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Items: 1 to 50 of 61

1.

Modifications in the branched arms of a class of dual inhibitors of HIV and EV71 replication expand their antiviral spectrum.

Martínez-Gualda B, Sun L, Martí-Marí O, Mirabelli C, Delang L, Neyts J, Schols D, Camarasa MJ, San-Félix A.

Antiviral Res. 2019 Aug;168:210-214. doi: 10.1016/j.antiviral.2019.06.006. Epub 2019 Jun 20.

PMID:
31228490
2.

Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid.

Sun L, Lee H, Thibaut HJ, Lanko K, Rivero-Buceta E, Bator C, Martinez-Gualda B, Dallmeier K, Delang L, Leyssen P, Gago F, San-Félix A, Hafenstein S, Mirabelli C, Neyts J.

PLoS Pathog. 2019 May 9;15(5):e1007760. doi: 10.1371/journal.ppat.1007760. eCollection 2019 May.

3.

Galloyl Carbohydrates with Antiangiogenic Activity Mediated by Capillary Morphogenesis Gene 2 (CMG2) Protein Binding.

G-Doyagüez E, Carrero P, Madrona A, Rodriguez-Salamanca P, Martínez-Gualda B, Camarasa MJ, Jimeno ML, Bennallack PR, Finnell JG, Tsang TM, Christensen KA, San-Félix A, Rogers MS.

J Med Chem. 2019 Apr 25;62(8):3958-3970. doi: 10.1021/acs.jmedchem.8b01988. Epub 2019 Apr 9.

PMID:
30964669
4.

A Novel Class of Cationic and Non-Peptidic Small Molecules as Hits for the Development of Antimicrobial Agents.

Jiménez A, García P, de la Puente S, Madrona A, Camarasa MJ, Pérez-Pérez MJ, Quintela JC, García-Del Portillo F, San-Félix A.

Molecules. 2018 Jun 22;23(7). pii: E1513. doi: 10.3390/molecules23071513.

5.

Novel Polyphenols That Inhibit Colon Cancer Cell Growth Affecting Cancer Cell Metabolism.

Gómez de Cedrón M, Vargas T, Madrona A, Jiménez A, Pérez-Pérez MJ, Quintela JC, Reglero G, San-Félix A, Ramírez de Molina A.

J Pharmacol Exp Ther. 2018 Aug;366(2):377-389. doi: 10.1124/jpet.118.248278. Epub 2018 Jun 5.

PMID:
29871992
6.

Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid.

Martínez-Gualda B, Sun L, Rivero-Buceta E, Flores A, Quesada E, Balzarini J, Noppen S, Liekens S, Schols D, Neyts J, Leyssen P, Mirabelli C, Camarasa MJ, San-Félix A.

Antiviral Res. 2017 Mar;139:32-40. doi: 10.1016/j.antiviral.2016.12.010. Epub 2016 Dec 23.

7.

Optimization of a Class of Tryptophan Dendrimers That Inhibit HIV Replication Leads to a Selective, Specific, and Low-Nanomolar Inhibitor of Clinical Isolates of Enterovirus A71.

Rivero-Buceta E, Sun L, Martínez-Gualda B, Doyagüez EG, Donckers K, Quesada E, Camarasa MJ, Delang L, San-Félix A, Neyts J, Leyssen P.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):5064-7. doi: 10.1128/AAC.00626-16. Print 2016 Aug.

8.

Anti-HIV-1 activity of a tripodal receptor that recognizes mannose oligomers.

Rivero-Buceta E, Carrero P, Casanova E, Doyagüez EG, Madrona A, Quesada E, Peréz-Pérez MJ, Mateos R, Bravo L, Mathys L, Noppen S, Kiselev E, Marchand C, Pommier Y, Liekens S, Balzarini J, Camarasa MJ, San-Félix A.

Eur J Med Chem. 2015 Dec 1;106:132-43. doi: 10.1016/j.ejmech.2015.10.027. Epub 2015 Oct 21.

PMID:
26540494
9.

Tryptophan dendrimers that inhibit HIV replication, prevent virus entry and bind to the HIV envelope glycoproteins gp120 and gp41.

Rivero-Buceta E, Doyagüez EG, Colomer I, Quesada E, Mathys L, Noppen S, Liekens S, Camarasa MJ, Pérez-Pérez MJ, Balzarini J, San-Félix A.

Eur J Med Chem. 2015 Dec 1;106:34-43. doi: 10.1016/j.ejmech.2015.10.031. Epub 2015 Oct 21.

PMID:
26513643
10.

Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.

Rivero-Buceta E, Carrero P, Doyagüez EG, Madrona A, Quesada E, Camarasa MJ, Peréz-Pérez MJ, Leyssen P, Paeshuyse J, Balzarini J, Neyts J, San-Félix A.

Eur J Med Chem. 2015 Mar 6;92:656-71. doi: 10.1016/j.ejmech.2015.01.033. Epub 2015 Jan 17.

PMID:
25617695
11.

Multivalent agents containing 1-substituted 2,3,4-trihydroxyphenyl moieties as novel synthetic polyphenols directed against HIV-1.

Flores A, Camarasa MJ, Pérez-Pérez MJ, San-Félix A, Balzarini J, Quesada E.

Org Biomol Chem. 2014 Jul 28;12(28):5278-94. doi: 10.1039/c4ob00445k.

PMID:
24927059
12.

Targeting HIV entry through interaction with envelope glycoprotein 120 (gp120): synthesis and antiviral evaluation of 1,3,5-triazines with aromatic amino acids.

Lozano V, Aguado L, Hoorelbeke B, Renders M, Camarasa MJ, Schols D, Balzarini J, San-Félix A, Pérez-Pérez MJ.

J Med Chem. 2011 Aug 11;54(15):5335-48. doi: 10.1021/jm200560r. Epub 2011 Jul 13.

PMID:
21749165
13.

Selective inhibition of Human Immunodeficiency Virus type 1 (HIV-1) by a novel family of tricyclic nucleosides.

Bonache MC, Cordeiro A, Quesada E, Vanstreels E, Daelemans D, Camarasa MJ, Balzarini J, San-Félix A.

Antiviral Res. 2011 Oct;92(1):37-44. doi: 10.1016/j.antiviral.2011.05.002. Epub 2011 May 12.

PMID:
21600933
14.

One-pot synthesis of polycyclic nucleosides with unusual molecular skeletons.

Bonache MC, Cordeiro A, Carrero P, Quesada E, Camarasa MJ, Jimeno ML, San-Félix A.

J Org Chem. 2009 Dec 4;74(23):9071-81. doi: 10.1021/jo9019144.

PMID:
19888745
15.

Novel N-3 substituted TSAO-T derivatives: synthesis and anti-HIV-evaluation.

Bonache MC, Quesada E, Sheen CW, Balzarini J, Sluis-Cremer N, Pérez-Pérez MJ, Camarasa MJ, San-Félix A.

Nucleosides Nucleotides Nucleic Acids. 2008 Apr;27(4):351-67. doi: 10.1080/15257770801943990.

PMID:
18404570
16.

Synthesis of highly condensed polycyclic carbohydrates by reaction of a spirocyclic enamino sulfonate derived from d-xylofuranose with bifunctional reagents.

Cordeiro A, Jimeno ML, Maestro MA, Camarasa MJ, Quesada E, San-Félix A.

J Org Chem. 2007 Dec 7;72(25):9713-21. Epub 2007 Nov 14.

PMID:
17999530
17.

A cyclic enamine derived from 1,2-O-isopropylidene-alpha-D-xylofuranose as a novel carbohydrate intermediate to achieve skeletal diversity.

Cordeiro A, Quesada E, Bonache MC, Velazquez S, Camarasa MJ, San-Félix A.

J Org Chem. 2006 Sep 15;71(19):7224-35.

PMID:
16958515
18.

Design and discovery of a novel dipeptidyl-peptidase IV (CD26)-based prodrug approach.

García-Aparicio C, Bonache MC, De Meester I, San-Félix A, Balzarini J, Camarasa MJ, Velazquez S.

J Med Chem. 2006 Aug 24;49(17):5339-51.

PMID:
16913724
20.

Dimerization inhibitors of HIV-1 reverse transcriptase, protease and integrase: a single mode of inhibition for the three HIV enzymes?

Camarasa MJ, Velázquez S, San-Félix A, Pérez-Pérez MJ, Gago F.

Antiviral Res. 2006 Sep;71(2-3):260-7. Epub 2006 Jun 28. Review.

PMID:
16872687
21.

TSAO derivatives, inhibitors of HIV-1 reverse transcriptase dimerization: recent progress.

Camarasa MJ, Velázquez S, San-Félix A, Pérez-Pérez MJ, Bonache MC, De Castro S.

Curr Pharm Des. 2006;12(15):1895-907. Review.

PMID:
16724955
22.
23.

Improving the antiviral efficacy and selectivity of HIV-1 reverse transcriptase inhibitor TSAO-T by the introduction of functional groups at the N-3 position.

Bonache MC, Chamorro C, Velázquez S, De Clercq E, Balzarini J, Barrios FR, Gago F, Camarasa MJ, San-Félix A.

J Med Chem. 2005 Oct 20;48(21):6653-60.

PMID:
16220981
24.

TSAO derivatives the first non-peptide inhibitors of HIV-1 RT dimerization.

Camarasa MJ, Velázquez S, San-Félix A, Pérez-Pérez MJ.

Antivir Chem Chemother. 2005;16(3):147-53. Review.

PMID:
16004078
25.

The role of Thr139 in the human immunodeficiency virus type 1 reverse transcriptase sensitivity to (+)-calanolide A.

Auwerx J, Rodríguez-Barrios F, Ceccherini-Silberstein F, San-Félix A, Velázquez S, De Clercq E, Camarasa MJ, Perno CF, Gago F, Balzarini J.

Mol Pharmacol. 2005 Sep;68(3):652-9. Epub 2005 Jun 16.

PMID:
15961674
26.

Novel [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2" -dioxide) derivatives with anti-HIV-1 and anti-human-cytomegalovirus activity.

de Castro S, Lobatón E, Pérez-Pérez MJ, San-Félix A, Cordeiro A, Andrei G, Snoeck R, De Clercq E, Balzarini J, Camarasa MJ, Velázquez S.

J Med Chem. 2005 Feb 24;48(4):1158-68.

PMID:
15715482
27.

Synthesis of novel Bi-, Tri-, and tetracyclic nucleosides by reaction of a common cyclic enamine derived from TSAO-T with nucleophiles.

Bonache MC, Chamorro C, Cordeiro A, Camarasa MJ, Jimeno ML, San-Félix A.

J Org Chem. 2004 Dec 10;69(25):8758-66.

PMID:
15575754
28.

TSAO compounds: the comprehensive story of a unique family of HIV-1 specific inhibitors of reverse transcriptase.

Camarasa MJ, San-Félix A, Velázquez S, Pérez-Pérez MJ, Gago F, Balzarini J.

Curr Top Med Chem. 2004;4(9):945-63. Review.

PMID:
15134550
29.

Structure-activity relationship studies on a novel family of specific HIV-1 reverse transcriptase inhibitors.

Bonache MC, Chamorro C, Lobatón E, De Clercq E, Balzarini J, Velázquez S, Camarasa MJ, San-Félix A.

Antivir Chem Chemother. 2003 Sep;14(5):249-62.

PMID:
14694988
30.

N-3 substituted TSAO derivatives as a probe to explore the dimeric interface of HIV-1 reverse transcriptase.

Bonache MC, Chamorro C, Velázquez S, De Clercq E, Balzarini J, Camarasa MJ, San-Félix A.

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):947-9. No abstract available.

PMID:
14565318
31.

Improving the selectivity of acyclic nucleoside analogues as inhibitors of human mitochondrial thymidine kinase: replacement of a triphenylmethoxy moiety with substituted amines and carboxamides.

Hernández AI, Balzarini J, Rodríguez-Barrios F, San-Félix A, Karlsson A, Gago F, Camarasa MJ, Pérez-Pérez MJ.

Bioorg Med Chem Lett. 2003 Sep 15;13(18):3027-30.

PMID:
12941326
32.

Synthesis and structural characterization of pyrimidine bi- and tricyclic nucleosides with sugar puckers conformationally locked into the eastern region of the pseudorotational cycle.

Chamorro C, Luengo SM, Bonache MC, Velázquez S, Pérez-Pérez MJ, Camarasa MJ, Gago F, Jimeno ML, San-Félix A.

J Org Chem. 2003 Aug 22;68(17):6695-704.

PMID:
12919035
33.

Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase.

Chamorro C, Lobatón E, Bonache MC, De Clercq E, Balzarini J, Velázquez S, San-Félix A, Camarasa MJ.

Bioorg Med Chem Lett. 2001 Dec 3;11(23):3085-8.

PMID:
11714616
34.

4"-H-TSAO-T, a novel prototype in the HIV-1 specific TSAO family.

Lobatón E, Velázquez S, San-Félix A, De Clercq E, Balzarini J, Camarasa MJ.

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):711-4.

PMID:
11563098
35.

"Second generation" of TSAO compounds directed against HIV-1 TSAO-resistant strains.

Lobatón E, Velázquez S, Pérez-Pérez MJ, Jimeno ML, San-Félix A, De Clercq E, Balzarini J, Camarasa MJ.

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):707-10.

PMID:
11563097
36.

Exploring the role of the 5'-position of TSAO-T. Synthesis and anti-HIV evaluation of novel TSAO-T derivatives.

Chamorro C, Pérez-Pérez MJ, Rodríguez-Barrios F, Gago F, De Clercq E, Balzarini J, San-Félix A, Camarasa MJ.

Antiviral Res. 2001 Jun;50(3):207-22.

PMID:
11397508
37.

Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV.

Balzarini J, Camarasa MJ, Pérez-Pérez MJ, San-Félix A, Velázquez S, Perno CF, De Clercq E, Anderson JN, Karlsson A.

J Virol. 2001 Jul;75(13):5772-7.

38.

Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase.

Rodríguez-Barrios F, Pérez C, Lobatón E, Velázquez S, Chamorro C, San-Félix A, Pérez-Pérez MJ, Camarasa MJ, Pelemans H, Balzarini J, Gago F.

J Med Chem. 2001 Jun 7;44(12):1853-65.

PMID:
11384232
39.

Site-directed mutagenesis of human immunodeficiency virus type 1 reverse transcriptase at amino acid position 138.

Pelemans H, Aertsen A, Van Laethem K, Vandamme AM, De Clercq E, Pérez-Pérez MJ, San-Félix A, Velázquez S, Camarasa MJ, Balzarini J.

Virology. 2001 Feb 1;280(1):97-106.

40.

TSAO-T analogues bearing amino acids at position N-3 of thymine: synthesis and anti-human immunodeficiency virus activity.

Chamorro C, De Clercq E, Balzarini J, Camarasa MJ, San-Félix A.

Antivir Chem Chemother. 2000 Jan;11(1):61-9.

PMID:
10693655
41.

Novel series of [ddN]-[TSAO-T] heterodimers as potential bi-functional inhibitors of HIV-1 RT. Studies in the linker and ddN region.

Velázquez S, Tuñón V, Jimeno ML, Pérez-Pérez MJ, San-Félix A, Chamorro C, Lobatón E, Esteban-Gamboa A, De Clercq E, Balzarini J, Camarasa MJ.

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):1029-30.

PMID:
10432737
42.

Novel TSAO derivatives modified at positions 3" and 4" of the spiro moiety.

Lobatón E, Velázquez S, San-Félix A, Chamorro C, Tuñón V, Esteban-Gamboa A, De Clercq E, Balzarini J, Camarasa MJ, Pérez-Pérez MJ.

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):675-6.

PMID:
10432663
43.

An approach towards the synthesis of potential metal-chelating TSAO-T derivatives as bidentate inhibitors of human immunodeficiency virus type 1 reverse transcriptase.

Chamorro C, Camarasa MJ, Pérez-Pérez MJ, de Clercq E, Balzarini J, San Félix A.

Antivir Chem Chemother. 1998 Sep;9(5):413-22.

PMID:
9875394
44.

Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase.

Velázquez S, Chamorro C, Pérez-Pérez MJ, Alvarez R, Jimeno ML, Martín-Domenech A, Pérez C, Gago F, De Clercq E, Balzarini J, San-Félix A, Camarasa MJ.

J Med Chem. 1998 Nov 5;41(23):4636-47.

PMID:
9804703
45.

Marked inhibitory activity of non-nucleoside reverse transcriptase inhibitors against human immunodeficiency virus type 1 when combined with (-)2',3'-dideoxy-3'-thiacytidine.

Balzarini J, Pelemans H, Pérez-Pérez MJ, San-Félix A, Camarasa MJ, De Clercq E, Karlsson A.

Mol Pharmacol. 1996 May;49(5):882-90.

PMID:
8622638
46.
47.

Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase.

Velázquez S, Alvarez R, San-Félix A, Jimeno ML, De Clercq E, Balzarini J, Camarasa MJ.

J Med Chem. 1995 May 12;38(10):1641-9.

PMID:
7538589
48.

1,2,3-Triazole-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D- ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"-oxathiole 2",2"-dioxide) (TSAO) analogues: synthesis and anti-HIV-1 activity.

Alvarez R, Velázquez S, San-Félix A, Aquaro S, De Clercq E, Perno CF, Karlsson A, Balzarini J, Camarasa MJ.

J Med Chem. 1994 Nov 25;37(24):4185-94.

PMID:
7527463
49.

Novel series of TSAO-T derivatives. Synthesis and anti-HIV-1 activity of 4-, 5-, and 6-substituted pyrimidine analogues.

San-Félix A, Velázquez S, Pérez-Pérez MJ, Balzarini J, De Clercq E, Camarasa MJ.

J Med Chem. 1994 Feb 18;37(4):453-60.

PMID:
7509877
50.

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