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Items: 26


Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics.

Flicker D, Sancak Y, Mick E, Goldberger O, Mootha VK.

Cell Rep. 2019 Apr 30;27(5):1364-1375.e5. doi: 10.1016/j.celrep.2019.04.013.


The role of metabolism in cellular processes.

Birsoy K, Sancak Y.

Mol Biol Cell. 2019 Mar 15;30(6):733. doi: 10.1091/mbc.E19-01-0004. No abstract available.


The Determination of Some Microbiological and Chemical Features in Herby Cheese.

Ekici K, Okut H, Isleyici O, Sancak YC, Tuncay RM.

Foods. 2019 Jan 11;8(1). pii: E23. doi: 10.3390/foods8010023.


MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+.

Kamer KJ, Sancak Y, Fomina Y, Meisel JD, Chaudhuri D, Grabarek Z, Mootha VK.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E7960-E7969. doi: 10.1073/pnas.1807811115. Epub 2018 Aug 6.


A Protective Role for Triacylglycerols during Apoptosis.

Li N, Sancak Y, Frasor J, Atilla-Gokcumen GE.

Biochemistry. 2018 Jan 9;57(1):72-80. doi: 10.1021/acs.biochem.7b00975. Epub 2017 Dec 13.


Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter.

Bick AG, Wakimoto H, Kamer KJ, Sancak Y, Goldberger O, Axelsson A, DeLaughter DM, Gorham JM, Mootha VK, Seidman JG, Seidman CE.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9096-E9104. doi: 10.1073/pnas.1711303114. Epub 2017 Oct 9.


Architecture of the mitochondrial calcium uniporter.

Oxenoid K, Dong Y, Cao C, Cui T, Sancak Y, Markhard AL, Grabarek Z, Kong L, Liu Z, Ouyang B, Cong Y, Mootha VK, Chou JJ.

Nature. 2016 May 12;533(7602):269-73. doi: 10.1038/nature17656. Epub 2016 May 2.


Reconstitution of the mitochondrial calcium uniporter in yeast.

Kovács-Bogdán E, Sancak Y, Kamer KJ, Plovanich M, Jambhekar A, Huber RJ, Myre MA, Blower MD, Mootha VK.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8985-90. doi: 10.1073/pnas.1400514111. Epub 2014 Jun 2.


The uniporter: from newly identified parts to function.

Kamer KJ, Sancak Y, Mootha VK.

Biochem Biophys Res Commun. 2014 Jul 11;449(4):370-2. doi: 10.1016/j.bbrc.2014.04.143. Epub 2014 May 9. No abstract available.


EMRE is an essential component of the mitochondrial calcium uniporter complex.

Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK.

Science. 2013 Dec 13;342(6164):1379-82. doi: 10.1126/science.1242993. Epub 2013 Nov 14.


MCU encodes the pore conducting mitochondrial calcium currents.

Chaudhuri D, Sancak Y, Mootha VK, Clapham DE.

Elife. 2013 Jun 4;2:e00704. doi: 10.7554/eLife.00704.


MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.

Csordás G, Golenár T, Seifert EL, Kamer KJ, Sancak Y, Perocchi F, Moffat C, Weaver D, de la Fuente Perez S, Bogorad R, Koteliansky V, Adijanto J, Mootha VK, Hajnóczky G.

Cell Metab. 2013 Jun 4;17(6):976-87. doi: 10.1016/j.cmet.2013.04.020.


MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling.

Plovanich M, Bogorad RL, Sancak Y, Kamer KJ, Strittmatter L, Li AA, Girgis HS, Kuchimanchi S, De Groot J, Speciner L, Taneja N, Oshea J, Koteliansky V, Mootha VK.

PLoS One. 2013;8(2):e55785. doi: 10.1371/journal.pone.0055785. Epub 2013 Feb 7.


Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy.

Martell JD, Deerinck TJ, Sancak Y, Poulos TL, Mootha VK, Sosinsky GE, Ellisman MH, Ting AY.

Nat Biotechnol. 2012 Nov;30(11):1143-8. doi: 10.1038/nbt.2375. Epub 2012 Oct 21.


mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.

Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM.

Science. 2011 Nov 4;334(6056):678-83. doi: 10.1126/science.1207056.


Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.

Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL, Koteliansky V, Mootha VK.

Nature. 2011 Jun 19;476(7360):341-5. doi: 10.1038/nature10234.


Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome.

DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, Sancak Y, Cui X, Steine EJ, Miller JC, Tam P, Bartsevich VV, Meng X, Rupniewski I, Gopalan SM, Sun HC, Pitz KJ, Rock JM, Zhang L, Davis GD, Rebar EJ, Cheeseman IM, Yamamoto KR, Sabatini DM, Jaenisch R, Gregory PD, Urnov FD.

Genome Res. 2010 Aug;20(8):1133-42. doi: 10.1101/gr.106773.110. Epub 2010 May 27.


Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM.

Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr 8.


DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.

Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM.

Cell. 2009 May 29;137(5):873-86. doi: 10.1016/j.cell.2009.03.046. Epub 2009 May 14.


Rag proteins regulate amino-acid-induced mTORC1 signalling.

Sancak Y, Sabatini DM.

Biochem Soc Trans. 2009 Feb;37(Pt 1):289-90. doi: 10.1042/BST0370289. Review.


The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.

Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM.

Science. 2008 Jun 13;320(5882):1496-501. doi: 10.1126/science.1157535. Epub 2008 May 22.


PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM.

Mol Cell. 2007 Mar 23;25(6):903-15.


Tissue-specific TAFs counteract Polycomb to turn on terminal differentiation.

Chen X, Hiller M, Sancak Y, Fuller MT.

Science. 2005 Nov 4;310(5749):869-72.


Testis-specific TAF homologs collaborate to control a tissue-specific transcription program.

Hiller M, Chen X, Pringle MJ, Suchorolski M, Sancak Y, Viswanathan S, Bolival B, Lin TY, Marino S, Fuller MT.

Development. 2004 Nov;131(21):5297-308. Epub 2004 Sep 29.


A note on histamine levels in Turkish style fermented sausages.

Ekıcı K, Sekeroǧlu R, Sancak YC, Noyan T.

Meat Sci. 2004 Sep;68(1):123-5.


Smt3/SUMO and Ubc9 are required for efficient APC/C-mediated proteolysis in budding yeast.

Dieckhoff P, Bolte M, Sancak Y, Braus GH, Irniger S.

Mol Microbiol. 2004 Mar;51(5):1375-87.

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