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Items: 37


Optical DNA Mapping Combined with Cas9-Targeted Resistance Gene Identification for Rapid Tracking of Resistance Plasmids in a Neonatal Intensive Care Unit Outbreak.

Bikkarolla SK, Nordberg V, Rajer F, Müller V, Kabir MH, Kk S, Dvirnas A, Ambjörnsson T, Giske CG, Navér L, Sandegren L, Westerlund F.

MBio. 2019 Jul 9;10(4). pii: e00347-19. doi: 10.1128/mBio.00347-19.


Dynamics of Resistance Plasmids in Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae during Postinfection Colonization.

Brolund A, Rajer F, Giske CG, Melefors Ö, Titelman E, Sandegren L.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02201-18. doi: 10.1128/AAC.02201-18. Print 2019 Apr.


Long-term carriage and rapid transmission of extended spectrum beta-lactamase-producing E. coli within a flock of Mallards in the absence of antibiotic selection.

Sandegren L, Stedt J, Lustig U, Bonnedahl J, Andersson DI, Järhult JD.

Environ Microbiol Rep. 2018 Oct;10(5):576-582. doi: 10.1111/1758-2229.12681. Epub 2018 Sep 18.


Facilitated sequence assembly using densely labeled optical DNA barcodes: A combinatorial auction approach.

Dvirnas A, Pichler C, Stewart CL, Quaderi S, Nyberg LK, Müller V, Kumar Bikkarolla S, Kristiansson E, Sandegren L, Westerlund F, Ambjörnsson T.

PLoS One. 2018 Mar 9;13(3):e0193900. doi: 10.1371/journal.pone.0193900. eCollection 2018.


Corrigendum: Rapid identification of intact bacterial resistance plasmids via optical mapping of single DNA molecules.

Nyberg LK, Quaderi S, Emilsson G, Karami N, Lagerstedt E, Müller V, Noble C, Hammarberg S, Nilsson AN, Sjöberg F, Fritzsche J, Kristiansson E, Sandegren L, Ambjörnsson T, Westerlund F.

Sci Rep. 2017 Dec 22;7:46911. doi: 10.1038/srep46911.


A blaOXA-181-harbouring multi-resistant ST147 Klebsiella pneumoniae isolate from Pakistan that represent an intermediate stage towards pan-drug resistance.

Nahid F, Zahra R, Sandegren L.

PLoS One. 2017 Dec 8;12(12):e0189438. doi: 10.1371/journal.pone.0189438. eCollection 2017.


Direct identification of antibiotic resistance genes on single plasmid molecules using CRISPR/Cas9 in combination with optical DNA mapping.

Müller V, Rajer F, Frykholm K, Nyberg LK, Quaderi S, Fritzsche J, Kristiansson E, Ambjörnsson T, Sandegren L, Westerlund F.

Sci Rep. 2016 Dec 1;6:37938. doi: 10.1038/srep37938.


Rapid identification of intact bacterial resistance plasmids via optical mapping of single DNA molecules.

Nyberg LK, Quaderi S, Emilsson G, Karami N, Lagerstedt E, Müller V, Noble C, Hammarberg S, Nilsson AN, Sjöberg F, Fritzsche J, Kristiansson E, Sandegren L, Ambjörnsson T, Westerlund F.

Sci Rep. 2016 Jul 27;6:30410. doi: 10.1038/srep30410. Erratum in: Sci Rep. 2017 Dec 22;7:46911.


A pharmacokinetic-pharmacodynamic model characterizing the emergence of resistant Escherichia coli subpopulations during ertapenem exposure.

Ungphakorn W, Tängdén T, Sandegren L, Nielsen EI.

J Antimicrob Chemother. 2016 Sep;71(9):2521-33. doi: 10.1093/jac/dkw205. Epub 2016 Jun 20.


Combinations of mutations in envZ, ftsI, mrdA, acrB and acrR can cause high-level carbapenem resistance in Escherichia coli.

Adler M, Anjum M, Andersson DI, Sandegren L.

J Antimicrob Chemother. 2016 May;71(5):1188-98. doi: 10.1093/jac/dkv475. Epub 2016 Feb 10.


Fitness of Escherichia coli mutants with reduced susceptibility to tigecycline.

Linkevicius M, Anderssen JM, Sandegren L, Andersson DI.

J Antimicrob Chemother. 2016 May;71(5):1307-13. doi: 10.1093/jac/dkv486. Epub 2016 Feb 6.


Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance.

Linkevicius M, Sandegren L, Andersson DI.

Antimicrob Agents Chemother. 2015 Nov 23;60(2):789-96. doi: 10.1128/AAC.02465-15. Print 2016 Feb.


Characterization of ESBL disseminating plasmids.

Brolund A, Sandegren L.

Infect Dis (Lond). 2016;48(1):18-25. doi: 10.3109/23744235.2015.1062536. Epub 2015 Jul 1. Review.


Fast size-determination of intact bacterial plasmids using nanofluidic channels.

Frykholm K, Nyberg LK, Lagerstedt E, Noble C, Fritzsche J, Karami N, Ambjörnsson T, Sandegren L, Westerlund F.

Lab Chip. 2015 Jul 7;15(13):2739-43. doi: 10.1039/c5lc00378d. Epub 2015 May 21.


Selection of a multidrug resistance plasmid by sublethal levels of antibiotics and heavy metals.

Gullberg E, Albrecht LM, Karlsson C, Sandegren L, Andersson DI.

MBio. 2014 Oct 7;5(5):e01918-14. doi: 10.1128/mBio.01918-14.


Silver resistance genes are overrepresented among Escherichia coli isolates with CTX-M production.

Sütterlin S, Edquist P, Sandegren L, Adler M, Tängdén T, Drobni M, Olsen B, Melhus A.

Appl Environ Microbiol. 2014 Nov;80(22):6863-9. doi: 10.1128/AEM.01803-14. Epub 2014 Aug 15.


Time lapse investigation of antibiotic susceptibility using a microfluidic linear gradient 3D culture device.

Hou Z, An Y, Hjort K, Hjort K, Sandegren L, Wu Z.

Lab Chip. 2014 Sep 7;14(17):3409-18. doi: 10.1039/c4lc00451e.


The gull (Chroicocephalus brunnicephalus) as an environmental bioindicator and reservoir for antibiotic resistance on the coastlines of the Bay of Bengal.

Hasan B, Melhus Å, Sandegren L, Alam M, Olsen B.

Microb Drug Resist. 2014 Oct;20(5):466-71. doi: 10.1089/mdr.2013.0233. Epub 2014 Apr 30.


Selection of antibiotic resistance at very low antibiotic concentrations.

Sandegren L.

Ups J Med Sci. 2014 May;119(2):103-7. doi: 10.3109/03009734.2014.904457. Epub 2014 Apr 3. Review.


Selection of orphan Rhs toxin expression in evolved Salmonella enterica serovar Typhimurium.

Koskiniemi S, Garza-Sánchez F, Sandegren L, Webb JS, Braaten BA, Poole SJ, Andersson DI, Hayes CS, Low DA.

PLoS Genet. 2014 Mar 27;10(3):e1004255. doi: 10.1371/journal.pgen.1004255. eCollection 2014 Mar.


High fitness costs and instability of gene duplications reduce rates of evolution of new genes by duplication-divergence mechanisms.

Adler M, Anjum M, Berg OG, Andersson DI, Sandegren L.

Mol Biol Evol. 2014 Jun;31(6):1526-35. doi: 10.1093/molbev/msu111. Epub 2014 Mar 22.


Pathoadaptive mutations in Salmonella enterica isolated after serial passage in mice.

Koskiniemi S, Gibbons HS, Sandegren L, Anwar N, Ouellette G, Broomall S, Karavis M, McGregor P, Liem A, Fochler E, McNew L, Rosenzweig CN, Rhen M, Skowronski EW, Andersson DI.

PLoS One. 2013 Jul 25;8(7):e70147. doi: 10.1371/journal.pone.0070147. Print 2013.


Mechanisms and fitness costs of tigecycline resistance in Escherichia coli.

Linkevicius M, Sandegren L, Andersson DI.

J Antimicrob Chemother. 2013 Dec;68(12):2809-19. doi: 10.1093/jac/dkt263. Epub 2013 Jul 9.


Plasmidome-analysis of ESBL-producing escherichia coli using conventional typing and high-throughput sequencing.

Brolund A, Franzén O, Melefors O, Tegmark-Wisell K, Sandegren L.

PLoS One. 2013 Jun 13;8(6):e65793. doi: 10.1371/journal.pone.0065793. Print 2013.


Frequent emergence of porin-deficient subpopulations with reduced carbapenem susceptibility in ESBL-producing Escherichia coli during exposure to ertapenem in an in vitro pharmacokinetic model.

Tängdén T, Adler M, Cars O, Sandegren L, Löwdin E.

J Antimicrob Chemother. 2013 Jun;68(6):1319-26. doi: 10.1093/jac/dkt044. Epub 2013 Mar 10.


Antimicrobial drug-resistant Escherichia coli in wild birds and free-range poultry, Bangladesh.

Hasan B, Sandegren L, Melhus A, Drobni M, Hernandez J, Waldenström J, Alam M, Olsen B.

Emerg Infect Dis. 2012 Dec;18(12):2055-8. doi: 10.3201/eid1812.120513.


Influence of acquired β-lactamases on the evolution of spontaneous carbapenem resistance in Escherichia coli.

Adler M, Anjum M, Andersson DI, Sandegren L.

J Antimicrob Chemother. 2013 Jan;68(1):51-9. doi: 10.1093/jac/dks368. Epub 2012 Sep 13.


Transfer of an Escherichia coli ST131 multiresistance cassette has created a Klebsiella pneumoniae-specific plasmid associated with a major nosocomial outbreak.

Sandegren L, Linkevicius M, Lytsy B, Melhus Å, Andersson DI.

J Antimicrob Chemother. 2012 Jan;67(1):74-83. doi: 10.1093/jac/dkr405. Epub 2011 Oct 11.


Selection of resistant bacteria at very low antibiotic concentrations.

Gullberg E, Cao S, Berg OG, Ilbäck C, Sandegren L, Hughes D, Andersson DI.

PLoS Pathog. 2011 Jul;7(7):e1002158. doi: 10.1371/journal.ppat.1002158. Epub 2011 Jul 21.


Genomic stability over 9 years of an isoniazid resistant Mycobacterium tuberculosis outbreak strain in Sweden.

Sandegren L, Groenheit R, Koivula T, Ghebremichael S, Advani A, Castro E, Pennhag A, Hoffner S, Mazurek J, Pawlowski A, Kan B, Bruchfeld J, Melefors Ö, Källenius G.

PLoS One. 2011 Jan 31;6(1):e16647. doi: 10.1371/journal.pone.0016647.


Bacterial gene amplification: implications for the evolution of antibiotic resistance.

Sandegren L, Andersson DI.

Nat Rev Microbiol. 2009 Aug;7(8):578-88. doi: 10.1038/nrmicro2174. Review.


Nitrofurantoin resistance mechanism and fitness cost in Escherichia coli.

Sandegren L, Lindqvist A, Kahlmeter G, Andersson DI.

J Antimicrob Chemother. 2008 Sep;62(3):495-503. doi: 10.1093/jac/dkn222. Epub 2008 Jun 10.


The first major extended-spectrum beta-lactamase outbreak in Scandinavia was caused by clonal spread of a multiresistant Klebsiella pneumoniae producing CTX-M-15.

Lytsy B, Sandegren L, Tano E, Torell E, Andersson DI, Melhus A.

APMIS. 2008 Apr;116(4):302-8. doi: 10.1111/j.1600-0463.2008.00922.x.


SegH and Hef: two novel homing endonucleases whose genes replace the mobC and mobE genes in several T4-related phages.

Sandegren L, Nord D, Sjöberg BM.

Nucleic Acids Res. 2005 Oct 27;33(19):6203-13. Print 2005.


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