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Association of the TLR1 variant rs5743557 with susceptibility to tuberculosis.

Zhang M, Wang J, Wang Y, Wu S, Sandford AJ, Luo J, He JQ.

J Thorac Dis. 2019 Feb;11(2):583-594. doi: 10.21037/jtd.2019.01.74.


Association Study of Myosin Heavy Chain 15 Polymorphisms with Asthma Susceptibility in Chinese Han.

Chen G, Luo L, Zhang MM, Wu SQ, Wang Y, Sandford AJ, He JQ.

Biomed Res Int. 2019 Feb 18;2019:3805405. doi: 10.1155/2019/3805405. eCollection 2019.


Abbott RealTime MTB and MTB RIF/INH assays for the diagnosis of tuberculosis and rifampicin/isoniazid resistance.

Wang MG, Xue M, Wu SQ, Zhang MM, Wang Y, Liu Q, Sandford AJ, He JQ.

Infect Genet Evol. 2019 Jul;71:54-59. doi: 10.1016/j.meegid.2019.03.012. Epub 2019 Mar 20.


Association of PXR and CAR Polymorphisms and Antituberculosis Drug-Induced Hepatotoxicity.

Wang Y, Xiang X, Huang WW, Sandford AJ, Wu SQ, Zhang MM, Wang MG, Chen G, He JQ.

Sci Rep. 2019 Feb 18;9(1):2217. doi: 10.1038/s41598-018-38452-z.


Adhesion molecule gene variants and plasma protein levels in patients with suspected obstructive sleep apnea.

Sandford AJ, Ha A, Ngan DA, Akhabir L, Saferali A, Fox N, Hirsch Allen AJ, Warby SC, van Eeden SF, Ayas NT.

PLoS One. 2019 Jan 17;14(1):e0210732. doi: 10.1371/journal.pone.0210732. eCollection 2019.


Association between tobacco smoking and drug-resistant tuberculosis.

Wang MG, Huang WW, Wang Y, Zhang YX, Zhang MM, Wu SQ, Sandford AJ, He JQ.

Infect Drug Resist. 2018 Jun 12;11:873-887. doi: 10.2147/IDR.S164596. eCollection 2018. Review.


Polymorphisms in Toll-Like Receptor 10 and Tuberculosis Susceptibility: Evidence from Three Independent Series.

Wang Y, Zhang MM, Huang WW, Wu SQ, Wang MG, Tang XY, Sandford AJ, He JQ.

Front Immunol. 2018 Feb 23;9:309. doi: 10.3389/fimmu.2018.00309. eCollection 2018.


Variants of TLR1 associated with tuberculosis susceptibility in the Chinese Tibetan population but not in Han Chinese.

Zhang M, Tang X, Wang Y, Wu S, Wang M, Liu Q, Sandford AJ, He JQ.

Infect Genet Evol. 2018 Jul;61:53-59. doi: 10.1016/j.meegid.2018.02.021. Epub 2018 Feb 15.


A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma.

Asai Y, Eslami A, van Ginkel CD, Akhabir L, Wan M, Yin D, Ellis G, Ben-Shoshan M, Marenholz I, Martino D, Ferreira MA, Allen K, Mazer B, de Groot H, de Jong NW, Gerth van Wijk R, Dubois AEJ, Grosche S, Ashley S, Rüschendorf F, Kalb B, Beyer K, Nöthen MM, Lee YA, Chin R, Cheuk S, Hoffman J, Jorgensen E, Witte JS, Melles RB, Hong X, Wang X, Hui J, Musk AWB, Hunter M, James AL, Koppelman GH, Sandford AJ, Clarke AE, Daley D.

J Allergy Clin Immunol. 2018 Apr;141(4):1513-1516. doi: 10.1016/j.jaci.2017.10.047. Epub 2018 Jan 8. No abstract available.


Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy.

Asai Y, Eslami A, van Ginkel CD, Akhabir L, Wan M, Ellis G, Ben-Shoshan M, Martino D, Ferreira MA, Allen K, Mazer B, de Groot H, de Jong NW, Gerth van Wijk RN, Dubois AEJ, Chin R, Cheuk S, Hoffman J, Jorgensen E, Witte JS, Melles RB, Hong X, Wang X, Hui J, Musk AWB, Hunter M, James AL, Koppelman GH, Sandford AJ, Clarke AE, Daley D.

J Allergy Clin Immunol. 2018 Mar;141(3):991-1001. doi: 10.1016/j.jaci.2017.09.015. Epub 2017 Oct 10.


Association of CYP2B6 gene polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in a Chinese population.

Wang Y, Xiang X, Wu SQ, Chen G, Zhang MM, Wang MG, Wang FJ, Sandford AJ, He JQ.

Infect Genet Evol. 2017 Jul;51:198-202. doi: 10.1016/j.meegid.2017.04.001. Epub 2017 Apr 5.


Heterozygote Advantage of the rs3794624 Polymorphism in CYBA for Resistance to Tuberculosis in Two Chinese Populations.

Liu Q, Wu S, Xue M, Sandford AJ, Wu J, Wang Y, Chen G, Tao C, Tang Y, Feng Y, Luo J, He JQ.

Sci Rep. 2016 Nov 30;6:38213. doi: 10.1038/srep38213.


Endoplasmic Reticulum Stress and Chemokine Production in Cystic Fibrosis Airway Cells: Regulation by STAT3 Modulation.

Tang AC, Saferali A, He G, Sandford AJ, Strug LJ, Turvey SE.

J Infect Dis. 2017 Jan 15;215(2):293-302. doi: 10.1093/infdis/jiw516.


Association between TXNRD1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in a prospective study.

Ji GY, Wang Y, Wu SQ, Liu QQ, Wu JC, Zhang MM, Sandford AJ, He JQ.

Genet Mol Res. 2016 Sep 2;15(3). doi: 10.4238/gmr.15038296.


Rifampicin-induced antineutrophil cytoplasmic antibody-positive vasculitis: a case report and review of the literature.

Ji G, Zeng X, Sandford AJ, He JQ.

Int J Clin Pharmacol Ther. 2016 Oct;54(10):804-7. doi: 10.5414/CP202576. Review.


Genetic Polymorphisms of Glutathione S-Transferase P1 (GSTP1) and the Incidence of Anti-Tuberculosis Drug-Induced Hepatotoxicity.

Wu S, Wang YJ, Tang X, Wang Y, Wu J, Ji G, Zhang M, Chen G, Liu Q, Sandford AJ, He JQ.

PLoS One. 2016 Jun 9;11(6):e0157478. doi: 10.1371/journal.pone.0157478. eCollection 2016.


The BuMPy Road to COPD Gene Discovery.

Sandford AJ.

EBioMedicine. 2016 Feb 6;5:18-9. doi: 10.1016/j.ebiom.2016.02.015. eCollection 2016 Mar. No abstract available.


Update meta-analysis of the CYP2E1 RsaI/PstI and DraI polymorphisms and risk of antituberculosis drug-induced hepatotoxicity: evidence from 26 studies.

Wang FJ, Wang Y, Niu T, Lu WX, Sandford AJ, He JQ.

J Clin Pharm Ther. 2016 Jun;41(3):334-40. doi: 10.1111/jcpt.12388. Epub 2016 Apr 9. Review.


Analysis of silent information regulator 1 (SIRT1) gene polymorphisms in antituberculosis- drug-induced hepatotoxicity in a prospective cohort study.

Wang Y, Yan XY, Wu JC, Ji GY, Wu SQ, Huang WW, Chen G, Sandford AJ, He JQ.

Int J Clin Pharmacol Ther. 2016 Oct;54(10):775-81. doi: 10.5414/CP202506.


Associations of interleukin-1 gene cluster polymorphisms with C-reactive protein concentration and lung function decline in smoking-induced chronic obstructive pulmonary disease.

Wang Y, Shumansky K, Sin DD, Man SF, Akhabir L, Connett JE, Anthonisen NR, Paré PD, Sandford AJ, He JQ.

Int J Clin Exp Pathol. 2015 Oct 1;8(10):13125-35. eCollection 2015.


Molecular mechanisms underlying variations in lung function: a systems genetics analysis.

Obeidat M, Hao K, Bossé Y, Nickle DC, Nie Y, Postma DS, Laviolette M, Sandford AJ, Daley DD, Hogg JC, Elliott WM, Fishbane N, Timens W, Hysi PG, Kaprio J, Wilson JF, Hui J, Rawal R, Schulz H, Stubbe B, Hayward C, Polasek O, Järvelin MR, Zhao JH, Jarvis D, Kähönen M, Franceschini N, North KE, Loth DW, Brusselle GG, Smith AV, Gudnason V, Bartz TM, Wilk JB, O'Connor GT, Cassano PA, Tang W, Wain LV, Soler Artigas M, Gharib SA, Strachan DP, Sin DD, Tobin MD, London SJ, Hall IP, Paré PD.

Lancet Respir Med. 2015 Oct;3(10):782-95. doi: 10.1016/S2213-2600(15)00380-X. Epub 2015 Sep 21. Erratum in: Lancet Respir Med. 2015 Dec;3(12):e44.


Association of CYBB polymorphisms with tuberculosis susceptibility in the Chinese Han population.

Liu Q, Wang J, Sandford AJ, Wu J, Wang Y, Wu S, Ji G, Chen G, Feng Y, Tao C, He JQ.

Infect Genet Evol. 2015 Jul;33:169-75. doi: 10.1016/j.meegid.2015.04.026. Epub 2015 Apr 27.


Transcriptomic profiling of peripheral blood CD4⁺ T-cells in asthmatics with and without depression.

Wang T, Ji YL, Yang YY, Xiong XY, Wang IM, Sandford AJ, Liang ZA, He JQ.

Gene. 2015 Jul 10;565(2):282-7. doi: 10.1016/j.gene.2015.04.029. Epub 2015 Apr 11.


Polymorphisms associated with expression of BPIFA1/BPIFB1 and lung disease severity in cystic fibrosis.

Saferali A, Obeidat M, Bérubé JC, Lamontagne M, Bossé Y, Laviolette M, Hao K, Nickle DC, Timens W, Sin DD, Postma DS, Strug LJ, Gallins PJ, Paré PD, Bingle CD, Sandford AJ.

Am J Respir Cell Mol Biol. 2015 Nov;53(5):607-14. doi: 10.1165/rcmb.2014-0182OC.


Thymic stromal lymphopoietin (TSLP) secretion from human nasal epithelium is a function of TSLP genotype.

Hui CC, Yu A, Heroux D, Akhabir L, Sandford AJ, Neighbour H, Denburg JA.

Mucosal Immunol. 2015 Sep;8(5):993-9. doi: 10.1038/mi.2014.126. Epub 2014 Dec 17.


Longer telomere length in COPD patients with α1-antitrypsin deficiency independent of lung function.

Saferali A, Lee J, Sin DD, Rouhani FN, Brantly ML, Sandford AJ.

PLoS One. 2014 Apr 24;9(4):e95600. doi: 10.1371/journal.pone.0095600. eCollection 2014.


Lung expression quantitative trait loci data set identifies important functional polymorphisms in the asthma-associated IL1RL1 region.

Akhabir L, Bérubé JC, Bossé Y, Laviolette M, Hao K, Nickle DC, Timens W, Sin DD, Paré PD, Postma DS, Sandford AJ.

J Allergy Clin Immunol. 2014 Sep;134(3):729-31. doi: 10.1016/j.jaci.2014.02.039. Epub 2014 Apr 18. No abstract available.


Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease.

Aminuddin F, Hackett TL, Stefanowicz D, Saferali A, Paré PD, Gulsvik A, Bakke P, Cho MH, Litonjua A, Lomas DA, Anderson WH, Beaty TH, Silverman EK, Sandford AJ.

BMC Pulm Med. 2013 Nov 6;13:64. doi: 10.1186/1471-2466-13-64.


Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels.

Thun GA, Imboden M, Ferrarotti I, Kumar A, Obeidat M, Zorzetto M, Haun M, Curjuric I, Couto Alves A, Jackson VE, Albrecht E, Ried JS, Teumer A, Lopez LM, Huffman JE, Enroth S, Bossé Y, Hao K, Timens W, Gyllensten U, Polasek O, Wilson JF, Rudan I, Hayward C, Sandford AJ, Deary IJ, Koch B, Reischl E, Schulz H, Hui J, James AL, Rochat T, Russi EW, Jarvelin MR, Strachan DP, Hall IP, Tobin MD, Dahl M, Fallgaard Nielsen S, Nordestgaard BG, Kronenberg F, Luisetti M, Probst-Hensch NM.

PLoS Genet. 2013;9(8):e1003585. doi: 10.1371/journal.pgen.1003585. Epub 2013 Aug 22.


Alveolar macrophage proteinase/antiproteinase expression in lung function and emphysema.

Ishii T, Abboud RT, Wallace AM, English JC, Coxson HO, Finley RJ, Shumansky K, Paré PD, Sandford AJ.

Eur Respir J. 2014 Jan;43(1):82-91. doi: 10.1183/09031936.00174612. Epub 2013 Jul 30.


Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia.

Ali S, Hirschfeld AF, Mayer ML, Fortuno ES 3rd, Corbett N, Kaplan M, Wang S, Schneiderman J, Fjell CD, Yan J, Akhabir L, Aminuddin F, Marr N, Lacaze-Masmonteil T, Hegele RG, Becker A, Chan-Yeung M, Hancock RE, Kollmann TR, Daley D, Sandford AJ, Lavoie PM, Turvey SE.

J Immunol. 2013 Apr 15;190(8):3949-58. doi: 10.4049/jimmunol.1201015. Epub 2013 Mar 13.


HLA-DQB1*02 and DQB1*06:03P are associated with peanut allergy.

Madore AM, Vaillancourt VT, Asai Y, Alizadehfar R, Ben-Shoshan M, Michel DL, Kozyrskyj AL, Becker A, Chan-Yeung M, Clarke AE, Hull P, Daley D, Sandford AJ, Laprise C.

Eur J Hum Genet. 2013 Oct;21(10):1181-4. doi: 10.1038/ejhg.2013.13. Epub 2013 Feb 27.


Personalised medicine and asthma diagnostics/management.

Wadsworth SJ, Sandford AJ.

Curr Allergy Asthma Rep. 2013 Feb;13(1):118-29. doi: 10.1007/s11882-012-0325-9. Review.


Selection of suitable housekeeping genes for real-time quantitative PCR in CD4(+) lymphocytes from asthmatics with or without depression.

Wang T, Liang ZA, Sandford AJ, Xiong XY, Yang YY, Ji YL, He JQ.

PLoS One. 2012;7(10):e48367. doi: 10.1371/journal.pone.0048367. Epub 2012 Oct 24.


Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes.

Daley D, Park JE, He JQ, Yan J, Akhabir L, Stefanowicz D, Becker AB, Chan-Yeung M, Bossé Y, Kozyrskyj AL, James AL, Musk AW, Laprise C, Hegele RG, Paré PD, Sandford AJ.

J Allergy Clin Immunol. 2012 Dec;130(6):1284-93. doi: 10.1016/j.jaci.2012.07.051. Epub 2012 Oct 9.


Functional characterization of the matrix metalloproteinase-1 cigarette smoke-responsive region and association with the lung health study.

Wallace AM, Mercer BA, He J, Foronjy RF, Accili D, Sandford AJ, Paré PD, D'Armiento JM.

Respir Res. 2012 Sep 19;13:79. doi: 10.1186/1465-9921-13-79.


NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease.

Sandford AJ, Malhotra D, Boezen HM, Siedlinski M, Postma DS, Wong V, Akhabir L, He JQ, Connett JE, Anthonisen NR, Paré PD, Biswal S.

Physiol Genomics. 2012 Aug 1;44(15):754-63. doi: 10.1152/physiolgenomics.00027.2012. Epub 2012 Jun 12.


Molecular signature of smoking in human lung tissues.

Bossé Y, Postma DS, Sin DD, Lamontagne M, Couture C, Gaudreault N, Joubert P, Wong V, Elliott M, van den Berge M, Brandsma CA, Tribouley C, Malkov V, Tsou JA, Opiteck GJ, Hogg JC, Sandford AJ, Timens W, Paré PD, Laviolette M.

Cancer Res. 2012 Aug 1;72(15):3753-63. Epub 2012 Jun 1.


The relationship between telomere length and mortality in chronic obstructive pulmonary disease (COPD).

Lee J, Sandford AJ, Connett JE, Yan J, Mui T, Li Y, Daley D, Anthonisen NR, Brooks-Wilson A, Man SF, Sin DD.

PLoS One. 2012;7(4):e35567. doi: 10.1371/journal.pone.0035567. Epub 2012 Apr 25.


Genetic association between human chitinases and lung function in COPD.

Aminuddin F, Akhabir L, Stefanowicz D, Paré PD, Connett JE, Anthonisen NR, Fahy JV, Seibold MA, Burchard EG, Eng C, Gulsvik A, Bakke P, Cho MH, Litonjua A, Lomas DA, Anderson WH, Beaty TH, Crapo JD, Silverman EK, Sandford AJ.

Hum Genet. 2012 Jul;131(7):1105-14. doi: 10.1007/s00439-011-1127-1. Epub 2011 Dec 28.


Effect of heme oxygenase-1 polymorphisms on lung function and gene expression.

Tanaka G, Aminuddin F, Akhabir L, He JQ, Shumansky K, Connett JE, Anthonisen NR, Abboud RT, Paré PD, Sandford AJ.

BMC Med Genet. 2011 Sep 8;12:117. doi: 10.1186/1471-2350-12-117.


Effect of gene environment interactions on lung function and cardiovascular disease in COPD.

Hackett TL, Stefanowicz D, Aminuddin F, Sin DD, Connett JE, Anthonisen NR, Paré PD, Sandford AJ.

Int J Chron Obstruct Pulmon Dis. 2011;6:277-87. doi: 10.2147/COPD.S18279. Epub 2011 May 10.


Genome-wide association studies for discovery of genes involved in asthma.

Akhabir L, Sandford AJ.

Respirology. 2011 Apr;16(3):396-406. doi: 10.1111/j.1440-1843.2011.01939.x. Review.


Cystic fibrosis modifier genes related to Pseudomonas aeruginosa infection.

Park JE, Yung R, Stefanowicz D, Shumansky K, Akhabir L, Durie PR, Corey M, Zielenski J, Dorfman R, Daley D, Sandford AJ.

Genes Immun. 2011 Jul;12(5):370-7. doi: 10.1038/gene.2011.5. Epub 2011 Jan 27.


TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis.

Blohmke CJ, Park J, Hirschfeld AF, Victor RE, Schneiderman J, Stefanowicz D, Chilvers MA, Durie PR, Corey M, Zielenski J, Dorfman R, Sandford AJ, Daley D, Turvey SE.

J Immunol. 2010 Dec 15;185(12):7731-8. doi: 10.4049/jimmunol.1001513. Epub 2010 Nov 10.


Understanding the population structure of North American patients with cystic fibrosis.

Li W, Sun L, Corey M, Zou F, Lee S, Cojocaru AL, Taylor C, Blackman SM, Stephenson A, Sandford AJ, Dorfman R, Drumm ML, Cutting GR, Knowles MR, Durie P, Wright FA, Strug LJ.

Clin Genet. 2011 Feb;79(2):136-46. doi: 10.1111/j.1399-0004.2010.01502.x.


Asthma susceptibility: The role of transforming growth factor beta1.

Sandford AJ.

Respirology. 2010 May;15(4):583-4. doi: 10.1111/j.1440-1843.2010.01760.x. No abstract available.


Telomere length and chronic obstructive pulmonary disease: evidence of accelerated aging.

Mui TS, Man JM, McElhaney JE, Sandford AJ, Coxson HO, Birmingham CL, Li Y, Man SF, Sin DD.

J Am Geriatr Soc. 2009 Dec;57(12):2372-4. doi: 10.1111/j.1532-5415.2009.02589.x. No abstract available.


Lack of association of TIM3 polymorphisms and allergic phenotypes.

Zhang J, Daley D, Akhabir L, Stefanowicz D, Chan-Yeung M, Becker AB, Laprise C, Paré PD, Sandford AJ.

BMC Med Genet. 2009 Jun 30;10:62. doi: 10.1186/1471-2350-10-62.


Role of genetic susceptibility to latent adenoviral infection and decreased lung function.

Kasuga I, Hogg JC, Paré PD, Hayashi S, Sedgwick EG, Ruan J, Wallace AM, He JQ, Zhang X, Sandford AJ.

Respir Med. 2009 Nov;103(11):1672-80. doi: 10.1016/j.rmed.2009.05.008. Epub 2009 Jun 6.

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