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Items: 49


Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration.

Sahu A, Mamiya H, Shinde SN, Cheikhi A, Winter LL, Vo NV, Stolz D, Roginskaya V, Tang WY, St Croix C, Sanders LH, Franti M, Van Houten B, Rando TA, Barchowsky A, Ambrosio F.

Nat Commun. 2018 Nov 19;9(1):4859. doi: 10.1038/s41467-018-07253-3.


LRRK2 activation in idiopathic Parkinson's disease.

Di Maio R, Hoffman EK, Rocha EM, Keeney MT, Sanders LH, De Miranda BR, Zharikov A, Van Laar A, Stepan AF, Lanz TA, Kofler JK, Burton EA, Alessi DR, Hastings TG, Greenamyre JT.

Sci Transl Med. 2018 Jul 25;10(451). pii: eaar5429. doi: 10.1126/scitranslmed.aar5429.


Newly Revised Quantitative PCR-Based Assay for Mitochondrial and Nuclear DNA Damage.

Sanders LH, Rouanet JP, Howlett EH, Leuthner TC, Rooney JP, Greenamyre JT, Meyer JN.

Curr Protoc Toxicol. 2018 May;76(1):e50. doi: 10.1002/cptx.50. Epub 2018 May 18.


Evidence for Compartmentalized Axonal Mitochondrial Biogenesis: Mitochondrial DNA Replication Increases in Distal Axons As an Early Response to Parkinson's Disease-Relevant Stress.

Van Laar VS, Arnold B, Howlett EH, Calderon MJ, St Croix CM, Greenamyre JT, Sanders LH, Berman SB.

J Neurosci. 2018 Aug 22;38(34):7505-7515. doi: 10.1523/JNEUROSCI.0541-18.2018. Epub 2018 Jul 20.


RAD52 is required for RNA-templated recombination repair in post-mitotic neurons.

Welty S, Teng Y, Liang Z, Zhao W, Sanders LH, Greenamyre JT, Rubio ME, Thathiah A, Kodali R, Wetzel R, Levine AS, Lan L.

J Biol Chem. 2018 Jan 26;293(4):1353-1362. doi: 10.1074/jbc.M117.808402. Epub 2017 Dec 7.


LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson's disease.

Howlett EH, Jensen N, Belmonte F, Zafar F, Hu X, Kluss J, Schüle B, Kaufman BA, Greenamyre JT, Sanders LH.

Hum Mol Genet. 2017 Nov 15;26(22):4340-4351. doi: 10.1093/hmg/ddx320.


Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production.

Tapias V, Hu X, Luk KC, Sanders LH, Lee VM, Greenamyre JT.

Cell Mol Life Sci. 2017 Aug;74(15):2851-2874. doi: 10.1007/s00018-017-2541-x. Epub 2017 May 22.


Editor's Highlight: Base Excision Repair Variants and Pesticide Exposure Increase Parkinson's Disease Risk.

Sanders LH, Paul KC, Howlett EH, Lawal H, Boppana S, Bronstein JM, Ritz B, Greenamyre JT.

Toxicol Sci. 2017 Jul 1;158(1):188-198. doi: 10.1093/toxsci/kfx086.


Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage.

Lindström V, Gustafsson G, Sanders LH, Howlett EH, Sigvardson J, Kasrayan A, Ingelsson M, Bergström J, Erlandsson A.

Mol Cell Neurosci. 2017 Jul;82:143-156. doi: 10.1016/j.mcn.2017.04.009. Epub 2017 Apr 24.


Exercise training for people following curative intent treatment for non-small cell lung cancer: a randomized controlled trial.

Cavalheri V, Jenkins S, Cecins N, Gain K, Phillips MJ, Sanders LH, Hill K.

Braz J Phys Ther. 2017 Jan - Feb;21(1):58-68. doi: 10.1016/j.bjpt.2016.12.005. Epub 2017 Jan 13.


Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease.

Rocha EM, De Miranda B, Sanders LH.

Neurobiol Dis. 2018 Jan;109(Pt B):249-257. doi: 10.1016/j.nbd.2017.04.004. Epub 2017 Apr 8. Review.


Surgical Pulmonary Embolectomy: Experience in a Series of 37 Consecutive Cases.

Edelman JJ, Okiwelu N, Anvardeen K, Joshi P, Murphy B, Sanders LH, Newman MA, Passage J.

Heart Lung Circ. 2016 Dec;25(12):1240-1244. doi: 10.1016/j.hlc.2016.03.010. Epub 2016 May 12.


Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.

Sahoo B, Arduini I, Drombosky KW, Kodali R, Sanders LH, Greenamyre JT, Wetzel R.

PLoS One. 2016 Jun 6;11(6):e0155747. doi: 10.1371/journal.pone.0155747. eCollection 2016.


Patterns of sedentary behaviour and physical activity in people following curative intent treatment for non-small cell lung cancer.

Cavalheri V, Jenkins S, Cecins N, Phillips M, Sanders LH, Hill K.

Chron Respir Dis. 2016 Feb;13(1):82-5. doi: 10.1177/1479972315616931. Epub 2015 Dec 31.


Impairments after curative intent treatment for non-small cell lung cancer: a comparison with age and gender-matched healthy controls.

Cavalheri V, Jenkins S, Cecins N, Gain K, Phillips M, Sanders LH, Hill K.

Respir Med. 2015 Oct;109(10):1332-9. doi: 10.1016/j.rmed.2015.08.015. Epub 2015 Aug 29.


Fruit flies, bile acids, and Parkinson disease: a mitochondrial connection?

Greenamyre JT, Sanders LH, Gasser T.

Neurology. 2015 Sep 8;85(10):838-9. doi: 10.1212/WNL.0000000000001912. Epub 2015 Aug 7. No abstract available.


LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease.

Tyurina YY, Polimova AM, Maciel E, Tyurin VA, Kapralova VI, Winnica DE, Vikulina AS, Domingues MR, McCoy J, Sanders LH, Bayır H, Greenamyre JT, Kagan VE.

Free Radic Res. 2015 May;49(5):681-91. doi: 10.3109/10715762.2015.1005085. Epub 2015 Mar 5.


PCR based determination of mitochondrial DNA copy number in multiple species.

Rooney JP, Ryde IT, Sanders LH, Howlett EH, Colton MD, Germ KE, Mayer GD, Greenamyre JT, Meyer JN.

Methods Mol Biol. 2015;1241:23-38. doi: 10.1007/978-1-4939-1875-1_3.


Mitochondrial DNA damage as a peripheral biomarker for mitochondrial toxin exposure in rats.

Sanders LH, Howlett EH, McCoy J, Greenamyre JT.

Toxicol Sci. 2014 Dec;142(2):395-402. doi: 10.1093/toxsci/kfu185. Epub 2014 Sep 18.


Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease.

Sanders LH, McCoy J, Hu X, Mastroberardino PG, Dickinson BC, Chang CJ, Chu CT, Van Houten B, Greenamyre JT.

Neurobiol Dis. 2014 Oct;70:214-23. doi: 10.1016/j.nbd.2014.06.014. Epub 2014 Jun 27.


A bleeding esophagopulmonary fistula: rare complication of stasis ulcer in refractory achalasia.

Tan JT, Dudi-Venkata NN, Neelankavil SI, Sanders LH.

Surg Laparosc Endosc Percutan Tech. 2014 Apr;24(2):e77-9. doi: 10.1097/SLE.0b013e31828fa078.


LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction.

Sanders LH, Laganière J, Cooper O, Mak SK, Vu BJ, Huang YA, Paschon DE, Vangipuram M, Sundararajan R, Urnov FD, Langston JW, Gregory PD, Zhang HS, Greenamyre JT, Isacson O, Schüle B.

Neurobiol Dis. 2014 Feb;62:381-6. doi: 10.1016/j.nbd.2013.10.013. Epub 2013 Oct 19.


CT pulmonary angiography during veno-arterial extracorporeal membrane oxygenation in an adult.

Al-Ogaili Z, Foulner D, Passage J, Weightman WM, Torre L, Baker S, Sanders LH.

J Med Imaging Radiat Oncol. 2013 Jun;57(3):345-7. doi: 10.1111/j.1754-9485.2012.02413.x. Epub 2012 Jul 25.


Oxidative damage to macromolecules in human Parkinson disease and the rotenone model.

Sanders LH, Timothy Greenamyre J.

Free Radic Biol Med. 2013 Sep;62:111-120. doi: 10.1016/j.freeradbiomed.2013.01.003. Epub 2013 Jan 15. Review.


Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity.

Muñoz P, Paris I, Sanders LH, Greenamyre JT, Segura-Aguilar J.

Biochim Biophys Acta. 2012 Jul;1822(7):1125-36. doi: 10.1016/j.bbadis.2012.03.010. Epub 2012 Mar 27.


Regulation of complex I by Engrailed is complex too.

Sanders LH, Greenamyre JT.

Nat Neurosci. 2011 Sep 27;14(10):1221-2. doi: 10.1038/nn.2939. No abstract available.


Sternotomy and crutches.

Sanders LH, Chen W, Cindric SE, Newman MA.

Interact Cardiovasc Thorac Surg. 2011 Aug;13(2):237-9. doi: 10.1510/icvts.2010.258509. Epub 2011 May 4.


Epistatic roles for Pseudomonas aeruginosa MutS and DinB (DNA Pol IV) in coping with reactive oxygen species-induced DNA damage.

Sanders LH, Devadoss B, Raja GV, O'Connor J, Su S, Wozniak DJ, Hassett DJ, Berdis AJ, Sutton MD.

PLoS One. 2011 Apr 18;6(4):e18824. doi: 10.1371/journal.pone.0018824.


Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line.

Paris I, Muñoz P, Huenchuguala S, Couve E, Sanders LH, Greenamyre JT, Caviedes P, Segura-Aguilar J.

Toxicol Sci. 2011 Jun;121(2):376-88. doi: 10.1093/toxsci/kfr060. Epub 2011 Apr 6.


Single-cell redox imaging demonstrates a distinctive response of dopaminergic neurons to oxidative insults.

Horowitz MP, Milanese C, Di Maio R, Hu X, Montero LM, Sanders LH, Tapias V, Sepe S, van Cappellen WA, Burton EA, Greenamyre JT, Mastroberardino PG.

Antioxid Redox Signal. 2011 Aug 15;15(4):855-71. doi: 10.1089/ars.2010.3629. Epub 2011 Jun 6.


Circumferential disruption of the ventriculo-aortic junction due to infective endocarditis: surgical repair with custom-made, accurately sized, pericardial tube.

Sanders LH, Sanders FB, van der Heide S, Soliman Hamad MA, Joost ter Woorst F.

Heart Lung Circ. 2011 Jul;20(7):473-5. doi: 10.1016/j.hlc.2011.01.022. Epub 2011 Feb 17.


Use of the Seldinger type movement over a J-shaped stylet for left ventricular vent insertion.

Sanders LH, Chen W, Schönberger JP, Shehatha J, Newman MA.

Ann Thorac Surg. 2009 Dec;88(6):2050-1. doi: 10.1016/j.athoracsur.2009.03.063.


Aortic valve replacement and coronary artery bypass grafting in a rare case of congenital hypofibrinogenemia.

Sanders LH, Anderson BJ, Shehatha J, Clarson M, Mundy JA.

Ann Thorac Surg. 2009 Oct;88(4):1329-31. doi: 10.1016/j.athoracsur.2009.01.062.


Intraoperative recognition of an intracavitary left anterior descending coronary artery.

Sanders LH, Soliman Hamad MA, Newman MA, van Straten BH.

J Thorac Cardiovasc Surg. 2010 Mar;139(3):777-8. doi: 10.1016/j.jtcvs.2009.01.016. Epub 2009 Apr 8. No abstract available.


Management of right ventricular injury after localization of the left anterior descending coronary artery.

Sanders LH, Soliman HM, van Straten BH.

Ann Thorac Surg. 2009 Aug;88(2):665-7. doi: 10.1016/j.athoracsur.2008.12.062. Review.


Antegrade and retrograde Stanford type A intimal intussusception.

Sanders LH, Newman MA.

Ann Thorac Surg. 2009 Jun;87(6):2003. doi: 10.1016/j.athoracsur.2008.12.015. No abstract available.


Sliding clamp-DNA interactions are required for viability and contribute to DNA polymerase management in Escherichia coli.

Heltzel JM, Scouten Ponticelli SK, Sanders LH, Duzen JM, Cody V, Pace J, Snell EH, Sutton MD.

J Mol Biol. 2009 Mar 20;387(1):74-91. doi: 10.1016/j.jmb.2009.01.050. Epub 2009 Jan 30.


The GO system prevents ROS-induced mutagenesis and killing in Pseudomonas aeruginosa.

Sanders LH, Sudhakaran J, Sutton MD.

FEMS Microbiol Lett. 2009 May;294(1):89-96. doi: 10.1111/j.1574-6968.2009.01550.x. Epub 2009 Mar 10.


Sternotomy and the beard.

Sanders LH, ter Woorst FJ, van der Meer AD, Giebelen DJ, Weightman WM.

Heart Lung Circ. 2008 Apr;17(2):139-40. Epub 2007 Dec 3.


Role of Escherichia coli DNA polymerase I in conferring viability upon the dnaN159 mutant strain.

Maul RW, Sanders LH, Lim JB, Benitez R, Sutton MD.

J Bacteriol. 2007 Jul;189(13):4688-95. Epub 2007 Apr 20.


Radiological diagnosis and classification of antegrade and retrograde Stanford type A intimal intussusception.

Sanders LH, Newman MA, Gara KL, Price RA.

Int J Cardiovasc Imaging. 2007 Oct;23(5):659-65. Epub 2006 Dec 8. Review.


Role of Pseudomonas aeruginosa dinB-encoded DNA polymerase IV in mutagenesis.

Sanders LH, Rockel A, Lu H, Wozniak DJ, Sutton MD.

J Bacteriol. 2006 Dec;188(24):8573-85. Epub 2006 Oct 13.


Intractable postoperative internal thoracic artery spasm managed with angiographic intraluminal papaverine.

Sanders LH, Newman MA.

J Thorac Cardiovasc Surg. 2005 Sep;130(3):938-40. No abstract available.


Use of intracostal sutures reduces thoracotomy pain with possible risk of lung hernia: another measure for prevention of pain.

Sanders LH, Newman MA.

Ann Thorac Surg. 2005 Feb;79(2):750; author reply 750. No abstract available.


Comparative molecular field analysis of selective A3 adenosine receptor agonists.

Siddiqi SM, Pearlstein RA, Sanders LH, Jacobson KA.

Bioorg Med Chem. 1995 Oct;3(10):1331-43.


Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists.

Gallo-Rodriguez C, Ji XD, Melman N, Siegman BD, Sanders LH, Orlina J, Fischer B, Pu Q, Olah ME, van Galen PJ, et al.

J Med Chem. 1994 Mar 4;37(5):636-46.


Evaluation of compounding accuracy and aseptic techniques for intravenous admixtures.

Sanders LH, Mabadeje SA, Avis KE, Cruze CA 3rd, Martinez DR.

Am J Hosp Pharm. 1978 May;35(5):531-6.


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