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Items: 15


Phenotypic screening-the fast track to novel antibody discovery.

Minter RR, Sandercock AM, Rust SJ.

Drug Discov Today Technol. 2017 Mar;23:83-90. doi: 10.1016/j.ddtec.2017.03.004. Epub 2017 Apr 25. Review.


Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy.

Williams GS, Mistry B, Guillard S, Ulrichsen JC, Sandercock AM, Wang J, González-Muñoz A, Parmentier J, Black C, Soden J, Freeth J, Jovanović J, Leyland R, Al-Lamki RS, Leishman AJ, Rust SJ, Stewart R, Jermutus L, Bradley JR, Bedian V, Valge-Archer V, Minter R, Wilkinson RW.

Oncotarget. 2016 Oct 18;7(42):68278-68291. doi: 10.18632/oncotarget.11943.


Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling.

Sandercock AM, Rust S, Guillard S, Sachsenmeier KF, Holoweckyj N, Hay C, Flynn M, Huang Q, Yan K, Herpers B, Price LS, Soden J, Freeth J, Jermutus L, Hollingsworth R, Minter R.

Mol Cancer. 2015 Jul 31;14:147. doi: 10.1186/s12943-015-0415-0.


Topological models of heteromeric protein assemblies from mass spectrometry: application to the yeast eIF3:eIF5 complex.

Politis A, Schmidt C, Tjioe E, Sandercock AM, Lasker K, Gordiyenko Y, Russel D, Sali A, Robinson CV.

Chem Biol. 2015 Jan 22;22(1):117-28. doi: 10.1016/j.chembiol.2014.11.010. Epub 2014 Dec 24.


Engineering neprilysin activity and specificity to create a novel therapeutic for Alzheimer's disease.

Webster CI, Burrell M, Olsson LL, Fowler SB, Digby S, Sandercock A, Snijder A, Tebbe J, Haupts U, Grudzinska J, Jermutus L, Andersson C.

PLoS One. 2014 Aug 4;9(8):e104001. doi: 10.1371/journal.pone.0104001. eCollection 2014.


Recombinant expression and in vitro characterisation of active Huwentoxin-IV.

Sermadiras I, Revell J, Linley JE, Sandercock A, Ravn P.

PLoS One. 2013 Dec 6;8(12):e83202. doi: 10.1371/journal.pone.0083202. eCollection 2013.


An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.

Motshwene PG, Moncrieffe MC, Grossmann JG, Kao C, Ayaluru M, Sandercock AM, Robinson CV, Latz E, Gay NJ.

J Biol Chem. 2009 Sep 11;284(37):25404-11. doi: 10.1074/jbc.M109.022392. Epub 2009 Jul 10.


AU-rich RNA-binding induces changes in the quaternary structure of AUH.

Kurimoto K, Kuwasako K, Sandercock AM, Unzai S, Robinson CV, Muto Y, Yokoyama S.

Proteins. 2009 May 1;75(2):360-72. doi: 10.1002/prot.22246.


Ion mobility-mass spectrometry analysis of large protein complexes.

Ruotolo BT, Benesch JL, Sandercock AM, Hyung SJ, Robinson CV.

Nat Protoc. 2008;3(7):1139-52. doi: 10.1038/nprot.2008.78. Epub 2008 Jun 19.


Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.

Zhou M, Sandercock AM, Fraser CS, Ridlova G, Stephens E, Schenauer MR, Yokoi-Fong T, Barsky D, Leary JA, Hershey JW, Doudna JA, Robinson CV.

Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18139-44. doi: 10.1073/pnas.0801313105. Epub 2008 Jul 1.


Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Spätzle.

Gangloff M, Murali A, Xiong J, Arnot CJ, Weber AN, Sandercock AM, Robinson CV, Sarisky R, Holzenburg A, Kao C, Gay NJ.

J Biol Chem. 2008 May 23;283(21):14629-35. doi: 10.1074/jbc.M800112200. Epub 2008 Mar 17.


Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication.

Li S, Sandercock AM, Conduit P, Robinson CV, Williams RL, Kilmartin JV.

J Cell Biol. 2006 Jun 19;173(6):867-77.


Evidence for macromolecular protein rings in the absence of bulk water.

Ruotolo BT, Giles K, Campuzano I, Sandercock AM, Bateman RH, Robinson CV.

Science. 2005 Dec 9;310(5754):1658-61. Epub 2005 Nov 17.


Order changes within receptor systems upon ligand binding: receptor tightening/oligomerisation and the interpretation of binding parameters.

Williams DH, O'Brien DP, Sandercock AM, Stephens E.

J Mol Biol. 2004 Jul 2;340(2):373-83.


Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics.

Li TL, Choroba OW, Charles EH, Sandercock AM, Williams DH, Spencer JB.

Chem Commun (Camb). 2001 Sep 21;(18):1752-3.


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