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Items: 1 to 50 of 132

1.

Mechanistic insight into the catalytic inhibition by nitroxides of tyrosine oxidation and nitration.

Maimon E, Samuni A, Goldstein S.

Biochim Biophys Acta Gen Subj. 2019 Nov;1863(11):129403. doi: 10.1016/j.bbagen.2019.07.012. Epub 2019 Jul 26.

PMID:
31356821
2.

Direct Observation of Acyl Nitroso Compounds in Aqueous Solution and the Kinetics of Their Reactions with Amines, Thiols, and Hydroxamic Acids.

Maimon E, Lerner A, Samuni A, Goldstein S.

J Phys Chem A. 2018 Sep 6;122(35):7006-7013. doi: 10.1021/acs.jpca.8b06672. Epub 2018 Aug 24.

PMID:
30111101
3.

Nitrogen Dioxide Reaction with Nitroxide Radical Derived from Hydroxamic Acids: The Intermediacy of Acyl Nitroso and Nitroxyl (HNO).

Maimon E, Samuni A, Goldstein S.

J Phys Chem A. 2018 Apr 19;122(15):3747-3753. doi: 10.1021/acs.jpca.8b02300. Epub 2018 Apr 9.

PMID:
29608853
4.

Mechanism of HRP-catalyzed nitrite oxidation by H2O2 revisited: Effect of nitroxides on enzyme inactivation and its catalytic activity.

Samuni A, Maimon E, Goldstein S.

Free Radic Biol Med. 2017 Jul;108:832-839. doi: 10.1016/j.freeradbiomed.2017.05.010. Epub 2017 May 8.

PMID:
28495446
5.

Nitroxides protect horseradish peroxidase from H2O2-induced inactivation and modulate its catalase-like activity.

Samuni A, Maimon E, Goldstein S.

Biochim Biophys Acta Gen Subj. 2017 Aug;1861(8):2060-2069. doi: 10.1016/j.bbagen.2017.03.021. Epub 2017 Mar 30.

PMID:
28365302
6.

Nitroxides catalytically inhibit nitrite oxidation and heme inactivation induced by H2O2, nitrite and metmyoglobin or methemoglobin.

Samuni A, Maimon E, Goldstein S.

Free Radic Biol Med. 2016 Dec;101:491-499. doi: 10.1016/j.freeradbiomed.2016.10.534. Epub 2016 Nov 5.

PMID:
27826125
7.

Cyclic nitroxide radicals attenuate inflammation and Hyper-responsiveness in a mouse model of allergic asthma.

Assayag M, Goldstein S, Samuni A, Berkman N.

Free Radic Biol Med. 2015 Oct;87:148-56. doi: 10.1016/j.freeradbiomed.2015.06.031. Epub 2015 Jun 26.

PMID:
26119784
8.

Redox properties and thiol reactivity of geldanamycin and its analogues in aqueous solutions.

Samuni A, Goldstein S.

J Phys Chem B. 2012 Jun 7;116(22):6404-10. doi: 10.1021/jp304206n. Epub 2012 May 25.

PMID:
22591491
9.

One-electron oxidation of acetohydroxamic acid: the intermediacy of nitroxyl and peroxynitrite.

Samuni A, Goldstein S.

J Phys Chem A. 2011 Apr 14;115(14):3022-8. doi: 10.1021/jp201796q. Epub 2011 Mar 22.

PMID:
21425838
10.

Kinetics of the reaction between nitroxide and thiyl radicals: nitroxides as antioxidants in the presence of thiols.

Goldstein S, Samuni A, Merenyi G.

J Phys Chem A. 2008 Sep 18;112(37):8600-5. doi: 10.1021/jp804743g. Epub 2008 Aug 27.

PMID:
18729428
11.

Oxidative stress in Cohen diabetic rat model by high-sucrose, low-copper diet: inducing pancreatic damage and diabetes.

Ryu S, Ornoy A, Samuni A, Zangen S, Kohen R.

Metabolism. 2008 Sep;57(9):1253-61. doi: 10.1016/j.metabol.2008.04.021.

PMID:
18702952
12.

Nitroxide radicals protect cultured rat embryos and yolk sacs from diabetic-induced damage.

Ryu S, Kohen R, Samuni A, Ornoy A.

Birth Defects Res A Clin Mol Teratol. 2007 Aug;79(8):604-11.

PMID:
17626261
13.

Dual activity of nitroxides as pro- and antioxidants: catalysis of copper-mediated DNA breakage and H2O2 dismutation.

Aronovitch Y, Godinger D, Israeli A, Krishna MC, Samuni A, Goldstein S.

Free Radic Biol Med. 2007 May 1;42(9):1317-25. Epub 2007 Jan 13.

PMID:
17395005
14.

Kinetics and mechanism of peroxyl radical reactions with nitroxides.

Goldstein S, Samuni A.

J Phys Chem A. 2007 Feb 15;111(6):1066-72.

PMID:
17286360
15.

Structure-activity relationship of cyclic nitroxides as SOD mimics and scavengers of nitrogen dioxide and carbonate radicals.

Goldstein S, Samuni A, Hideg K, Merenyi G.

J Phys Chem A. 2006 Mar 16;110(10):3679-85.

PMID:
16526651
16.
17.

Effects of hypoxia on radiation-responsive stress-activated protein kinase, p53, and caspase 3 signals in TK6 human lymphoblastoid cells.

Samuni AM, Kasid U, Chuang EY, Suy S, Degraff W, Krishna MC, Russo A, Mitchell JB.

Cancer Res. 2005 Jan 15;65(2):579-86.

18.
19.

Kinetics and mechanism of the comproportionation reaction between oxoammonium cation and hydroxylamine derived from cyclic nitroxides.

Israeli A, Patt M, Oron M, Samuni A, Kohen R, Goldstein S.

Free Radic Biol Med. 2005 Feb 1;38(3):317-24.

PMID:
15629861
20.

ESR detection of 1O2 reveals enhanced redox activity in illuminated cell cultures.

Lavi R, Sinyakov M, Samuni A, Shatz S, Friedmann H, Shainberg A, Breitbart H, Lubart R.

Free Radic Res. 2004 Sep;38(9):893-902.

PMID:
15621706
21.

Kinetics and mechanism of *NO2 reacting with various oxidation states of myoglobin.

Goldstein S, Merenyi G, Samuni A.

J Am Chem Soc. 2004 Dec 8;126(48):15694-701.

PMID:
15571391
22.

The effects of antioxidants on radiation-induced apoptosis pathways in TK6 cells.

Samuni AM, DeGraff W, Cook JA, Krishna MC, Russo A, Mitchell JB.

Free Radic Biol Med. 2004 Nov 15;37(10):1648-55.

PMID:
15477016
23.

Use of nitroxides to protect liposomes against oxidative damage.

Samuni AM, Barenholz Y.

Methods Enzymol. 2004;387:299-314. No abstract available.

PMID:
15172172
24.

Factors influencing nitroxide reduction and cytotoxicity in vitro.

Samuni Y, Gamson J, Samuni A, Yamada K, Russo A, Krishna MC, Mitchell JB.

Antioxid Redox Signal. 2004 Jun;6(3):587-95.

PMID:
15130285
25.

Reactions of nitric oxide, peroxynitrite, and carbonate radicals with nitroxides and their corresponding oxoammonium cations.

Goldstein S, Samuni A, Merenyi G.

Chem Res Toxicol. 2004 Feb;17(2):250-7. Erratum in: Chem Res Toxicol. 2004 Nov;17(11):1549.

PMID:
14967013
26.

Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone.

Xavier S, Piek E, Fujii M, Javelaud D, Mauviel A, Flanders KC, Samuni AM, Felici A, Reiss M, Yarkoni S, Sowers A, Mitchell JB, Roberts AB, Russo A.

J Biol Chem. 2004 Apr 9;279(15):15167-76. Epub 2004 Jan 19.

27.

Effect of nitric oxide and nitroxide SOD-mimic on the recovery of isolated rat heart following ischemia and reperfusion.

Hoffman A, Goldstein S, Samuni A, Borman JB, Schwalb H.

Biochem Pharmacol. 2003 Oct 1;66(7):1279-86.

PMID:
14505807
28.

Reactions of PTIO and carboxy-PTIO with *NO, *NO2, and O2-*.

Goldstein S, Russo A, Samuni A.

J Biol Chem. 2003 Dec 19;278(51):50949-55. Epub 2003 Sep 3.

29.

Do stable nitroxide radicals catalyze or inhibit the degradation of hyaluronic acid?

Lurie Z, Offer T, Russo A, Samuni A, Nitzan D.

Free Radic Biol Med. 2003 Jul 15;35(2):169-78.

PMID:
12853073
30.

Reaction of cyclic nitroxides with nitrogen dioxide: the intermediacy of the oxoammonium cations.

Goldstein S, Samuni A, Russo A.

J Am Chem Soc. 2003 Jul 9;125(27):8364-70.

PMID:
12837108
31.

Semiquinone radical intermediate in catecholic estrogen-mediated cytotoxicity and mutagenesis: chemoprevention strategies with antioxidants.

Samuni AM, Chuang EY, Krishna MC, Stein W, DeGraff W, Russo A, Mitchell JB.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5390-5. Epub 2003 Apr 17.

32.

The role of oxoammonium cation in the SOD-mimic activity of cyclic nitroxides.

Goldstein S, Merenyi G, Russo A, Samuni A.

J Am Chem Soc. 2003 Jan 22;125(3):789-95.

PMID:
12526680
33.

Site-activity relationship of nitroxide radical's antioxidative effect.

Samuni AM, Barenholz Y.

Free Radic Biol Med. 2003 Jan 15;34(2):177-85.

PMID:
12521599
34.

Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage.

Xavier S, Yamada K, Samuni AM, Samuni A, DeGraff W, Krishna MC, Mitchell JB.

Biochim Biophys Acta. 2002 Nov 14;1573(2):109-20.

PMID:
12399020
35.

Molecular and cellular assessment of ginkgo biloba extract as a possible ophthalmic drug.

Thiagarajan G, Chandani S, Harinarayana Rao S, Samuni AM, Chandrasekaran K, Balasubramanian D.

Exp Eye Res. 2002 Oct;75(4):421-30.

PMID:
12387790
36.

Nitroxides as antioxidants: Tempol protects against EO9 cytotoxicity.

Samuni AM, DeGraff W, Krishna MC, Mitchell JB.

Mol Cell Biochem. 2002 May-Jun;234-235(1-2):327-33.

PMID:
12162451
37.

Kinetics and mechanism of hydroxyl radical and OH-adduct radical reactions with nitroxides and with their hydroxylamines.

Samuni A, Goldstein S, Russo A, Mitchell JB, Krishna MC, Neta P.

J Am Chem Soc. 2002 Jul 24;124(29):8719-24.

PMID:
12121116
38.

Mechanisms underlying the cytotoxic effects of Tachpyr--a novel metal chelator.

Samuni AM, Krishna MC, DeGraff W, Russo A, Planalp RP, Brechbiel MW, Mitchell JB.

Biochim Biophys Acta. 2002 Jul 3;1571(3):211-8.

PMID:
12090935
39.

Kinetics of paraquat and copper reactions with nitroxides: the effects of nitroxides on the aerobic and anoxic toxicity of paraquat.

Goldstein S, Samuni A, Aronovitch Y, Godinger D, Russo A, Mitchell JB.

Chem Res Toxicol. 2002 May;15(5):686-91.

PMID:
12018990
40.

Time window of nitroxide effect on myocardial ischemic-reperfusion injury potentiated by iron.

Zeltcer G, Berenshtein E, Kitrossky N, Chevion M, Samuni A.

Free Radic Biol Med. 2002 May 1;32(9):912-9.

PMID:
11978493
41.

Nitroxides inhibit peroxyl radical-mediated DNA scission and enzyme inactivation.

Offer T, Samuni A.

Free Radic Biol Med. 2002 May 1;32(9):872-81.

PMID:
11978488
42.

Superoxide dismutase mimics: antioxidative and adverse effects.

Czapski G, Samuni A, Goldstein S.

Methods Enzymol. 2002;349:234-42. No abstract available.

PMID:
11912913
43.

Cellular sites of H2O2-induced damage and their protection by nitroxides.

Samuni AM, DeGraff W, Krishna MC, Mitchell JB.

Biochim Biophys Acta. 2001 Feb 16;1525(1-2):70-6.

PMID:
11342255
44.

Novel anthraquinone derivatives with redox-active functional groups capable of producing free radicals by metabolism: are free radicals essential for cytotoxicity?

Barasch D, Zipori O, Ringel I, Ginsburg I, Samuni A, Katzhendler J.

Eur J Med Chem. 1999 Jul-Aug;34(7-8):597-615.

PMID:
11278045
45.

Multifunctional antioxidant activity of HBED iron chelator.

Samuni AM, Afeworki M, Stein W, Yordanov AT, DeGraff W, Krishna MC, Mitchell JB, Brechbiel MW.

Free Radic Biol Med. 2001 Jan 15;30(2):170-7.

PMID:
11163534
46.

The pro-oxidative activity of SOD and nitroxide SOD mimics.

Offer T, Russo A, Samuni A.

FASEB J. 2000 Jun;14(9):1215-23.

PMID:
10834943
47.

Damage to liposomal lipids: protection by antioxidants and cholesterol-mediated dehydration.

Samuni AM, Lipman A, Barenholz Y.

Chem Phys Lipids. 2000 Apr;105(2):121-34.

PMID:
10823461
48.

Nitroxide stable radical suppresses autoimmune uveitis in rats.

Zamir E, Zhang R, Samuni A, Kogan M, Pe'er J.

Free Radic Biol Med. 1999 Jul;27(1-2):7-15.

PMID:
10443914
49.

The role of superoxide dismutation in malaria parasites.

Schwartz E, Samuni A, Friedman I, Hempelmann E, Golenser J.

Inflammation. 1999 Aug;23(4):361-70.

PMID:
10443798
50.

Kinetics of superoxide-induced exchange among nitroxide antioxidants and their oxidized and reduced forms.

Zhang R, Goldstein S, Samuni A.

Free Radic Biol Med. 1999 May;26(9-10):1245-52.

PMID:
10381196

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