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Antibody responses elicited by immunization with BG505 trimer-immune complexes.

Gach JS, Mara KJV, LaBranche CC, van Gils MJ, McCoy LE, Klasse PJ, Montefiori DC, Sanders RW, Moore JP, Forthal DN.

J Virol. 2019 Aug 2. pii: JVI.01188-19. doi: 10.1128/JVI.01188-19. [Epub ahead of print]


Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics.

Torrents de la Peña A, Rantalainen K, Cottrell CA, Allen JD, van Gils MJ, Torres JL, Crispin M, Sanders RW, Ward AB.

PLoS Pathog. 2019 Jul 15;15(7):e1007920. doi: 10.1371/journal.ppat.1007920. eCollection 2019 Jul.


Symptomatic Iliosacral Screw Removal After Pelvic Trauma-Incidence and Clinical Impact.

Quade J, Busel G, Beebe M, Auston D, Shah AR, Infante A, Maxson B, Watson D, Sanders RW, Mir HR.

J Orthop Trauma. 2019 Jul;33(7):351-353. doi: 10.1097/BOT.0000000000001453.


Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies.

Yuan M, Cottrell CA, Ozorowski G, van Gils MJ, Kumar S, Wu NC, Sarkar A, Torres JL, de Val N, Copps J, Moore JP, Sanders RW, Ward AB, Wilson IA.

Cell Host Microbe. 2019 Jun 12;25(6):873-883.e5. doi: 10.1016/j.chom.2019.04.011.


Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence.

Sliepen K, Han BW, Bontjer I, Mooij P, Garces F, Behrens AJ, Rantalainen K, Kumar S, Sarkar A, Brouwer PJM, Hua Y, Tolazzi M, Schermer E, Torres JL, Ozorowski G, van der Woude P, de la Peña AT, van Breemen MJ, Camacho-Sánchez JM, Burger JA, Medina-Ramírez M, González N, Alcami J, LaBranche C, Scarlatti G, van Gils MJ, Crispin M, Montefiori DC, Ward AB, Koopman G, Moore JP, Shattock RJ, Bogers WM, Wilson IA, Sanders RW.

Nat Commun. 2019 May 29;10(1):2355. doi: 10.1038/s41467-019-10262-5.


Extreme Nailing: Is It Safe to Allow Immediate Weightbearing After Intramedullary Nail Fixation of Extra-articular Distal Tibial Fractures (OTA/AO 43-A)?

Beebe MJ, Morwood M, Serrano R, Quade JH, Auston DA, Watson DT, Sanders RW, Mir HR.

J Orthop Trauma. 2019 Aug;33(8):392-396. doi: 10.1097/BOT.0000000000001484.


Lower Broadly Neutralizing Antibody Responses in Female Versus Male HIV-1 Infected Injecting Drug Users.

Euler Z, VAN DEN Kerkhof TL, Kouyos RD, Tully DC, Allen TM, Trkola A, Sanders RW, Schuitemaker H, VAN Gils MJ.

Viruses. 2019 Apr 25;11(4). pii: E384. doi: 10.3390/v11040384.


Broadly neutralising antibodies in post-treatment control.

de Bree GJ, Sanders RW.

Lancet HIV. 2019 May;6(5):e271-e272. doi: 10.1016/S2352-3018(19)30075-X. Epub 2019 Apr 15. No abstract available.


Presentation of HIV-1 envelope glycoprotein trimers on diverse nanoparticle platforms.

Brouwer PJM, Sanders RW.

Curr Opin HIV AIDS. 2019 Jul;14(4):302-308. doi: 10.1097/COH.0000000000000549.


"Orthopaedic Surgeons Responding to the US Opioid Crisis." Commentary on: "Clinical Practice Guidelines for Pain Management in Acute Musculoskeletal Injury."

Mir HR, Sanders RW.

J Orthop Trauma. 2019 May;33(5):215. doi: 10.1097/BOT.0000000000001479. No abstract available.


Developability Assessment of Physicochemical Properties and Stability Profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 Envelope Glycoprotein Trimers as Candidate Vaccine Antigens.

Whitaker N, Hickey JM, Kaur K, Xiong J, Sawant N, Cupo A, Lee WH, Ozorowski G, Medina-Ramírez M, Ward AB, Sanders RW, Moore JP, Joshi SB, Volkin DB, Dey AK.

J Pharm Sci. 2019 Jul;108(7):2264-2277. doi: 10.1016/j.xphs.2019.01.033. Epub 2019 Feb 15.


Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide.

Kumar S, Sarkar A, Pugach P, Sanders RW, Moore JP, Ward AB, Wilson IA.

Nat Commun. 2019 Feb 15;10(1):763. doi: 10.1038/s41467-019-08738-5.


Stabilization of the V2 loop improves the presentation of V2 loop-associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers.

de Taeye SW, Go EP, Sliepen K, de la Peña AT, Badal K, Medina-Ramírez M, Lee WH, Desaire H, Wilson IA, Moore JP, Ward AB, Sanders RW.

J Biol Chem. 2019 Apr 5;294(14):5616-5631. doi: 10.1074/jbc.RA118.005396. Epub 2019 Feb 6.


HIV-1 anchor inhibitors and membrane fusion inhibitors target distinct but overlapping steps in virus entry.

Eggink D, Bontjer I, de Taeye SW, Langedijk JPM, Berkhout B, Sanders RW.

J Biol Chem. 2019 Apr 12;294(15):5736-5746. doi: 10.1074/jbc.RA119.007360. Epub 2019 Jan 29.


Carbon Monoxide Levels in the Extravehicular Mobility Unit by Modeling and Operational Testing.

Makowski MS, Norcross JR, Alexander D, Sanders RW, Conkin J, Young M.

Aerosp Med Hum Perform. 2019 Feb 1;90(2):84-91. doi: 10.3357/AMHP.5220.2019.


Slow waves, cognitive disintegration, and delirium.

Sleigh J, Sanders RW.

Br J Anaesth. 2019 Jan;122(1):9-11. doi: 10.1016/j.bja.2018.10.024. Epub 2018 Nov 22. No abstract available.


Biomechanical Investigation of an Integrated 2-Screw Cephalomedullary Nail Versus a Sliding Hip Screw in Unstable Intertrochanteric Fractures.

Santoni BG, Diaz MA, Stoops TK, Lannon S, Ali A, Sanders RW.

J Orthop Trauma. 2019 Feb;33(2):82-87. doi: 10.1097/BOT.0000000000001351.


Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers.

Pauthner MG, Nkolola JP, Havenar-Daughton C, Murrell B, Reiss SM, Bastidas R, Prévost J, Nedellec R, von Bredow B, Abbink P, Cottrell CA, Kulp DW, Tokatlian T, Nogal B, Bianchi M, Li H, Lee JH, Butera ST, Evans DT, Hangartner L, Finzi A, Wilson IA, Wyatt RT, Irvine DJ, Schief WR, Ward AB, Sanders RW, Crotty S, Shaw GM, Barouch DH, Burton DR.

Immunity. 2019 Jan 15;50(1):241-252.e6. doi: 10.1016/j.immuni.2018.11.011. Epub 2018 Dec 11.


Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier.

Bonsignori M, Scott E, Wiehe K, Easterhoff D, Alam SM, Hwang KK, Cooper M, Xia SM, Zhang R, Montefiori DC, Henderson R, Nie X, Kelsoe G, Moody MA, Chen X, Joyce MG, Kwong PD, Connors M, Mascola JR, McGuire AT, Stamatatos L, Medina-Ramírez M, Sanders RW, Saunders KO, Kepler TB, Haynes BF.

Immunity. 2018 Dec 18;49(6):1162-1174.e8. doi: 10.1016/j.immuni.2018.10.015. Epub 2018 Dec 11.


Closing and Opening Holes in the Glycan Shield of HIV-1 Envelope Glycoprotein SOSIP Trimers Can Redirect the Neutralizing Antibody Response to the Newly Unmasked Epitopes.

Ringe RP, Pugach P, Cottrell CA, LaBranche CC, Seabright GE, Ketas TJ, Ozorowski G, Kumar S, Schorcht A, van Gils MJ, Crispin M, Montefiori DC, Wilson IA, Ward AB, Sanders RW, Klasse PJ, Moore JP.

J Virol. 2019 Feb 5;93(4). pii: e01656-18. doi: 10.1128/JVI.01656-18. Print 2019 Feb 15.


A Systematic Review and Meta-Analysis of Decompression Sickness in Altitude Physiological Training.

Conkin J, Sanders RW, Koslovsky MD, Wear ML, Kozminski AG, Abercromby AFJ.

Aerosp Med Hum Perform. 2018 Nov 1;89(11):941-951. doi: 10.3357/AMHP.5135.2018.


Potential Economic Benefits of Limited Clinical and Radiographic Follow-up After Plate Fixation of Midshaft Clavicle Fractures.

Sanchez Morales D, Borade A, Serrano-Riera R, Maniar HH, Sanders RW, Horwitz DS.

J Am Acad Orthop Surg. 2019 Jun 1;27(11):405-409. doi: 10.5435/JAAOS-D-17-00598.


Oxygen exposures at NASA's Neutral Buoyancy Lab: a 20-year experience.

Walker SC, Garbino A, Ray K, Hardwick R, Fitzpatrick DT, Sanders RW.

Undersea Hyperb Med. 2018 Jul-Aug;45(4):427-436.


Stabilizing HIV-1 envelope glycoprotein trimers to induce neutralizing antibodies.

Torrents de la Peña A, Sanders RW.

Retrovirology. 2018 Sep 12;15(1):63. doi: 10.1186/s12977-018-0445-y. Review.


Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen.

Struwe WB, Chertova E, Allen JD, Seabright GE, Watanabe Y, Harvey DJ, Medina-Ramirez M, Roser JD, Smith R, Westcott D, Keele BF, Bess JW Jr, Sanders RW, Lifson JD, Moore JP, Crispin M.

Cell Rep. 2018 Aug 21;24(8):1958-1966.e5. doi: 10.1016/j.celrep.2018.07.080.


Hitting HIV's Harpoon.

van Gils MJ, Sanders RW.

Immunity. 2018 Jul 17;49(1):14-15. doi: 10.1016/j.immuni.2018.07.003.


Short Communication: Protective Efficacy of Broadly Neutralizing Antibody PGDM1400 Against HIV-1 Challenge in Humanized Mice.

van der Velden YU, Villaudy J, Siteur-van Rijnstra E, van der Linden CA, Frankin E, Weijer K, Schermer E, Vink MA, Berkhout B, Sanders RW, van Gils MJ.

AIDS Res Hum Retroviruses. 2018 Sep;34(9):790-793. doi: 10.1089/AID.2018.0114. Epub 2018 Aug 22.


Harnessing post-translational modifications for next-generation HIV immunogens.

Allen JD, Sanders RW, Doores KJ, Crispin M.

Biochem Soc Trans. 2018 Jun 19;46(3):691-698. doi: 10.1042/BST20170394. Epub 2018 May 21. Review.


Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.

Schiffner T, Pallesen J, Russell RA, Dodd J, de Val N, LaBranche CC, Montefiori D, Tomaras GD, Shen X, Harris SL, Moghaddam AE, Kalyuzhniy O, Sanders RW, McCoy LE, Moore JP, Ward AB, Sattentau QJ.

PLoS Pathog. 2018 May 10;14(5):e1006986. doi: 10.1371/journal.ppat.1006986. eCollection 2018 May.


Variable Domain N-Linked Glycans Acquired During Antigen-Specific Immune Responses Can Contribute to Immunoglobulin G Antibody Stability.

van de Bovenkamp FS, Derksen NIL, van Breemen MJ, de Taeye SW, Ooijevaar-de Heer P, Sanders RW, Rispens T.

Front Immunol. 2018 Apr 12;9:740. doi: 10.3389/fimmu.2018.00740. eCollection 2018.


Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques.

Klasse PJ, Ketas TJ, Cottrell CA, Ozorowski G, Debnath G, Camara D, Francomano E, Pugach P, Ringe RP, LaBranche CC, van Gils MJ, Bricault CA, Barouch DH, Crotty S, Silvestri G, Kasturi S, Pulendran B, Wilson IA, Montefiori DC, Sanders RW, Ward AB, Moore JP.

PLoS Pathog. 2018 Feb 23;14(2):e1006913. doi: 10.1371/journal.ppat.1006913. eCollection 2018 Feb.


Integrity of Glycosylation Processing of a Glycan-Depleted Trimeric HIV-1 Immunogen Targeting Key B-Cell Lineages.

Behrens AJ, Kumar A, Medina-Ramirez M, Cupo A, Marshall K, Cruz Portillo VM, Harvey DJ, Ozorowski G, Zitzmann N, Wilson IA, Ward AB, Struwe WB, Moore JP, Sanders RW, Crispin M.

J Proteome Res. 2018 Mar 2;17(3):987-999. doi: 10.1021/acs.jproteome.7b00639. Epub 2018 Feb 8.


Immunogenicity in Rabbits of HIV-1 SOSIP Trimers from Clades A, B, and C, Given Individually, Sequentially, or in Combination.

Torrents de la Peña A, de Taeye SW, Sliepen K, LaBranche CC, Burger JA, Schermer EE, Montefiori DC, Moore JP, Klasse PJ, Sanders RW.

J Virol. 2018 Mar 28;92(8). pii: e01957-17. doi: 10.1128/JVI.01957-17. Print 2018 Apr 15.


Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers.

de Taeye SW, de la Peña AT, Vecchione A, Scutigliani E, Sliepen K, Burger JA, van der Woude P, Schorcht A, Schermer EE, van Gils MJ, LaBranche CC, Montefiori DC, Wilson IA, Moore JP, Ward AB, Sanders RW.

J Biol Chem. 2018 Feb 2;293(5):1688-1701. doi: 10.1074/jbc.RA117.000709. Epub 2017 Dec 8.


Effects of Temperature and Photorepair Radiation on a Marine Ciliate Exposed to UVB Radiation.

Hamsher SE, Sung CYT, Sanders RW.

J Eukaryot Microbiol. 2018 Jul;65(4):458-467. doi: 10.1111/jeu.12491. Epub 2018 Jan 13.


cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV-1 envelope glycoprotein vaccine candidate.

Dey AK, Cupo A, Ozorowski G, Sharma VK, Behrens AJ, Go EP, Ketas TJ, Yasmeen A, Klasse PJ, Sayeed E, Desaire H, Crispin M, Wilson IA, Sanders RW, Hassell T, Ward AB, Moore JP.

Biotechnol Bioeng. 2018 Apr;115(4):885-899. doi: 10.1002/bit.26498. Epub 2017 Dec 11.


The microanatomic segregation of selection by apoptosis in the germinal center.

Mayer CT, Gazumyan A, Kara EE, Gitlin AD, Golijanin J, Viant C, Pai J, Oliveira TY, Wang Q, Escolano A, Medina-Ramirez M, Sanders RW, Nussenzweig MC.

Science. 2017 Oct 13;358(6360). pii: eaao2602. doi: 10.1126/science.aao2602. Epub 2017 Sep 21.


High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers.

Sullivan JT, Sulli C, Nilo A, Yasmeen A, Ozorowski G, Sanders RW, Ward AB, Klasse PJ, Moore JP, Doranz BJ.

J Virol. 2017 Oct 27;91(22). pii: e00862-17. doi: 10.1128/JVI.00862-17. Print 2017 Nov 15.


Opposites attract in bispecific antibody engineering.

van Gils MJ, Sanders RW.

J Biol Chem. 2017 Sep 1;292(35):14718-14719. doi: 10.1074/jbc.H117.793497.


Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

Medina-Ramírez M, Garces F, Escolano A, Skog P, de Taeye SW, Del Moral-Sanchez I, McGuire AT, Yasmeen A, Behrens AJ, Ozorowski G, van den Kerkhof TLGM, Freund NT, Dosenovic P, Hua Y, Gitlin AD, Cupo A, van der Woude P, Golabek M, Sliepen K, Blane T, Kootstra N, van Breemen MJ, Pritchard LK, Stanfield RL, Crispin M, Ward AB, Stamatatos L, Klasse PJ, Moore JP, Nemazee D, Nussenzweig MC, Wilson IA, Sanders RW.

J Exp Med. 2017 Sep 4;214(9):2573-2590. doi: 10.1084/jem.20161160. Epub 2017 Aug 28.


Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization.

Torrents de la Peña A, Julien JP, de Taeye SW, Garces F, Guttman M, Ozorowski G, Pritchard LK, Behrens AJ, Go EP, Burger JA, Schermer EE, Sliepen K, Ketas TJ, Pugach P, Yasmeen A, Cottrell CA, Torres JL, Vavourakis CD, van Gils MJ, LaBranche C, Montefiori DC, Desaire H, Crispin M, Klasse PJ, Lee KK, Moore JP, Ward AB, Wilson IA, Sanders RW.

Cell Rep. 2017 Aug 22;20(8):1805-1817. doi: 10.1016/j.celrep.2017.07.077.


Cephalomedullary Nail Fixation of Intertrochanteric Femur Fractures: Are Two Proximal Screws Better Than One?

Serrano R, Blair JA, Watson DT, Infante AF Jr, Shah AR, Mir HR, Maxson BJ, Downes KL, Sanders RW.

J Orthop Trauma. 2017 Nov;31(11):577-582. doi: 10.1097/BOT.0000000000000967. Erratum in: J Orthop Trauma. 2018 Feb;32(2):e75.


HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers.

Capucci S, Wee EG, Schiffner T, LaBranche CC, Borthwick N, Cupo A, Dodd J, Dean H, Sattentau Q, Montefiori D, Klasse PJ, Sanders RW, Moore JP, Hanke T.

PLoS One. 2017 Aug 9;12(8):e0181886. doi: 10.1371/journal.pone.0181886. eCollection 2017.


Hypertension screening of commercial divers from an occupational medicine perspective.

Garbino A, Sanders RW, Mathers CH.

Undersea Hyperb Med. 2017 Mar-Apr;44(2):133-139.


Oceanic protists with different forms of acquired phototrophy display contrasting biogeographies and abundance.

Leles SG, Mitra A, Flynn KJ, Stoecker DK, Hansen PJ, Calbet A, McManus GB, Sanders RW, Caron DA, Not F, Hallegraeff GM, Pitta P, Raven JA, Johnson MD, Glibert PM, Våge S.

Proc Biol Sci. 2017 Aug 16;284(1860). pii: 20170664. doi: 10.1098/rspb.2017.0664.


Structure and topology around the cleavage site regulate post-translational cleavage of the HIV-1 gp160 signal peptide.

Snapp EL, McCaul N, Quandte M, Cabartova Z, Bontjer I, Källgren C, Nilsson I, Land A, von Heijne G, Sanders RW, Braakman I.

Elife. 2017 Jul 28;6. pii: e26067. doi: 10.7554/eLife.26067.


A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors.

de Vries RP, Tzarum N, Peng W, Thompson AJ, Ambepitiya Wickramasinghe IN, de la Pena ATT, van Breemen MJ, Bouwman KM, Zhu X, McBride R, Yu W, Sanders RW, Verheije MH, Wilson IA, Paulson JC.

EMBO Mol Med. 2017 Sep;9(9):1314-1325. doi: 10.15252/emmm.201707726.


Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.

Pauthner M, Havenar-Daughton C, Sok D, Nkolola JP, Bastidas R, Boopathy AV, Carnathan DG, Chandrashekar A, Cirelli KM, Cottrell CA, Eroshkin AM, Guenaga J, Kaushik K, Kulp DW, Liu J, McCoy LE, Oom AL, Ozorowski G, Post KW, Sharma SK, Steichen JM, de Taeye SW, Tokatlian T, Torrents de la Peña A, Butera ST, LaBranche CC, Montefiori DC, Silvestri G, Wilson IA, Irvine DJ, Sanders RW, Schief WR, Ward AB, Wyatt RT, Barouch DH, Crotty S, Burton DR.

Immunity. 2017 Jun 20;46(6):1073-1088.e6. doi: 10.1016/j.immuni.2017.05.007.


Three mutations switch H7N9 influenza to human-type receptor specificity.

de Vries RP, Peng W, Grant OC, Thompson AJ, Zhu X, Bouwman KM, de la Pena ATT, van Breemen MJ, Ambepitiya Wickramasinghe IN, de Haan CAM, Yu W, McBride R, Sanders RW, Woods RJ, Verheije MH, Wilson IA, Paulson JC.

PLoS Pathog. 2017 Jun 15;13(6):e1006390. doi: 10.1371/journal.ppat.1006390. eCollection 2017 Jun.


OTA/AO Classification Is Highly Predictive of Acute Compartment Syndrome After Tibia Fracture: A Cohort of 2885 Fractures.

Beebe MJ, Auston DA, Quade JH, Serrano-Riera R, Shah AR, Watson DT, Sanders RW, Mir HR.

J Orthop Trauma. 2017 Nov;31(11):600-605. doi: 10.1097/BOT.0000000000000918.


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