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Items: 1 to 50 of 220

1.

Validation of Reference Genes for Gene Expression Studies by RT-qPCR in HepaRG Cells during Toxicity Testing and Disease Modelling.

Brzeszczyńska J, Brzeszczyński F, Samuel K, Morgan K, Morley SD, Plevris JN, Hayes PC.

Cells. 2020 Mar 21;9(3). pii: E770. doi: 10.3390/cells9030770.

2.

Human umbilical cord perivascular cells improve human pancreatic islet transplant function by increasing vascularization.

Forbes S, Bond AR, Thirlwell KL, Burgoyne P, Samuel K, Noble J, Borthwick G, Colligan D, McGowan NWA, Lewis PS, Fraser AR, Mountford JC, Carter RN, Morton NM, Turner ML, Graham GJ, Campbell JDM.

Sci Transl Med. 2020 Jan 15;12(526). pii: eaan5907. doi: 10.1126/scitranslmed.aan5907.

PMID:
31941825
3.

Gender inequality in research: does UK trainee-led research herald an equal future?

Samuel K, Ellicott H.

Br J Anaesth. 2020 Mar;124(3):e77-e78. doi: 10.1016/j.bja.2019.12.012. Epub 2020 Jan 11. No abstract available.

PMID:
31932025
4.

Application of Impedance-Based Techniques in Hepatology Research.

Morgan K, Gamal W, Samuel K, Morley SD, Hayes PC, Bagnaninchi P, Plevris JN.

J Clin Med. 2019 Dec 24;9(1). pii: E50. doi: 10.3390/jcm9010050. Review.

5.

Perioperative anaemia and patient blood management.

Samuel K.

Br J Hosp Med (Lond). 2019 Dec 2;80(12):741. doi: 10.12968/hmed.2019.80.12.741. No abstract available.

PMID:
31822189
6.

Infraspinatus Tenotomy Improves Glenoid Visualization With the Modified Judet Approach.

Garlich JM, Samuel K, Nelson TJ, Monfiston C, Kremen T, Metzger MF, Little MTM.

J Orthop Trauma. 2020 Mar;34(3):158-162. doi: 10.1097/BOT.0000000000001659.

PMID:
31725084
7.

Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester.

Shang J, Tschirret-Guth R, Cancilla M, Samuel K, Chen Q, Chobanian HR, Thomas A, Tong W, Josien H, Buevich AV, Mitra K.

Chem Res Toxicol. 2020 Jan 21;33(1):191-201. doi: 10.1021/acs.chemrestox.9b00226. Epub 2019 Oct 14.

PMID:
31566356
8.

Chemosensitivity and chemoresistance in endometriosis - differences for ectopic versus eutopic cells.

Lavogina D, Samuel K, Lavrits A, Meltsov A, Sõritsa D, Kadastik Ü, Peters M, Rinken A, Salumets A.

Reprod Biomed Online. 2019 Oct;39(4):556-568. doi: 10.1016/j.rbmo.2019.05.019. Epub 2019 May 31.

PMID:
31377021
9.

Spinal anaesthesia for elective caesarean section in a patient with hereditary neuropathy with liability to pressure palsies.

Samuel K, Mead K, Cominos T, Weale N.

Int J Obstet Anesth. 2019 Nov;40:162-163. doi: 10.1016/j.ijoa.2019.05.004. Epub 2019 May 16. No abstract available.

PMID:
31229414
10.

Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs.

Pio B, Chobanian HR, Guo Y, Josien H, Hagmann WK, Miller M, Trujillo ME, Kirkland M, Kosinski D, Mane J, Pachanski M, Cheewatrakoolpong B, Ashley E, Orr R, Wright MJ, Bugianesi R, Souza S, Zhang X, Di Salvo J, Weinglass AB, Tschirret-Guth R, Samuel K, Chen Q, Shang J, Lamca J, Ehrhart J, Nargund R, Howard AD, Colletti SL.

Bioorg Med Chem Lett. 2019 Jul 15;29(14):1842-1848. doi: 10.1016/j.bmcl.2019.04.050. Epub 2019 May 2.

PMID:
31109791
12.

1,25-Dihydroxyvitamin D3 Restrains CD4+ T Cell Priming Ability of CD11c+ Dendritic Cells by Upregulating Expression of CD31.

Saul L, Mair I, Ivens A, Brown P, Samuel K, Campbell JDM, Soong DY, Kamenjarin N, Mellanby RJ.

Front Immunol. 2019 Mar 28;10:600. doi: 10.3389/fimmu.2019.00600. eCollection 2019.

13.

Chlorpromazine toxicity is associated with disruption of cell membrane integrity and initiation of a pro-inflammatory response in the HepaRG hepatic cell line.

Morgan K, Martucci N, Kozlowska A, Gamal W, Brzeszczyński F, Treskes P, Samuel K, Hayes P, Nelson L, Bagnaninchi P, Brzeszczynska J, Plevris J.

Biomed Pharmacother. 2019 Mar;111:1408-1416. doi: 10.1016/j.biopha.2019.01.020. Epub 2019 Jan 19.

14.

Delayed antibiotic prescribing for respiratory tract infections: protocol of an individual patient data meta-analysis.

Stuart B, Hounkpatin H, Becque T, Yao G, Zhu S, Alonso-Coello P, Altiner A, Arroll B, Böhning D, Bostock J, Bucher HCC, de la Poza M, Francis NA, Gillespie D, Hay AD, Kenealy T, Löffler C, Mas-Dalmau G, Muñoz L, Samuel K, Moore M, Little P.

BMJ Open. 2019 Jan 21;9(1):e026925. doi: 10.1136/bmjopen-2018-026925.

15.

Differentially-Expressed miRNAs in Ectopic Stromal Cells Contribute to Endometriosis Development: The Plausible Role of miR-139-5p and miR-375.

Rekker K, Tasa T, Saare M, Samuel K, Kadastik Ü, Karro H, Götte M, Salumets A, Peters M.

Int J Mol Sci. 2018 Nov 28;19(12). pii: E3789. doi: 10.3390/ijms19123789.

16.

Letter to the editor: 'Human based systems: Mechanistic NASH modelling just around the corner?'

Morgan K, Fassoula V, Samuel K, Morley SD, Hayes PC, Plevris JN.

Pharmacol Res. 2018 Nov;137:280-281. doi: 10.1016/j.phrs.2018.09.028. Epub 2018 Oct 10. No abstract available.

PMID:
30315964
17.

Colonization efficiency of Pseudomonas putida is influenced by Fis-controlled transcription of nuoA-N operon.

Teppo A, Lahesaare A, Ainelo H, Samuel K, Kivisaar M, Teras R.

PLoS One. 2018 Aug 2;13(8):e0201841. doi: 10.1371/journal.pone.0201841. eCollection 2018.

18.

Role of patient and public involvement in implementation research: a consensus study.

Gray-Burrows KA, Willis TA, Foy R, Rathfelder M, Bland P, Chin A, Hodgson S, Ibegbuna G, Prestwich G, Samuel K, Wood L, Yaqoob F, McEachan RRC.

BMJ Qual Saf. 2018 Oct;27(10):858-864. doi: 10.1136/bmjqs-2017-006954. Epub 2018 Apr 17.

19.

Microalbuminuria among Newly Diagnosed Diabetic Patients at Mulago National Referral Hospital in Uganda: A Cross Sectional Study.

Martin M, Edrisa M, SSinabulya I, Samuel K, Frank M, Kiiza MC.

J Obes Weight Loss Medicat. 2018;4(1). pii: 021. doi: 10.23937/2572-4010.1510021. Epub 2018 Aug 23.

20.

A new cross-speciality educational collaboration in perioperative medicine.

Samuel K, Rogerson A, Pinho-Gomes AC.

Br J Hosp Med (Lond). 2017 Oct 2;78(10):546-547. doi: 10.12968/hmed.2017.78.10.546. No abstract available.

21.

Absorption, metabolism and excretion of [14C]omarigliptin, a once-weekly DPP-4 inhibitor, in humans.

Xu S, Tatosian D, Mcintosh I, Caceres M, Matthews C, Samuel K, Selverian D, Kumar S, Kauh E.

Xenobiotica. 2018 Jun;48(6):584-591. doi: 10.1080/00498254.2017.1346333. Epub 2017 Jul 25.

PMID:
28665228
22.

Effects of dietary gallic acid supplementation on performance, antioxidant status, and jejunum intestinal morphology in broiler chicks.

Samuel KG, Wang J, Yue HY, Wu SG, Zhang HJ, Duan ZY, Qi GH.

Poult Sci. 2017 Aug 1;96(8):2768-2775. doi: 10.3382/ps/pex091.

23.

Expanding the Haitian rehabilitation workforce: employment situation and perceptions of graduates from three rehabilitation technician training programs.

Descôteaux N, Chagnon V, Di Dong X, Ellemo E, Hamelin A, Juste E, Laplante X, Miron A, Morency P, Samuel K, Charles D, Hunt M.

Disabil Rehabil. 2018 May;40(10):1227-1236. doi: 10.1080/09638288.2017.1291763. Epub 2017 Feb 25.

PMID:
28508717
24.

High-throughput mRNA sequencing of stromal cells from endometriomas and endometrium.

Rekker K, Saare M, Eriste E, Tasa T, Kukuškina V, Roost AM, Anderson K, Samuel K, Karro H, Salumets A, Peters M.

Reproduction. 2017 Jul;154(1):93-100. doi: 10.1530/REP-17-0092. Epub 2017 May 11.

PMID:
28495852
25.

Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver.

Gamal W, Treskes P, Samuel K, Sullivan GJ, Siller R, Srsen V, Morgan K, Bryans A, Kozlowska A, Koulovasilopoulos A, Underwood I, Smith S, Del-Pozo J, Moss S, Thompson AI, Henderson NC, Hayes PC, Plevris JN, Bagnaninchi PO, Nelson LJ.

Sci Rep. 2017 Jan 30;7:37541. doi: 10.1038/srep37541.

26.

Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells.

Paulus A, Akhtar S, Caulfield TR, Samuel K, Yousaf H, Bashir Y, Paulus SM, Tran D, Hudec R, Cogen D, Jiang J, Edenfield B, Novak A, Ansell SM, Witzig T, Martin P, Coleman M, Roy V, Ailawadhi S, Chitta K, Linder S, Chanan-Khan A.

Blood Cancer J. 2016 Nov 4;6(11):e492. doi: 10.1038/bcj.2016.93.

27.

The circadian clock modulates anti-cancer properties of curcumin.

Sarma A, Sharma VP, Sarkar AB, Sekar MC, Samuel K, Geusz ME.

BMC Cancer. 2016 Sep 29;16(1):759.

28.

Characterisation of probiotic properties in human vaginal lactobacilli strains.

Hütt P, Lapp E, Štšepetova J, Smidt I, Taelma H, Borovkova N, Oopkaup H, Ahelik A, Rööp T, Hoidmets D, Samuel K, Salumets A, Mändar R.

Microb Ecol Health Dis. 2016 Aug 12;27:30484. doi: 10.3402/mehd.v27.30484. eCollection 2016.

29.

Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications.

Nelson LJ, Morgan K, Treskes P, Samuel K, Henderson CJ, LeBled C, Homer N, Grant MH, Hayes PC, Plevris JN.

Basic Clin Pharmacol Toxicol. 2017 Jan;120(1):30-37. doi: 10.1111/bcpt.12631. Epub 2016 Jul 15.

30.

SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists.

He S, Dobbelaar PH, Guo L, Ye Z, Liu J, Jian T, Truong Q, Shah SK, Du W, Qi H, Bakshi RK, Hong Q, Dellureficio JD, Sherer E, Pasternak A, Feng Z, Reibarkh M, Lin M, Samuel K, Reddy VB, Mitelman S, Tong SX, Chicchi GG, Tsao KL, Trusca D, Wu M, Shao Q, Trujillo ME, Fernandez G, Nelson D, Bunting P, Kerr J, Fitzgerald P, Morissette P, Volksdorf S, Eiermann GJ, Li C, Zhang BB, Howard AD, Zhou YP, Nargund RP, Hagmann WK.

Bioorg Med Chem Lett. 2016 Mar 15;26(6):1529-1535. doi: 10.1016/j.bmcl.2016.02.022. Epub 2016 Feb 10.

PMID:
26898814
31.

Single-cell transcriptome analysis of endometrial tissue.

Krjutškov K, Katayama S, Saare M, Vera-Rodriguez M, Lubenets D, Samuel K, Laisk-Podar T, Teder H, Einarsdottir E, Salumets A, Kere J.

Hum Reprod. 2016 Apr;31(4):844-53. doi: 10.1093/humrep/dew008. Epub 2016 Feb 13.

32.

Dietary supplementation of pyrroloquinoline quinone disodium protects against oxidative stress and liver damage in laying hens fed an oxidized sunflower oil-added diet.

Wang J, Zhang HJ, Xu L, Long C, Samuel KG, Yue HY, Sun LL, Wu SG, Qi GH.

Animal. 2016 Jul;10(7):1129-36. doi: 10.1017/S175173111600001X. Epub 2016 Feb 3.

PMID:
26837542
33.

Deep Quantitative Proteomics Reveals Extensive Metabolic Reprogramming and Cancer-Like Changes of Ectopic Endometriotic Stromal Cells.

Kasvandik S, Samuel K, Peters M, Eimre M, Peet N, Roost AM, Padrik L, Paju K, Peil L, Salumets A.

J Proteome Res. 2016 Feb 5;15(2):572-84. doi: 10.1021/acs.jproteome.5b00965. Epub 2015 Dec 23.

PMID:
26654049
34.

Acetaminophen cytotoxicity is ameliorated in a human liver organotypic co-culture model.

Nelson LJ, Navarro M, Treskes P, Samuel K, Tura-Ceide O, Morley SD, Hayes PC, Plevris JN.

Sci Rep. 2015 Dec 3;5:17455. doi: 10.1038/srep17455.

35.

Efficient episomal reprogramming of blood mononuclear cells and differentiation to hepatocytes with functional drug metabolism.

Liu J, Brzeszczynska J, Samuel K, Black J, Palakkan A, Anderson RA, Gallagher R, Ross JA.

Exp Cell Res. 2015 Nov 1;338(2):203-13. doi: 10.1016/j.yexcr.2015.08.004. Epub 2015 Aug 6.

PMID:
26256888
36.

Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes.

Shah SK, He S, Guo L, Truong Q, Qi H, Du W, Lai Z, Liu J, Jian T, Hong Q, Dobbelaar P, Ye Z, Sherer E, Feng Z, Yu Y, Wong F, Samuel K, Madiera M, Karanam BV, Reddy VB, Mitelman S, Tong SX, Chicchi GG, Tsao KL, Trusca D, Feng Y, Wu M, Shao Q, Trujillo ME, Eiermann GJ, Li C, Pachanski M, Fernandez G, Nelson D, Bunting P, Morissette P, Volksdorf S, Kerr J, Zhang BB, Howard AD, Zhou YP, Pasternak A, Nargund RP, Hagmann WK.

ACS Med Chem Lett. 2015 Mar 18;6(5):513-7. doi: 10.1021/ml500514w. eCollection 2015 May 14.

37.

WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited.

Boulter L, Guest RV, Kendall TJ, Wilson DH, Wojtacha D, Robson AJ, Ridgway RA, Samuel K, Van Rooijen N, Barry ST, Wigmore SJ, Sansom OJ, Forbes SJ.

J Clin Invest. 2015 Mar 2;125(3):1269-85. doi: 10.1172/JCI76452. Epub 2015 Feb 17.

38.

Effects of dietary pyrroloquinoline quinone disodium on growth, carcass characteristics, redox status, and mitochondria metabolism in broilers.

Wang J, Zhang HJ, Samuel KG, Long C, Wu SG, Yue HY, Sun LL, Qi GH.

Poult Sci. 2015 Feb;94(2):215-25. doi: 10.3382/ps/peu050. Epub 2015 Jan 20.

39.

High-throughput sequencing approach uncovers the miRNome of peritoneal endometriotic lesions and adjacent healthy tissues.

Saare M, Rekker K, Laisk-Podar T, Sõritsa D, Roost AM, Simm J, Velthut-Meikas A, Samuel K, Metsalu T, Karro H, Sõritsa A, Salumets A, Peters M.

PLoS One. 2014 Nov 11;9(11):e112630. doi: 10.1371/journal.pone.0112630. eCollection 2014.

40.

Renal artery stenting: one year outcome on BP control and antihypertensive medication.

Sathyamurthy I, Sudhakar K, Jayanthi K, Subramanyan K, Ramachandran P, Mao R, Samuel KM.

J Assoc Physicians India. 2014 Mar;62(3):228-31.

PMID:
25327064
41.

Effects of dietary pyrroloquinoline quinone disodium on growth performance, carcass yield and antioxidant status of broiler chicks.

Samuel KG, Zhang HJ, Wang J, Wu SG, Yue HY, Sun LL, Qi GH.

Animal. 2015 Mar;9(3):409-16. doi: 10.1017/S1751731114002328. Epub 2014 Sep 17.

PMID:
25229409
42.

Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists.

He S, Lai Z, Ye Z, Dobbelaar PH, Shah SK, Truong Q, Du W, Guo L, Liu J, Jian T, Qi H, Bakshi RK, Hong Q, Dellureficio J, Reibarkh M, Samuel K, Reddy VB, Mitelman S, Tong SX, Chicchi GG, Tsao KL, Trusca D, Wu M, Shao Q, Trujillo ME, Fernandez G, Nelson D, Bunting P, Kerr J, Fitzgerald P, Morissette P, Volksdorf S, Eiermann GJ, Li C, Zhang B, Howard AD, Zhou YP, Nargund RP, Hagmann WK.

ACS Med Chem Lett. 2014 Apr 21;5(7):748-53. doi: 10.1021/ml500028c. eCollection 2014 Jul 10.

43.

Differentiation and molecular profiling of human embryonic stem cell-derived corneal epithelial cells.

Brzeszczynska J, Samuel K, Greenhough S, Ramaesh K, Dhillon B, Hay DC, Ross JA.

Int J Mol Med. 2014 Jun;33(6):1597-606. doi: 10.3892/ijmm.2014.1714. Epub 2014 Mar 27.

PMID:
24676408
44.

[Status epilepticus and its treatment--update 2013].

Csilla G, Vera J, Réka H, Beáta B, Márton T, András F, Sámuel K, József J.

Ideggyogy Sz. 2013 Nov 30;66(11-12):372-82. Review. Hungarian.

PMID:
24555236
45.

A novel malaria vaccine candidate antigen expressed in Tetrahymena thermophila.

Cowan GJ, Bockau U, Eleni-Muus J, Aldag I, Samuel K, Creasey AM, Hartmann MW, Cavanagh DR.

PLoS One. 2014 Jan 29;9(1):e87198. doi: 10.1371/journal.pone.0087198. eCollection 2014.

46.

Use of IL3 and chromatin-modifying reagents valproic acid and 5-aza-2'-deoxycytidine to affect mobilized peripheral blood CD34+ cell fate decisions.

Liu J, Samuel K, Turner ML, Gallagher RC.

Vox Sang. 2014 Jul;107(1):83-9. doi: 10.1111/vox.12124. Epub 2014 Jan 27.

PMID:
24460712
47.

Antibody responses to a novel Plasmodium falciparum merozoite surface protein vaccine correlate with protection against experimental malaria infection in Aotus monkeys.

Cavanagh DR, Kocken CH, White JH, Cowan GJ, Samuel K, Dubbeld MA, Voorberg-van der Wel A, Thomas AW, McBride JS, Arnot DE.

PLoS One. 2014 Jan 8;9(1):e83704. doi: 10.1371/journal.pone.0083704. eCollection 2014.

48.

Haematopoietic differentiation is inhibited when Notch activity is enhanced in FLK1(+) mesoderm progenitors.

Huang C, Jackson M, Samuel K, Taylor AH, Lowell S, Forrester LM.

Stem Cell Res. 2013 Nov;11(3):1273-87. doi: 10.1016/j.scr.2013.08.012. Epub 2013 Sep 5.

49.

The constituents and mechanisms of generation of 'endothelial cell--colony forming units'.

Padfield GJ, Short A, Mills NL, Samuel K, Turner M, Newby DE, Barclay GR, Tura-Ceide O.

Cardiovasc Res. 2013 Nov 1;100(2):288-96. doi: 10.1093/cvr/cvt182. Epub 2013 Jul 18.

PMID:
23867632
50.

2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways.

Kassick AJ, Jiang J, Bunda J, Wilson D, Bao J, Lu H, Lin P, Ball RG, Doss GA, Tong X, Tsao KL, Wang H, Chicchi G, Karanam B, Tschirret-Guth R, Samuel K, Hora DF, Kumar S, Madeira M, Eng W, Hargreaves R, Purcell M, Gantert L, Cook J, DeVita RJ, Mills SG.

J Med Chem. 2013 Jul 25;56(14):5940-8. doi: 10.1021/jm400751p. Epub 2013 Jul 9.

PMID:
23808489

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