;301(1):H29-40. doi: 10.1152/ajpheart.00134.2011. Epub 2011 May 2.


Non-linear relationship between hyperpolarisation and relaxation enables long distance propagation of vasodilatation.

Wölfle SE, Chaston DJ, Goto K, Sandow SL, Edwards FR, Hill CE.

J Physiol. 2011 May 15;589(Pt 10):2607-23. doi: 10.1113/jphysiol.2010.202580. Epub 2011 Mar 21.


Diet-induced obesity impairs endothelium-derived hyperpolarization via altered potassium channel signaling mechanisms.

Haddock RE, Grayson TH, Morris MJ, Howitt L, Chadha PS, Sandow SL.

PLoS One. 2011 Jan 21;6(1):e16423. doi: 10.1371/journal.pone.0016423.


Endothelium-dependent vasodilation in human mesenteric artery is primarily mediated by myoendothelial gap junctions intermediate conductance calcium-activated K+ channel and nitric oxide.

Chadha PS, Liu L, Rikard-Bell M, Senadheera S, Howitt L, Bertrand RL, Grayson TH, Murphy TV, Sandow SL.

J Pharmacol Exp Ther. 2011 Mar;336(3):701-8. doi: 10.1124/jpet.110.165795. Epub 2010 Dec 20.


A Western diet increases serotonin availability in rat small intestine.

Bertrand RL, Senadheera S, Markus I, Liu L, Howitt L, Chen H, Murphy TV, Sandow SL, Bertrand PP.

Endocrinology. 2011 Jan;152(1):36-47. doi: 10.1210/en.2010-0377. Epub 2010 Nov 10.


Role of mitochondria in contraction and pacemaking in the mouse uterus.

Gravina FS, Parkington HC, Kerr KP, de Oliveira RB, Jobling P, Coleman HA, Sandow SL, Davies MM, Imtiaz MS, van Helden DF.

Br J Pharmacol. 2010 Nov;161(6):1375-90. doi: 10.1111/j.1476-5381.2010.00949.x.


Under pressure - Kv channels and myogenic control of cerebral blood flow.

Sandow SL, Murphy TV.

J Physiol. 2010 Oct 1;588(Pt 19):3635-6. doi: 10.1113/jphysiol.2010.197996. No abstract available.


Obesity up-regulates intermediate conductance calcium-activated potassium channels and myoendothelial gap junctions to maintain endothelial vasodilator function.

Chadha PS, Haddock RE, Howitt L, Morris MJ, Murphy TV, Grayson TH, Sandow SL.

J Pharmacol Exp Ther. 2010 Nov;335(2):284-93. doi: 10.1124/jpet.110.167593. Epub 2010 Jul 29.


Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries.

Kuo IY, Ellis A, Seymour VA, Sandow SL, Hill CE.

J Cereb Blood Flow Metab. 2010 Jun;30(6):1226-39. doi: 10.1038/jcbfm.2010.11. Epub 2010 Feb 3.


Vascular remodeling arterioles: plasticity of the vessel wall.

Lee RM, Sandow SL, Demey JG.

Physiology (Bethesda). 2009 Oct;24:271-2; author reply 273-5. doi: 10.1152/physiol.00027.2009. No abstract available.


Limits of isolation and culture: intact vascular endothelium and BKCa.

Sandow SL, Grayson TH.

Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H1-7. doi: 10.1152/ajpheart.00042.2009. Epub 2009 May 1. Review.


Arterial internal elastic lamina holes: relationship to function?

Sandow SL, Gzik DJ, Lee RM.

J Anat. 2009 Feb;214(2):258-66. doi: 10.1111/j.1469-7580.2008.01020.x.


What's where and why at a vascular myoendothelial microdomain signalling complex.

Sandow SL, Haddock RE, Hill CE, Chadha PS, Kerr PM, Welsh DG, Plane F.

Clin Exp Pharmacol Physiol. 2009 Jan;36(1):67-76. doi: 10.1111/j.1440-1681.2008.05076.x. Epub 2008 Oct 31. Review.


Improved functional expression of recombinant human ether-a-go-go (hERG) K+ channels by cultivation at reduced temperature.

Chen MX, Sandow SL, Doceul V, Chen YH, Harper H, Hamilton B, Meadows HJ, Trezise DJ, Clare JJ.

BMC Biotechnol. 2007 Dec 20;7:93.


KIR channels function as electrical amplifiers in rat vascular smooth muscle.

Smith PD, Brett SE, Luykenaar KD, Sandow SL, Marrelli SP, Vigmond EJ, Welsh DG.

J Physiol. 2008 Feb 15;586(4):1147-60. Epub 2007 Dec 6.


Vascular microarray profiling in two models of hypertension identifies caveolin-1, Rgs2 and Rgs5 as antihypertensive targets.

Grayson TH, Ohms SJ, Brackenbury TD, Meaney KR, Peng K, Pittelkow YE, Wilson SR, Sandow SL, Hill CE.

BMC Genomics. 2007 Nov 7;8:404.

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