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Architecture, Function, and Substrates of the Type II Secretion System.

Korotkov KV, Sandkvist M.

EcoSal Plus. 2019 Feb;8(2). doi: 10.1128/ecosalplus.ESP-0034-2018. Review.


CpaA Is a Glycan-Specific Adamalysin-like Protease Secreted by Acinetobacter baumannii That Inactivates Coagulation Factor XII.

Waack U, Warnock M, Yee A, Huttinger Z, Smith S, Kumar A, Deroux A, Ginsburg D, Mobley HLT, Lawrence DA, Sandkvist M.

MBio. 2018 Dec 18;9(6). pii: e01606-18. doi: 10.1128/mBio.01606-18.


C-terminal processing of GlyGly-CTERM containing proteins by rhombosortase in Vibrio cholerae.

Gadwal S, Johnson TL, Remmer H, Sandkvist M.

PLoS Pathog. 2018 Oct 23;14(10):e1007341. doi: 10.1371/journal.ppat.1007341. eCollection 2018 Oct.


Targeting the Type II Secretion System: Development, Optimization, and Validation of a High-Throughput Screen for the Identification of Small Molecule Inhibitors.

Waack U, Johnson TL, Chedid K, Xi C, Simmons LA, Mobley HLT, Sandkvist M.

Front Cell Infect Microbiol. 2017 Aug 28;7:380. doi: 10.3389/fcimb.2017.00380. eCollection 2017.


Measuring In Vitro ATPase Activity for Enzymatic Characterization.

Rule CS, Patrick M, Sandkvist M.

J Vis Exp. 2016 Aug 23;(114). doi: 10.3791/54305.


Zinc coordination is essential for the function and activity of the type II secretion ATPase EpsE.

Rule CS, Patrick M, Camberg JL, Maricic N, Hol WG, Sandkvist M.

Microbiologyopen. 2016 Oct;5(5):870-882. doi: 10.1002/mbo3.376. Epub 2016 May 10.


Acinetobacter baumannii Is Dependent on the Type II Secretion System and Its Substrate LipA for Lipid Utilization and In Vivo Fitness.

Johnson TL, Waack U, Smith S, Mobley H, Sandkvist M.

J Bacteriol. 2015 Dec 14;198(4):711-9. doi: 10.1128/JB.00622-15.


Outer Membrane Vesicle-Mediated Export of Processed PrtV Protease from Vibrio cholerae.

Rompikuntal PK, Vdovikova S, Duperthuy M, Johnson TL, Åhlund M, Lundmark R, Oscarsson J, Sandkvist M, Uhlin BE, Wai SN.

PLoS One. 2015 Jul 29;10(7):e0134098. doi: 10.1371/journal.pone.0134098. eCollection 2015.


The Type II secretion system delivers matrix proteins for biofilm formation by Vibrio cholerae.

Johnson TL, Fong JC, Rule C, Rogers A, Yildiz FH, Sandkvist M.

J Bacteriol. 2014 Dec;196(24):4245-52. doi: 10.1128/JB.01944-14. Epub 2014 Sep 29.


Functional and structural characterization of Vibrio cholerae extracellular serine protease B, VesB.

Gadwal S, Korotkov KV, Delarosa JR, Hol WG, Sandkvist M.

J Biol Chem. 2014 Mar 21;289(12):8288-98. doi: 10.1074/jbc.M113.525261. Epub 2014 Jan 23.


Hexamers of the type II secretion ATPase GspE from Vibrio cholerae with increased ATPase activity.

Lu C, Turley S, Marionni ST, Park YJ, Lee KK, Patrick M, Shah R, Sandkvist M, Bush MF, Hol WG.

Structure. 2013 Sep 3;21(9):1707-17. doi: 10.1016/j.str.2013.06.027. Epub 2013 Aug 15.


Fluorescence microscopy and proteomics to investigate subcellular localization, assembly, and function of the type II secretion system.

Johnson TL, Sikora AE, Zielke RA, Sandkvist M.

Methods Mol Biol. 2013;966:157-72. doi: 10.1007/978-1-62703-245-2_10.


The type II secretion system: biogenesis, molecular architecture and mechanism.

Korotkov KV, Sandkvist M, Hol WG.

Nat Rev Microbiol. 2012 Apr 2;10(5):336-51. doi: 10.1038/nrmicro2762. Review.


Structural and functional studies on the interaction of GspC and GspD in the type II secretion system.

Korotkov KV, Johnson TL, Jobling MG, Pruneda J, Pardon E, Héroux A, Turley S, Steyaert J, Holmes RK, Sandkvist M, Hol WG.

PLoS Pathog. 2011 Sep;7(9):e1002228. doi: 10.1371/journal.ppat.1002228. Epub 2011 Sep 8.


Long helical filaments are not seen encircling cells in electron cryotomograms of rod-shaped bacteria.

Swulius MT, Chen S, Jane Ding H, Li Z, Briegel A, Pilhofer M, Tocheva EI, Lybarger SR, Johnson TL, Sandkvist M, Jensen GJ.

Biochem Biophys Res Commun. 2011 Apr 22;407(4):650-5. doi: 10.1016/j.bbrc.2011.03.062. Epub 2011 Mar 16.


Proteomic analysis of the Vibrio cholerae type II secretome reveals new proteins, including three related serine proteases.

Sikora AE, Zielke RA, Lawrence DA, Andrews PC, Sandkvist M.

J Biol Chem. 2011 May 13;286(19):16555-66. doi: 10.1074/jbc.M110.211078. Epub 2011 Mar 8.


Involvement of the GspAB complex in assembly of the type II secretion system secretin of Aeromonas and Vibrio species.

Strozen TG, Stanley H, Gu Y, Boyd J, Bagdasarian M, Sandkvist M, Howard SP.

J Bacteriol. 2011 May;193(9):2322-31. doi: 10.1128/JB.01413-10. Epub 2011 Mar 4.


In vivo cross-linking of EpsG to EpsL suggests a role for EpsL as an ATPase-pseudopilin coupling protein in the Type II secretion system of Vibrio cholerae.

Gray MD, Bagdasarian M, Hol WG, Sandkvist M.

Mol Microbiol. 2011 Feb;79(3):786-98. doi: 10.1111/j.1365-2958.2010.07487.x.


Oligomerization of EpsE coordinates residues from multiple subunits to facilitate ATPase activity.

Patrick M, Korotkov KV, Hol WG, Sandkvist M.

J Biol Chem. 2011 Mar 25;286(12):10378-86. doi: 10.1074/jbc.M110.167031. Epub 2011 Jan 5.


Type II Secretion in Escherichia coli.

Patrick M, Gray MD, Sandkvist M, Johnson TL.

EcoSal Plus. 2010 Sep;4(1). doi: 10.1128/ecosalplus.4.3.4.


Calcium is essential for the major pseudopilin in the type 2 secretion system.

Korotkov KV, Gray MD, Kreger A, Turley S, Sandkvist M, Hol WG.

J Biol Chem. 2009 Sep 18;284(38):25466-70. doi: 10.1074/jbc.C109.037655. Epub 2009 Jul 29.


Cell envelope perturbation induces oxidative stress and changes in iron homeostasis in Vibrio cholerae.

Sikora AE, Beyhan S, Bagdasarian M, Yildiz FH, Sandkvist M.

J Bacteriol. 2009 Sep;191(17):5398-408. doi: 10.1128/JB.00092-09. Epub 2009 Jun 19.


The three-dimensional structure of the cytoplasmic domains of EpsF from the type 2 secretion system of Vibrio cholerae.

Abendroth J, Mitchell DD, Korotkov KV, Johnson TL, Kreger A, Sandkvist M, Hol WG.

J Struct Biol. 2009 Jun;166(3):303-15. doi: 10.1016/j.jsb.2009.03.009. Epub 2009 Mar 24.


Docking and assembly of the type II secretion complex of Vibrio cholerae.

Lybarger SR, Johnson TL, Gray MD, Sikora AE, Sandkvist M.

J Bacteriol. 2009 May;191(9):3149-61. doi: 10.1128/JB.01701-08. Epub 2009 Feb 27.


Mapping critical interactive sites within the periplasmic domain of the Vibrio cholerae type II secretion protein EpsM.

Johnson TL, Scott ME, Sandkvist M.

J Bacteriol. 2007 Dec;189(24):9082-9. Epub 2007 Oct 5.


Compromised outer membrane integrity in Vibrio cholerae Type II secretion mutants.

Sikora AE, Lybarger SR, Sandkvist M.

J Bacteriol. 2007 Dec;189(23):8484-95. Epub 2007 Sep 21.


Synergistic stimulation of EpsE ATP hydrolysis by EpsL and acidic phospholipids.

Camberg JL, Johnson TL, Patrick M, Abendroth J, Hol WG, Sandkvist M.

EMBO J. 2007 Jan 10;26(1):19-27. Epub 2006 Dec 7.


Identification of a novel targeting sequence for regulated secretion in the serine protease inhibitor neuroserpin.

Ishigami S, Sandkvist M, Tsui F, Moore E, Coleman TA, Lawrence DA.

Biochem J. 2007 Feb 15;402(1):25-34.


Type II secretion: from structure to function.

Johnson TL, Abendroth J, Hol WG, Sandkvist M.

FEMS Microbiol Lett. 2006 Feb;255(2):175-86. Review.


Molecular analysis of the Vibrio cholerae type II secretion ATPase EpsE.

Camberg JL, Sandkvist M.

J Bacteriol. 2005 Jan;187(1):249-56.


Microbiology. A hitchhiker's guide to type IV secretion.

Lybarger SR, Sandkvist M.

Science. 2004 May 21;304(5674):1122-3. No abstract available.


Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein.

Yepes M, Sandkvist M, Moore EG, Bugge TH, Strickland DK, Lawrence DA.

J Clin Invest. 2003 Nov;112(10):1533-40.


Crystal structure of the extracellular protein secretion NTPase EpsE of Vibrio cholerae.

Robien MA, Krumm BE, Sandkvist M, Hol WG.

J Mol Biol. 2003 Oct 24;333(3):657-74.


Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent.

Yepes M, Sandkvist M, Coleman TA, Moore E, Wu JY, Mitola D, Bugge TH, Lawrence DA.

J Clin Invest. 2002 Jun;109(12):1571-8.


Directed polar secretion of protease from single cells of Vibrio cholerae via the type II secretion pathway.

Scott ME, Dossani ZY, Sandkvist M.

Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13978-83. Epub 2001 Nov 6.


Type II secretion and pathogenesis.

Sandkvist M.

Infect Immun. 2001 Jun;69(6):3523-35. Review. No abstract available.


Biology of type II secretion.

Sandkvist M.

Mol Microbiol. 2001 Apr;40(2):271-83. Review.


Characterization of the multimeric Eps complex required for cholera toxin secretion.

Sandkvist M, Bagdasarian M, Howard SP.

Int J Med Microbiol. 2000 Oct;290(4-5):345-50.


Neuroserpin reduces cerebral infarct volume and protects neurons from ischemia-induced apoptosis.

Yepes M, Sandkvist M, Wong MK, Coleman TA, Smith E, Cohan SL, Lawrence DA.

Blood. 2000 Jul 15;96(2):569-76.


Convergence of the secretory pathways for cholera toxin and the filamentous phage, CTXphi.

Davis BM, Lawson EH, Sandkvist M, Ali A, Sozhamannan S, Waldor MK.

Science. 2000 Apr 14;288(5464):333-5.


Direct interaction of the EpsL and EpsM proteins of the general secretion apparatus in Vibrio cholerae.

Sandkvist M, Hough LP, Bagdasarian MM, Bagdasarian M.

J Bacteriol. 1999 May;181(10):3129-35.


Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival.

Hastings GA, Coleman TA, Haudenschild CC, Stefansson S, Smith EP, Barthlow R, Cherry S, Sandkvist M, Lawrence DA.

J Biol Chem. 1997 Dec 26;272(52):33062-7.


General secretion pathway (eps) genes required for toxin secretion and outer membrane biogenesis in Vibrio cholerae.

Sandkvist M, Michel LO, Hough LP, Morales VM, Bagdasarian M, Koomey M, DiRita VJ, Bagdasarian M.

J Bacteriol. 1997 Nov;179(22):6994-7003.


Secretion of recombinant proteins by Gram-negative bacteria.

Sandkvist M, Bagdasarian M.

Curr Opin Biotechnol. 1996 Oct;7(5):505-11. Review.


Suppression of temperature-sensitive assembly mutants of heat-labile enterotoxin B subunits.

Sandkvist M, Bagdasarian M.

Mol Microbiol. 1993 Nov;10(3):635-45.


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