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Items: 1 to 50 of 87

1.

Considering the links between NAFLD and insulin resistance: revisiting the role of protein kinase c ε.

Samuel VT, Petersen MC, Gassaway BM, Vatner DF, Rinehart J, Shulman GI.

Hepatology. 2019 Jun 20. doi: 10.1002/hep.30829. [Epub ahead of print]

PMID:
31220350
2.

Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action.

Abulizi A, Camporez JP, Jurczak MJ, Høyer KF, Zhang D, Cline GW, Samuel VT, Shulman GI, Vatner DF.

FASEB J. 2019 Mar 28:fj201802706R. doi: 10.1096/fj.201802706R. [Epub ahead of print]

PMID:
30922125
3.

Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice.

Abulizi A, Camporez JP, Zhang D, Samuel VT, Shulman GI, Vatner DF.

Metabolism. 2019 Apr;93:1-9. doi: 10.1016/j.metabol.2018.12.003. Epub 2018 Dec 19.

PMID:
30576689
4.

PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats.

Beddow SA, Gattu AK, Vatner DF, Paolella L, Alqarzaee A, Tashkandi N, Popov VB, Church CD, Rodeheffer MS, Cline GW, Geisler JG, Bhanot S, Samuel VT.

Endocrinology. 2019 Jan 1;160(1):205-219. doi: 10.1210/en.2018-00630.

PMID:
30445425
5.

PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling.

Gassaway BM, Petersen MC, Surovtseva YV, Barber KW, Sheetz JB, Aerni HR, Merkel JS, Samuel VT, Shulman GI, Rinehart J.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8996-E9005. doi: 10.1073/pnas.1804379115. Epub 2018 Sep 4.

6.

IndEcho study: cohort study investigating birth size, childhood growth and young adult cardiovascular risk factors as predictors of midlife myocardial structure and function in South Asians.

Vasan SK, Roy A, Samuel VT, Antonisamy B, Bhargava SK, Alex AG, Singh B, Osmond C, Geethanjali FS, Karpe F, Sachdev H, Agrawal K, Ramakrishnan L, Tandon N, Thomas N, Premkumar PS, Asaithambi P, Princy SFX, Sinha S, Paul TV, Prabhakaran D, Fall CHD.

BMJ Open. 2018 Apr 10;8(4):e019675. doi: 10.1136/bmjopen-2017-019675.

7.

Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents.

Vatner DF, Goedeke L, Camporez JG, Lyu K, Nasiri AR, Zhang D, Bhanot S, Murray SF, Still CD, Gerhard GS, Shulman GI, Samuel VT.

Diabetologia. 2018 Jun;61(6):1435-1446. doi: 10.1007/s00125-018-4579-1. Epub 2018 Mar 1.

8.

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases.

Samuel VT, Shulman GI.

Cell Metab. 2018 Jan 9;27(1):22-41. doi: 10.1016/j.cmet.2017.08.002. Epub 2017 Aug 31. Review.

9.

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans.

Ter Horst KW, Gilijamse PW, Versteeg RI, Ackermans MT, Nederveen AJ, la Fleur SE, Romijn JA, Nieuwdorp M, Zhang D, Samuel VT, Vatner DF, Petersen KF, Shulman GI, Serlie MJ.

Cell Rep. 2017 Jun 6;19(10):1997-2004. doi: 10.1016/j.celrep.2017.05.035.

10.

Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation.

Lee HY, Lee JS, Alves T, Ladiges W, Rabinovitch PS, Jurczak MJ, Choi CS, Shulman GI, Samuel VT.

Diabetes. 2017 Aug;66(8):2072-2081. doi: 10.2337/db16-1334. Epub 2017 May 5.

11.

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance.

Petersen MC, Madiraju AK, Gassaway BM, Marcel M, Nasiri AR, Butrico G, Marcucci MJ, Zhang D, Abulizi A, Zhang XM, Philbrick W, Hubbard SR, Jurczak MJ, Samuel VT, Rinehart J, Shulman GI.

J Clin Invest. 2016 Nov 1;126(11):4361-4371. doi: 10.1172/JCI86013. Epub 2016 Oct 17.

12.

The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis.

Herman MA, Samuel VT.

Trends Endocrinol Metab. 2016 Oct;27(10):719-730. doi: 10.1016/j.tem.2016.06.005. Epub 2016 Jul 4. Review.

13.

Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism.

Madiraju AK, Alves T, Zhao X, Cline GW, Zhang D, Bhanot S, Samuel VT, Kibbey RG, Shulman GI.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3423-30. doi: 10.1073/pnas.1606022113. Epub 2016 May 31.

14.

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux.

Samuel VT, Shulman GI.

J Clin Invest. 2016 Jan;126(1):12-22. doi: 10.1172/JCI77812. Epub 2016 Jan 4. Review.

15.

Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5).

Pesta DH, Perry RJ, Guebre-Egziabher F, Zhang D, Jurczak M, Fischer-Rosinsky A, Daniels MA, Willmes DM, Bhanot S, Bornstein SR, Knauf F, Samuel VT, Shulman GI, Birkenfeld AL.

Aging (Albany NY). 2015 Dec;7(12):1086-93.

16.

Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance.

Popov VB, Jornayvaz FR, Akgul EO, Kanda S, Jurczak MJ, Zhang D, Abudukadier A, Majumdar SK, Guigni B, Petersen KF, Manchem VP, Bhanot S, Shulman GI, Samuel VT.

FASEB J. 2016 Mar;30(3):1207-17. doi: 10.1096/fj.15-271999. Epub 2015 Dec 7.

17.

3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats.

Vatner DF, Snikeris J, Popov V, Perry RJ, Rahimi Y, Samuel VT.

PLoS One. 2015 Oct 20;10(10):e0140837. doi: 10.1371/journal.pone.0140837. eCollection 2015.

18.

Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21.

Camporez JP, Asrih M, Zhang D, Kahn M, Samuel VT, Jurczak MJ, Jornayvaz FR.

J Endocrinol. 2015 Sep;226(3):207-17. doi: 10.1530/JOE-15-0136. Epub 2015 Jul 22.

PMID:
26203166
19.

Coordinated Regulation of Vasopressin Inactivation and Glucose Uptake by Action of TUG Protein in Muscle.

Habtemichael EN, Alcázar-Román A, Rubin BR, Grossi LR, Belman JP, Julca O, Löffler MG, Li H, Chi NW, Samuel VT, Bogan JS.

J Biol Chem. 2015 Jun 5;290(23):14454-61. doi: 10.1074/jbc.C115.639203. Epub 2015 May 5.

20.

Short-term food restriction followed by controlled refeeding promotes gorging behavior, enhances fat deposition, and diminishes insulin sensitivity in mice.

Kliewer KL, Ke JY, Lee HY, Stout MB, Cole RM, Samuel VT, Shulman GI, Belury MA.

J Nutr Biochem. 2015 Jul;26(7):721-8. doi: 10.1016/j.jnutbio.2015.01.010. Epub 2015 Mar 13.

21.

Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.

Vatner DF, Majumdar SK, Kumashiro N, Petersen MC, Rahimi Y, Gattu AK, Bears M, Camporez JP, Cline GW, Jurczak MJ, Samuel VT, Shulman GI.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1143-8. doi: 10.1073/pnas.1423952112. Epub 2015 Jan 6.

22.

ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content.

Camporez JP, Kanda S, Petersen MC, Jornayvaz FR, Samuel VT, Bhanot S, Petersen KF, Jurczak MJ, Shulman GI.

J Lipid Res. 2015 Mar;56(3):526-36. doi: 10.1194/jlr.M054080. Epub 2014 Dec 29.

23.

A high-protein diet for reducing body fat: mechanisms and possible caveats.

Pesta DH, Samuel VT.

Nutr Metab (Lond). 2014 Nov 19;11(1):53. doi: 10.1186/1743-7075-11-53. eCollection 2014. Review.

24.

The emerging role of oestrogen-related receptor γ as a regulator of energy metabolism.

Samuel VT.

Diabetologia. 2014 Dec;57(12):2440-3. doi: 10.1007/s00125-014-3377-7. Epub 2014 Sep 26.

25.

Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats.

Cantley JL, Vatner DF, Galbo T, Madiraju A, Petersen M, Perry RJ, Kumashiro N, Guebre-Egziabher F, Gattu AK, Stacy MR, Dione DP, Sinusas AJ, Ragolia L, Hall CE, Manchem VP, Bhanot S, Bogan JS, Samuel VT.

Am J Physiol Endocrinol Metab. 2014 Nov 1;307(9):E773-83. doi: 10.1152/ajpendo.00148.2014. Epub 2014 Aug 26.

26.

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes.

Perry RJ, Samuel VT, Petersen KF, Shulman GI.

Nature. 2014 Jun 5;510(7503):84-91. doi: 10.1038/nature13478. Review.

27.

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.

Madiraju AK, Erion DM, Rahimi Y, Zhang XM, Braddock DT, Albright RA, Prigaro BJ, Wood JL, Bhanot S, MacDonald MJ, Jurczak MJ, Camporez JP, Lee HY, Cline GW, Samuel VT, Kibbey RG, Shulman GI.

Nature. 2014 Jun 26;510(7506):542-6. doi: 10.1038/nature13270. Epub 2014 May 21.

28.

Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice.

Lee HY, Gattu AK, Camporez JP, Kanda S, Guigni B, Kahn M, Zhang D, Galbo T, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Choi CS, Yan Z, Williams RS, Shulman GI, Samuel VT.

Diabetologia. 2014 Jun;57(6):1232-41. doi: 10.1007/s00125-014-3212-1. Epub 2014 Apr 11.

29.

Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.

Gattu AK, Birkenfeld AL, Iwakiri Y, Jay S, Saltzman M, Doll J, Protiva P, Samuel VT, Crawford SE, Chung C.

Endocrinology. 2014 Apr;155(4):1373-85. doi: 10.1210/en.2013-1785. Epub 2014 Jan 23.

30.

Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity.

Wheeler SG, Hammond CL, Jornayvaz FR, Samuel VT, Shulman GI, Soroka CJ, Boyer JL, Hinkle PM, Ballatori N.

Am J Physiol Gastrointest Liver Physiol. 2014 Mar 1;306(5):G425-38. doi: 10.1152/ajpgi.00368.2013. Epub 2013 Dec 31.

31.

PP2A inhibition results in hepatic insulin resistance despite Akt2 activation.

Galbo T, Perry RJ, Nishimura E, Samuel VT, Quistorff B, Shulman GI.

Aging (Albany NY). 2013 Oct;5(10):770-81.

32.

Obesity, adiposity, and dyslipidemia: a consensus statement from the National Lipid Association.

Bays HE, Toth PP, Kris-Etherton PM, Abate N, Aronne LJ, Brown WV, Gonzalez-Campoy JM, Jones SR, Kumar R, La Forge R, Samuel VT.

J Clin Lipidol. 2013 Jul-Aug;7(4):304-83. doi: 10.1016/j.jacl.2013.04.001. Epub 2013 May 31.

PMID:
23890517
33.

Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content.

Gattu AK, Swenson ES, Iwakiri Y, Samuel VT, Troiano N, Berry R, Church CD, Rodeheffer MS, Carpenter TO, Chung C.

FASEB J. 2013 Nov;27(11):4384-94. doi: 10.1096/fj.13-232900. Epub 2013 Jul 25.

34.

Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo.

Galbo T, Perry RJ, Jurczak MJ, Camporez JP, Alves TC, Kahn M, Guigni BA, Serr J, Zhang D, Bhanot S, Samuel VT, Shulman GI.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12780-5. doi: 10.1073/pnas.1311176110. Epub 2013 Jul 9.

35.

Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice.

Camporez JP, Jornayvaz FR, Petersen MC, Pesta D, Guigni BA, Serr J, Zhang D, Kahn M, Samuel VT, Jurczak MJ, Shulman GI.

Endocrinology. 2013 Sep;154(9):3099-109. doi: 10.1210/en.2013-1191. Epub 2013 Jun 13.

36.

Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal muscle.

Löffler MG, Birkenfeld AL, Philbrick KM, Belman JP, Habtemichael EN, Booth CJ, Castorena CM, Choi CS, Jornayvaz FR, Gassaway BM, Lee HY, Cartee GD, Philbrick W, Shulman GI, Samuel VT, Bogan JS.

J Biol Chem. 2013 Jul 12;288(28):20135-50. doi: 10.1074/jbc.M113.458075. Epub 2013 Jun 6.

37.

Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways.

Vatner DF, Weismann D, Beddow SA, Kumashiro N, Erion DM, Liao XH, Grover GJ, Webb P, Phillips KJ, Weiss RE, Bogan JS, Baxter J, Shulman GI, Samuel VT.

Am J Physiol Endocrinol Metab. 2013 Jul 1;305(1):E89-100. doi: 10.1152/ajpendo.00573.2012. Epub 2013 May 7.

38.

cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis.

Erion DM, Kotas ME, McGlashon J, Yonemitsu S, Hsiao JJ, Nagai Y, Iwasaki T, Murray SF, Bhanot S, Cline GW, Samuel VT, Shulman GI, Gillum MP.

J Biol Chem. 2013 May 31;288(22):16167-76. doi: 10.1074/jbc.M113.460246. Epub 2013 Apr 17.

39.

Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance.

Kumashiro N, Beddow SA, Vatner DF, Majumdar SK, Cantley JL, Guebre-Egziabher F, Fat I, Guigni B, Jurczak MJ, Birkenfeld AL, Kahn M, Perler BK, Puchowicz MA, Manchem VP, Bhanot S, Still CD, Gerhard GS, Petersen KF, Cline GW, Shulman GI, Samuel VT.

Diabetes. 2013 Jul;62(7):2183-94. doi: 10.2337/db12-1311. Epub 2013 Feb 19.

40.

Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance.

Camporez JP, Jornayvaz FR, Lee HY, Kanda S, Guigni BA, Kahn M, Samuel VT, Carvalho CR, Petersen KF, Jurczak MJ, Shulman GI.

Endocrinology. 2013 Mar;154(3):1021-8. doi: 10.1210/en.2012-1989. Epub 2013 Jan 30.

41.

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance.

Cantley JL, Yoshimura T, Camporez JP, Zhang D, Jornayvaz FR, Kumashiro N, Guebre-Egziabher F, Jurczak MJ, Kahn M, Guigni BA, Serr J, Hankin J, Murphy RC, Cline GW, Bhanot S, Manchem VP, Brown JM, Samuel VT, Shulman GI.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1869-74. doi: 10.1073/pnas.1219456110. Epub 2013 Jan 9.

42.

Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats.

Kumashiro N, Yoshimura T, Cantley JL, Majumdar SK, Guebre-Egziabher F, Kursawe R, Vatner DF, Fat I, Kahn M, Erion DM, Zhang XM, Zhang D, Manchem VP, Bhanot S, Gerhard GS, Petersen KF, Cline GW, Samuel VT, Shulman GI.

Hepatology. 2013 May;57(5):1763-72. doi: 10.1002/hep.26170. Epub 2013 Jan 25.

43.

The role of the carbohydrate response element-binding protein in male fructose-fed rats.

Erion DM, Popov V, Hsiao JJ, Vatner D, Mitchell K, Yonemitsu S, Nagai Y, Kahn M, Gillum MP, Dong J, Murray SF, Manchem VP, Bhanot S, Cline GW, Shulman GI, Samuel VT.

Endocrinology. 2013 Jan;154(1):36-44. doi: 10.1210/en.2012-1725. Epub 2012 Nov 16.

44.

Hepatic glucose production pathways after three days of a high-fat diet.

Jin ES, Beddow SA, Malloy CR, Samuel VT.

Metabolism. 2013 Jan;62(1):152-62. doi: 10.1016/j.metabol.2012.07.012. Epub 2012 Sep 12.

45.

Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.

Brown WH, Gillum MP, Lee HY, Camporez JP, Zhang XM, Jeong JK, Alves TC, Erion DM, Guigni BA, Kahn M, Samuel VT, Cravatt BF, Diano S, Shulman GI.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14966-71. doi: 10.1073/pnas.1212887109. Epub 2012 Aug 21.

46.

O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability.

Ruan HB, Han X, Li MD, Singh JP, Qian K, Azarhoush S, Zhao L, Bennett AM, Samuel VT, Wu J, Yates JR 3rd, Yang X.

Cell Metab. 2012 Aug 8;16(2):226-37. doi: 10.1016/j.cmet.2012.07.006.

47.

Fasting hyperglycemia in the Goto-Kakizaki rat is dependent on corticosterone: a confounding variable in rodent models of type 2 diabetes.

Beddow SA, Samuel VT.

Dis Model Mech. 2012 Sep;5(5):681-5. doi: 10.1242/dmm.009035. Epub 2012 Aug 3.

48.

Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.

Li X, Shan J, Chang W, Kim I, Bao J, Lee HJ, Zhang X, Samuel VT, Shulman GI, Liu D, Zheng JJ, Wu D.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11402-7. doi: 10.1073/pnas.1205015109. Epub 2012 Jun 25. Erratum in: Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17141.

49.

Mechanisms for insulin resistance: common threads and missing links.

Samuel VT, Shulman GI.

Cell. 2012 Mar 2;148(5):852-71. doi: 10.1016/j.cell.2012.02.017. Review.

50.

Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes.

Morino K, Petersen KF, Sono S, Choi CS, Samuel VT, Lin A, Gallo A, Zhao H, Kashiwagi A, Goldberg IJ, Wang H, Eckel RH, Maegawa H, Shulman GI.

Diabetes. 2012 Apr;61(4):877-87. doi: 10.2337/db11-1391. Epub 2012 Feb 24.

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