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Inhibitors of fatty acid oxidation enhance death of acute myeloid leukemia cells lacking NIX or SQSTM1.

Tcheng M, Samudio I, Spagnuolo PA.

Leuk Lymphoma. 2019 Nov 11:1-4. doi: 10.1080/10428194.2019.1682570. [Epub ahead of print] No abstract available.


UV Light-inactivated HSV-1 Stimulates Natural Killer Cell-induced Killing of Prostate Cancer Cells.

Samudio I, Hofs E, Cho B, Li M, Bolduc K, Bu L, Liu G, Lam V, Rennie P, Jia W, Elisia I, Krystal G.

J Immunother. 2019 Jun;42(5):162-174. doi: 10.1097/CJI.0000000000000261.


Cell-surface proteomics for the identification of novel therapeutic targets in cancer.

Kuhlmann L, Cummins E, Samudio I, Kislinger T.

Expert Rev Proteomics. 2018 Mar;15(3):259-275. doi: 10.1080/14789450.2018.1429924. Epub 2018 Jan 23. Review.


High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia.

Zeng Z, Liu W, Tsao T, Qiu Y, Zhao Y, Samudio I, Sarbassov DD, Kornblau SM, Baggerly KA, Kantarjian HM, Konopleva M, Andreeff M.

Haematologica. 2017 Sep;102(9):1537-1548. doi: 10.3324/haematol.2016.162230. Epub 2017 Jun 28.


All Trans Retinoic Acid, Transforming Growth Factor β and Prostaglandin E2 in Mouse Plasma Synergize with Basophil-Secreted Interleukin-4 to M2 Polarize Murine Macrophages.

Ho VW, Hofs E, Elisia I, Lam V, Hsu BE, Lai J, Luk B, Samudio I, Krystal G.

PLoS One. 2016 Dec 15;11(12):e0168072. doi: 10.1371/journal.pone.0168072. eCollection 2016.


Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes.

Matre P, Velez J, Jacamo R, Qi Y, Su X, Cai T, Chan SM, Lodi A, Sweeney SR, Ma H, Davis RE, Baran N, Haferlach T, Su X, Flores ER, Gonzalez D, Konoplev S, Samudio I, DiNardo C, Majeti R, Schimmer AD, Li W, Wang T, Tiziani S, Konopleva M.

Oncotarget. 2016 Nov 29;7(48):79722-79735. doi: 10.18632/oncotarget.12944.


The mitochondria target drug avocatin B synergizes with induction chemotherapeutics to induce leukemia cell death.

Tcheng M, Samudio I, Lee EA, Minden MD, Spagnuolo PA.

Leuk Lymphoma. 2017 Apr;58(4):986-988. doi: 10.1080/10428194.2016.1218005. Epub 2016 Aug 25. No abstract available.


Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport.

Velez J, Pan R, Lee JT, Enciso L, Suarez M, Duque JE, Jaramillo D, Lopez C, Morales L, Bornmann W, Konopleva M, Krystal G, Andreeff M, Samudio I.

Oncotarget. 2016 Aug 9;7(32):51435-51449. doi: 10.18632/oncotarget.9843.


DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis.

Elisia I, Nakamura H, Lam V, Hofs E, Cederberg R, Cait J, Hughes MR, Lee L, Jia W, Adomat HH, Guns ES, McNagny KM, Samudio I, Krystal G.

PLoS One. 2016 Mar 31;11(3):e0152538. doi: 10.1371/journal.pone.0152538. eCollection 2016.


UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells.

Samudio I, Rezvani K, Shaim H, Hofs E, Ngom M, Bu L, Liu G, Lee JT, Imren S, Lam V, Poon GF, Ghaedi M, Takei F, Humphries K, Jia W, Krystal G.

Blood. 2016 May 26;127(21):2575-86. doi: 10.1182/blood-2015-04-639088. Epub 2016 Mar 3.


Targeting leukemia's "fatty tooth".

Samudio I, Konopleva M.

Blood. 2015 Oct 15;126(16):1874-5. doi: 10.1182/blood-2015-08-665125.


The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming.

Phan L, Chou PC, Velazquez-Torres G, Samudio I, Parreno K, Huang Y, Tseng C, Vu T, Gully C, Su CH, Wang E, Chen J, Choi HH, Fuentes-Mattei E, Shin JH, Shiang C, Grabiner B, Blonska M, Skerl S, Shao Y, Cody D, Delacerda J, Kingsley C, Webb D, Carlock C, Zhou Z, Hsieh YC, Lee J, Elliott A, Ramirez M, Bankson J, Hazle J, Wang Y, Li L, Weng S, Rizk N, Wen YY, Lin X, Wang H, Wang H, Zhang A, Xia X, Wu Y, Habra M, Yang W, Pusztai L, Yeung SC, Lee MH.

Nat Commun. 2015 Jul 16;6:7530. doi: 10.1038/ncomms8530.


Effects over time of two platelet gel supernatants on growth factor, cytokine and hyaluronan concentrations in normal synovial membrane explants challenged with lipopolysaccharide.

Ríos DL, López C, Álvarez ME, Samudio IJ, Carmona JU.

BMC Musculoskelet Disord. 2015 Jun 20;16:153. doi: 10.1186/s12891-015-0605-3.


Platelets promote mitochondrial uncoupling and resistance to apoptosis in leukemia cells: a novel paradigm for the bone marrow microenvironment.

Velez J, Enciso LJ, Suarez M, Fiegl M, Grismaldo A, López C, Barreto A, Cardozo C, Palacios P, Morales L, Duque JE, Carmona JU, Konopleva M, Andreeff M, Samudio I.

Cancer Microenviron. 2014 Aug;7(1-2):79-90. doi: 10.1007/s12307-014-0149-3. Epub 2014 Aug 12.


A low carbohydrate, high protein diet combined with celecoxib markedly reduces metastasis.

Ho VW, Hamilton MJ, Dang NH, Hsu BE, Adomat HH, Guns ES, Weljie A, Samudio I, Bennewith KL, Krystal G.

Carcinogenesis. 2014 Oct;35(10):2291-9. doi: 10.1093/carcin/bgu147. Epub 2014 Jul 14.


Asparaginase unveils glutamine-addicted AML.

Samudio I, Konopleva M.

Blood. 2013 Nov 14;122(20):3398-400. doi: 10.1182/blood-2013-09-526392.


Paracrine factors of human mesenchymal stem cells increase wound closure and reduce reactive oxygen species production in a traumatic brain injury in vitro model.

Torrente D, Avila MF, Cabezas R, Morales L, Gonzalez J, Samudio I, Barreto GE.

Hum Exp Toxicol. 2014 Jul;33(7):673-84. doi: 10.1177/0960327113509659. Epub 2013 Oct 31.


Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors.

Nair V, Pathi S, Jutooru I, Sreevalsan S, Basha R, Abdelrahim M, Samudio I, Safe S.

Carcinogenesis. 2013 Dec;34(12):2870-9. doi: 10.1093/carcin/bgt231. Epub 2013 Jun 26.


Mitochondrial uncoupling and the reprograming of intermediary metabolism in leukemia cells.

Vélez J, Hail N Jr, Konopleva M, Zeng Z, Kojima K, Samudio I, Andreeff M.

Front Oncol. 2013 Apr 2;3:67. doi: 10.3389/fonc.2013.00067. eCollection 2013.


Effects of the breed, sex and age on cellular content and growth factor release from equine pure-platelet rich plasma and pure-platelet rich gel.

Giraldo CE, López C, Álvarez ME, Samudio IJ, Prades M, Carmona JU.

BMC Vet Res. 2013 Feb 12;9:29. doi: 10.1186/1746-6148-9-29.


Tumor stroma engraftment of gene-modified mesenchymal stem cells as anti-tumor therapy against ovarian cancer.

Dembinski JL, Wilson SM, Spaeth EL, Studeny M, Zompetta C, Samudio I, Roby K, Andreeff M, Marini FC.

Cytotherapy. 2013 Jan;15(1):20-32. doi: 10.1016/j.jcyt.2012.10.003.


HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML.

Zhou L, Ruvolo VR, McQueen T, Chen W, Samudio IJ, Conneely O, Konopleva M, Andreeff M.

Leukemia. 2013 Jun;27(6):1358-68. doi: 10.1038/leu.2012.366. Epub 2012 Dec 18.


Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment.

Frolova O, Samudio I, Benito JM, Jacamo R, Kornblau SM, Markovic A, Schober W, Lu H, Qiu YH, Buglio D, McQueen T, Pierce S, Shpall E, Konoplev S, Thomas D, Kantarjian H, Lock R, Andreeff M, Konopleva M.

Cancer Biol Ther. 2012 Aug;13(10):858-70. doi: 10.4161/cbt.20838. Epub 2012 Aug 1.


Cellular and molecular mechanisms of antioxidants in Parkinson's disease.

Sutachan JJ, Casas Z, Albarracin SL, Stab BR 2nd, Samudio I, Gonzalez J, Morales L, Barreto GE.

Nutr Neurosci. 2012 May;15(3):120-6. doi: 10.1179/1476830511Y.0000000033. Review.


Effects of natural antioxidants in neurodegenerative disease.

Albarracin SL, Stab B, Casas Z, Sutachan JJ, Samudio I, Gonzalez J, Gonzalo L, Capani F, Morales L, Barreto GE.

Nutr Neurosci. 2012 Jan;15(1):1-9. doi: 10.1179/1476830511Y.0000000028. Review.


Physiological hypoxia promotes lipid raft and PI3K-dependent activation of MAPK 42/44 in leukemia cells.

Fiegl M, Samudio I, Mnjoyan Z, Korchin B, Fritsche H, Andreeff M.

Leukemia. 2010 Jul;24(7):1364-7. doi: 10.1038/leu.2010.94. Epub 2010 May 27. No abstract available.


Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a.

Jutooru I, Chadalapaka G, Abdelrahim M, Basha MR, Samudio I, Konopleva M, Andreeff M, Safe S.

Mol Pharmacol. 2010 Aug;78(2):226-36. doi: 10.1124/mol.110.064451. Epub 2010 May 20. Erratum in: Mol Pharmacol. 2011 Feb;79(2):336.


Activation of p53 signaling by MI-63 induces apoptosis in acute myeloid leukemia cells.

Samudio IJ, Duvvuri S, Clise-Dwyer K, Watt JC, Mak D, Kantarjian H, Yang D, Ruvolo V, Borthakur G.

Leuk Lymphoma. 2010 May;51(5):911-919. doi: 10.3109/10428191003731325.


Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment.

Kidd S, Caldwell L, Dietrich M, Samudio I, Spaeth EL, Watson K, Shi Y, Abbruzzese J, Konopleva M, Andreeff M, Marini FC.

Cytotherapy. 2010 Sep;12(5):615-25. doi: 10.3109/14653241003631815. Erratum in: Cytotherapy. 2011 Apr;13(4):498.


Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction.

Samudio I, Harmancey R, Fiegl M, Kantarjian H, Konopleva M, Korchin B, Kaluarachchi K, Bornmann W, Duvvuri S, Taegtmeyer H, Andreeff M.

J Clin Invest. 2010 Jan;120(1):142-56. doi: 10.1172/JCI38942. Epub 2009 Dec 21.


Mitochondrial uncoupling and the Warburg effect: molecular basis for the reprogramming of cancer cell metabolism.

Samudio I, Fiegl M, Andreeff M.

Cancer Res. 2009 Mar 15;69(6):2163-6. doi: 10.1158/0008-5472.CAN-08-3722. Epub 2009 Mar 3. Review.


Apoptosis in leukemias: regulation and therapeutic targeting.

Samudio I, Konopleva M, Carter B, Andreeff M.

Cancer Treat Res. 2010;145:197-217. doi: 10.1007/978-0-387-69259-3_12. Review.


CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure.

Fiegl M, Samudio I, Clise-Dwyer K, Burks JK, Mnjoyan Z, Andreeff M.

Blood. 2009 Feb 12;113(7):1504-12. doi: 10.1182/blood-2008-06-161539. Epub 2008 Oct 28.


Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.

Zeng Z, Shi YX, Samudio IJ, Wang RY, Ling X, Frolova O, Levis M, Rubin JB, Negrin RR, Estey EH, Konoplev S, Andreeff M, Konopleva M.

Blood. 2009 Jun 11;113(24):6215-24. doi: 10.1182/blood-2008-05-158311. Epub 2008 Oct 27.


The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation.

Samudio I, Fiegl M, McQueen T, Clise-Dwyer K, Andreeff M.

Cancer Res. 2008 Jul 1;68(13):5198-205. doi: 10.1158/0008-5472.CAN-08-0555.


The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML.

Kojima K, Shimanuki M, Shikami M, Samudio IJ, Ruvolo V, Corn P, Hanaoka N, Konopleva M, Andreeff M, Nakakuma H.

Leukemia. 2008 Sep;22(9):1728-36. doi: 10.1038/leu.2008.158. Epub 2008 Jun 12.


Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells.

Samudio I, Kurinna S, Ruvolo P, Korchin B, Kantarjian H, Beran M, Dunner K Jr, Kondo S, Andreeff M, Konopleva M.

Mol Cancer Ther. 2008 May;7(5):1130-9. doi: 10.1158/1535-7163.MCT-07-0553.


Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

Konopleva M, Watt J, Contractor R, Tsao T, Harris D, Estrov Z, Bornmann W, Kantarjian H, Viallet J, Samudio I, Andreeff M.

Cancer Res. 2008 May 1;68(9):3413-20. doi: 10.1158/0008-5472.CAN-07-1919.


Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells.

Kojima K, Konopleva M, Samudio IJ, Ruvolo V, Andreeff M.

Cancer Res. 2007 Apr 1;67(7):3210-9.


Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

Zeng Z, Sarbassov dos D, Samudio IJ, Yee KW, Munsell MF, Ellen Jackson C, Giles FJ, Sabatini DM, Andreeff M, Konopleva M.

Blood. 2007 Apr 15;109(8):3509-12. Epub 2006 Dec 19.


Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML.

Kojima K, Konopleva M, Samudio IJ, Schober WD, Bornmann WG, Andreeff M.

Cell Cycle. 2006 Dec;5(23):2778-86. Epub 2006 Dec 1.


Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias.

Zeng Z, Samudio IJ, Munsell M, An J, Huang Z, Estey E, Andreeff M, Konopleva M.

Mol Cancer Ther. 2006 Dec;5(12):3113-21.


Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.

Konopleva M, Contractor R, Tsao T, Samudio I, Ruvolo PP, Kitada S, Deng X, Zhai D, Shi YX, Sneed T, Verhaegen M, Soengas M, Ruvolo VR, McQueen T, Schober WD, Watt JC, Jiffar T, Ling X, Marini FC, Harris D, Dietrich M, Estrov Z, McCubrey J, May WS, Reed JC, Andreeff M.

Cancer Cell. 2006 Nov;10(5):375-88.


Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.

Zeng Z, Samudio IJ, Zhang W, Estrov Z, Pelicano H, Harris D, Frolova O, Hail N Jr, Chen W, Kornblau SM, Huang P, Lu Y, Mills GB, Andreeff M, Konopleva M.

Cancer Res. 2006 Apr 1;66(7):3737-46.


A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis.

Samudio I, Konopleva M, Pelicano H, Huang P, Frolova O, Bornmann W, Ying Y, Evans R, Contractor R, Andreeff M.

Mol Pharmacol. 2006 Apr;69(4):1182-93. Epub 2006 Jan 12.


3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5.

Abdelrahim M, Newman K, Vanderlaag K, Samudio I, Safe S.

Carcinogenesis. 2006 Apr;27(4):717-28. Epub 2005 Dec 6.


2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer.

Samudio I, Konopleva M, Hail N Jr, Shi YX, McQueen T, Hsu T, Evans R, Honda T, Gribble GW, Sporn M, Gilbert HF, Safe S, Andreeff M.

J Biol Chem. 2005 Oct 28;280(43):36273-82. Epub 2005 Aug 23.

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