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Items: 14


BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT.

Wang ZH, Wu W, Kang SS, Liu X, Wu Z, Peng J, Yu SP, Manfredsson FP, Sandoval IM, Liu X, Wang JZ, Ye K.

JCI Insight. 2018 Aug 23;3(16). pii: 99007. doi: 10.1172/jci.insight.99007. [Epub ahead of print]


α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease.

Kang SS, Ahn EH, Zhang Z, Liu X, Manfredsson FP, Sandoval IM, Dhakal S, Iuvone PM, Cao X, Ye K.

EMBO J. 2018 Jun 15;37(12). pii: e98878. doi: 10.15252/embj.201798878. Epub 2018 May 16.


C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease.

Wang ZH, Gong K, Liu X, Zhang Z, Sun X, Wei ZZ, Yu SP, Manfredsson FP, Sandoval IM, Johnson PF, Jia J, Wang JZ, Ye K.

Nat Commun. 2018 May 3;9(1):1784. doi: 10.1038/s41467-018-04120-z.


Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity.

Benskey MJ, Sellnow RC, Sandoval IM, Sortwell CE, Lipton JW, Manfredsson FP.

Front Mol Neurosci. 2018 Feb 13;11:36. doi: 10.3389/fnmol.2018.00036. eCollection 2018.


Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology.

Manfredsson FP, Luk KC, Benskey MJ, Gezer A, Garcia J, Kuhn NC, Sandoval IM, Patterson JR, O'Mara A, Yonkers R, Kordower JH.

Neurobiol Dis. 2018 Apr;112:106-118. doi: 10.1016/j.nbd.2018.01.008. Epub 2018 Jan 16.


Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.

Wang ZH, Liu P, Liu X, Manfredsson FP, Sandoval IM, Yu SP, Wang JZ, Ye K.

Mol Cell. 2017 Sep 7;67(5):812-825.e5. doi: 10.1016/j.molcel.2017.07.018. Epub 2017 Aug 17.


Impact of age and vector construct on striatal and nigral transgene expression.

Polinski NK, Manfredsson FP, Benskey MJ, Fischer DL, Kemp CJ, Steece-Collier K, Sandoval IM, Paumier KL, Sortwell CE.

Mol Ther Methods Clin Dev. 2016 Dec 7;3:16082. eCollection 2016.


Continuous Collection of Adeno-Associated Virus from Producer Cell Medium Significantly Increases Total Viral Yield.

Benskey MJ, Sandoval IM, Manfredsson FP.

Hum Gene Ther Methods. 2016 Feb;27(1):32-45. doi: 10.1089/hgtb.2015.117.


Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration.

Paumier KL, Luk KC, Manfredsson FP, Kanaan NM, Lipton JW, Collier TJ, Steece-Collier K, Kemp CJ, Celano S, Schulz E, Sandoval IM, Fleming S, Dirr E, Polinski NK, Trojanowski JQ, Lee VM, Sortwell CE.

Neurobiol Dis. 2015 Oct;82:185-199. doi: 10.1016/j.nbd.2015.06.003. Epub 2015 Jun 17.


Abrupt onset of mutations in a developmentally regulated gene during terminal differentiation of post-mitotic photoreceptor neurons in mice.

Sandoval IM, Price BA, Gross AK, Chan F, Sammons JD, Wilson JH, Wensel TG.

PLoS One. 2014 Sep 29;9(9):e108135. doi: 10.1371/journal.pone.0108135. eCollection 2014.


Rhodopsin gene expression determines rod outer segment size and rod cell resistance to a dominant-negative neurodegeneration mutant.

Price BA, Sandoval IM, Chan F, Nichols R, Roman-Sanchez R, Wensel TG, Wilson JH.

PLoS One. 2012;7(11):e49889. doi: 10.1371/journal.pone.0049889. Epub 2012 Nov 21.


Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration.

Gilliam JC, Chang JT, Sandoval IM, Zhang Y, Li T, Pittler SJ, Chiu W, Wensel TG.

Cell. 2012 Nov 21;151(5):1029-41. doi: 10.1016/j.cell.2012.10.038.


Mislocalization and degradation of human P23H-rhodopsin-GFP in a knockin mouse model of retinitis pigmentosa.

Price BA, Sandoval IM, Chan F, Simons DL, Wu SM, Wensel TG, Wilson JH.

Invest Ophthalmol Vis Sci. 2011 Dec 28;52(13):9728-36. doi: 10.1167/iovs.11-8654.


Defective development of photoreceptor membranes in a mouse model of recessive retinal degeneration.

Gross AK, Decker G, Chan F, Sandoval IM, Wilson JH, Wensel TG.

Vision Res. 2006 Dec;46(27):4510-8. Epub 2006 Sep 18.

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