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Clinical Orthopaedics and Related Research, The Bone & Joint Journal, the Journal of Orthopaedic Research, and The Journal of Bone and Joint Surgery will not accept clinical research manuscripts previously posted to preprint servers.

Leopold SS, Haddad FS, Sandell LJ, Swiontkowski M.

Bone Joint J. 2019 Jan;101-B(1):1-3. doi: 10.1302/0301-620X.101B1.BJJ-2018-1289. No abstract available.


Osteoarthritis following meniscus and ligament injury: insights from translational studies and animal models.

Rai MF, Brophy RH, Sandell LJ.

Curr Opin Rheumatol. 2019 Jan;31(1):70-79. doi: 10.1097/BOR.0000000000000566.


Evidence for Genetic Contribution to Variation in Post-Traumatic Osteoarthritis in Mice.

Chinzei N, Rai MF, Hashimoto S, Schmidt EJ, Takebe K, Cheverud JM, Sandell LJ.

Arthritis Rheumatol. 2018 Sep 18. doi: 10.1002/art.40730. [Epub ahead of print]


A Microarray Study of Articular Cartilage in Relation to Obesity and Severity of Knee Osteoarthritis.

Rai MF, Sandell LJ, Barrack TN, Cai L, Tycksen ED, Tang SY, Silva MJ, Barrack RL.

Cartilage. 2018 Sep 3:1947603518796122. doi: 10.1177/1947603518796122. [Epub ahead of print]


Regenerative medicine will make orthopaedic implants obsolete in our time Orthopaedic Research Society first annual meeting debate, San Diego, March 21st, 2017.

Johnstone B, Jacobs JJ, Sandell LJ, Wilkinson JM.

J Orthop Res. 2018 Oct;36(10):2579-2585. doi: 10.1002/jor.24033. Epub 2018 May 24.


Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice.

Patra D, DeLassus E, Mueller J, Abou-Ezzi G, Sandell LJ.

Biol Open. 2018 Feb 22;7(2). pii: bio032094. doi: 10.1242/bio.032094.


Musculoskeletal mechanobiology: A new era for MechanoMedicine.

Guo XE, Hung CT, Sandell LJ, Silva MJ.

J Orthop Res. 2018 Feb;36(2):531-532. doi: 10.1002/jor.23789. Epub 2018 Feb 6. No abstract available.


Molecular influence of anterior cruciate ligament tear remnants on chondrocytes: a biologic connection between injury and osteoarthritis.

Chinzei N, Brophy RH, Duan X, Cai L, Nunley RM, Sandell LJ, Rai MF.

Osteoarthritis Cartilage. 2018 Apr;26(4):588-599. doi: 10.1016/j.joca.2018.01.017. Epub 2018 Jan 31.


Transcriptome comparison of meniscus from patients with and without osteoarthritis.

Brophy RH, Zhang B, Cai L, Wright RW, Sandell LJ, Rai MF.

Osteoarthritis Cartilage. 2018 Mar;26(3):422-432. doi: 10.1016/j.joca.2017.12.004. Epub 2017 Dec 16.


JOR Virtual Issue on stem cells in orthopaedics.

Sandell LJ.

J Orthop Res. 2017 Dec;35(12):2593-2594. doi: 10.1002/jor.23803. Epub 2017 Dec 11. No abstract available.


Biomarkers for equine joint injury and osteoarthritis.

McIlwraith CW, Kawcak CE, Frisbie DD, Little CB, Clegg PD, Peffers MJ, Karsdal MA, Ekman S, Laverty S, Slayden RA, Sandell LJ, Lohmander LS, Kraus VB.

J Orthop Res. 2018 Mar;36(3):823-831. doi: 10.1002/jor.23738. Epub 2018 Jan 24. Review.


Advantages of RNA-seq compared to RNA microarrays for transcriptome profiling of anterior cruciate ligament tears.

Rai MF, Tycksen ED, Sandell LJ, Brophy RH.

J Orthop Res. 2018 Jan;36(1):484-497. doi: 10.1002/jor.23661. Epub 2017 Aug 29.


Therapeutic efficacy of intra-articular hyaluronan derivative and platelet-rich plasma in mice following axial tibial loading.

Duan X, Sandell LJ, Chinzei N, Holguin N, Silva MJ, Schiavinato A, Rai MF.

PLoS One. 2017 Apr 13;12(4):e0175682. doi: 10.1371/journal.pone.0175682. eCollection 2017.


Post-Traumatic Osteoarthritis in Mice Following Mechanical Injury to the Synovial Joint.

Rai MF, Duan X, Quirk JD, Holguin N, Schmidt EJ, Chinzei N, Silva MJ, Sandell LJ.

Sci Rep. 2017 Mar 27;7:45223. doi: 10.1038/srep45223.


2016-The year in review at the JOR.

Sandell LJ.

J Orthop Res. 2016 Dec;34(12):2043. doi: 10.1002/jor.23480. No abstract available.


Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury.

Yan H, Duan X, Pan H, Holguin N, Rai MF, Akk A, Springer LE, Wickline SA, Sandell LJ, Pham CT.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6199-E6208. Epub 2016 Sep 28. Erratum in: Proc Natl Acad Sci U S A. 2017 May 9;114(19):E3871.


Traumatic and Degenerative Meniscus Tears Have Different Gene Expression Signatures.

Brophy RH, Sandell LJ, Rai MF.

Am J Sports Med. 2017 Jan;45(1):114-120. doi: 10.1177/0363546516664889. Epub 2016 Oct 1.


Early changes in the knee of healer and non-healer mice following non-invasive mechanical injury.

Duan X, Rai MF, Holguin N, Silva MJ, Patra D, Liao W, Sandell LJ.

J Orthop Res. 2017 Mar;35(3):524-536. doi: 10.1002/jor.23413. Epub 2016 Sep 16.


Gene expression in human meniscal tears has limited association with early degenerative changes in knee articular cartilage.

Brophy RH, Sandell LJ, Cheverud JM, Rai MF.

Connect Tissue Res. 2017 May - Jul;58(3-4):295-304. doi: 10.1080/03008207.2016.1211114. Epub 2016 Jul 19.


Predictive validity of biochemical biomarkers in knee osteoarthritis: data from the FNIH OA Biomarkers Consortium.

Kraus VB, Collins JE, Hargrove D, Losina E, Nevitt M, Katz JN, Wang SX, Sandell LJ, Hoffmann SC, Hunter DJ; OA Biomarkers Consortium.

Ann Rheum Dis. 2017 Jan;76(1):186-195. doi: 10.1136/annrheumdis-2016-209252. Epub 2016 Jun 13.


RNA Microarray Analysis of Macroscopically Normal Articular Cartilage from Knees Undergoing Partial Medial Meniscectomy: Potential Prediction of the Risk for Developing Osteoarthritis.

Rai MF, Sandell LJ, Zhang B, Wright RW, Brophy RH.

PLoS One. 2016 May 12;11(5):e0155373. doi: 10.1371/journal.pone.0155373. eCollection 2016.


Changes in Transcriptome-Wide Gene Expression of Anterior Cruciate Ligament Tears Based on Time From Injury.

Brophy RH, Tycksen ED, Sandell LJ, Rai MF.

Am J Sports Med. 2016 Aug;44(8):2064-75. doi: 10.1177/0363546516643810. Epub 2016 May 6.



Sandell LJ.

J Orthop Res. 2016 Jan;34(1):7. doi: 10.1002/jor.23124. No abstract available.


Emerging Concepts in Gene Therapy for Osteoarthritis.

Rai MF, Sandell LJ.

J Am Acad Orthop Surg. 2015 Oct;23(10):e56-7. doi: 10.5435/JAAOS-D-15-00339. Epub 2015 Aug 28. No abstract available.


Kappa Delta Awards.

Sandell LJ.

J Orthop Res. 2015 Sep;33(9):1265. doi: 10.1002/jor.22986. No abstract available.


Non-invasive mouse models of post-traumatic osteoarthritis.

Christiansen BA, Guilak F, Lockwood KA, Olson SA, Pitsillides AA, Sandell LJ, Silva MJ, van der Meulen MC, Haudenschild DR.

Osteoarthritis Cartilage. 2015 Oct;23(10):1627-38. doi: 10.1016/j.joca.2015.05.009. Epub 2015 May 21. Review.


Genetic loci that regulate ectopic calcification in response to knee trauma in LG/J by SM/J advanced intercross mice.

Rai MF, Schmidt EJ, Hashimoto S, Cheverud JM, Sandell LJ.

J Orthop Res. 2015 Oct;33(10):1412-23. doi: 10.1002/jor.22944. Epub 2015 Jun 19.


Celebrate orthopedic research.

Sandell LJ.

J Orthop Res. 2015 Apr;33(4):449. doi: 10.1002/jor.22863. No abstract available.


The chemokine receptor CCR5 plays a role in post-traumatic cartilage loss in mice, but does not affect synovium and bone.

Takebe K, Rai MF, Schmidt EJ, Sandell LJ.

Osteoarthritis Cartilage. 2015 Mar;23(3):454-61. doi: 10.1016/j.joca.2014.12.002. Epub 2014 Dec 9.


Resistin stimulates expression of chemokine genes in chondrocytes via combinatorial regulation of C/EBPβ and NF-κB.

Zhang Z, Zhang Z, Kang Y, Hou C, Duan X, Sheng P, Sandell LJ, Liao W.

Int J Mol Sci. 2014 Sep 26;15(10):17242-55. doi: 10.3390/ijms151017242.


Regeneration of articular cartilage in healer and non-healer mice.

Rai MF, Sandell LJ.

Matrix Biol. 2014 Oct;39:50-5. doi: 10.1016/j.matbio.2014.08.011. Epub 2014 Aug 28. Review.


Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.

Patra D, DeLassus E, Liang G, Sandell LJ.

PLoS One. 2014 Aug 22;9(8):e105674. doi: 10.1371/journal.pone.0105674. eCollection 2014.


Relationship of gene expression in the injured human meniscus to body mass index: a biologic connection between obesity and osteoarthritis.

Rai MF, Patra D, Sandell LJ, Brophy RH.

Arthritis Rheumatol. 2014 Aug;66(8):2152-64. doi: 10.1002/art.38643.


Republished: Value of biomarkers in osteoarthritis: current status and perspectives.

Lotz M, Martel-Pelletier J, Christiansen C, Brandi ML, Bruyère O, Chapurlat R, Collette J, Cooper C, Giacovelli G, Kanis JA, Karsdal MA, Kraus V, Lems WF, Meulenbelt I, Pelletier JP, Raynauld JP, Reiter-Niesert S, Rizzoli R, Sandell LJ, Van Spil WE, Reginster JY.

Postgrad Med J. 2014 Mar;90(1061):171-8. doi: 10.1136/postgradmedj-2013-203726rep.


Early response of mouse joint tissue to noninvasive knee injury suggests treatment targets.

Wu P, Holguin N, Silva MJ, Fu M, Liao W, Sandell LJ.

Arthritis Rheumatol. 2014 May;66(5):1256-65. doi: 10.1002/art.38375.


Novel functions for type II procollagen.

Sandell LJ.

Connect Tissue Res. 2014 Jan-Feb;55(1):20-5. doi: 10.3109/03008207.2013.867340. Review.


Characterization of a murine type IIB procollagen-specific antibody.

Patra D, DeLassus E, McAlinden A, Sandell LJ.

Matrix Biol. 2014 Feb;34:154-60. doi: 10.1016/j.matbio.2013.10.014. Epub 2013 Nov 7.


Molecular insight into the association between cartilage regeneration and ear wound healing in genetic mouse models: targeting new genes in regeneration.

Rai MF, Schmidt EJ, McAlinden A, Cheverud JM, Sandell LJ.

G3 (Bethesda). 2013 Nov 6;3(11):1881-91. doi: 10.1534/g3.113.007302.


Molecular characterization of articular cartilage from young adults with femoroacetabular impingement.

Hashimoto S, Rai MF, Gill CS, Zhang Z, Sandell LJ, Clohisy JC.

J Bone Joint Surg Am. 2013 Aug 21;95(16):1457-64. doi: 10.2106/JBJS.L.00497.


Value of biomarkers in osteoarthritis: current status and perspectives.

Lotz M, Martel-Pelletier J, Christiansen C, Brandi ML, Bruyère O, Chapurlat R, Collette J, Cooper C, Giacovelli G, Kanis JA, Karsdal MA, Kraus V, Lems WF, Meulenbelt I, Pelletier JP, Raynauld JP, Reiter-Niesert S, Rizzoli R, Sandell LJ, Van Spil WE, Reginster JY.

Ann Rheum Dis. 2013 Nov;72(11):1756-63. doi: 10.1136/annrheumdis-2013-203726. Epub 2013 Jul 29. Review. Erratum in: Ann Rheum Dis. 2017 May 25;:.


Transcriptome analysis of injured human meniscus reveals a distinct phenotype of meniscus degeneration with aging.

Rai MF, Patra D, Sandell LJ, Brophy RH.

Arthritis Rheum. 2013 Aug;65(8):2090-101. doi: 10.1002/art.37984.


Effects of serum and compressive loading on the cartilage matrix synthesis and spatiotemporal deposition around chondrocytes in 3D culture.

Wu P, DeLassus E, Patra D, Liao W, Sandell LJ.

Tissue Eng Part A. 2013 May;19(9-10):1199-208. doi: 10.1089/ten.tea.2012.0559. Epub 2013 Feb 14.


Relationship of age and body mass index to the expression of obesity and osteoarthritis-related genes in human meniscus.

Rai MF, Sandell LJ, Cheverud JM, Brophy RH.

Int J Obes (Lond). 2013 Sep;37(9):1238-46. doi: 10.1038/ijo.2012.221. Epub 2013 Jan 15.


Antiangiogenic and anticancer molecules in cartilage.

Patra D, Sandell LJ.

Expert Rev Mol Med. 2012 Jan 19;14:e10. doi: 10.1017/erm.2012.3. Review.


Biomarkers in osteoarthritis.

Sandell LJ.

HSS J. 2012 Feb;8(1):33-4. doi: 10.1007/s11420-011-9246-8. Epub 2012 Feb 23. No abstract available.


Molecular analysis of age and sex-related gene expression in meniscal tears with and without a concomitant anterior cruciate ligament tear.

Brophy RH, Rai MF, Zhang Z, Torgomyan A, Sandell LJ.

J Bone Joint Surg Am. 2012 Mar 7;94(5):385-93. doi: 10.2106/JBJS.K.00919.


Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice.

Hashimoto S, Rai MF, Janiszak KL, Cheverud JM, Sandell LJ.

Osteoarthritis Cartilage. 2012 Jun;20(6):562-71. doi: 10.1016/j.joca.2012.01.022. Epub 2012 Feb 8.

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