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Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells.

Pataer A, Ozpolat B, Shao R, Cashman NR, Plotkin SS, Samuel CE, Lin SH, Kabil NN, Wang J, Majidi M, Fang B, Roth JA, Vaporciyan AA, Wistuba II, Hung MC, Swisher SG.

Oncogene. 2020 Jan;39(4):801-813. doi: 10.1038/s41388-019-1010-4. Epub 2019 Sep 25.


3D Columnar Phase of Stacked Short DNA Organized by Coherent Membrane Undulations.

Bouxsein NF, Leal C, McAllister CS, Li Y, Ewert KK, Samuel CE, Safinya CR.

Langmuir. 2019 Sep 10;35(36):11891-11901. doi: 10.1021/acs.langmuir.9b01726. Epub 2019 Aug 22.


Measles Virus Forms Inclusion Bodies with Properties of Liquid Organelles.

Zhou Y, Su JM, Samuel CE, Ma D.

J Virol. 2019 Oct 15;93(21). pii: e00948-19. doi: 10.1128/JVI.00948-19. Print 2019 Nov 1.


Adenosine deaminase acting on RNA (ADAR1), a suppressor of double-stranded RNA-triggered innate immune responses.

Samuel CE.

J Biol Chem. 2019 Feb 1;294(5):1710-1720. doi: 10.1074/jbc.TM118.004166. Review.


Upon Infection, Cellular WD Repeat-Containing Protein 5 (WDR5) Localizes to Cytoplasmic Inclusion Bodies and Enhances Measles Virus Replication.

Ma D, George CX, Nomburg JL, Pfaller CK, Cattaneo R, Samuel CE.

J Virol. 2018 Feb 12;92(5). pii: e01726-17. doi: 10.1128/JVI.01726-17. Print 2018 Mar 1.


Dynamic landscape and regulation of RNA editing in mammals.

Tan MH, Li Q, Shanmugam R, Piskol R, Kohler J, Young AN, Liu KI, Zhang R, Ramaswami G, Ariyoshi K, Gupte A, Keegan LP, George CX, Ramu A, Huang N, Pollina EA, Leeman DS, Rustighi A, Goh YPS; GTEx Consortium; Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group; Statistical Methods groups—Analysis Working Group; Enhancing GTEx (eGTEx) groups; NIH Common Fund; NIH/NCI; NIH/NHGRI; NIH/NIMH; NIH/NIDA; Biospecimen Collection Source Site—NDRI; Biospecimen Collection Source Site—RPCI; Biospecimen Core Resource—VARI; Brain Bank Repository—University of Miami Brain Endowment Bank; Leidos Biomedical—Project Management; ELSI Study; Genome Browser Data Integration &Visualization—EBI; Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz, Chawla A, Del Sal G, Peltz G, Brunet A, Conrad DF, Samuel CE, O'Connell MA, Walkley CR, Nishikura K, Li JB.

Nature. 2017 Oct 11;550(7675):249-254. doi: 10.1038/nature24041.


NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and β-TRCP1 To Degrade the Antiviral Protein Kinase PKR.

Kainulainen M, Lau S, Samuel CE, Hornung V, Weber F.

J Virol. 2016 Jun 10;90(13):6140-7. doi: 10.1128/JVI.00016-16. Print 2016 Jul 1.


Editing of Cellular Self-RNAs by Adenosine Deaminase ADAR1 Suppresses Innate Immune Stress Responses.

George CX, Ramaswami G, Li JB, Samuel CE.

J Biol Chem. 2016 Mar 18;291(12):6158-68. doi: 10.1074/jbc.M115.709014. Epub 2016 Jan 27.


Measles Virus Defective Interfering RNAs Are Generated Frequently and Early in the Absence of C Protein and Can Be Destabilized by Adenosine Deaminase Acting on RNA-1-Like Hypermutations.

Pfaller CK, Mastorakos GM, Matchett WE, Ma X, Samuel CE, Cattaneo R.

J Virol. 2015 Aug;89(15):7735-47. doi: 10.1128/JVI.01017-15. Epub 2015 May 13.


Poor growth of human adenovirus-12 compared to adenovirus-2 correlates with a failure to impair PKR activation during the late phase of infection.

Wu C, Bai L, Li Z, Samuel CE, Akusjärvi G, Svensson C.

Virology. 2015 Jan 15;475:120-8. doi: 10.1016/j.virol.2014.11.012. Epub 2014 Nov 29.


An RNA editor, adenosine deaminase acting on double-stranded RNA (ADAR1).

George CX, John L, Samuel CE.

J Interferon Cytokine Res. 2014 Jun;34(6):437-46. doi: 10.1089/jir.2014.0001. Review.


Induction of stress granules by interferon and down-regulation by the cellular RNA adenosine deaminase ADAR1.

John L, Samuel CE.

Virology. 2014 Apr;454-455:299-310. doi: 10.1016/j.virol.2014.02.025. Epub 2014 Mar 21.


Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R.

Pfaller CK, Radeke MJ, Cattaneo R, Samuel CE.

J Virol. 2014 Jan;88(1):456-68. doi: 10.1128/JVI.02572-13. Epub 2013 Oct 23.


Stress granule formation induced by measles virus is protein kinase PKR dependent and impaired by RNA adenosine deaminase ADAR1.

Okonski KM, Samuel CE.

J Virol. 2013 Jan;87(2):756-66. doi: 10.1128/JVI.02270-12. Epub 2012 Oct 31.


Introduction to thematic minireview series: Understanding human immunodeficiency virus-host interactions at the biochemical level.

Samuel CE.

J Biol Chem. 2012 Nov 30;287(49):40838-40. doi: 10.1074/jbc.R112.422436. Epub 2012 Oct 5. No abstract available.


Protein kinase PKR amplification of interferon β induction occurs through initiation factor eIF-2α-mediated translational control.

McAllister CS, Taghavi N, Samuel CE.

J Biol Chem. 2012 Oct 19;287(43):36384-92. doi: 10.1074/jbc.M112.390039. Epub 2012 Sep 4.


Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection.

Ruggieri A, Dazert E, Metz P, Hofmann S, Bergeest JP, Mazur J, Bankhead P, Hiet MS, Kallis S, Alvisi G, Samuel CE, Lohmann V, Kaderali L, Rohr K, Frese M, Stoecklin G, Bartenschlager R.

Cell Host Microbe. 2012 Jul 19;12(1):71-85. doi: 10.1016/j.chom.2012.05.013.


Adenosine deaminase acting on RNA 1 (ADAR1) suppresses the induction of interferon by measles virus.

Li Z, Okonski KM, Samuel CE.

J Virol. 2012 Apr;86(7):3787-94. doi: 10.1128/JVI.06307-11. Epub 2012 Jan 25.


Protein kinase PKR and RNA adenosine deaminase ADAR1: new roles for old players as modulators of the interferon response.

Pfaller CK, Li Z, George CX, Samuel CE.

Curr Opin Immunol. 2011 Oct;23(5):573-82. doi: 10.1016/j.coi.2011.08.009. Epub 2011 Sep 15. Review.


ADARs: viruses and innate immunity.

Samuel CE.

Curr Top Microbiol Immunol. 2012;353:163-95. doi: 10.1007/82_2011_148. Review.


Host response to polyomavirus infection is modulated by RNA adenosine deaminase ADAR1 but not by ADAR2.

George CX, Samuel CE.

J Virol. 2011 Aug;85(16):8338-47. doi: 10.1128/JVI.02666-10. Epub 2011 Jun 1.


Two-dimensional packing of short DNA with nonpairing overhangs in cationic liposome-DNA complexes: from Onsager nematics to columnar nematics with finite-length columns.

Bouxsein NF, Leal C, McAllister CS, Ewert KK, Li Y, Samuel CE, Safinya CR.

J Am Chem Soc. 2011 May 18;133(19):7585-95. doi: 10.1021/ja202082c. Epub 2011 Apr 26.


Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral.

Samuel CE.

Virology. 2011 Mar 15;411(2):180-93. doi: 10.1016/j.virol.2010.12.004. Epub 2011 Jan 5. Review.


Adenosine deaminases acting on RNA, RNA editing, and interferon action.

George CX, Gan Z, Liu Y, Samuel CE.

J Interferon Cytokine Res. 2011 Jan;31(1):99-117. doi: 10.1089/jir.2010.0097. Epub 2010 Dec 23. Review.


RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis.

Ward SV, George CX, Welch MJ, Liou LY, Hahm B, Lewicki H, de la Torre JC, Samuel CE, Oldstone MB.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):331-6. doi: 10.1073/pnas.1017241108. Epub 2010 Dec 20.


Thematic minireview series: toward a structural basis for understanding influenza virus-host cell interactions.

Samuel CE.

J Biol Chem. 2010 Sep 10;285(37):28399-401. doi: 10.1074/jbc.R110.149625. Epub 2010 Jun 10. Review. No abstract available.


Thematic minireview series: elucidating hepatitis C virus-host interactions at the biochemical level.

Samuel CE.

J Biol Chem. 2010 Jul 23;285(30):22723-4. doi: 10.1074/jbc.R110.142240. Epub 2010 May 10. No abstract available.


Cationic liposome-nucleic acid complexes for gene delivery and silencing: pathways and mechanisms for plasmid DNA and siRNA.

Ewert KK, Zidovska A, Ahmad A, Bouxsein NF, Evans HM, McAllister CS, Samuel CE, Safinya CR.

Top Curr Chem. 2010;296:191-226. Review.


Mechanisms of protein kinase PKR-mediated amplification of beta interferon induction by C protein-deficient measles virus.

McAllister CS, Toth AM, Zhang P, Devaux P, Cattaneo R, Samuel CE.

J Virol. 2010 Jan;84(1):380-6. doi: 10.1128/JVI.02630-08.


Tipping the balance: antagonism of PKR kinase and ADAR1 deaminase functions by virus gene products.

George CX, Li Z, Okonski KM, Toth AM, Wang Y, Samuel CE.

J Interferon Cytokine Res. 2009 Sep;29(9):477-87. doi: 10.1089/jir.2009.0065. Review.


RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR.

Toth AM, Li Z, Cattaneo R, Samuel CE.

J Biol Chem. 2009 Oct 23;284(43):29350-6. doi: 10.1074/jbc.M109.045146. Epub 2009 Aug 25.


Protein kinase PKR-dependent activation of mitogen-activated protein kinases occurs through mitochondrial adapter IPS-1 and is antagonized by vaccinia virus E3L.

Zhang P, Langland JO, Jacobs BL, Samuel CE.

J Virol. 2009 Jun;83(11):5718-25. doi: 10.1128/JVI.00224-09. Epub 2009 Mar 25.


The RNA-activated protein kinase enhances the induction of interferon-beta and apoptosis mediated by cytoplasmic RNA sensors.

McAllister CS, Samuel CE.

J Biol Chem. 2009 Jan 16;284(3):1644-51. doi: 10.1074/jbc.M807888200. Epub 2008 Nov 20.


Protein kinase PKR mediates the apoptosis induction and growth restriction phenotypes of C protein-deficient measles virus.

Toth AM, Devaux P, Cattaneo R, Samuel CE.

J Virol. 2009 Jan;83(2):961-8. doi: 10.1128/JVI.01669-08. Epub 2008 Nov 12.


Induction of protein kinase PKR-dependent activation of interferon regulatory factor 3 by vaccinia virus occurs through adapter IPS-1 signaling.

Zhang P, Samuel CE.

J Biol Chem. 2008 Dec 12;283(50):34580-7. doi: 10.1074/jbc.M807029200. Epub 2008 Oct 15.


Strategic planning in the financing of school-based health clinics within urban communities.

Samuel CE.

J Natl Black Nurses Assoc. 2008 Jul;19(1):69-72.


Innate immunity minireview series: making biochemical sense of nucleic acid sensors that trigger antiviral innate immunity.

Samuel CE.

J Biol Chem. 2007 May 25;282(21):15313-4. Epub 2007 Mar 29. Review. No abstract available.


Structure and gene silencing activities of monovalent and pentavalent cationic lipid vectors complexed with siRNA.

Bouxsein NF, McAllister CS, Ewert KK, Samuel CE, Safinya CR.

Biochemistry. 2007 Apr 24;46(16):4785-92. Epub 2007 Mar 29.


Activation of NF-kappaB-dependent gene expression by Salmonella flagellins FliC and FljB.

Simon R, Samuel CE.

Biochem Biophys Res Commun. 2007 Mar 30;355(1):280-5. Epub 2007 Feb 5.

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