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Items: 12

1.

Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain.

Bigalke JM, Aibara S, Roth R, Dahl G, Gordon E, Dorbéus S, Amunts A, Sandmark J.

Sci Adv. 2019 Jul 31;5(7):eaau4202. doi: 10.1126/sciadv.aau4202. eCollection 2019 Jul.

2.

Design of Selective sPLA2-X Inhibitor (-)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1H-indol-1-yl]pyridine-2-yl}propanoic Acid.

Giordanetto F, Knerr L, Nordberg P, Pettersen D, Selmi N, Beisel HG, de la Motte H, Månsson Å, Dahlström M, Broddefalk J, Saarinen G, Klingegård F, Hurt-Camejo E, Rosengren B, Wikström J, Wågberg M, Brengdahl J, Rohman M, Sandmark J, Åkerud T, Roth RG, Jansen F, Ahlqvist M.

ACS Med Chem Lett. 2018 Jun 23;9(7):600-605. doi: 10.1021/acsmedchemlett.7b00507. eCollection 2018 Jul 12.

3.

Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2 Type X (sPLA2-X) Inhibitors.

Knerr L, Giordanetto F, Nordberg P, Pettersen D, Selmi N, Beisel HG, de la Motte H, Olsson T, Perkins TDJ, Herslöf M, Månsson Å, Dahlström M, Starke I, Broddefalk J, Saarinen G, Klingegård F, Hurt-Camejo E, Rosengren B, Brengdahl J, Jansen F, Rohman M, Sandmark J, Hallberg K, Åkerud T, Roth RG, Ahlqvist M.

ACS Med Chem Lett. 2018 Jun 23;9(7):594-599. doi: 10.1021/acsmedchemlett.7b00505. eCollection 2018 Jul 12.

4.

Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.

Sandmark J, Dahl G, Öster L, Xu B, Johansson P, Akerud T, Aagaard A, Davidsson P, Bigalke JM, Winzell MS, Rainey GJ, Roth RG.

J Biol Chem. 2018 Apr 13;293(15):5492-5508. doi: 10.1074/jbc.RA117.000820. Epub 2018 Feb 2.

5.

Discovery of AZD2716: A Novel Secreted Phospholipase A2 (sPLA2) Inhibitor for the Treatment of Coronary Artery Disease.

Giordanetto F, Pettersen D, Starke I, Nordberg P, Dahlström M, Knerr L, Selmi N, Rosengren B, Larsson LO, Sandmark J, Castaldo M, Dekker N, Karlsson U, Hurt-Camejo E.

ACS Med Chem Lett. 2016 Aug 9;7(10):884-889. eCollection 2016 Oct 13.

6.

Creating novel activated factor XI inhibitors through fragment based lead generation and structure aided drug design.

Fjellström O, Akkaya S, Beisel HG, Eriksson PO, Erixon K, Gustafsson D, Jurva U, Kang D, Karis D, Knecht W, Nerme V, Nilsson I, Olsson T, Redzic A, Roth R, Sandmark J, Tigerström A, Öster L.

PLoS One. 2015 Jan 28;10(1):e0113705. doi: 10.1371/journal.pone.0113705. eCollection 2015.

7.

Discovery of a novel pyrazole series of group X secreted phospholipase A2 inhibitor (sPLA2X) via fragment based virtual screening.

Chen H, Knerr L, Åkerud T, Hallberg K, Öster L, Rohman M, Österlund K, Beisel HG, Olsson T, Brengdhal J, Sandmark J, Bodin C.

Bioorg Med Chem Lett. 2014 Nov 15;24(22):5251-5. doi: 10.1016/j.bmcl.2014.09.058. Epub 2014 Sep 30.

PMID:
25316315
8.
9.

The dual-specific active site of 7,8-diaminopelargonic acid synthase and the effect of the R391A mutation.

Eliot AC, Sandmark J, Schneider G, Kirsch JF.

Biochemistry. 2002 Oct 22;41(42):12582-9.

PMID:
12379100
10.

Structural basis for the inhibition of the biosynthesis of biotin by the antibiotic amiclenomycin.

Sandmark J, Mann S, Marquet A, Schneider G.

J Biol Chem. 2002 Nov 8;277(45):43352-8. Epub 2002 Sep 5.

11.

Crystal structure of diaminopelargonic acid synthase: evolutionary relationships between pyridoxal-5'-phosphate-dependent enzymes.

Käck H, Sandmark J, Gibson K, Schneider G, Lindqvist Y.

J Mol Biol. 1999 Aug 27;291(4):857-76.

PMID:
10452893

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