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Items: 1 to 50 of 79


G-CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche.

Li Z, Hardij J, Evers SS, Hutch CR, Choi SM, Shao Y, Learman BS, Lewis KT, Schill RL, Mori H, Bagchi DP, Romanelli SM, Kim KS, Bowers E, Griffin C, Seeley RJ, Singer K, Sandoval DA, Rosen CJ, MacDougald OA.

J Clin Invest. 2019 May 6;130:2404-2416. doi: 10.1172/JCI126173. eCollection 2019 May 6.


Inflammatory responses to dietary and surgical weight loss in male and female mice.

Griffin C, Hutch CR, Abrishami S, Stelmak D, Eter L, Li Z, Chang E, Agarwal D, Zamarron B, Varghese M, Subbaiah P, MacDougald OA, Sandoval DA, Singer K.

Biol Sex Differ. 2019 Apr 3;10(1):16. doi: 10.1186/s13293-019-0229-7.


Mechanisms for the metabolic success of bariatric surgery.

Sandoval DA.

J Neuroendocrinol. 2019 May;31(5):e12708. doi: 10.1111/jne.12708. Epub 2019 Apr 10. Review.


Oea Signaling Pathways and the Metabolic Benefits of Vertical Sleeve Gastrectomy.

Hutch CR, Trakimas DR, Roelofs K, Pressler J, Sorrell J, Cota D, Obici S, Sandoval DA.

Ann Surg. 2018 Nov 20. doi: 10.1097/SLA.0000000000003093. [Epub ahead of print]


Vertical sleeve gastrectomy improves ventilatory drive through a leptin-dependent mechanism.

Arble DM, Schwartz AR, Polotsky VY, Sandoval DA, Seeley RJ.

JCI Insight. 2019 Jan 10;4(1). pii: 124469. doi: 10.1172/jci.insight.124469. [Epub ahead of print]


Liraglutide Modulates Appetite and Body Weight Through Glucagon-Like Peptide 1 Receptor-Expressing Glutamatergic Neurons.

Adams JM, Pei H, Sandoval DA, Seeley RJ, Chang RB, Liberles SD, Olson DP.

Diabetes. 2018 Aug;67(8):1538-1548. doi: 10.2337/db17-1385. Epub 2018 May 18.


Vertical sleeve gastrectomy corrects metabolic perturbations in a low-exercise capacity rat model.

Wood L, Roelofs K, Koch LG, Britton SL, Sandoval DA.

Mol Metab. 2018 May;11:189-196. doi: 10.1016/j.molmet.2018.02.009. Epub 2018 Feb 26.


Signalling from the periphery to the brain that regulates energy homeostasis.

Kim KS, Seeley RJ, Sandoval DA.

Nat Rev Neurosci. 2018 Apr;19(4):185-196. doi: 10.1038/nrn.2018.8. Epub 2018 Feb 22. Review.


The glucagon-like peptide-1 receptor in the ventromedial hypothalamus reduces short-term food intake in male mice by regulating nutrient sensor activity.

Burmeister MA, Brown JD, Ayala JE, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE.

Am J Physiol Endocrinol Metab. 2017 Dec 1;313(6):E651-E662. doi: 10.1152/ajpendo.00113.2017. Epub 2017 Aug 15.


The endogenous preproglucagon system is not essential for gut growth homeostasis in mice.

Wismann P, Barkholt P, Secher T, Vrang N, Hansen HB, Jeppesen PB, Baggio LL, Koehler JA, Drucker DJ, Sandoval DA, Jelsing J.

Mol Metab. 2017 Apr 27;6(7):681-692. doi: 10.1016/j.molmet.2017.04.007. eCollection 2017 Jul.


Endocrine Function after Bariatric Surgery.

Kim KS, Sandoval DA.

Compr Physiol. 2017 Jun 18;7(3):783-798. doi: 10.1002/cphy.c160019. Review.


Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons.

Cady G, Landeryou T, Garratt M, Kopchick JJ, Qi N, Garcia-Galiano D, Elias CF, Myers MG Jr, Miller RA, Sandoval DA, Sadagurski M.

Mol Metab. 2017 Mar 16;6(5):393-405. doi: 10.1016/j.molmet.2017.03.001. eCollection 2017 May.


Weight loss independent changes in adipose tissue macrophage and T cell populations after sleeve gastrectomy in mice.

Frikke-Schmidt H, Zamarron BF, O'Rourke RW, Sandoval DA, Lumeng CN, Seeley RJ.

Mol Metab. 2017 Feb 16;6(4):317-326. doi: 10.1016/j.molmet.2017.02.004. eCollection 2017 Apr.


The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice.

Chambers AP, Sorrell JE, Haller A, Roelofs K, Hutch CR, Kim KS, Gutierrez-Aguilar R, Li B, Drucker DJ, D'Alessio DA, Seeley RJ, Sandoval DA.

Cell Metab. 2017 Apr 4;25(4):927-934.e3. doi: 10.1016/j.cmet.2017.02.008. Epub 2017 Mar 16.


Physiology: Gut feeling for food choice.

Sandoval DA, Seeley RJ.

Nature. 2017 Feb 16;542(7641):302-303. doi: 10.1038/nature21499. Epub 2017 Feb 8. No abstract available.


Bariatric surgery emphasizes biological sex differences in rodent hepatic lipid handling.

Grayson BE, Gutierrez-Aguilar R, Sorrell JE, Matter EK, Adams MR, Howles P, Karns R, Seeley RJ, Sandoval DA.

Biol Sex Differ. 2017 Jan 28;8:4. doi: 10.1186/s13293-017-0126-x. eCollection 2017.


The Physiology and Molecular Underpinnings of the Effects of Bariatric Surgery on Obesity and Diabetes.

Evers SS, Sandoval DA, Seeley RJ.

Annu Rev Physiol. 2017 Feb 10;79:313-334. doi: 10.1146/annurev-physiol-022516-034423. Epub 2016 Nov 28. Review.


The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice.

Burmeister MA, Ayala JE, Smouse H, Landivar-Rocha A, Brown JD, Drucker DJ, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE.

Diabetes. 2017 Feb;66(2):372-384. doi: 10.2337/db16-1102. Epub 2016 Dec 1.


Physiological and molecular responses to bariatric surgery: markers or mechanisms underlying T2DM resolution?

Hutch CR, Sandoval DA.

Ann N Y Acad Sci. 2017 Mar;1391(1):5-19. doi: 10.1111/nyas.13194. Epub 2016 Sep 26. Review.


Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding.

Loyd C, Magrisso IJ, Haas M, Balusu S, Krishna R, Itoh N, Sandoval DA, Perez-Tilve D, Obici S, Habegger KM.

J Appl Physiol (1985). 2016 Sep 1;121(3):687-98. doi: 10.1152/japplphysiol.00456.2016. Epub 2016 Jul 21.


Sleeve gastrectomy leads to weight loss in the Magel2 knockout mouse.

Arble DM, Pressler JW, Sorrell J, Wevrick R, Sandoval DA.

Surg Obes Relat Dis. 2016 Dec;12(10):1795-1802. doi: 10.1016/j.soard.2016.04.023. Epub 2016 Apr 27.


Targeting the brain as a cure for type 2 diabetes.

Seeley RJ, Sandoval DA.

Nat Med. 2016 Jul 7;22(7):709-11. doi: 10.1038/nm.4137. No abstract available.


Does bariatric surgery improve adipose tissue function?

Frikke-Schmidt H, O'Rourke RW, Lumeng CN, Sandoval DA, Seeley RJ.

Obes Rev. 2016 Sep;17(9):795-809. doi: 10.1111/obr.12429. Epub 2016 Jun 8. Review.


Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight.

Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Gardner D, Moore DD, Seeley RJ, Sandoval DA.

Diabetes. 2016 Sep;65(9):2732-41. doi: 10.2337/db16-0309. Epub 2016 May 23.


Moderate voluntary exercise attenuates the metabolic syndrome in melanocortin-4 receptor-deficient rats showing central dopaminergic dysregulation.

Obici S, Magrisso IJ, Ghazarian AS, Shirazian A, Miller JR, Loyd CM, Begg DP, Krawczewski Carhuatanta KA, Haas MK, Davis JF, Woods SC, Sandoval DA, Seeley RJ, Goodyear LJ, Pothos EN, Mul JD.

Mol Metab. 2015 Jul 17;4(10):692-705. doi: 10.1016/j.molmet.2015.07.003. eCollection 2015 Oct.


Bile Acid Signaling: Mechanism for Bariatric Surgery, Cure for NASH?

Kohli R, Myronovych A, Tan BK, Salazar-Gonzalez RM, Miles L, Zhang W, Oehrle M, Sandoval DA, Ryan KK, Seeley RJ, Setchell KD.

Dig Dis. 2015;33(3):440-6. doi: 10.1159/000371699. Epub 2015 May 27. Review.


Metabolic effects of bariatric surgery in mouse models of circadian disruption.

Arble DM, Sandoval DA, Turek FW, Woods SC, Seeley RJ.

Int J Obes (Lond). 2015 Aug;39(8):1310-8. doi: 10.1038/ijo.2015.54. Epub 2015 Apr 14.


Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease.

Sandoval DA, D'Alessio DA.

Physiol Rev. 2015 Apr;95(2):513-48. doi: 10.1152/physrev.00013.2014. Review.


The melanocortin-4 receptor integrates circadian light cues and metabolism.

Arble DM, Holland J, Ottaway N, Sorrell J, Pressler JW, Morano R, Woods SC, Seeley RJ, Herman JP, Sandoval DA, Perez-Tilve D.

Endocrinology. 2015 May;156(5):1685-91. doi: 10.1210/en.2014-1937. Epub 2015 Mar 2.


The role of gut adaptation in the potent effects of multiple bariatric surgeries on obesity and diabetes.

Seeley RJ, Chambers AP, Sandoval DA.

Cell Metab. 2015 Mar 3;21(3):369-78. doi: 10.1016/j.cmet.2015.01.001. Epub 2015 Feb 5. Review.


Mechanisms underlying weight loss and metabolic improvements in rodent models of bariatric surgery.

Arble DM, Sandoval DA, Seeley RJ.

Diabetologia. 2015 Feb;58(2):211-20. doi: 10.1007/s00125-014-3433-3. Epub 2014 Nov 6. Review.


MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse.

Mul JD, Begg DP, Haller AM, Pressler JW, Sorrell J, Woods SC, Farese RV Jr, Seeley RJ, Sandoval DA.

Am J Physiol Endocrinol Metab. 2014 Dec 1;307(11):E1065-72. doi: 10.1152/ajpendo.00376.2014. Epub 2014 Oct 14.


Vertical sleeve gastrectomy restores glucose homeostasis in apolipoprotein A-IV KO mice.

Pressler JW, Haller A, Sorrell J, Wang F, Seeley RJ, Tso P, Sandoval DA.

Diabetes. 2015 Feb;64(2):498-507. doi: 10.2337/db14-0825. Epub 2014 Aug 25.


Differences in acute anorectic effects of long-acting GLP-1 receptor agonists in rats.

Sisley S, Smith K, Sandoval DA, Seeley RJ.

Peptides. 2014 Aug;58:1-6. doi: 10.1016/j.peptides.2014.05.008. Epub 2014 May 29.


Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect.

Sisley S, Gutierrez-Aguilar R, Scott M, D'Alessio DA, Sandoval DA, Seeley RJ.

J Clin Invest. 2014 Jun;124(6):2456-63. doi: 10.1172/JCI72434. Epub 2014 Apr 24.


FXR is a molecular target for the effects of vertical sleeve gastrectomy.

Ryan KK, Tremaroli V, Clemmensen C, Kovatcheva-Datchary P, Myronovych A, Karns R, Wilson-Pérez HE, Sandoval DA, Kohli R, Bäckhed F, Seeley RJ.

Nature. 2014 May 8;509(7499):183-8. doi: 10.1038/nature13135. Epub 2014 Mar 26.


Regulation of gastric emptying rate and its role in nutrient-induced GLP-1 secretion in rats after vertical sleeve gastrectomy.

Chambers AP, Smith EP, Begg DP, Grayson BE, Sisley S, Greer T, Sorrell J, Lemmen L, LaSance K, Woods SC, Seeley RJ, D'Alessio DA, Sandoval DA.

Am J Physiol Endocrinol Metab. 2014 Feb 15;306(4):E424-32. doi: 10.1152/ajpendo.00469.2013. Epub 2013 Dec 24.


Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors.

Heppner KM, Piechowski CL, Müller A, Ottaway N, Sisley S, Smiley DL, Habegger KM, Pfluger PT, Dimarchi R, Biebermann H, Tschöp MH, Sandoval DA, Perez-Tilve D.

Diabetes. 2014 Jan;63(1):122-31. doi: 10.2337/db13-0414. Epub 2013 Sep 23.


Identification of optimal reference genes for RT-qPCR in the rat hypothalamus and intestine for the study of obesity.

Li B, Matter EK, Hoppert HT, Grayson BE, Seeley RJ, Sandoval DA.

Int J Obes (Lond). 2014 Feb;38(2):192-7. doi: 10.1038/ijo.2013.86. Epub 2013 May 24.


Integration of satiety signals by the central nervous system.

Chambers AP, Sandoval DA, Seeley RJ.

Curr Biol. 2013 May 6;23(9):R379-88. doi: 10.1016/j.cub.2013.03.020. Review.


High-fat diet changes the temporal profile of GLP-1 receptor-mediated hypophagia in rats.

Mul JD, Begg DP, Barrera JG, Li B, Matter EK, D'Alessio DA, Woods SC, Seeley RJ, Sandoval DA.

Am J Physiol Regul Integr Comp Physiol. 2013 Jul 1;305(1):R68-77. doi: 10.1152/ajpregu.00588.2012. Epub 2013 Apr 24.


CNS control of glucose metabolism: response to environmental challenges.

Arble DM, Sandoval DA.

Front Neurosci. 2013 Feb 26;7:20. doi: 10.3389/fnins.2013.00020. eCollection 2013.


Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency.

Wilson-Pérez HE, Chambers AP, Ryan KK, Li B, Sandoval DA, Stoffers D, Drucker DJ, Pérez-Tilve D, Seeley RJ.

Diabetes. 2013 Jul;62(7):2380-5. doi: 10.2337/db12-1498. Epub 2013 Feb 22.


Wired on sugar: the role of the CNS in the regulation of glucose homeostasis.

Grayson BE, Seeley RJ, Sandoval DA.

Nat Rev Neurosci. 2013 Jan;14(1):24-37. doi: 10.1038/nrn3409. Epub 2012 Dec 12. Review.


Female rats are relatively more sensitive to reduced lipid versus reduced carbohydrate availability.

Sandoval DA, Ryan KK, de Kloet AD, Woods SC, Seeley RJ.

Nutr Diabetes. 2012 Feb 13;2:e27. doi: 10.1038/nutd.2011.23.


The effects of vertical sleeve gastrectomy in rodents are ghrelin independent.

Chambers AP, Kirchner H, Wilson-Perez HE, Willency JA, Hale JE, Gaylinn BD, Thorner MO, Pfluger PT, Gutierrez JA, Tschöp MH, Sandoval DA, Seeley RJ.

Gastroenterology. 2013 Jan;144(1):50-52.e5. doi: 10.1053/j.gastro.2012.09.009. Epub 2012 Sep 17.


Effect of vertical sleeve gastrectomy on food selection and satiation in rats.

Chambers AP, Wilson-Perez HE, McGrath S, Grayson BE, Ryan KK, D'Alessio DA, Woods SC, Sandoval DA, Seeley RJ.

Am J Physiol Endocrinol Metab. 2012 Oct 15;303(8):E1076-84. doi: 10.1152/ajpendo.00211.2012. Epub 2012 Aug 28.


All bariatric surgeries are not created equal: insights from mechanistic comparisons.

Stefater MA, Wilson-Pérez HE, Chambers AP, Sandoval DA, Seeley RJ.

Endocr Rev. 2012 Aug;33(4):595-622. doi: 10.1210/er.2011-1044. Epub 2012 May 1. Review.


Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats.

Mul JD, Begg DP, Alsters SI, van Haaften G, Duran KJ, D'Alessio DA, le Roux CW, Woods SC, Sandoval DA, Blakemore AI, Cuppen E, van Haelst MM, Seeley RJ.

Am J Physiol Endocrinol Metab. 2012 Jul 1;303(1):E103-10. doi: 10.1152/ajpendo.00159.2012. Epub 2012 Apr 24.


The effect of vertical sleeve gastrectomy on food choice in rats.

Wilson-Pérez HE, Chambers AP, Sandoval DA, Stefater MA, Woods SC, Benoit SC, Seeley RJ.

Int J Obes (Lond). 2013 Feb;37(2):288-95. doi: 10.1038/ijo.2012.18. Epub 2012 Feb 14.

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