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The vexing complexity of the amyloidogenic pathway.

Castro MA, Hadziselimovic A, Sanders CR.

Protein Sci. 2019 Jul;28(7):1177-1193. doi: 10.1002/pro.3606. Epub 2019 Apr 11. Review.


Reciprocal modulation between amyloid precursor protein and synaptic membrane cholesterol revealed by live cell imaging.

DelBove CE, Strothman CE, Lazarenko RM, Huang H, Sanders CR, Zhang Q.

Neurobiol Dis. 2019 Mar 15;127:449-461. doi: 10.1016/j.nbd.2019.03.009. [Epub ahead of print]


Protein structure aids predicting functional perturbation of missense variants in SCN5A and KCNQ1.

Kroncke BM, Mendenhall J, Smith DK, Sanders CR, Capra JA, George AL, Blume JD, Meiler J, Roden DM.

Comput Struct Biotechnol J. 2019 Feb 1;17:206-214. doi: 10.1016/j.csbj.2019.01.008. eCollection 2019.


Probing the Dynamics and Structural Topology of the Reconstituted Human KCNQ1 Voltage Sensor Domain (Q1-VSD) in Lipid Bilayers Using Electron Paramagnetic Resonance Spectroscopy.

Dixit G, Sahu ID, Reynolds WD, Wadsworth TM, Harding BD, Jaycox CK, Dabney-Smith C, Sanders CR, Lorigan GA.

Biochemistry. 2019 Feb 19;58(7):965-973. doi: 10.1021/acs.biochem.8b01042. Epub 2019 Jan 30.


Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis.

Marinko JT, Huang H, Penn WD, Capra JA, Schlebach JP, Sanders CR.

Chem Rev. 2019 May 8;119(9):5537-5606. doi: 10.1021/acs.chemrev.8b00532. Epub 2019 Jan 4.


NMR resonance assignments and secondary structure of a mutant form of the human KCNE1 channel accessory protein that exhibits KCNE3-like function.

Law CL, Sanders CR.

Biomol NMR Assign. 2019 Apr;13(1):143-147. doi: 10.1007/s12104-018-09867-6. Epub 2019 Jan 2.


High-Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance.

Vanoye CG, Desai RR, Fabre KL, Gallagher SL, Potet F, DeKeyser JM, Macaya D, Meiler J, Sanders CR, George AL Jr.

Circ Genom Precis Med. 2018 Nov;11(11):e002345. doi: 10.1161/CIRCGEN.118.002345.


LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

Tseng HY, Samarelli AV, Kammerer P, Scholze S, Ziegler T, Immler R, Zent R, Sperandio M, Sanders CR, Fässler R, Böttcher RT.

J Cell Sci. 2018 Nov 21;131(22). pii: jcs218214. doi: 10.1242/jcs.218214.


De novo designed transmembrane peptides activating the α5β1 integrin.

Mravic M, Hu H, Lu Z, Bennett JS, Sanders CR, Orr AW, DeGrado WF.

Protein Eng Des Sel. 2018 May 1;31(5):181-190. doi: 10.1093/protein/gzy014.


Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its α-Helical Conformation, and Inhibits γ-Secretase Nonselectively in Liposomes.

Kamp F, Scheidt HA, Winkler E, Basset G, Heinel H, Hutchison JM, LaPointe LM, Sanders CR, Steiner H, Huster D.

ACS Chem Neurosci. 2018 Jul 18;9(7):1702-1713. doi: 10.1021/acschemneuro.8b00068. Epub 2018 May 11.


Membrane properties that shape the evolution of membrane enzymes.

Sanders CR, Hutchison JM.

Curr Opin Struct Biol. 2018 Aug;51:80-91. doi: 10.1016/ Epub 2018 Mar 27. Review.


Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations.

Huang H, Kuenze G, Smith JA, Taylor KC, Duran AM, Hadziselimovic A, Meiler J, Vanoye CG, George AL Jr, Sanders CR.

Sci Adv. 2018 Mar 7;4(3):eaar2631. doi: 10.1126/sciadv.aar2631. eCollection 2018 Mar.


Predicting the Functional Impact of KCNQ1 Variants of Unknown Significance.

Li B, Mendenhall JL, Kroncke BM, Taylor KC, Huang H, Smith DK, Vanoye CG, Blume JD, George AL Jr, Sanders CR, Meiler J.

Circ Cardiovasc Genet. 2017 Oct;10(5). pii: e001754. doi: 10.1161/CIRCGENETICS.117.001754.


Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development.

Mathew S, Palamuttam RJ, Mernaugh G, Ramalingam H, Lu Z, Zhang MZ, Ishibe S, Critchley DR, Fässler R, Pozzi A, Sanders CR, Carroll TJ, Zent R.

Development. 2017 Nov 15;144(22):4148-4158. doi: 10.1242/dev.149914. Epub 2017 Oct 9.


Dodecyl-β-melibioside Detergent Micelles as a Medium for Membrane Proteins.

Hutchison JM, Lu Z, Li GC, Travis B, Mittal R, Deatherage CL, Sanders CR.

Biochemistry. 2017 Oct 17;56(41):5481-5484. doi: 10.1021/acs.biochem.7b00810. Epub 2017 Oct 9.


Structural Dynamics of 15-Lipoxygenase-2 via Hydrogen-Deuterium Exchange.

Droege KD, Keithly ME, Sanders CR, Armstrong RN, Thompson MK.

Biochemistry. 2017 Sep 26;56(38):5065-5074. doi: 10.1021/acs.biochem.7b00559. Epub 2017 Sep 7.


Peripheral myelin protein 22 alters membrane architecture.

Mittendorf KF, Marinko JT, Hampton CM, Ke Z, Hadziselimovic A, Schlebach JP, Law CL, Li J, Wright ER, Sanders CR, Ohi MD.

Sci Adv. 2017 Jul 5;3(7):e1700220. doi: 10.1126/sciadv.1700220. eCollection 2017 Jul.


Backbone Hydrogen Bond Strengths Can Vary Widely in Transmembrane Helices.

Cao Z, Hutchison JM, Sanders CR, Bowie JU.

J Am Chem Soc. 2017 Aug 9;139(31):10742-10749. doi: 10.1021/jacs.7b04819. Epub 2017 Jul 25.


Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains.

Deatherage CL, Lu Z, Kroncke BM, Ma S, Smith JA, Voehler MW, McFeeters RL, Sanders CR.

Sci Adv. 2017 Apr 12;3(4):e1602794. doi: 10.1126/sciadv.1602794. eCollection 2017 Apr.


Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function.

Lu Z, Mathew S, Chen J, Hadziselimovic A, Palamuttam R, Hudson BG, Fässler R, Pozzi A, Sanders CR, Zent R.

Elife. 2016 Dec 8;5. pii: e18633. doi: 10.7554/eLife.18633.


Regulation of KCNQ/Kv7 family voltage-gated K+ channels by lipids.

Taylor KC, Sanders CR.

Biochim Biophys Acta Biomembr. 2017 Apr;1859(4):586-597. doi: 10.1016/j.bbamem.2016.10.023. Epub 2016 Nov 4. Review.


Structural basis for KCNE3 modulation of potassium recycling in epithelia.

Kroncke BM, Van Horn WD, Smith J, Kang C, Welch RC, Song Y, Nannemann DP, Taylor KC, Sisco NJ, George AL Jr, Meiler J, Vanoye CG, Sanders CR.

Sci Adv. 2016 Sep 9;2(9):e1501228. doi: 10.1126/sciadv.1501228. eCollection 2016 Sep.


How γ-secretase hits a moving target.

Sanders CR.

Elife. 2016 Aug 31;5. pii: e20043. doi: 10.7554/eLife.20043.


Documentation of an Imperative To Improve Methods for Predicting Membrane Protein Stability.

Kroncke BM, Duran AM, Mendenhall JL, Meiler J, Blume JD, Sanders CR.

Biochemistry. 2016 Sep 13;55(36):5002-9. doi: 10.1021/acs.biochem.6b00537. Epub 2016 Aug 30.


A pH-Mediated Topological Switch within the N-Terminal Domain of Human Caveolin-3.

Kim JH, Schlebach JP, Lu Z, Peng D, Reasoner KC, Sanders CR.

Biophys J. 2016 Jun 7;110(11):2475-2485. doi: 10.1016/j.bpj.2016.05.004.


Transthyretin Suppresses Amyloid-β Secretion by Interfering with Processing of the Amyloid-β Protein Precursor.

Li X, Song Y, Sanders CR, Buxbaum JN.

J Alzheimers Dis. 2016 Apr 8;52(4):1263-75. doi: 10.3233/JAD-160033.


Structural and Molecular Determinants of Membrane Binding by the HIV-1 Matrix Protein.

Mercredi PY, Bucca N, Loeliger B, Gaines CR, Mehta M, Bhargava P, Tedbury PR, Charlier L, Floquet N, Muriaux D, Favard C, Sanders CR, Freed EO, Marchant J, Summers MF.

J Mol Biol. 2016 Apr 24;428(8):1637-55. doi: 10.1016/j.jmb.2016.03.005. Epub 2016 Mar 16.


Topologically Diverse Human Membrane Proteins Partition to Liquid-Disordered Domains in Phase-Separated Lipid Vesicles.

Schlebach JP, Barrett PJ, Day CA, Kim JH, Kenworthy AK, Sanders CR.

Biochemistry. 2016 Feb 23;55(7):985-8. doi: 10.1021/acs.biochem.5b01154. Epub 2016 Feb 11.


Perplexing new insight into the dynamics of the EmrE transporter.

Sanders CR.

J Gen Physiol. 2015 Dec;146(6):441-4. doi: 10.1085/jgp.201511523. Epub 2015 Nov 16. No abstract available.


Probing Structural Dynamics and Topology of the KCNE1 Membrane Protein in Lipid Bilayers via Site-Directed Spin Labeling and Electron Paramagnetic Resonance Spectroscopy.

Sahu ID, Craig AF, Dunagan MM, Troxel KR, Zhang R, Meiberg AG, Harmon CN, McCarrick RM, Kroncke BM, Sanders CR, Lorigan GA.

Biochemistry. 2015 Oct 20;54(41):6402-12. doi: 10.1021/acs.biochem.5b00505. Epub 2015 Oct 7.


Influence of Arrestin on the Photodecay of Bovine Rhodopsin.

Chatterjee D, Eckert CE, Slavov C, Saxena K, Fürtig B, Sanders CR, Gurevich VV, Wachtveitl J, Schwalbe H.

Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13555-60. doi: 10.1002/anie.201505798. Epub 2015 Sep 18.


Development of electron spin echo envelope modulation spectroscopy to probe the secondary structure of recombinant membrane proteins in a lipid bilayer.

Zhang R, Sahu ID, Gibson KR, Muhammad NB, Bali AP, Comer RG, Liu L, Craig AF, Mccarrick RM, Dabney-Smith C, Sanders CR, Lorigan GA.

Protein Sci. 2015 Nov;24(11):1707-13. doi: 10.1002/pro.2795. Epub 2015 Sep 9.


Conformational Stability and Pathogenic Misfolding of the Integral Membrane Protein PMP22.

Schlebach JP, Narayan M, Alford C, Mittendorf KF, Carter BD, Li J, Sanders CR.

J Am Chem Soc. 2015 Jul 15;137(27):8758-68. doi: 10.1021/jacs.5b03743. Epub 2015 Jul 2.


Notch Transmembrane Domain: Secondary Structure and Topology.

Deatherage CL, Lu Z, Kim JH, Sanders CR.

Biochemistry. 2015 Jun 16;54(23):3565-8. doi: 10.1021/acs.biochem.5b00456. Epub 2015 Jun 4.


Personalized biochemistry and biophysics.

Kroncke BM, Vanoye CG, Meiler J, George AL Jr, Sanders CR.

Biochemistry. 2015 Apr 28;54(16):2551-9. doi: 10.1021/acs.biochem.5b00189. Epub 2015 Apr 15.


Biophysical characterization of interactions between the C-termini of peripheral nerve claudins and the PDZ₁ domain of zonula occludens.

Wu J, Peng D, Zhang Y, Lu Z, Voehler M, Sanders CR, Li J.

Biochem Biophys Res Commun. 2015 Mar 27;459(1):87-93. doi: 10.1016/j.bbrc.2015.02.075. Epub 2015 Feb 21.


The rhodopsin-arrestin-1 interaction in bicelles.

Chen Q, Vishnivetskiy SA, Zhuang T, Cho MK, Thaker TM, Sanders CR, Gurevich VV, Iverson TM.

Methods Mol Biol. 2015;1271:77-95. doi: 10.1007/978-1-4939-2330-4_6.


The safety dance: biophysics of membrane protein folding and misfolding in a cellular context.

Schlebach JP, Sanders CR.

Q Rev Biophys. 2015 Feb;48(1):1-34. doi: 10.1017/S0033583514000110. Epub 2014 Nov 25.


The homology model of PMP22 suggests mutations resulting in peripheral neuropathy disrupt transmembrane helix packing.

Mittendorf KF, Kroncke BM, Meiler J, Sanders CR.

Biochemistry. 2014 Oct 7;53(39):6139-41. doi: 10.1021/bi500809t. Epub 2014 Sep 25.


Structural investigation of the transmembrane domain of KCNE1 in proteoliposomes.

Sahu ID, Kroncke BM, Zhang R, Dunagan MM, Smith HJ, Craig A, McCarrick RM, Sanders CR, Lorigan GA.

Biochemistry. 2014 Oct 14;53(40):6392-401. doi: 10.1021/bi500943p. Epub 2014 Oct 3.


Influence of Pathogenic Mutations on the Energetics of Translocon-Mediated Bilayer Integration of Transmembrane Helices.

Schlebach JP, Sanders CR.

J Membr Biol. 2015 Jun;248(3):371-81. doi: 10.1007/s00232-014-9726-0. Epub 2014 Sep 6.


Modest effects of lipid modifications on the structure of caveolin-3.

Kim JH, Peng D, Schlebach JP, Hadziselimovic A, Sanders CR.

Biochemistry. 2014 Jul 15;53(27):4320-2. doi: 10.1021/bi5005238. Epub 2014 Jun 26.


Purification and structural study of the voltage-sensor domain of the human KCNQ1 potassium ion channel.

Peng D, Kim JH, Kroncke BM, Law CL, Xia Y, Droege KD, Van Horn WD, Vanoye CG, Sanders CR.

Biochemistry. 2014 Apr 1;53(12):2032-42. doi: 10.1021/bi500102w. Epub 2014 Mar 18.


Impact of bilayer lipid composition on the structure and topology of the transmembrane amyloid precursor C99 protein.

Song Y, Mittendorf KF, Lu Z, Sanders CR.

J Am Chem Soc. 2014 Mar 19;136(11):4093-6. doi: 10.1021/ja4114374. Epub 2014 Mar 11.


The integrin β1 subunit regulates paracellular permeability of kidney proximal tubule cells.

Elias BC, Mathew S, Srichai MB, Palamuttam R, Bulus N, Mernaugh G, Singh AB, Sanders CR, Harris RC, Pozzi A, Zent R.

J Biol Chem. 2014 Mar 21;289(12):8532-44. doi: 10.1074/jbc.M113.526509. Epub 2014 Feb 7.


Cholesterol as a co-solvent and a ligand for membrane proteins.

Song Y, Kenworthy AK, Sanders CR.

Protein Sci. 2014 Jan;23(1):1-22. doi: 10.1002/pro.2385. Epub 2013 Nov 18. Review.


Structure and expression of a novel compact myelin protein - small VCP-interacting protein (SVIP).

Wu J, Peng D, Voehler M, Sanders CR, Li J.

Biochem Biophys Res Commun. 2013 Oct 11;440(1):173-8. doi: 10.1016/j.bbrc.2013.09.056. Epub 2013 Sep 18.


DEER EPR measurements for membrane protein structures via bifunctional spin labels and lipodisq nanoparticles.

Sahu ID, McCarrick RM, Troxel KR, Zhang R, Smith HJ, Dunagan MM, Swartz MS, Rajan PV, Kroncke BM, Sanders CR, Lorigan GA.

Biochemistry. 2013 Sep 24;52(38):6627-32. doi: 10.1021/bi4009984. Epub 2013 Sep 9.


Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein.

Song Y, Hustedt EJ, Brandon S, Sanders CR.

Biochemistry. 2013 Jul 30;52(30):5051-64. doi: 10.1021/bi400735x. Epub 2013 Jul 18.


Reversible folding of human peripheral myelin protein 22, a tetraspan membrane protein.

Schlebach JP, Peng D, Kroncke BM, Mittendorf KF, Narayan M, Carter BD, Sanders CR.

Biochemistry. 2013 May 14;52(19):3229-41. doi: 10.1021/bi301635f. Epub 2013 May 2.

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