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Items: 1 to 50 of 57

1.

Molecular determinants of Kv7.1/KCNE1 channel inhibition by amitriptyline.

Villatoro-Gómez K, Pacheco-Rojas DO, Moreno-Galindo EG, Navarro-Polanco RA, Tristani-Firouzi M, Gazgalis D, Cui M, Sánchez-Chapula JA, Ferrer T.

Biochem Pharmacol. 2018 Jun;152:264-271. doi: 10.1016/j.bcp.2018.03.016. Epub 2018 Apr 3.

PMID:
29621539
2.

High-potency block of Kir4.1 channels by pentamidine: Molecular basis.

Aréchiga-Figueroa IA, Marmolejo-Murillo LG, Cui M, Delgado-Ramírez M, van der Heyden MAG, Sánchez-Chapula JA, Rodríguez-Menchaca AA.

Eur J Pharmacol. 2017 Nov 15;815:56-63. doi: 10.1016/j.ejphar.2017.10.009. Epub 2017 Oct 6.

PMID:
28993158
3.

Inhibition of Kir4.1 potassium channels by quinacrine.

Marmolejo-Murillo LG, Aréchiga-Figueroa IA, Cui M, Moreno-Galindo EG, Navarro-Polanco RA, Sánchez-Chapula JA, Ferrer T, Rodríguez-Menchaca AA.

Brain Res. 2017 May 15;1663:87-94. doi: 10.1016/j.brainres.2017.03.009. Epub 2017 Mar 11.

4.

Chloroquine blocks the Kir4.1 channels by an open-pore blocking mechanism.

Marmolejo-Murillo LG, Aréchiga-Figueroa IA, Moreno-Galindo EG, Navarro-Polanco RA, Rodríguez-Menchaca AA, Cui M, Sánchez-Chapula JA, Ferrer T.

Eur J Pharmacol. 2017 Apr 5;800:40-47. doi: 10.1016/j.ejphar.2017.02.024. Epub 2017 Feb 20.

PMID:
28216048
5.

Mechanisms of IhERG/IKr Modulation by α1-Adrenoceptors in HEK293 Cells and Cardiac Myocytes.

Urrutia J, Alday A, Gallego M, Malagueta-Vieira LL, Aréchiga-Figueroa IA, Casis O, Sánchez-Chapula JA.

Cell Physiol Biochem. 2016;40(6):1261-1273. doi: 10.1159/000453180. Epub 2016 Dec 19.

6.

Pharmacological Conversion of a Cardiac Inward Rectifier into an Outward Rectifier Potassium Channel.

Moreno-Galindo EG, Sanchez-Chapula JA, Tristani-Firouzi M, Navarro-Polanco RA.

Mol Pharmacol. 2016 Sep;90(3):334-40. doi: 10.1124/mol.116.104950. Epub 2016 May 31. Review.

7.

The agonist-specific voltage dependence of M2 muscarinic receptors modulates the deactivation of the acetylcholine-gated K(+) current (I KACh).

Moreno-Galindo EG, Alamilla J, Sanchez-Chapula JA, Tristani-Firouzi M, Navarro-Polanco RA.

Pflugers Arch. 2016 Jul;468(7):1207-14. doi: 10.1007/s00424-016-1812-y. Epub 2016 Mar 29.

PMID:
27023349
8.

The molecular basis of chloroethylclonidine block of inward rectifier (Kir2.1 and Kir4.1) K(+) channels.

Rodríguez-Menchaca AA, Aréchiga-Figueroa IA, Sánchez-Chapula JA.

Pharmacol Rep. 2016 Apr;68(2):383-9. doi: 10.1016/j.pharep.2015.10.005. Epub 2015 Nov 2.

PMID:
26922543
9.

ABCC9 is a novel Brugada and early repolarization syndrome susceptibility gene.

Hu D, Barajas-Martínez H, Terzic A, Park S, Pfeiffer R, Burashnikov E, Wu Y, Borggrefe M, Veltmann C, Schimpf R, Cai JJ, Nam GB, Deshmukh P, Scheinman M, Preminger M, Steinberg J, López-Izquierdo A, Ponce-Balbuena D, Wolpert C, Haïssaguerre M, Sánchez-Chapula JA, Antzelevitch C.

Int J Cardiol. 2014 Feb 15;171(3):431-42. doi: 10.1016/j.ijcard.2013.12.084. Epub 2014 Jan 4.

10.

Impact of the whole-cell patch-clamp configuration on the pharmacological assessment of the hERG channel: trazodone as a case example.

Rodriguez-Menchaca AA, Ferrer T, Navarro-Polanco RA, Sanchez-Chapula JA, Moreno-Galindo EG.

J Pharmacol Toxicol Methods. 2014 May-Jun;69(3):237-44. doi: 10.1016/j.vascn.2013.12.007. Epub 2014 Jan 9.

PMID:
24412489
11.

Tamoxifen inhibition of kv7.2/kv7.3 channels.

Ferrer T, Aréchiga-Figueroa IA, Shapiro MS, Tristani-Firouzi M, Sanchez-Chapula JA.

PLoS One. 2013 Sep 24;8(9):e76085. doi: 10.1371/journal.pone.0076085. eCollection 2013.

12.

The principal conductance in Giardia lamblia trophozoites possesses functional properties similar to the mammalian ClC-2 current.

Moreno-Galindo EG, Rodríguez-Elías JC, Ramírez-Herrera MA, Sánchez-Chapula JA, Navarro-Polanco RA.

Pflugers Arch. 2014 May;466(5):915-24. doi: 10.1007/s00424-013-1350-9. Epub 2013 Sep 17.

PMID:
24043571
13.

Voltage sensitivity of M2 muscarinic receptors underlies the delayed rectifier-like activation of ACh-gated K(+) current by choline in feline atrial myocytes.

Navarro-Polanco RA, Aréchiga-Figueroa IA, Salazar-Fajardo PD, Benavides-Haro DE, Rodríguez-Elías JC, Sachse FB, Tristani-Firouzi M, Sánchez-Chapula JA, Moreno-Galindo EG.

J Physiol. 2013 Sep 1;591(17):4273-86. doi: 10.1113/jphysiol.2013.255166. Epub 2013 May 7.

14.

Inhibition of cardiac inward rectifier currents by cationic amphiphilic drugs.

van der Heyden MA, Stary-Weinzinger A, Sanchez-Chapula JA.

Curr Mol Med. 2013 Sep;13(8):1284-98. Review.

PMID:
23448372
15.

Improvement of the metabolic status recovers cardiac potassium channel synthesis in experimental diabetes.

Torres-Jacome J, Gallego M, Rodríguez-Robledo JM, Sanchez-Chapula JA, Casis O.

Acta Physiol (Oxf). 2013 Mar;207(3):447-59. doi: 10.1111/apha.12043. Epub 2012 Dec 27.

PMID:
23181465
16.

Molecular mechanisms of chloroquine inhibition of heterologously expressed Kir6.2/SUR2A channels.

Ponce-Balbuena D, Rodríguez-Menchaca AA, López-Izquierdo A, Ferrer T, Kurata HT, Nichols CG, Sánchez-Chapula JA.

Mol Pharmacol. 2012 Nov;82(5):803-13. doi: 10.1124/mol.112.079152. Epub 2012 Jul 31.

17.

Molecular genetic and functional association of Brugada and early repolarization syndromes with S422L missense mutation in KCNJ8.

Barajas-Martínez H, Hu D, Ferrer T, Onetti CG, Wu Y, Burashnikov E, Boyle M, Surman T, Urrutia J, Veltmann C, Schimpf R, Borggrefe M, Wolpert C, Ibrahim BB, Sánchez-Chapula JA, Winters S, Haïssaguerre M, Antzelevitch C.

Heart Rhythm. 2012 Apr;9(4):548-55. doi: 10.1016/j.hrthm.2011.10.035. Epub 2011 Nov 3.

18.

Mechanisms responsible for the altered cardiac repolarization dispersion in experimental hypothyroidism.

Ferrer T, Arín RM, Casis E, Torres-Jacome J, Sanchez-Chapula JA, Casis O.

Acta Physiol (Oxf). 2012 Apr;204(4):502-12. doi: 10.1111/j.1748-1716.2011.02364.x. Epub 2011 Oct 17.

PMID:
21933354
19.

Mechanisms for Kir channel inhibition by quinacrine: acute pore block of Kir2.x channels and interference in PIP2 interaction with Kir2.x and Kir6.2 channels.

López-Izquierdo A, Aréchiga-Figueroa IA, Moreno-Galindo EG, Ponce-Balbuena D, Rodríguez-Martínez M, Ferrer-Villada T, Rodríguez-Menchaca AA, van der Heyden MA, Sánchez-Chapula JA.

Pflugers Arch. 2011 Oct;462(4):505-17. doi: 10.1007/s00424-011-0995-5. Epub 2011 Jul 22.

PMID:
21779761
20.

Voltage-dependent potassium currents in feline sino-atrial node myocytes.

Aréchiga-Figueroa IA, Rodríguez-Martínez M, Sánchez-Chapula JA.

Pflugers Arch. 2011 Sep;462(3):385-96. doi: 10.1007/s00424-011-0984-8. Epub 2011 Jun 23.

PMID:
21698391
21.

Carvedilol inhibits Kir2.3 channels by interference with PIP₂-channel interaction.

Ferrer T, Ponce-Balbuena D, López-Izquierdo A, Aréchiga-Figueroa IA, de Boer TP, van der Heyden MA, Sánchez-Chapula JA.

Eur J Pharmacol. 2011 Oct 1;668(1-2):72-7. doi: 10.1016/j.ejphar.2011.05.067. Epub 2011 Jun 6.

PMID:
21663737
22.

The antimalarial drug mefloquine inhibits cardiac inward rectifier K+ channels: evidence for interference in PIP2-channel interaction.

López-Izquierdo A, Ponce-Balbuena D, Moreno-Galindo EG, Aréchiga-Figueroa IA, Rodríguez-Martínez M, Ferrer T, Rodríguez-Menchaca AA, Sánchez-Chapula JA.

J Cardiovasc Pharmacol. 2011 Apr;57(4):407-15. doi: 10.1097/FJC.0b013e31820b7c03.

PMID:
21502926
23.

Muscarinic-activated potassium current mediates the negative chronotropic effect of pilocarpine on the rabbit sinoatrial node.

Rodríguez-Martínez M, Aréchiga-Figueroa IA, Moreno-Galindo EG, Navarro-Polanco RA, Sánchez-Chapula JA.

Pflugers Arch. 2011 Aug;462(2):235-43. doi: 10.1007/s00424-011-0962-1. Epub 2011 Apr 13.

PMID:
21487692
24.

Toward specific cardiac I(K1) modulators for in vivo application: old drugs point the way.

van der Heyden MA, Sánchez-Chapula JA.

Heart Rhythm. 2011 Jul;8(7):1076-80. doi: 10.1016/j.hrthm.2011.01.038. Epub 2011 Feb 2. Review. No abstract available.

PMID:
21296684
25.

Conformational changes in the M2 muscarinic receptor induced by membrane voltage and agonist binding.

Navarro-Polanco RA, Moreno Galindo EG, Ferrer-Villada T, Arias M, Rigby JR, Sánchez-Chapula JA, Tristani-Firouzi M.

J Physiol. 2011 Apr 1;589(Pt 7):1741-53. doi: 10.1113/jphysiol.2010.204107. Epub 2011 Jan 31.

26.

Relaxation gating of the acetylcholine-activated inward rectifier K+ current is mediated by intrinsic voltage sensitivity of the muscarinic receptor.

Moreno-Galindo EG, Sánchez-Chapula JA, Sachse FB, Rodríguez-Paredes JA, Tristani-Firouzi M, Navarro-Polanco RA.

J Physiol. 2011 Apr 1;589(Pt 7):1755-67. doi: 10.1113/jphysiol.2010.204115. Epub 2011 Jan 31.

27.

Structural bases for the different anti-fibrillatory effects of chloroquine and quinidine.

Noujaim SF, Stuckey JA, Ponce-Balbuena D, Ferrer-Villada T, López-Izquierdo A, Pandit SV, Sánchez-Chapula JA, Jalife J.

Cardiovasc Res. 2011 Mar 1;89(4):862-9. doi: 10.1093/cvr/cvr008. Epub 2011 Jan 13.

28.

Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification.

Caballero R, Dolz-Gaitón P, Gómez R, Amorós I, Barana A, González de la Fuente M, Osuna L, Duarte J, López-Izquierdo A, Moraleda I, Gálvez E, Sánchez-Chapula JA, Tamargo J, Delpón E.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15631-6. doi: 10.1073/pnas.1004021107. Epub 2010 Aug 16.

29.

Tamoxifen inhibits cardiac ATP-sensitive and acetylcholine-activated K+ currents in part by interfering with phosphatidylinositol 4,5-bisphosphate-channel interaction.

Ponce-Balbuena D, Moreno-Galindo EG, López-Izquierdo A, Ferrer T, Sánchez-Chapula JA.

J Pharmacol Sci. 2010;113(1):66-75.

30.

Thiopental inhibits function of different inward rectifying potassium channel isoforms by a similar mechanism.

López-Izquierdo A, Ponce-Balbuena D, Ferrer T, Rodríguez-Menchaca AA, Sánchez-Chapula JA.

Eur J Pharmacol. 2010 Jul 25;638(1-3):33-41. doi: 10.1016/j.ejphar.2010.04.026. Epub 2010 May 4.

PMID:
20447386
31.

Molecular basis for a high-potency open-channel block of Kv1.5 channel by the endocannabinoid anandamide.

Moreno-Galindo EG, Barrio-Echavarría GF, Vásquez JC, Decher N, Sachse FB, Tristani-Firouzi M, Sánchez-Chapula JA, Navarro-Polanco RA.

Mol Pharmacol. 2010 May;77(5):751-8. doi: 10.1124/mol.109.063008. Epub 2010 Feb 4.

32.

Multiple effects of 4-aminopyridine on feline and rabbit sinoatrial node myocytes and multicellular preparations.

Aréchiga-Figueroa IA, Rodríguez-Martínez M, Albarado A, Torres-Jácome J, Sánchez-Chapula JA.

Pflugers Arch. 2010 Feb;459(3):345-55. doi: 10.1007/s00424-009-0734-3. Epub 2009 Sep 18.

PMID:
19763605
33.

Chloroquine blocks a mutant Kir2.1 channel responsible for short QT syndrome and normalizes repolarization properties in silico.

Lopez-Izquierdo A, Ponce-Balbuena D, Ferrer T, Sachse FB, Tristani-Firouzi M, Sanchez-Chapula JA.

Cell Physiol Biochem. 2009;24(3-4):153-60. doi: 10.1159/000233241. Epub 2009 Aug 3.

34.

Tamoxifen inhibits inward rectifier K+ 2.x family of inward rectifier channels by interfering with phosphatidylinositol 4,5-bisphosphate-channel interactions.

Ponce-Balbuena D, López-Izquierdo A, Ferrer T, Rodríguez-Menchaca AA, Aréchiga-Figueroa IA, Sánchez-Chapula JA.

J Pharmacol Exp Ther. 2009 Nov;331(2):563-73. doi: 10.1124/jpet.109.156075. Epub 2009 Aug 4.

35.

Kv1.5 open channel block by the antiarrhythmic drug disopyramide: molecular determinants of block.

Aréchiga IA, Barrio-Echavarria GF, Rodríguez-Menchaca AA, Moreno-Galindo EG, Decher N, Tristani-Firouzi M, Sánchez-Chapula JA, Navarro-Polanco RA.

J Pharmacol Sci. 2008 Sep;108(1):49-55.

36.

The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel.

Rodríguez-Menchaca AA, Navarro-Polanco RA, Ferrer-Villada T, Rupp J, Sachse FB, Tristani-Firouzi M, Sánchez-Chapula JA.

Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1364-8. doi: 10.1073/pnas.0708153105. Epub 2008 Jan 23.

37.

The D3-dopaminergic agonist 7-hydroxy-dipropylaminotetralin (7-OH-DPAT) increases cardiac action potential duration and blocks human ether-a-go-go-related gene K+ channel.

Torres-Jácome J, Tejeda-Chávez HR, Rodríguez-Menchaca AA, Sánchez-Chapula JA, Navarro-Polanco RA.

J Cardiovasc Pharmacol. 2006 May;47(5):656-62.

PMID:
16775504
38.

DITPA restores the repolarizing potassium currents Itof and Iss in cardiac ventricular myocytes of diabetic rats.

Ferrer T, Gallego M, Madrigal-Quiñónez R, Torres-Jácome J, Navarro-Polanco R, Cásis O, Sánchez-Chapula JA.

Life Sci. 2006 Jul 24;79(9):883-9. Epub 2006 Mar 21.

PMID:
16616210
39.

Block of HERG channels by berberine: mechanisms of voltage- and state-dependence probed with site-directed mutant channels.

Rodriguez-Menchaca A, Ferrer-Villada T, Lara J, Fernandez D, Navarro-Polanco RA, Sanchez-Chapula JA.

J Cardiovasc Pharmacol. 2006 Jan;47(1):21-9.

PMID:
16424781
40.

Inhibition of cardiac HERG potassium channels by antidepressant maprotiline.

Ferrer-Villada T, Navarro-Polanco RA, Rodríguez-Menchaca AA, Benavides-Haro DE, Sánchez-Chapula JA.

Eur J Pharmacol. 2006 Feb 15;531(1-3):1-8. Epub 2006 Jan 19.

PMID:
16423345
41.

Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs.

Sanguinetti MC, Chen J, Fernandez D, Kamiya K, Mitcheson J, Sanchez-Chapula JA.

Novartis Found Symp. 2005;266:159-66; discussion 166-70. Review.

PMID:
16050267
42.

Block of wild-type and inactivation-deficient human ether-a-go-go-related gene K+ channels by halofantrine.

Sánchez-Chapula JA, Navarro-Polanco RA, Sanguinetti MC.

Naunyn Schmiedebergs Arch Pharmacol. 2004 Dec;370(6):484-91. Epub 2004 Nov 19.

PMID:
15558243
43.

The cholinomimetic agent bethanechol activates IK(ACh) in feline atrial myocytes.

Benavides-Haro DE, Navarro-Polanco RA, Sánchez-Chapula JA.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Oct;368(4):309-15. Epub 2003 Sep 5.

PMID:
12961062
44.

Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain.

Sănchez-Chapula JA, Ferrer T, Navarro-Polanco RA, Sanguinetti MC.

Mol Pharmacol. 2003 May;63(5):1051-8.

45.

Modulation of cardiac action potential and underlying ionic currents by the pyrethroid insecticide deltamethrin.

de la Cerda E, Navarro-Polanco RA, Sánchez-Chapula JA.

Arch Med Res. 2002 Sep-Oct;33(5):448-54.

PMID:
12459314
46.

Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block.

Sánchez-Chapula JA, Navarro-Polanco RA, Culberson C, Chen J, Sanguinetti MC.

J Biol Chem. 2002 Jun 28;277(26):23587-95. Epub 2002 Apr 17.

47.

Imipramine, mianserine and maprotiline block delayed rectifier potassium current in ventricular myocytes.

Casis O, Gallego M, Sánchez-Chapula JA.

Pharmacol Res. 2002 Feb;45(2):141-6.

PMID:
11846627
48.

Blockade of currents by the antimalarial drug chloroquine in feline ventricular myocytes.

Sánchez-Chapula JA, Salinas-Stefanon E, Torres-Jácome J, Benavides-Haro DE, Navarro-Polanco RA.

J Pharmacol Exp Ther. 2001 Apr;297(1):437-45.

49.

Altered gating of HERG potassium channels by cobalt and lanthanum.

Sanchez-Chapula JA, Sanguinetti MC.

Pflugers Arch. 2000 Jun;440(2):264-74.

PMID:
10898527
50.

Chloroquine blocks the background potassium current in guinea pig atrial myocytes.

Benavides-Haro DE, Sánchez-Chapula JA.

Naunyn Schmiedebergs Arch Pharmacol. 2000 Mar;361(3):311-8.

PMID:
10731045

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